Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | glutathione reductase | 0.0052 | 0 | 0.5 |
Brugia malayi | glutaminase DH11.1 | 0.028 | 0.4033 | 0.5194 |
Echinococcus multilocularis | geminin | 0.0186 | 0.237 | 0.844 |
Wolbachia endosymbiont of Brugia malayi | O-methyltransferase | 0.0064 | 0.0216 | 0.5 |
Trichomonas vaginalis | glutaminase, putative | 0.028 | 0.4033 | 1 |
Mycobacterium tuberculosis | Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) | 0.0491 | 0.7765 | 0.8757 |
Brugia malayi | Ribonuclease 2-5A family protein | 0.0211 | 0.2809 | 0.3617 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0132 | 0.1409 | 0.1589 |
Loa Loa (eye worm) | glutaminase | 0.028 | 0.4033 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0211 | 0.2809 | 0.5 |
Brugia malayi | O-methyltransferase family protein | 0.0064 | 0.0216 | 0.0278 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0052 | 0 | 0.5 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0052 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0118 | 0.1175 | 0.1326 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0118 | 0.1175 | 0.1326 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0216 | 0.0535 |
Mycobacterium tuberculosis | Probable reductase | 0.0118 | 0.1175 | 0.1326 |
Schistosoma mansoni | hypothetical protein | 0.0186 | 0.237 | 0.5645 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0132 | 0.1409 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0186 | 0.237 | 0.5645 |
Entamoeba histolytica | protein kinase, putative | 0.0211 | 0.2809 | 0.5 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0118 | 0.1175 | 0.8043 |
Trypanosoma brucei | trypanothione reductase | 0.0052 | 0 | 0.5 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0118 | 0.1175 | 0.1326 |
Leishmania major | trypanothione reductase | 0.0052 | 0 | 0.5 |
Loa Loa (eye worm) | O-methyltransferase | 0.0064 | 0.0216 | 0.0535 |
Mycobacterium tuberculosis | Probable methyltransferase | 0.0064 | 0.0216 | 0.0243 |
Schistosoma mansoni | glutaminase | 0.028 | 0.4033 | 1 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0132 | 0.1409 | 0.1589 |
Brugia malayi | O-methyltransferase family protein | 0.0064 | 0.0216 | 0.0278 |
Loa Loa (eye worm) | IRE protein kinase | 0.0211 | 0.2809 | 0.6964 |
Onchocerca volvulus | 0.0064 | 0.0216 | 0.5 | |
Brugia malayi | O-methyltransferase family protein | 0.0064 | 0.0216 | 0.0278 |
Echinococcus multilocularis | serine:threonine protein kinase:endoribonuclease | 0.0211 | 0.2809 | 1 |
Loa Loa (eye worm) | glutaminase 2 | 0.028 | 0.4033 | 1 |
Onchocerca volvulus | 0.0064 | 0.0216 | 0.5 | |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0132 | 0.1409 | 0.1589 |
Mycobacterium tuberculosis | Probable catechol-O-methyltransferase | 0.0554 | 0.8867 | 1 |
Brugia malayi | O-methyltransferase | 0.0064 | 0.0216 | 0.0278 |
Mycobacterium ulcerans | L-lysine aminotransferase | 0.0491 | 0.7765 | 0.7715 |
Plasmodium vivax | glutathione reductase, putative | 0.0052 | 0 | 0.5 |
Toxoplasma gondii | thioredoxin reductase | 0.0052 | 0 | 0.5 |
Brugia malayi | 4-aminobutyrate aminotransferase, mitochondrial precursor | 0.0491 | 0.7765 | 1 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0118 | 0.1175 | 0.1326 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0118 | 0.1175 | 0.1326 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0108 | 0.0993 | 0.2036 |
Mycobacterium ulcerans | glutaminase | 0.028 | 0.4033 | 0.3902 |
Plasmodium falciparum | thioredoxin reductase | 0.0052 | 0 | 0.5 |
Echinococcus granulosus | geminin | 0.0186 | 0.237 | 0.844 |
Echinococcus granulosus | serine:threonine protein kinase:endoribonuclease | 0.0211 | 0.2809 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 28 uM | Inhibition of recombinant HIV1 integrase strand transfer activity in prescence of magnesium | ChEMBL. | 18095643 |
IC50 (binding) | = 28 uM | Inhibition of recombinant HIV1 integrase strand transfer activity in prescence of magnesium | ChEMBL. | 18095643 |
IC50 (binding) | > 333 uM | Inhibition of recombinant HIV1 integrase-mediated 3'-processing activity in prescence of magnesium | ChEMBL. | 18095643 |
IC50 (binding) | > 333 uM | Inhibition of recombinant HIV1 integrase-mediated 3'-processing activity in prescence of magnesium | ChEMBL. | 18095643 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.