Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | 6-phosphogluconolactonase | 0.011 | 1 | 0.5 |
Echinococcus granulosus | 6 phosphogluconolactonase | 0.011 | 1 | 0.5 |
Schistosoma mansoni | 6-phosphogluconolactonase | 0.011 | 1 | 0.5 |
Trypanosoma brucei | 6-phosphogluconolactonase | 0.011 | 1 | 0.5 |
Mycobacterium leprae | Probable 6-phosphogluconolactonase DevB (6PGL) | 0.011 | 1 | 0.5 |
Mycobacterium ulcerans | 6-phosphogluconolactonase | 0.011 | 1 | 0.5 |
Leishmania major | 6-phosphogluconolactonase | 0.011 | 1 | 0.5 |
Echinococcus multilocularis | 6 phosphogluconolactonase | 0.011 | 1 | 0.5 |
Chlamydia trachomatis | 6-phosphogluconolactonase | 0.011 | 1 | 0.5 |
Loa Loa (eye worm) | 6-phosphogluconolactonase | 0.011 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable 6-phosphogluconolactonase DevB (6PGL) | 0.0078 | 0 | 0.5 |
Treponema pallidum | glucose-6-phosphate 1-dehydrogenase | 0.011 | 1 | 0.5 |
Trypanosoma cruzi | 6-phosphogluconolactonase, putative | 0.011 | 1 | 0.5 |
Trypanosoma cruzi | 6-phosphogluconolactonase, putative | 0.011 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
log(10^6/IC50) (binding) | = 2.86 | Inhibition of MMP1 (unknown origin) | ChEMBL. | 17590339 |
log(10^6/IC50) (binding) | = 4.41 | Inhibition of MMP9 (unknown origin) | ChEMBL. | 17590339 |
log(10^6/IC50) (binding) | = 5.15 | Inhibition of MMP13 (unknown origin) | ChEMBL. | 17590339 |
log(10^6/IC50) (binding) | = 2.86 | Inhibition of MMP1 (unknown origin) | ChEMBL. | 17590339 |
log(10^6/IC50) (binding) | = 4.41 | Inhibition of MMP9 (unknown origin) | ChEMBL. | 17590339 |
log(10^6/IC50) (binding) | = 5.15 | Inhibition of MMP13 (unknown origin) | ChEMBL. | 17590339 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.