Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Peroxisome proliferator-activated receptor alpha | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | IPR008946,Nuclear receptor, ligand-binding,domain-containing | Get druggable targets OG5_137778 | All targets in OG5_137778 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | Get druggable targets OG5_137778 | All targets in OG5_137778 |
Schistosoma japonicum | ko:K08701 nuclear receptor, subfamily 1, invertebrate, putative | Get druggable targets OG5_137778 | All targets in OG5_137778 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | ecdysone induced protein 78C | Peroxisome proliferator-activated receptor alpha | 468 aa | 409 aa | 30.8 % |
Loa Loa (eye worm) | hypothetical protein | Peroxisome proliferator-activated receptor alpha | 468 aa | 376 aa | 27.9 % |
Schistosoma mansoni | retinoic acid receptor RXR | Peroxisome proliferator-activated receptor alpha | 468 aa | 398 aa | 28.4 % |
Brugia malayi | ecdysteroid receptor | Peroxisome proliferator-activated receptor alpha | 468 aa | 375 aa | 25.1 % |
Brugia malayi | Steroid receptor seven-up type 2 | Peroxisome proliferator-activated receptor alpha | 468 aa | 381 aa | 24.1 % |
Echinococcus granulosus | ecdysone induced protein 78C | Peroxisome proliferator-activated receptor alpha | 468 aa | 409 aa | 30.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | oxidoreductase, putative | 0.0056 | 0.0481 | 1 |
Onchocerca volvulus | 0.0056 | 0.0481 | 0.0481 | |
Mycobacterium leprae | Probable S-nitrosomycothiol reductase MscR | 0.0462 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0422 | 0.9069 | 0.9022 |
Leishmania major | zinc binding dehydrogenase-like protein | 0.0056 | 0.0481 | 1 |
Entamoeba histolytica | NADP-dependent alcohol dehydrogenase, putative | 0.0056 | 0.0481 | 0.5 |
Leishmania major | oxidoreductase-like protein | 0.0056 | 0.0481 | 1 |
Trypanosoma cruzi | nuclear receptor binding factor, putative | 0.0056 | 0.0481 | 1 |
Mycobacterium tuberculosis | Possible zinc-containing alcohol dehydrogenase NAD dependent AdhB | 0.0406 | 0.8678 | 0.8612 |
Toxoplasma gondii | Zn-containing alcohol dehydrogenase | 0.0462 | 1 | 1 |
Trypanosoma brucei | oxidoreductase, putative | 0.0056 | 0.0481 | 1 |
Trypanosoma cruzi | NADP-dependent alcohol hydrogenase, putative | 0.0056 | 0.0481 | 1 |
Wolbachia endosymbiont of Brugia malayi | NADPH:quinone reductase | 0.0056 | 0.0481 | 0.5 |
Mycobacterium tuberculosis | Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase) | 0.0462 | 1 | 1 |
Trypanosoma cruzi | oxidoreductase, putative | 0.0056 | 0.0481 | 1 |
Mycobacterium ulcerans | zinc-containing alcohol dehydrogenase NAD dependent AdhB | 0.0462 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0481 | 0.0481 |
Entamoeba histolytica | NADP-dependent alcohol dehydrogenase, putative | 0.0056 | 0.0481 | 0.5 |
Echinococcus multilocularis | mitochondrial trans 2 enoyl coenzyme A reductase | 0.0056 | 0.0481 | 0.5 |
Onchocerca volvulus | Putative alcohol dehydrogenase | 0.0462 | 1 | 1 |
Mycobacterium ulcerans | short-chain dehydrogenase | 0.0056 | 0.0481 | 0.0481 |
Mycobacterium ulcerans | Zn-dependent alcohol dehydrogenase, AdhX | 0.0056 | 0.0481 | 0.0481 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0481 | 0.0481 |
Mycobacterium ulcerans | zinc-type alcohol dehydrogenase AdhD | 0.0462 | 1 | 1 |
Trichomonas vaginalis | alcohol dehydrogenase, putative | 0.0056 | 0.0481 | 0.5 |
Leishmania major | quinone oxidoreductase, putative | 0.0056 | 0.0481 | 1 |
Mycobacterium ulcerans | zinc-dependent alcohol dehydrogenase | 0.0462 | 1 | 1 |
Mycobacterium ulcerans | NADPH quinone oxidoreductase FadB4 | 0.0056 | 0.0481 | 0.0481 |
Entamoeba histolytica | NADP-dependent alcohol dehydrogenase | 0.0056 | 0.0481 | 0.5 |
Schistosoma mansoni | alcohol dehydrogenase | 0.0462 | 1 | 1 |
Mycobacterium tuberculosis | Probable zinc-type alcohol dehydrogenase (E subunit) AdhE1 | 0.0406 | 0.8678 | 0.8612 |
Mycobacterium ulcerans | dehydrogenase | 0.0056 | 0.0481 | 0.0481 |
Leishmania major | d-xylulose reductase, putative | 0.0056 | 0.0481 | 1 |
Mycobacterium ulcerans | zinc-containing alcohol dehydrogenase NAD-dependent AdhB | 0.0462 | 1 | 1 |
Trypanosoma cruzi | NADP-dependent alcohol hydrogenase, putative | 0.0056 | 0.0481 | 1 |
Loa Loa (eye worm) | alcohol dehydrogenase class III | 0.0462 | 1 | 1 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0056 | 0.0481 | 0.0481 |
Brugia malayi | oxidoreductase, zinc-binding dehydrogenase family protein | 0.0056 | 0.0481 | 0.0481 |
Mycobacterium ulcerans | quinone oxidoreductase | 0.0056 | 0.0481 | 0.0481 |
Trypanosoma cruzi | NADP-dependent alcohol hydrogenase, putative | 0.0056 | 0.0481 | 1 |
Mycobacterium ulcerans | NADP-dependent alcohol dehydrogenase AdhC | 0.0056 | 0.0481 | 0.0481 |
Leishmania major | oxidoreductase, putative | 0.0056 | 0.0481 | 1 |
Trypanosoma cruzi | oxidoreductase, putative | 0.0056 | 0.0481 | 1 |
Leishmania major | NADP-dependent alcohol dehydrogenase, putative | 0.0056 | 0.0481 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0481 | 0.0481 |
Mycobacterium ulcerans | zinc-dependent alcohol dehydrogenase AdhE2 | 0.0462 | 1 | 1 |
Mycobacterium ulcerans | polyketide synthase | 0.0056 | 0.0481 | 0.0481 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0056 | 0.0481 | 0.0481 |
Mycobacterium ulcerans | quinone oxidoreductase | 0.0056 | 0.0481 | 0.0481 |
Brugia malayi | oxidoreductase, zinc-binding dehydrogenase family protein | 0.0056 | 0.0481 | 0.0481 |
Echinococcus granulosus | mitochondrial trans 2 enoyl coenzyme A reductase | 0.0056 | 0.0481 | 0.5 |
Mycobacterium ulcerans | quinone reductase Qor | 0.0056 | 0.0481 | 0.0481 |
Mycobacterium ulcerans | oxidoreductase | 0.0056 | 0.0481 | 0.0481 |
Trichomonas vaginalis | alcohol dehydrogenase, putative | 0.0056 | 0.0481 | 0.5 |
Trypanosoma cruzi | nuclear receptor binding factor, putative | 0.0056 | 0.0481 | 1 |
Trypanosoma cruzi | NADP-dependent alcohol hydrogenase, putative | 0.0056 | 0.0481 | 1 |
Mycobacterium ulcerans | oxidoreductase FadB5 | 0.0056 | 0.0481 | 0.0481 |
Trichomonas vaginalis | alcohol dehydrogenase, putative | 0.0056 | 0.0481 | 0.5 |
Mycobacterium ulcerans | NADP-dependent alcohol dehydrogenase Adh | 0.0056 | 0.0481 | 0.0481 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 2.85 uM | Agonist activity at rat PPARalpha in rat H4IIE cells assesed as gene induction | ChEMBL. | 18029176 |
EC50 (functional) | = 2.85 uM | Agonist activity at rat PPARalpha in rat H4IIE cells assesed as gene induction | ChEMBL. | 18029176 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.