Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Peroxisome proliferator-activated receptor alpha | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | IPR008946,Nuclear receptor, ligand-binding,domain-containing | Get druggable targets OG5_137778 | All targets in OG5_137778 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | Get druggable targets OG5_137778 | All targets in OG5_137778 |
Schistosoma japonicum | ko:K08701 nuclear receptor, subfamily 1, invertebrate, putative | Get druggable targets OG5_137778 | All targets in OG5_137778 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | ecdysone induced protein 78C | Peroxisome proliferator-activated receptor alpha | 468 aa | 409 aa | 30.8 % |
Loa Loa (eye worm) | hypothetical protein | Peroxisome proliferator-activated receptor alpha | 468 aa | 376 aa | 27.9 % |
Schistosoma mansoni | retinoic acid receptor RXR | Peroxisome proliferator-activated receptor alpha | 468 aa | 398 aa | 28.4 % |
Brugia malayi | Steroid receptor seven-up type 2 | Peroxisome proliferator-activated receptor alpha | 468 aa | 381 aa | 24.1 % |
Brugia malayi | ecdysteroid receptor | Peroxisome proliferator-activated receptor alpha | 468 aa | 375 aa | 25.1 % |
Echinococcus granulosus | ecdysone induced protein 78C | Peroxisome proliferator-activated receptor alpha | 468 aa | 409 aa | 30.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0056 | 0.0481 | 0.0481 |
Entamoeba histolytica | NADP-dependent alcohol dehydrogenase, putative | 0.0056 | 0.0481 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0481 | 0.0481 |
Mycobacterium ulcerans | zinc-dependent alcohol dehydrogenase | 0.0462 | 1 | 1 |
Leishmania major | oxidoreductase-like protein | 0.0056 | 0.0481 | 1 |
Leishmania major | d-xylulose reductase, putative | 0.0056 | 0.0481 | 1 |
Trypanosoma cruzi | NADP-dependent alcohol hydrogenase, putative | 0.0056 | 0.0481 | 1 |
Entamoeba histolytica | NADP-dependent alcohol dehydrogenase | 0.0056 | 0.0481 | 0.5 |
Mycobacterium ulcerans | short-chain dehydrogenase | 0.0056 | 0.0481 | 0.0481 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0056 | 0.0481 | 0.0481 |
Mycobacterium ulcerans | zinc-type alcohol dehydrogenase AdhD | 0.0462 | 1 | 1 |
Mycobacterium tuberculosis | Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase) | 0.0462 | 1 | 1 |
Trypanosoma brucei | oxidoreductase, putative | 0.0056 | 0.0481 | 1 |
Echinococcus granulosus | mitochondrial trans 2 enoyl coenzyme A reductase | 0.0056 | 0.0481 | 0.5 |
Mycobacterium ulcerans | dehydrogenase | 0.0056 | 0.0481 | 0.0481 |
Mycobacterium ulcerans | quinone oxidoreductase | 0.0056 | 0.0481 | 0.0481 |
Mycobacterium leprae | Probable S-nitrosomycothiol reductase MscR | 0.0462 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0481 | 0.0481 |
Schistosoma mansoni | alcohol dehydrogenase | 0.0462 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | NADPH:quinone reductase | 0.0056 | 0.0481 | 0.5 |
Mycobacterium ulcerans | oxidoreductase FadB5 | 0.0056 | 0.0481 | 0.0481 |
Mycobacterium tuberculosis | Possible zinc-containing alcohol dehydrogenase NAD dependent AdhB | 0.0406 | 0.8678 | 0.8612 |
Trypanosoma brucei | oxidoreductase, putative | 0.0056 | 0.0481 | 1 |
Mycobacterium ulcerans | quinone oxidoreductase | 0.0056 | 0.0481 | 0.0481 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0422 | 0.9069 | 0.9022 |
Echinococcus multilocularis | mitochondrial trans 2 enoyl coenzyme A reductase | 0.0056 | 0.0481 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0481 | 0.0481 |
Mycobacterium ulcerans | zinc-containing alcohol dehydrogenase NAD-dependent AdhB | 0.0462 | 1 | 1 |
Trypanosoma cruzi | oxidoreductase, putative | 0.0056 | 0.0481 | 1 |
Leishmania major | oxidoreductase, putative | 0.0056 | 0.0481 | 1 |
Mycobacterium ulcerans | polyketide synthase | 0.0056 | 0.0481 | 0.0481 |
Trypanosoma cruzi | NADP-dependent alcohol hydrogenase, putative | 0.0056 | 0.0481 | 1 |
Onchocerca volvulus | Putative alcohol dehydrogenase | 0.0462 | 1 | 1 |
Mycobacterium ulcerans | NADP-dependent alcohol dehydrogenase Adh | 0.0056 | 0.0481 | 0.0481 |
Leishmania major | quinone oxidoreductase, putative | 0.0056 | 0.0481 | 1 |
Toxoplasma gondii | Zn-containing alcohol dehydrogenase | 0.0462 | 1 | 1 |
Brugia malayi | oxidoreductase, zinc-binding dehydrogenase family protein | 0.0056 | 0.0481 | 0.0481 |
Mycobacterium ulcerans | NADP-dependent alcohol dehydrogenase AdhC | 0.0056 | 0.0481 | 0.0481 |
Trypanosoma cruzi | NADP-dependent alcohol hydrogenase, putative | 0.0056 | 0.0481 | 1 |
Onchocerca volvulus | 0.0056 | 0.0481 | 0.0481 | |
Mycobacterium ulcerans | oxidoreductase | 0.0056 | 0.0481 | 0.0481 |
Trypanosoma cruzi | nuclear receptor binding factor, putative | 0.0056 | 0.0481 | 1 |
Trichomonas vaginalis | alcohol dehydrogenase, putative | 0.0056 | 0.0481 | 0.5 |
Leishmania major | zinc binding dehydrogenase-like protein | 0.0056 | 0.0481 | 1 |
Mycobacterium ulcerans | quinone reductase Qor | 0.0056 | 0.0481 | 0.0481 |
Leishmania major | NADP-dependent alcohol dehydrogenase, putative | 0.0056 | 0.0481 | 1 |
Trypanosoma cruzi | nuclear receptor binding factor, putative | 0.0056 | 0.0481 | 1 |
Trypanosoma cruzi | oxidoreductase, putative | 0.0056 | 0.0481 | 1 |
Brugia malayi | oxidoreductase, zinc-binding dehydrogenase family protein | 0.0056 | 0.0481 | 0.0481 |
Trichomonas vaginalis | alcohol dehydrogenase, putative | 0.0056 | 0.0481 | 0.5 |
Entamoeba histolytica | NADP-dependent alcohol dehydrogenase, putative | 0.0056 | 0.0481 | 0.5 |
Trypanosoma cruzi | NADP-dependent alcohol hydrogenase, putative | 0.0056 | 0.0481 | 1 |
Loa Loa (eye worm) | alcohol dehydrogenase class III | 0.0462 | 1 | 1 |
Mycobacterium ulcerans | zinc-dependent alcohol dehydrogenase AdhE2 | 0.0462 | 1 | 1 |
Mycobacterium ulcerans | Zn-dependent alcohol dehydrogenase, AdhX | 0.0056 | 0.0481 | 0.0481 |
Mycobacterium tuberculosis | Probable zinc-type alcohol dehydrogenase (E subunit) AdhE1 | 0.0406 | 0.8678 | 0.8612 |
Mycobacterium ulcerans | NADPH quinone oxidoreductase FadB4 | 0.0056 | 0.0481 | 0.0481 |
Trichomonas vaginalis | alcohol dehydrogenase, putative | 0.0056 | 0.0481 | 0.5 |
Mycobacterium ulcerans | zinc-containing alcohol dehydrogenase NAD dependent AdhB | 0.0462 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 0.146 uM | Agonist activity at rat PPARalpha in rat H4IIE cells assesed as gene induction | ChEMBL. | 18029176 |
EC50 (functional) | = 0.146 uM | Agonist activity at rat PPARalpha in rat H4IIE cells assesed as gene induction | ChEMBL. | 18029176 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.