Detailed information for compound 502303

Basic information

Technical information
  • TDR Targets ID: 502303
  • Name: 4-[2-[bis(4-fluorophenyl)methoxy]ethyl]-1-[[( 1S,2S)-2-phenylcyclopropyl]methyl]piperidine
  • MW: 461.586 | Formula: C30H33F2NO
  • H donors: 0 H acceptors: 0 LogP: 6.75 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)C(c1ccc(cc1)F)OCCC1CCN(CC1)C[C@H]1C[C@@H]1c1ccccc1
  • InChi: 1S/C30H33F2NO/c31-27-10-6-24(7-11-27)30(25-8-12-28(32)13-9-25)34-19-16-22-14-17-33(18-15-22)21-26-20-29(26)23-4-2-1-3-5-23/h1-13,22,26,29-30H,14-21H2/t26-,29-/m1/s1
  • InChiKey: OKMFPHWGPZHZKX-GGXMVOPNSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Dopamine transporter Starlite/ChEMBL References
Rattus norvegicus Serotonin transporter Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Onchocerca volvulus Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Brugia malayi Sodium:neurotransmitter symporter family protein Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Treponema pallidum sodium- and chloride- dependent transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus multilocularis serotonin transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma mansoni sodium/chloride dependent transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum ko:K05336 solute carrier family 6 (neurotransmitter transporter), invertebrate, putative Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus granulosus serotonin transporter Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) solute carrier family 6 member 4 Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) norepinephrine transporter Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) serotonin transporter b Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma mansoni norepinephrine/norepinephrine transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent noradrenaline transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum IPR000175,Sodium:neurotransmitter symporter,domain-containing Get druggable targets OG5_128364 All targets in OG5_128364
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus Serotonin transporter   630 aa 611 aa 26.4 %
Drosophila melanogaster CG13796 gene product from transcript CG13796-RD Serotonin transporter   630 aa 638 aa 25.1 %
Drosophila melanogaster CG1698 gene product from transcript CG1698-RA Serotonin transporter   630 aa 585 aa 34.2 %
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein Serotonin transporter   630 aa 582 aa 35.2 %
Plasmodium knowlesi transporter, putative Serotonin transporter   630 aa 514 aa 20.2 %
Onchocerca volvulus High affinity copper uptake protein 1 homolog Serotonin transporter   630 aa 629 aa 47.1 %
Brugia malayi Sodium:neurotransmitter symporter family protein Serotonin transporter   630 aa 576 aa 30.9 %
Schistosoma japonicum ko:K05046 solute carrier family 6 (neurotransmitter transporter, GABA), member, putative Serotonin transporter   630 aa 581 aa 40.1 %
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein Serotonin transporter   630 aa 576 aa 31.8 %
Echinococcus multilocularis sodium and chloride dependent glycine Serotonin transporter   630 aa 617 aa 39.4 %
Echinococcus granulosus sodium and chloride dependent glycine Serotonin transporter   630 aa 617 aa 39.4 %
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter Dopamine transporter   619 aa 604 aa 37.9 %
Toxoplasma gondii Sodium:neurotransmitter symporter family protein Serotonin transporter   630 aa 509 aa 28.3 %
Plasmodium vivax hypothetical protein, conserved Serotonin transporter   630 aa 528 aa 21.2 %
Schistosoma mansoni sodium/chloride dependent transporter Serotonin transporter   630 aa 605 aa 37.7 %
Schistosoma japonicum ko:K05042 solute carrier family 6 (neurotransmitter transporter, glycine),, putative Serotonin transporter   630 aa 520 aa 36.2 %
Neospora caninum sodium-dependent transporter, putative Dopamine transporter   619 aa 498 aa 32.3 %
Onchocerca volvulus Transmembrane protein 120 homolog Serotonin transporter   630 aa 571 aa 31.2 %
Schistosoma mansoni sodium/chloride dependent transporter Serotonin transporter   630 aa 552 aa 41.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum transporter, putative 0.0031 0.0073 0.0599
Loa Loa (eye worm) GMP reductase 0.0067 0.0322 0.0342
Toxoplasma gondii IMP dehydrogenas 0.0161 0.0972 0.209
Toxoplasma gondii hypothetical protein 0.0083 0.043 0.0926
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.006 0.0273 0.0588
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.0327 0.2114 1
Trypanosoma cruzi GMP reductase 0.0161 0.0972 0.209
Onchocerca volvulus 0.0031 0.0073 0.0277
Leishmania major eukaryotic translation initiation factor, putative 0.0083 0.043 0.0926
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.006 0.0273 0.0273
Trypanosoma brucei telomerase reverse transcriptase 0.0087 0.0459 0.0988
Mycobacterium ulcerans two component transcriptional regulatory protein TcrX 0.0031 0.0076 0.0438
Trypanosoma cruzi Eukaryotic translation initiation factor 4E type 5, putative 0.0083 0.043 0.0926
Loa Loa (eye worm) IMP dehydrogenase 1 0.0161 0.0972 0.1033
Mycobacterium tuberculosis Two component transcriptional regulator TrcR 0.0031 0.0076 0.0555
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.006 0.0273 0.0588
Schistosoma mansoni phosphoglucomutase 0.0023 0.0015 0.0015
Trypanosoma brucei Eukaryotic translation initiation factor 4E-4 0.0083 0.043 0.0926
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0073 0.0413
Mycobacterium ulcerans two component response transcriptional regulatory protein MprA 0.0031 0.0076 0.0438
Mycobacterium tuberculosis Two component DNA binding transcriptional regulatory protein TcrA 0.0031 0.0076 0.0555
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0024 0.0051
Mycobacterium tuberculosis Probable pyrimidine operon regulatory protein PyrR 0.0046 0.0179 0.164
Plasmodium falciparum hypoxanthine-guanine phosphoribosyltransferase 0.0198 0.1225 1
Echinococcus multilocularis ribonuclease H1 0.0023 0.0015 0.0033
Chlamydia trachomatis two component regulatory system response regulator/ATPase 0.0031 0.0076 1
Mycobacterium tuberculosis Two component sensory transduction protein RegX3 (transcriptional regulatory protein) (probably LuxR-family) 0.0031 0.0076 0.0555
Mycobacterium ulcerans two component transcriptional regulatory protein DevR 0.0031 0.0076 0.0438
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.000000000063953 0.0000000001376
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.006 0.0273 0.0588
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0694 0.4648 1
Trypanosoma cruzi eukaryotic translation initiation factor 4E (eIF4E) interacting protein, putative 0.0083 0.043 0.0926
Trypanosoma cruzi hypoxanthine-guanine phosphoribosyltransferase, putative 0.0198 0.1225 0.2635
Schistosoma mansoni sodium/chloride dependent transporter 0.0031 0.0073 0.0073
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0152 0.0908 0.1953
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.0085 0.0443 0.4427
Schistosoma mansoni uracil phosphoribosyltransferase 0.0046 0.0179 0.0179
Plasmodium falciparum cGMP-specific phosphodiesterase 0.006 0.0273 0.2232
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0273 0.0588
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.006 0.0273 0.0291
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0273 0.0588
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.006 0.0273 0.0588
Trichomonas vaginalis Ribose-phosphate pyrophosphokinase, putative 0.0046 0.0179 0.0386
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0304 0.0304
Loa Loa (eye worm) hypothetical protein 0.025 0.1589 0.1688
Mycobacterium ulcerans two component sensory transduction protein RegX3 0.0031 0.0076 0.0438
Loa Loa (eye worm) hypothetical protein 0.0031 0.0073 0.0078
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0182 0.1119 0.119
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.006 0.0273 0.0588
Plasmodium vivax phosphodiesterase gamma, putative 0.006 0.0273 0.2077
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0064 0.0304 0.0653
Loa Loa (eye worm) hypothetical protein 0.0031 0.0073 0.0078
Mycobacterium tuberculosis Probable orotidine 5'-phosphate decarboxylase PyrF (OMP decarboxylase) (ompdecase) 0.005 0.0207 0.1931
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0083 0.043 0.0926
Mycobacterium tuberculosis Probable transcriptional regulatory protein KdpE 0.0031 0.0076 0.0555
Trypanosoma cruzi Adenine phosphoribosyltransferase, putative 0.0046 0.0179 0.0386
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.006 0.0273 0.0273
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-4 0.0083 0.043 0.0926
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.006 0.0273 0.0588
Mycobacterium leprae Probable hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (IMP pho 0.0151 0.0905 0.9301
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.006 0.0273 0.0291
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.006 0.0273 0.0588
Onchocerca volvulus 0.0198 0.1225 0.5763
Brugia malayi Eukaryotic translation initiation factor 4E type 3, putative 0.0083 0.043 0.0457
Mycobacterium ulcerans hypoxanthine-guanine phosphoribosyltransferase Hpt 0.0198 0.1225 1
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0031 0.0073 0.0073
Plasmodium falciparum telomerase reverse transcriptase 0.0087 0.0459 0.3751
Brugia malayi Phosphoribosyl transferase domain containing protein 0.0198 0.1225 0.1302
Mycobacterium tuberculosis Mycobacterial persistence regulator MRPA (two component response transcriptional regulatory protein) 0.0031 0.0076 0.0555
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0083 0.043 0.0926
Trypanosoma cruzi orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative 0.016 0.0967 0.2081
Trypanosoma cruzi hypothetical protein, conserved 0.006 0.0273 0.0588
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.006 0.0273 0.0273
Brugia malayi RNase H family protein 0.0023 0.0015 0.0016
Trypanosoma brucei Eukaryotic translation initiation factor 4E type 5 0.0083 0.043 0.0926
Brugia malayi eukaryotic translation initiation factor 4E-1 0.0083 0.043 0.0457
Plasmodium vivax telomerase reverse transcriptase, putative 0.0087 0.0459 0.3627
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.006 0.0273 0.0588
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.0161 0.0972 1
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.006 0.0273 0.2232
Trypanosoma cruzi hypothetical protein, conserved 0.006 0.0273 0.0588
Brugia malayi hypothetical protein 0.025 0.1589 0.1688
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.006 0.0273 0.0588
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0152 0.0908 0.0965
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0087 0.0459 0.0988
Schistosoma mansoni Adenine phosphoribosyltransferase 0.0046 0.0179 0.0179
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.006 0.0273 0.2077
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0031 0.0073 0.0158
Toxoplasma gondii eukaryotic initiation factor-4E, putative 0.0694 0.4648 1
Echinococcus multilocularis hypoxanthine guanine phosphoribosyltransferase 0.0198 0.1225 0.2635
Giardia lamblia Hypothetical protein 0.006 0.0273 0.2232
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.006 0.0273 0.0588
Trichomonas vaginalis ribonuclease H1, putative 0.0023 0.0015 0.0033
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.006 0.0273 0.0588
Trypanosoma brucei Adenine phosphoribosyltransferase, putative 0.0046 0.0179 0.0386
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0024 0.0024 0.0077
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.006 0.0273 0.0588
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.006 0.0273 0.0588
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0694 0.4648 1
Giardia lamblia hypothetical protein 0.006 0.0273 0.2232
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0304 0.2329
Toxoplasma gondii RNA-directed DNA polymerase 0.0087 0.0459 0.0988
Echinococcus multilocularis expressed protein 0.0395 0.2589 0.557
Trypanosoma brucei Eukaryotic translation initiation factor 4E-2 0.0083 0.043 0.0926
Brugia malayi RNase H family protein 0.0023 0.0015 0.0016
Leishmania major eukaryotic translation initiation factor eIF-4E, putative 0.0694 0.4648 1
Mycobacterium leprae Probable two-component system transcriptional regulator 0.0031 0.0076 0.0555
Brugia malayi RNase H family protein 0.0023 0.0015 0.0016
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.006 0.0273 0.0588
Loa Loa (eye worm) hypothetical protein 0.0031 0.0073 0.0078
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0083 0.043 0.0926
Toxoplasma gondii aldehyde dehydrogenase 0.0064 0.0304 0.0653
Trichomonas vaginalis ribose-phosphate pyrophosphokinase, putative 0.0046 0.0179 0.0386
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0273 0.0588
Echinococcus granulosus ribonuclease H1 0.0023 0.0015 0.0033
Leishmania major telomerase reverse transcriptase, putative 0.0087 0.0459 0.0988
Wolbachia endosymbiont of Brugia malayi orotate phosphoribosyltransferase 0.0097 0.0526 0.5345
Loa Loa (eye worm) solute carrier family 6 member 4 0.0182 0.1119 0.119
Echinococcus granulosus uridine 5' monophosphate synthase 0.016 0.0967 0.2081
Onchocerca volvulus 0.0051 0.0212 0.0938
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0024 0.0024 0.0051
Plasmodium falciparum eukaryotic translation initiation factor 4E, putative 0.0083 0.043 0.3514
Loa Loa (eye worm) hypothetical protein 0.006 0.0273 0.0291
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.006 0.0273 0.0588
Treponema pallidum protein-glutamate methylesterase (cheB) 0.0031 0.0076 0.0554
Trypanosoma cruzi hypoxanthine-guanine phosphoribosyltransferase, putative 0.0198 0.1225 0.2635
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0161 0.0972 1
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0083 0.043 0.0926
Trypanosoma brucei Eukaryotic translation initiation factor 4E-3 0.0083 0.043 0.0926
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.0161 0.0972 0.209
Onchocerca volvulus 0.0085 0.0444 0.2041
Mycobacterium tuberculosis Conserved hypothetical protein 0.0155 0.093 0.9561
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.006 0.0273 0.2077
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.006 0.0273 0.0291
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0083 0.043 0.0926
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0273 0.0588
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.006 0.0273 0.0588
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0067 0.0322 0.0342
Schistosoma mansoni phosphoglucomutase 0.0023 0.0015 0.0015
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.006 0.0273 0.0588
Mycobacterium tuberculosis Probable two component transcriptional regulatory protein TcrX 0.0031 0.0076 0.0555
Echinococcus multilocularis eukaryotic translation initiation factor 4E 0.0694 0.4648 1
Leishmania major adenine phosphoribosyltransferase 0.0046 0.0179 0.0386
Treponema pallidum chemotaxis response regulator (cheY) 0.0031 0.0076 0.0554
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0031 0.0073 0.0158
Mycobacterium tuberculosis Two component sensory transduction transcriptional regulatory protein MtrA 0.0031 0.0076 0.0555
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0031 0.0076 0.0639
Leishmania major hypoxanthine-guanine phosphoribosyltransferase 0.0198 0.1225 0.2635
Onchocerca volvulus 0.0031 0.0073 0.0277
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0085 0.0443 0.4427
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0031 0.0073 0.0073
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.006 0.0273 0.0588
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.0161 0.0972 0.1033
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0083 0.043 0.0926
Trichomonas vaginalis receptor histidine kinase, putative 0.0031 0.0076 0.0164
Toxoplasma gondii eukaryotic initiation factor-4E, putative 0.0083 0.043 0.0926
Wolbachia endosymbiont of Brugia malayi response regulator PleD 0.0031 0.0076 0.0639
Echinococcus granulosus eukaryotic translation initiation factor 4E 0.0694 0.4648 1
Plasmodium falciparum phosphodiesterase gamma, putative 0.006 0.0273 0.2232
Plasmodium vivax amine transporter, putative 0.0031 0.0073 0.0413
Schistosoma mansoni hypoxanthine-guanine phosphoribosyltransferase 0.0198 0.1225 0.1225
Echinococcus multilocularis sodium and chloride dependent glycine 0.0031 0.0073 0.0158
Schistosoma mansoni Adenine phosphoribosyltransferase 0.0046 0.0179 0.0179
Trypanosoma cruzi ribonuclease H1, putative 0.0023 0.0015 0.0033
Entamoeba histolytica translation initiation factor 4e, putative 0.0083 0.043 0.0926
Echinococcus granulosus sodium and chloride dependent glycine 0.0031 0.0073 0.0158
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.006 0.0273 0.0588
Trypanosoma cruzi Adenine phosphoribosyltransferase, putative 0.0046 0.0179 0.0386
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0083 0.043 0.0926
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.006 0.0273 0.0588
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0273 0.0588
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0152 0.0908 0.1953
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0152 0.0905 0.7341
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.006 0.0273 0.0273
Echinococcus multilocularis adenine phosphoribosyltransferase 0.0046 0.0179 0.0386
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0077 0.0388 0.303
Trypanosoma brucei cAMP-specific phosphodiesterase 0.006 0.0273 0.0588
Trypanosoma cruzi hypothetical protein, conserved 0.006 0.0273 0.0588
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0083 0.043 0.0926
Brugia malayi translation initiation factor 4E 0.0694 0.4648 0.494
Wolbachia endosymbiont of Brugia malayi response regulator 0.0031 0.0076 0.0639
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.0161 0.0972 0.789
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.006 0.0273 0.0588
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.006 0.0273 0.0588
Trichomonas vaginalis hypoxanthine-guanine phosphoribosyltransferase, putative 0.0198 0.1225 0.2635
Schistosoma mansoni hypothetical protein 0.0374 0.2438 0.2438
Echinococcus granulosus ras gtpase 0.0148 0.0879 0.1891
Trypanosoma cruzi orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative 0.0114 0.0647 0.1393
Leishmania major guanosine monophosphate reductase 0.0161 0.0972 0.209
Schistosoma mansoni phosphoglucomutase 0.0023 0.0015 0.0015
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.006 0.0273 0.0273
Leishmania major orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative,OMPDCase-OPRTase, putative 0.016 0.0967 0.2081
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0031 0.0073 0.0078
Echinococcus multilocularis sodium and chloride dependent glycine 0.0031 0.0073 0.0158
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0083 0.043 0.0926
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.006 0.0273 0.0588
Entamoeba histolytica hypothetical protein 0.0083 0.043 0.0926
Trichomonas vaginalis sensor histidine kinase, putative 0.0031 0.0076 0.0164
Brugia malayi hypothetical protein 0.0031 0.0073 0.0078
Onchocerca volvulus Putative GMP reductase 0.0067 0.0322 0.146
Mycobacterium leprae PROBABLE OROTATE PHOSPHORIBOSYLTRANSFERASE PYRE (OPRT) (OPRTASE) 0.0097 0.0526 0.5304
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.006 0.0273 0.0273
Schistosoma mansoni cell polarity protein 0.0148 0.0879 0.0879
Trypanosoma brucei hypothetical protein, conserved 0.006 0.0273 0.0588
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0064 0.0304 0.0653
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0152 0.0908 0.1953
Plasmodium vivax hypothetical protein, conserved 0.0083 0.043 0.3385
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0083 0.043 0.0926
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.0161 0.0972 0.209
Trypanosoma brucei hypoxanthine-guanine phosphoribosyltransferase, putative 0.0198 0.1225 0.2635
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0024 0.0024 0.0051
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.006 0.0273 0.0588
Trypanosoma cruzi Adenine phosphoribosyltransferase, putative 0.0046 0.0179 0.0386
Trichomonas vaginalis eukaryotic translation initiation factor 4E type, putative 0.0083 0.043 0.0926
Loa Loa (eye worm) orotate phosphoribosyltransferase 0.016 0.0967 0.1028
Treponema pallidum phosphoribosylpyrophosphate synthetase 0.0046 0.0179 0.1485
Echinococcus granulosus L aminoadipate semialdehyde 0.0085 0.0444 0.0954
Treponema pallidum sodium- and chloride- dependent transporter 0.0182 0.1119 1
Loa Loa (eye worm) hypothetical protein 0.0182 0.1119 0.119
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0273 0.0588
Entamoeba histolytica hypothetical protein 0.0083 0.043 0.0926
Leishmania major hypothetical protein, conserved 0.0083 0.043 0.0926
Schistosoma mansoni sodium/chloride dependent transporter 0.0031 0.0073 0.0073
Schistosoma mansoni sodium-dependent amino acid transporter 0.0031 0.0073 0.0073
Mycobacterium tuberculosis Probable orotate phosphoribosyltransferase PyrE (OPRT) (oprtase) 0.0097 0.0526 0.5304
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0024 0.0024 0.0089
Giardia lamblia Guanine phosphoribosyltransferase 0.0198 0.1225 1
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0031 0.0073 0.0158
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0024 0.0051
Trypanosoma brucei RNA helicase, putative 0.0374 0.2438 0.5246
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0031 0.0073 0.0158
Loa Loa (eye worm) hypothetical protein 0.0031 0.0073 0.0078
Brugia malayi GTP-binding protein, identical 0.0148 0.0879 0.0934
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0152 0.0908 0.1953
Mycobacterium tuberculosis Conserved hypothetical protein 0.0155 0.093 0.9561
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0064 0.0304 0.0653
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.006 0.0273 0.0588
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0031 0.0073 0.0078
Trichomonas vaginalis receptor histidine kinase, putative 0.0031 0.0076 0.0164
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0031 0.0073 0.0158
Brugia malayi Adenine phosphoribosyltransferase 0.0046 0.0179 0.019
Loa Loa (eye worm) hypothetical protein 0.1383 0.9409 1
Plasmodium vivax orotate phosphoribosyltransferase, putative 0.0097 0.0526 0.4185
Schistosoma mansoni sodium/chloride dependent transporter 0.0182 0.1119 0.1119
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0083 0.043 0.0926
Trypanosoma brucei ingi protein (ORF1) 0.0031 0.0074 0.0159
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.006 0.0273 0.0588
Echinococcus multilocularis uridine 5' monophosphate synthase 0.016 0.0967 0.2081
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.006 0.0273 0.0588
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0273 0.0588
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.006 0.0273 0.0588
Brugia malayi GMP reductase 0.0067 0.0322 0.0342
Mycobacterium leprae AMIDOPHOSPHORIBOSYLTRANSFERASE PURF (GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE) (ATASE) (GPATASE) 0.0046 0.0179 0.164
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.006 0.0273 0.0588
Echinococcus multilocularis survival motor neuron protein 1 0.025 0.1589 0.3418
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.006 0.0273 0.0291
Trichomonas vaginalis eukaryotic translation initiation factor 4E type, putative 0.0083 0.043 0.0926
Loa Loa (eye worm) translation initiation factor 4E 0.0694 0.4648 0.494
Mycobacterium ulcerans two component sensory transduction transcriptional regulatory protein MtrA 0.0031 0.0076 0.0438
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0031 0.0074 0.0159
Trypanosoma cruzi ribonuclease H1, putative 0.0023 0.0015 0.0033
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.006 0.0273 0.0588
Giardia lamblia hypothetical protein 0.0083 0.043 0.3514
Toxoplasma gondii hypothetical protein 0.0031 0.0073 0.0158
Plasmodium falciparum orotidine 5'-phosphate decarboxylase 0.0114 0.0647 0.5286
Mycobacterium ulcerans two component regulator receiver domain-containing protein 0.0031 0.0076 0.0438
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0085 0.0444 0.0444
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0161 0.0972 0.209
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0694 0.4648 1
Mycobacterium tuberculosis Possible nitrate/nitrite response transcriptional regulatory protein NarL 0.0031 0.0076 0.0555
Mycobacterium ulcerans orotidine 5'-phosphate decarboxylase 0.0114 0.0647 0.5192
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0182 0.1119 0.1119
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.006 0.0273 0.0588
Toxoplasma gondii hypoxanthine-xanthine-guanine phosphoribosyl transferase HXGPRT 0.0198 0.1225 0.2635
Plasmodium falciparum amino acid transporter, putative 0.0031 0.0073 0.0599
Mycobacterium ulcerans two-component system transcriptional regulator 0.0031 0.0076 0.0438
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.006 0.0273 0.0273
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0273 0.0588
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0152 0.0908 0.1953
Mycobacterium tuberculosis Hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (imp pyrophosphor 0.0151 0.0905 0.9301
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0273 0.0588
Mycobacterium leprae conserved hypothetical protein 0.0155 0.093 0.9561
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0161 0.0972 0.209
Loa Loa (eye worm) adenine phosphoribosyltransferase 0.0046 0.0179 0.019
Treponema pallidum hypothetical protein 0.0046 0.0179 0.1485
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0031 0.0073 0.0073
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0064 0.0304 0.2952
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.006 0.0273 0.0588
Brugia malayi Telomerase reverse transcriptase 0.0231 0.1456 0.1547
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0031 0.0073 0.0158
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.006 0.0273 0.0588
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0152 0.0908 0.1953
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0212 0.0226
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0273 0.0588
Leishmania major eukaryotic translation initiation factor-like protein 0.0694 0.4648 1
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-1 0.0694 0.4648 1
Onchocerca volvulus Adenine phosphoribosyltransferase homolog 0.0046 0.0179 0.0781
Mycobacterium ulcerans two component system response phosphate regulon transcriptional regulator, PhoP 0.0031 0.0076 0.0438
Loa Loa (eye worm) eukaryotic translation initiation factor 4E type 3 0.0083 0.043 0.0457
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.006 0.0273 0.0588
Onchocerca volvulus 0.0182 0.1119 0.526
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.006 0.0273 0.0588
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.0161 0.0972 0.209
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.006 0.0273 0.0588
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0304 0.2329
Echinococcus multilocularis serotonin transporter 0.0182 0.1119 0.2408
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0031 0.0073 0.0078
Echinococcus multilocularis hypoxanthine guanine phosphoribosyltransferase 0.0198 0.1225 0.2635
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0152 0.0908 0.1953
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0304 0.2329
Loa Loa (eye worm) hypothetical protein 0.0182 0.1119 0.119
Leishmania major hypothetical protein, conserved 0.0083 0.043 0.0926
Trypanosoma brucei cAMP-specific phosphodiesterase 0.006 0.0273 0.0588
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.006 0.0273 0.0588
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0273 0.0588
Echinococcus granulosus adenine phosphoribosyltransferase 0.0046 0.0179 0.0386
Mycobacterium tuberculosis Possible two component system response transcriptional positive regulator PhoP 0.0031 0.0076 0.0555
Loa Loa (eye worm) norepinephrine transporter 0.0182 0.1119 0.119
Mycobacterium tuberculosis Conserved hypothetical protein 0.0046 0.0179 0.164
Schistosoma mansoni eukaryotic translation initiation factor 4e 0.0694 0.4648 0.4648
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0273 0.0588
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0161 0.0972 0.209
Trypanosoma brucei unspecified product 0.0031 0.0074 0.0159
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.006 0.0273 0.0588
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0152 0.0908 0.1953
Trypanosoma cruzi hypoxanthine-guanine phosphoribosyltransferase, putative 0.0198 0.1225 0.2635
Giardia lamblia Ribonuclease H 0.0023 0.0015 0.0125
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0031 0.0073 0.0078
Echinococcus granulosus serotonin transporter 0.0182 0.1119 0.2408
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0091 0.049 0.1055
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.006 0.0273 0.0588
Leishmania major inosine-5-monophosphate dehydrogenase 0.0161 0.0972 0.209
Mycobacterium leprae conserved hypothetical protein 0.0155 0.093 0.9561
Schistosoma mansoni cell polarity protein 0.0148 0.0879 0.0879
Loa Loa (eye worm) hypothetical protein 0.1324 0.8996 0.956
Schistosoma mansoni hypoxanthine-guanine phosphoribosyltransferase 0.0198 0.1225 0.1225
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.006 0.0273 0.0588
Trypanosoma cruzi hypothetical protein, conserved 0.006 0.0273 0.0588
Leishmania major hypothetical protein, conserved 0.006 0.0273 0.0588
Trichomonas vaginalis sensor histidine kinase, putative 0.0031 0.0076 0.0164
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0031 0.0073 0.0158
Trypanosoma cruzi eukaryotic translation initiation factor 4E (eIF4E) interacting protein, putative 0.0083 0.043 0.0926
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0087 0.0459 0.0988
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0024 0.0195
Onchocerca volvulus 0.0031 0.0073 0.0277
Plasmodium falciparum orotate phosphoribosyltransferase 0.0097 0.0526 0.4298
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0273 0.0588
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0273 0.0588
Brugia malayi GTP-binding protein 0.0148 0.0879 0.0934
Loa Loa (eye worm) PDE1B protein 0.0152 0.0908 0.0965
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.006 0.0273 0.0588
Loa Loa (eye worm) hypothetical protein 0.006 0.0273 0.0291
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.0161 0.0972 0.0972
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.006 0.0273 0.0291
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.0161 0.0972 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0273 0.0588
Mycobacterium tuberculosis Adenine phosphoribosyltransferase Apt (APRT) (AMP diphosphorylase) (AMP pyrophosphorylase) (transphosphoribosidase) 0.0046 0.0179 0.164
Loa Loa (eye worm) hypothetical protein 0.0031 0.0073 0.0078
Mycobacterium leprae TWO COMPONENT SENSORY TRANSDUCTION PROTEIN REGX3 (TRANSCRIPTIONAL REGULATORY PROTEIN) (PROBABLY LUXR-FAMILY) 0.0031 0.0076 0.0555
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.0152 0.0905 0.7392
Loa Loa (eye worm) serotonin transporter b 0.0182 0.1119 0.119
Mycobacterium ulcerans two component response transcriptional regulatory protein PrrA 0.0031 0.0076 0.0438
Schistosoma mansoni survival motor neuron protein 0.0051 0.0212 0.0212
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0694 0.4648 1
Plasmodium falciparum phosphodiesterase delta, putative 0.006 0.0273 0.2232
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-3 0.0083 0.043 0.0926
Trypanosoma brucei Eukaryotic translation initiation factor 4E-1 0.0694 0.4648 1
Entamoeba histolytica hypothetical protein 0.0024 0.0024 0.0051
Treponema pallidum adenine phosphoribosyltransferase 0.0046 0.0179 0.1485
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.043 0.0926
Trichomonas vaginalis eukaryotic translation initiation factor 4E type, putative 0.0083 0.043 0.0926
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.006 0.0273 0.0588
Entamoeba histolytica eukaryotic initiation factor 4E, putative 0.0083 0.043 0.0926
Schistosoma mansoni hypoxanthine-guanine phosphoribosyltransferase 0.0046 0.0179 0.0179
Mycobacterium tuberculosis Conserved protein 0.0046 0.0179 0.164
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.006 0.0273 0.0588
Mycobacterium ulcerans nitrate/nitrite response regulator protein NarL 0.0031 0.0076 0.0438
Leishmania major cAMP-specific phosphodiesterase, putative 0.0289 0.1853 0.3988
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.006 0.0273 0.0588
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0031 0.0073 0.0158
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0152 0.0908 0.0908
Plasmodium falciparum cGMP-specific phosphodiesterase 0.006 0.0273 0.2232
Mycobacterium ulcerans two component transcriptional regulator TrcR 0.0031 0.0076 0.0438
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.006 0.0273 0.0588
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.006 0.0273 0.0588
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0031 0.0073 0.0073
Loa Loa (eye worm) eukaryotic translation initiation factor 4E-1 0.0083 0.043 0.0457
Schistosoma mansoni hypothetical protein 0.0051 0.0212 0.0212
Loa Loa (eye worm) hypothetical protein 0.0085 0.0444 0.0471
Trypanosoma cruzi Eukaryotic translation initiation factor 4E type 5, putative 0.0083 0.043 0.0926
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.006 0.0273 0.0588
Mycobacterium leprae Probable orotidine 5'-phosphate decarboxylase PyrF (OMP decarboxylase) (OMPDCase) (OMPdecase) 0.0114 0.0647 0.6581
Plasmodium vivax hypoxanthine-guanine phosphoribosyltransferase, putative 0.0198 0.1225 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.006 0.0273 0.0588
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0031 0.0073 0.0078
Mycobacterium tuberculosis Amidophosphoribosyltransferase PurF (glutamine phosphoribosylpyrophosphate amidotransferase) (ATASE) (gpatase) 0.0046 0.0179 0.164
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0031 0.0076 0.0164
Plasmodium falciparum eukaryotic translation initiation factor 4E 0.0083 0.043 0.3514
Mycobacterium ulcerans bifunctional pyrimidine regulatory protein PyrR/uracil phosphoribosyltransferase 0.0046 0.0179 0.1294
Schistosoma mansoni hypoxanthine-guanine phosphoribosyltransferase 0.0046 0.0179 0.0179
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0152 0.0908 0.1953
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0694 0.4648 1
Brugia malayi orotate phosphoribosyltransferase family protein 0.016 0.0967 0.1028
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.006 0.0273 0.0588
Leishmania major hypothetical protein, conserved 0.006 0.0273 0.0588
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.006 0.0273 0.0588
Mycobacterium tuberculosis Two component response transcriptional regulatory protein PrrA 0.0031 0.0076 0.0555
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.1383 0.9409 1
Plasmodium vivax translation initiation factor 4E, putative 0.0083 0.043 0.3385
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.006 0.0273 0.0273
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-1 0.0694 0.4648 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.006 0.0273 0.0588
Mycobacterium ulcerans hypothetical protein 0.0031 0.0076 0.0438
Leishmania major ribonuclease H1, putative 0.0023 0.0015 0.0033
Entamoeba histolytica eukaryotic initiation factor 4E, putative 0.0083 0.043 0.0926
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0031 0.0076 0.0164
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.006 0.0273 0.0588
Mycobacterium tuberculosis Probable two-component system transcriptional regulator 0.0031 0.0076 0.0555
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.006 0.0273 0.0588
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0031 0.0073 0.0078
Trypanosoma cruzi GMP reductase 0.0161 0.0972 0.209
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.006 0.0273 0.0273
Schistosoma mansoni sensor histidine kinase/response regulator 0.0031 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0182 0.1119 0.119
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.006 0.0273 0.2232
Mycobacterium ulcerans two component transcriptional regulator 0.0031 0.0076 0.0438
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0152 0.0908 0.736
Onchocerca volvulus Putative eukaryotic translation initiation factor 4e 0.0083 0.043 0.1978
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0273 0.0588
Leishmania major xanthine phosphoribosyltransferase 0.0198 0.1225 0.2635
Toxoplasma gondii hypothetical protein 0.0031 0.0073 0.0158
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0289 0.1853 0.3988
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.0152 0.0905 0.7341
Leishmania major eukaryotic translation initiation factor-like 0.0694 0.4648 1
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0031 0.0073 0.0158
Echinococcus granulosus expressed protein 0.0395 0.2589 0.557
Schistosoma mansoni orotidine 5'-phosphate decarboxylase 0.016 0.0967 0.0967
Trypanosoma cruzi Adenine phosphoribosyltransferase, putative 0.0046 0.0179 0.0386
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0031 0.0073 0.0073
Mycobacterium ulcerans adenylylate/guanylate cyclase 0.0031 0.0076 0.0438
Echinococcus granulosus hypoxanthine guanine phosphoribosyltransferase 0.0198 0.1225 0.2635
Mycobacterium ulcerans amidophosphoribosyltransferase 0.0046 0.0179 0.1294
Echinococcus granulosus hypoxanthine guanine phosphoribosyltransferase 0.0198 0.1225 0.2635
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.006 0.0273 0.0273
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0273 0.0588
Echinococcus multilocularis ras gtpase 0.0148 0.0879 0.1891
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0031 0.0073 0.0073
Trichomonas vaginalis eukaryotic translation initiation factor 4E type, putative 0.0083 0.043 0.0926
Giardia lamblia Hypothetical protein 0.0083 0.043 0.3514
Toxoplasma gondii orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase 0.0114 0.0647 0.1393
Leishmania major eukaryotic translation initiation factor 4e, putative 0.0083 0.043 0.0926
Giardia lamblia Telomerase catalytic subunit 0.0087 0.0459 0.3751
Treponema pallidum response regulatory protein (atoC) 0.0031 0.0076 0.0554
Mycobacterium tuberculosis Conserved protein 0.0046 0.0179 0.164
Loa Loa (eye worm) hypothetical protein 0.0031 0.0073 0.0078
Loa Loa (eye worm) hypothetical protein 0.0031 0.0073 0.0078
Echinococcus granulosus eukaryotic translation initiation factor 4E type 0.0083 0.043 0.0926
Giardia lamblia Adenine phosphoribosyltransferase 0.0046 0.0179 0.1463
Trypanosoma brucei Adenine phosphoribosyltransferase, putative 0.0046 0.0179 0.0386
Wolbachia endosymbiont of Brugia malayi amidophosphoribosyltransferase 0.0046 0.0179 0.1714
Toxoplasma gondii ribonuclease HI protein 0.0023 0.0015 0.0033
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0273 0.0588
Echinococcus granulosus survival motor neuron protein 1 0.025 0.1589 0.3418
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0031 0.0073 0.0073
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.006 0.0273 0.0588
Mycobacterium leprae TWO COMPONENT RESPONSE TRANSCRIPTIONAL REGULATORY PROTEIN PRRA 0.0031 0.0076 0.0555
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0031 0.0073 0.0158
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.006 0.0273 0.0588
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.006 0.0273 0.0588
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.0077 0.0388 0.384
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.006 0.0273 0.0588
Trypanosoma cruzi hypothetical protein, conserved 0.006 0.0273 0.0588
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0289 0.1853 0.3988
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0304 0.0304
Mycobacterium ulcerans two component transcriptional regulator 0.0031 0.0076 0.0438
Trypanosoma brucei hypoxanthine-guanine phosphoribosyltransferase 0.0198 0.1225 0.2635
Mycobacterium ulcerans hypothetical protein 0.0046 0.0179 0.1294
Loa Loa (eye worm) hypothetical protein 0.006 0.0273 0.0291
Trypanosoma brucei hypothetical protein, conserved 0.0031 0.0074 0.0159
Trypanosoma cruzi orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative 0.016 0.0967 0.2081
Trypanosoma brucei orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative 0.016 0.0967 0.2081
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.006 0.0273 0.0588
Trypanosoma brucei GMP reductase 0.0161 0.0972 0.209
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.006 0.0273 0.2232
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.043 0.0926
Trypanosoma cruzi hypoxanthine-guanine phosphoribosyltransferase, putative 0.0198 0.1225 0.2635
Toxoplasma gondii orotate phosphoribosyltransferase 0.0097 0.0526 0.1133
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0031 0.0073 0.9423
Trypanosoma brucei hypoxanthine-guanine phosphoribosyltransferase 0.0198 0.1225 0.2635
Wolbachia endosymbiont of Brugia malayi orotidine-5'-phosphate decarboxylase 0.0064 0.03 0.298
Echinococcus granulosus sodium and chloride dependent glycine 0.0031 0.0073 0.0158
Trypanosoma brucei ribonuclease H1 0.0023 0.0015 0.0033
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0273 0.0588
Trypanosoma cruzi hypothetical protein, conserved 0.006 0.0273 0.0588
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.006 0.0273 0.0588
Plasmodium vivax orotidine 5'-phosphate decarboxylase, putative 0.0114 0.0647 0.5192
Trichomonas vaginalis eukaryotic translation initiation factor 4E type, putative 0.0083 0.043 0.0926
Trichomonas vaginalis hypothetical protein 0.0083 0.043 0.0926
Echinococcus multilocularis L aminoadipate semialdehyde 0.0085 0.0444 0.0954
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0031 0.0076 0.0164
Mycobacterium ulcerans orotate phosphoribosyltransferase 0.0097 0.0526 0.4185
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0031 0.0073 0.0073
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.043 0.0926
Trypanosoma brucei ingi protein (ORF1) 0.0031 0.0074 0.0159
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0152 0.0908 0.1953
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0031 0.0076 0.0164
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0273 0.0588
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0085 0.0444 0.0471
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0694 0.4648 1
Loa Loa (eye worm) GTP-binding protein 0.0148 0.0879 0.0934
Mycobacterium ulcerans adenine phosphoribosyltransferase 0.0046 0.0179 0.1294
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0067 0.0322 0.0342
Giardia lamblia Translation elongation factor 0.0083 0.043 0.3514
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-4 0.0083 0.043 0.0926
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0273 0.0588
Giardia lamblia Hypothetical protein 0.0083 0.043 0.3514

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 1.3 nM Displacement of [125I]RTI55 from DAT in rat brain synaptosomes ChEMBL. 17127069
Ki (binding) = 1.3 nM Displacement of [125I]RTI55 from DAT in rat brain synaptosomes ChEMBL. 17127069
Ki (binding) = 136 nM Displacement of [125I]RTI55 from SERT in rat brain synaptosomes ChEMBL. 17127069
Ki (binding) = 136 nM Displacement of [125I]RTI55 from SERT in rat brain synaptosomes ChEMBL. 17127069
Ratio pKi (binding) = 2.02 Selectivity for rat DAT over rat SERT ChEMBL. 17127069

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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