Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Geobacillus stearothermophilus | Alpha-glucosidase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Alpha-glucosidase | 555 aa | 507 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | alpha amylase | 0.0089 | 0.3085 | 0.3007 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0076 | 0.2517 | 0.2433 |
Chlamydia trachomatis | glycogen hydrolase | 0.0021 | 0.0112 | 0.5 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0021 | 0.0112 | 1 |
Echinococcus multilocularis | geminin | 0.0135 | 0.5135 | 0.508 |
Schistosoma mansoni | importin beta-1 | 0.0023 | 0.0192 | 0.0081 |
Echinococcus granulosus | geminin | 0.0135 | 0.5135 | 0.508 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0021 | 0.0112 | 1 |
Echinococcus multilocularis | snurportin 1 | 0.0245 | 1 | 1 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0021 | 0.0112 | 1 |
Brugia malayi | RNA, U transporter 1 | 0.0065 | 0.2061 | 0.6556 |
Schistosoma mansoni | hypothetical protein | 0.0135 | 0.5135 | 0.508 |
Entamoeba histolytica | alpha-amylase family protein | 0.0021 | 0.0112 | 0.0362 |
Brugia malayi | Alpha amylase, catalytic domain containing protein | 0.0089 | 0.3085 | 1 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0021 | 0.0112 | 1 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0023 | 0.0192 | 1 |
Chlamydia trachomatis | 1,4-alpha-glucan branching enzyme | 0.0021 | 0.0112 | 0.5 |
Mycobacterium ulcerans | trehalose synthase TreS | 0.0089 | 0.3085 | 1 |
Entamoeba histolytica | alpha-amylase, putative | 0.0021 | 0.0112 | 0.0362 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0021 | 0.0112 | 1 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0023 | 0.0192 | 0.0081 |
Plasmodium falciparum | importin beta, putative | 0.0023 | 0.0192 | 0.5 |
Entamoeba histolytica | 1,4-alpha-glucan branching enzyme, putative | 0.0021 | 0.0112 | 0.0362 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0021 | 0.0112 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0076 | 0.2517 | 0.2433 |
Trichomonas vaginalis | amylase, putative | 0.0021 | 0.0112 | 1 |
Loa Loa (eye worm) | alpha amylase | 0.0089 | 0.3085 | 0.3007 |
Trichomonas vaginalis | starch branching enzyme II, putative | 0.0021 | 0.0112 | 1 |
Giardia lamblia | 1,4-alpha-glucan branching enzyme | 0.0021 | 0.0112 | 0.5 |
Entamoeba histolytica | alpha-amylase, putative | 0.0021 | 0.0112 | 0.0362 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0021 | 0.0112 | 1 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0019 | 0 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0076 | 0.2517 | 0.2433 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0076 | 0.2517 | 0.2433 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0021 | 0.0112 | 1 |
Plasmodium vivax | importin-beta 2, putative | 0.0023 | 0.0192 | 0.5 |
Entamoeba histolytica | alpha-amylase family protein | 0.0021 | 0.0112 | 0.0362 |
Leishmania major | importin beta-1 subunit, putative | 0.0019 | 0 | 0.5 |
Trichomonas vaginalis | amylase, putative | 0.0021 | 0.0112 | 1 |
Mycobacterium tuberculosis | Probable alpha-glucosidase AglA (maltase) (glucoinvertase) (glucosidosucrase) (maltase-glucoamylase) (lysosomal alpha-glucosidas | 0.0089 | 0.3085 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0135 | 0.5135 | 0.508 |
Brugia malayi | Alpha amylase, catalytic domain containing protein | 0.0089 | 0.3085 | 1 |
Schistosoma mansoni | alpha-amylase | 0.0089 | 0.3085 | 0.3007 |
Echinococcus granulosus | importin subunit beta 1 | 0.0023 | 0.0192 | 0.0081 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0021 | 0.0112 | 1 |
Entamoeba histolytica | beta/alpha-amylase precursor, putative | 0.0021 | 0.0112 | 0.0362 |
Echinococcus granulosus | alpha glucosidase | 0.0089 | 0.3085 | 0.3007 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0076 | 0.2517 | 0.8091 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0076 | 0.2517 | 0.2433 |
Schistosoma mansoni | hypothetical protein | 0.0245 | 1 | 1 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0021 | 0.0112 | 1 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0023 | 0.0192 | 0.5 |
Entamoeba histolytica | alpha-amylase family protein | 0.0021 | 0.0112 | 0.0362 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0021 | 0.0112 | 1 |
Schistosoma mansoni | alpha-amylase | 0.0089 | 0.3085 | 0.3007 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0023 | 0.0192 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0192 | 0.0081 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0021 | 0.0112 | 1 |
Mycobacterium leprae | Putative uncharacterized protein ML2045 | 0.0089 | 0.3085 | 0.5 |
Schistosoma mansoni | alpha-amylase | 0.0089 | 0.3085 | 0.3007 |
Entamoeba histolytica | hypothetical protein | 0.0021 | 0.0112 | 0.0362 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0076 | 0.2517 | 0.2433 |
Mycobacterium tuberculosis | Trehalose synthase TreS | 0.0089 | 0.3085 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0076 | 0.2517 | 0.2433 |
Trichomonas vaginalis | amylase, putative | 0.0021 | 0.0112 | 1 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0021 | 0.0112 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0076 | 0.2517 | 0.2433 |
Entamoeba histolytica | oligo-1,6-glucosidase, putative | 0.0089 | 0.3085 | 1 |
Entamoeba histolytica | 1,4-alpha-glucan branching enzyme, putative | 0.0021 | 0.0112 | 0.0362 |
Trichomonas vaginalis | amylase, putative | 0.0021 | 0.0112 | 1 |
Brugia malayi | Importin beta-1 subunit | 0.0023 | 0.0192 | 0.0269 |
Entamoeba histolytica | alpha-amylase family protein | 0.0021 | 0.0112 | 0.0362 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0021 | 0.0112 | 1 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0245 | 1 | 1 |
Schistosoma mansoni | alpha-amylase | 0.0089 | 0.3085 | 0.3007 |
Schistosoma mansoni | alpha-amylase | 0.0089 | 0.3085 | 0.3007 |
Echinococcus multilocularis | alpha glucosidase | 0.0089 | 0.3085 | 0.3007 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | 0 | Antiangiogenesis activity in bovine BAEC cells assessed as inhibition of tube formation on matrigel at 0.2 mM | ChEMBL. | 18166456 |
IC50 (functional) | = 0.61 mM | Growth inhibition of bovine BAEC by MTT assay | ChEMBL. | 18166456 |
IC50 (functional) | = 2 uM | Growth inhibition of mouse MS1 cells by MTT assay | ChEMBL. | 18166456 |
IC50 (functional) | = 2 uM | Growth inhibition of HUVEC cells by MTT assay | ChEMBL. | 18166456 |
IC50 (functional) | = 2 uM | Growth inhibition of mouse MS1 cells by MTT assay | ChEMBL. | 18166456 |
IC50 (functional) | = 2 uM | Growth inhibition of HUVEC cells by MTT assay | ChEMBL. | 18166456 |
IC50 (ADMET) | = 2 uM | Growth inhibition of HUVEC cells by MTT assay | ChEMBL. | 18504133 |
IC50 (binding) | = 2.41 uM | Inhibition of alpha glucosidase from bacillus sterothermophilus | ChEMBL. | 18166456 |
IC50 (binding) | = 2.41 uM | Inhibition of alpha glucosidase from bacillus sterothermophilus | ChEMBL. | 18166456 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 18166456 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.