Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Peroxisome proliferator-activated receptor alpha | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | IPR008946,Nuclear receptor, ligand-binding,domain-containing | Get druggable targets OG5_137778 | All targets in OG5_137778 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | Get druggable targets OG5_137778 | All targets in OG5_137778 |
Schistosoma japonicum | ko:K08701 nuclear receptor, subfamily 1, invertebrate, putative | Get druggable targets OG5_137778 | All targets in OG5_137778 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Peroxisome proliferator-activated receptor alpha | 468 aa | 376 aa | 27.9 % |
Echinococcus multilocularis | ecdysone induced protein 78C | Peroxisome proliferator-activated receptor alpha | 468 aa | 409 aa | 30.8 % |
Echinococcus granulosus | ecdysone induced protein 78C | Peroxisome proliferator-activated receptor alpha | 468 aa | 409 aa | 30.8 % |
Brugia malayi | Steroid receptor seven-up type 2 | Peroxisome proliferator-activated receptor alpha | 468 aa | 381 aa | 24.1 % |
Brugia malayi | ecdysteroid receptor | Peroxisome proliferator-activated receptor alpha | 468 aa | 375 aa | 25.1 % |
Schistosoma mansoni | retinoic acid receptor RXR | Peroxisome proliferator-activated receptor alpha | 468 aa | 398 aa | 28.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | zinc-containing alcohol dehydrogenase NAD dependent AdhB | 0.0462 | 1 | 1 |
Trichomonas vaginalis | alcohol dehydrogenase, putative | 0.0056 | 0.0481 | 0.5 |
Mycobacterium ulcerans | NADPH quinone oxidoreductase FadB4 | 0.0056 | 0.0481 | 0.0481 |
Mycobacterium tuberculosis | Probable zinc-type alcohol dehydrogenase (E subunit) AdhE1 | 0.0406 | 0.8678 | 0.8612 |
Mycobacterium ulcerans | Zn-dependent alcohol dehydrogenase, AdhX | 0.0056 | 0.0481 | 0.0481 |
Mycobacterium ulcerans | zinc-dependent alcohol dehydrogenase AdhE2 | 0.0462 | 1 | 1 |
Loa Loa (eye worm) | alcohol dehydrogenase class III | 0.0462 | 1 | 1 |
Trichomonas vaginalis | alcohol dehydrogenase, putative | 0.0056 | 0.0481 | 0.5 |
Brugia malayi | oxidoreductase, zinc-binding dehydrogenase family protein | 0.0056 | 0.0481 | 0.0481 |
Trypanosoma cruzi | NADP-dependent alcohol hydrogenase, putative | 0.0056 | 0.0481 | 1 |
Entamoeba histolytica | NADP-dependent alcohol dehydrogenase, putative | 0.0056 | 0.0481 | 0.5 |
Trypanosoma cruzi | oxidoreductase, putative | 0.0056 | 0.0481 | 1 |
Trypanosoma cruzi | nuclear receptor binding factor, putative | 0.0056 | 0.0481 | 1 |
Leishmania major | NADP-dependent alcohol dehydrogenase, putative | 0.0056 | 0.0481 | 1 |
Mycobacterium ulcerans | quinone reductase Qor | 0.0056 | 0.0481 | 0.0481 |
Trichomonas vaginalis | alcohol dehydrogenase, putative | 0.0056 | 0.0481 | 0.5 |
Trypanosoma cruzi | nuclear receptor binding factor, putative | 0.0056 | 0.0481 | 1 |
Leishmania major | zinc binding dehydrogenase-like protein | 0.0056 | 0.0481 | 1 |
Mycobacterium ulcerans | oxidoreductase | 0.0056 | 0.0481 | 0.0481 |
Onchocerca volvulus | 0.0056 | 0.0481 | 0.0481 | |
Trypanosoma cruzi | NADP-dependent alcohol hydrogenase, putative | 0.0056 | 0.0481 | 1 |
Brugia malayi | oxidoreductase, zinc-binding dehydrogenase family protein | 0.0056 | 0.0481 | 0.0481 |
Mycobacterium ulcerans | NADP-dependent alcohol dehydrogenase AdhC | 0.0056 | 0.0481 | 0.0481 |
Toxoplasma gondii | Zn-containing alcohol dehydrogenase | 0.0462 | 1 | 1 |
Leishmania major | quinone oxidoreductase, putative | 0.0056 | 0.0481 | 1 |
Mycobacterium ulcerans | NADP-dependent alcohol dehydrogenase Adh | 0.0056 | 0.0481 | 0.0481 |
Onchocerca volvulus | Putative alcohol dehydrogenase | 0.0462 | 1 | 1 |
Trypanosoma cruzi | NADP-dependent alcohol hydrogenase, putative | 0.0056 | 0.0481 | 1 |
Mycobacterium ulcerans | polyketide synthase | 0.0056 | 0.0481 | 0.0481 |
Leishmania major | oxidoreductase, putative | 0.0056 | 0.0481 | 1 |
Trypanosoma cruzi | oxidoreductase, putative | 0.0056 | 0.0481 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0481 | 0.0481 |
Echinococcus multilocularis | mitochondrial trans 2 enoyl coenzyme A reductase | 0.0056 | 0.0481 | 0.5 |
Mycobacterium ulcerans | zinc-containing alcohol dehydrogenase NAD-dependent AdhB | 0.0462 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0422 | 0.9069 | 0.9022 |
Mycobacterium ulcerans | quinone oxidoreductase | 0.0056 | 0.0481 | 0.0481 |
Trypanosoma brucei | oxidoreductase, putative | 0.0056 | 0.0481 | 1 |
Mycobacterium tuberculosis | Possible zinc-containing alcohol dehydrogenase NAD dependent AdhB | 0.0406 | 0.8678 | 0.8612 |
Mycobacterium ulcerans | oxidoreductase FadB5 | 0.0056 | 0.0481 | 0.0481 |
Wolbachia endosymbiont of Brugia malayi | NADPH:quinone reductase | 0.0056 | 0.0481 | 0.5 |
Schistosoma mansoni | alcohol dehydrogenase | 0.0462 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0481 | 0.0481 |
Mycobacterium leprae | Probable S-nitrosomycothiol reductase MscR | 0.0462 | 1 | 1 |
Mycobacterium ulcerans | quinone oxidoreductase | 0.0056 | 0.0481 | 0.0481 |
Mycobacterium ulcerans | dehydrogenase | 0.0056 | 0.0481 | 0.0481 |
Echinococcus granulosus | mitochondrial trans 2 enoyl coenzyme A reductase | 0.0056 | 0.0481 | 0.5 |
Trypanosoma brucei | oxidoreductase, putative | 0.0056 | 0.0481 | 1 |
Mycobacterium tuberculosis | Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase) | 0.0462 | 1 | 1 |
Mycobacterium ulcerans | zinc-type alcohol dehydrogenase AdhD | 0.0462 | 1 | 1 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0056 | 0.0481 | 0.0481 |
Mycobacterium ulcerans | short-chain dehydrogenase | 0.0056 | 0.0481 | 0.0481 |
Entamoeba histolytica | NADP-dependent alcohol dehydrogenase | 0.0056 | 0.0481 | 0.5 |
Leishmania major | oxidoreductase-like protein | 0.0056 | 0.0481 | 1 |
Leishmania major | d-xylulose reductase, putative | 0.0056 | 0.0481 | 1 |
Trypanosoma cruzi | NADP-dependent alcohol hydrogenase, putative | 0.0056 | 0.0481 | 1 |
Mycobacterium ulcerans | zinc-dependent alcohol dehydrogenase | 0.0462 | 1 | 1 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0056 | 0.0481 | 0.0481 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0481 | 0.0481 |
Entamoeba histolytica | NADP-dependent alcohol dehydrogenase, putative | 0.0056 | 0.0481 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 0.096 uM | Agonist activity at rat PPARalpha in rat H4IIE cells assesed as gene induction | ChEMBL. | 18029176 |
EC50 (functional) | = 0.096 uM | Agonist activity at rat PPARalpha in rat H4IIE cells assesed as gene induction | ChEMBL. | 18029176 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.