Detailed information for compound 508925

Basic information

Technical information
  • TDR Targets ID: 508925
  • Name: 2-[1-[4-[2-(4-chlorophenoxy)acetyl]piperazin- 1-yl]ethyl]-3-(2-ethoxyphenyl)quinazolin-4-on e
  • MW: 547.045 | Formula: C30H31ClN4O4
  • H donors: 0 H acceptors: 2 LogP: 4.84 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCOc1ccccc1n1c(nc2c(c1=O)cccc2)C(N1CCN(CC1)C(=O)COc1ccc(cc1)Cl)C
  • InChi: 1S/C30H31ClN4O4/c1-3-38-27-11-7-6-10-26(27)35-29(32-25-9-5-4-8-24(25)30(35)37)21(2)33-16-18-34(19-17-33)28(36)20-39-23-14-12-22(31)13-15-23/h4-15,21H,3,16-20H2,1-2H3
  • InChiKey: BKQFRNYHFIQEKN-UHFFFAOYSA-N  

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[1-[4-[2-(4-chlorophenoxy)-1-oxoethyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4-quinazolinone
  • 2-[1-[4-[2-(4-chlorophenoxy)ethanoyl]piperazin-1-yl]ethyl]-3-(2-ethoxyphenyl)quinazolin-4-one
  • 2-[1-[4-[2-(4-chlorophenoxy)acetyl]piperazino]ethyl]-3-o-phenetyl-quinazolin-4-one

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens voltage-dependent anion channel 2 Starlite/ChEMBL References
Homo sapiens solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus voltage dependent anion channel protein 2 Get druggable targets OG5_127746 All targets in OG5_127746
Echinococcus multilocularis voltage dependent anion channel protein 2 Get druggable targets OG5_127746 All targets in OG5_127746
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127746 All targets in OG5_127746
Schistosoma mansoni voltage-dependent anion-selective channel Get druggable targets OG5_127746 All targets in OG5_127746
Schistosoma mansoni voltage-dependent anion-selective channel Get druggable targets OG5_127746 All targets in OG5_127746
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127746 All targets in OG5_127746
Schistosoma japonicum ko:K05862 voltage-dependent anion channel, putative Get druggable targets OG5_127746 All targets in OG5_127746
Schistosoma mansoni voltage-dependent anion-selective channel Get druggable targets OG5_127746 All targets in OG5_127746
Brugia malayi Probable voltage-dependent anion-selective channel, putative Get druggable targets OG5_127746 All targets in OG5_127746
Schistosoma japonicum ko:K05862 voltage-dependent anion channel, putative Get druggable targets OG5_127746 All targets in OG5_127746
Candida albicans outer mitochondrial membrane porin Get druggable targets OG5_127746 All targets in OG5_127746
Candida albicans outer mitochondrial membrane porin Get druggable targets OG5_127746 All targets in OG5_127746

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis adenylate cyclase 9 voltage-dependent anion channel 2 309 aa 278 aa 24.1 %
Trypanosoma brucei cationic amino acid transporter, putative solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 501 aa 462 aa 22.1 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Echinococcus granulosus voltage dependent anion channel protein 2 0.0049 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0049 1 1
Echinococcus multilocularis voltage dependent anion channel protein 2 0.0049 1 0.5
Schistosoma mansoni voltage-dependent anion-selective channel 0.0049 1 0.5
Schistosoma mansoni voltage-dependent anion-selective channel 0.0049 1 0.5
Schistosoma mansoni voltage-dependent anion-selective channel 0.0049 1 0.5

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) 0 Increase in intracellular oxidative species in human BJ cells expressing TERT, LT, ST and RAS G12V mutant genes cells at 4.6 uM ChEMBL. 17568748
Activity (functional) 0 Induction of cell death in human BJ cells expressing TERT, LT, ST and RAS G12V mutant genes cells at 9 uM ChEMBL. 17568748
Activity (functional) 0 Prevention of induction of cell death in human BJ cells expressing TERT, LT, ST and RAS G12V mutant genes cells after 24 hrs in presence of butylated hydroxytoluene ChEMBL. 17568748
Activity (functional) 0 Prevention of induction of cell death in human BJ cells expressing TERT, LT, ST and RAS G12V mutant genes cells after 24 hrs in presence of alpha-tocopherol ChEMBL. 17568748
Activity (functional) 0 Prevention of induction of cell death in human BJ cells expressing TERT, LT, ST and RAS G12V mutant genes cells after 24 hrs in presence of beta-carotene ChEMBL. 17568748
Activity (functional) 0 Effect on intracellular oxidative species in TERT expressing human BJ cells at 4.6 uM ChEMBL. 17568748
Activity (functional) 0 Suppression of induction of cell death in human HT1080 cells at 5 mM by Alamar Blue assay in presence of butylated hydroxytoluene ChEMBL. 17568748
Activity (functional) 0 Suppression of induction of cell death in human HT1080 cells at 5 mM by Alamar Blue assay in presence of in presence of alpha-tocopherol ChEMBL. 17568748
Activity (functional) 0 Suppression of induction of cell death in human HT1080 cells at 5 mM by Alamar Blue assay in presence of glutathione ChEMBL. 17568748
Activity (functional) 0 Induction of PARP1 cleavage in human BJ cells expressing TERT, LT, ST and RAS G12V mutant genes cells after 14 hrs ChEMBL. 17568748
Activity (functional) 0 Induction of pro-caspase 3 cleavage in human A673 cells ChEMBL. 17568748
Activity (functional) 0 Induction of pro-caspase 3 cleavage in human HT1080 cells ChEMBL. 17568748
Activity (functional) 0 Induction of pro-caspase 3 cleavage in human HeLa cells ChEMBL. 17568748
Activity (functional) 0 Induction of pro-caspase 3 cleavage in human BJ cells expressing TERT, LT, ST and RAS G12V mutant genes ChEMBL. 17568748
Activity (functional) 0 Induction of PARP1 cleavage in human A673 cells ChEMBL. 17568748
Activity (functional) 0 Induction of PARP1 cleavage in human HT1080 cells ChEMBL. 17568748
Activity (functional) 0 Induction of PARP1 cleavage in human HeLa cells ChEMBL. 17568748
Activity (functional) 0 Induction of cytochrome c release in mitochondrial fraction of human BJ cell expressing TERT, LT, ST and RAS G12V mutant genes at 20 ug/ml ChEMBL. 17568748
Activity (functional) 0 Induction of cytochrome c release in cytosolic fraction of human BJ cells expressing TERT, LT, ST and RAS G12V mutant genes at 20 ug/ml ChEMBL. 17568748
Activity (functional) 0 Induction of mitochondrial structural integrity loss in human BJ cells expressing TERT, LT, ST and RAS G12V mutant genes cells at 37 uM after 10 hrs ChEMBL. 17568748
Activity (functional) = 0 % Induction of cell death in human HL60 cells ChEMBL. 17568748
Activity (functional) = 0 % Induction of cell death in human SW872 cells ChEMBL. 17568748
Activity (functional) = 0 % Induction of cell death in human HCT116 cells ChEMBL. 17568748
Activity (functional) = 0 % Induction of cell death in human SW982 cells ChEMBL. 17568748
Activity (functional) = 0 % Induction of cell death in human A431NS cells ChEMBL. 17568748
Activity (functional) = 0 % Induction of cell death in human HL60 cells ChEMBL. 17568748
Activity (functional) = 0 % Induction of cell death in human SW872 cells ChEMBL. 17568748
Activity (functional) = 0 % Induction of cell death in human HCT116 cells ChEMBL. 17568748
Activity (functional) = 0 % Induction of cell death in human SW982 cells ChEMBL. 17568748
Activity (functional) = 20 % Induction of cell death in human SVR cells ChEMBL. 17568748
Activity (functional) = 20 % Induction of cell death in human SVR cells ChEMBL. 17568748
Activity (functional) = 21 % Induction of cell death in human C33A cells ChEMBL. 17568748
Activity (functional) = 21 % Induction of cell death in human C33A cells ChEMBL. 17568748
Activity (functional) = 22 % Induction of cell death in TERT expressing human BJ cells ChEMBL. 17568748
Activity (functional) = 22 % Induction of cell death in TERT expressing human BJ cells ChEMBL. 17568748
Activity (functional) = 32 % Induction of cell death in human LNCaP cells ChEMBL. 17568748
Activity (functional) = 32 % Induction of cell death in human LNCaP cells ChEMBL. 17568748
Activity (functional) = 42 % Induction of cell death in human EWS502 cells ChEMBL. 17568748
Activity (functional) = 54 % Induction of cell death in human A673 cells ChEMBL. 17568748
Activity (functional) = 54 % Induction of cell death in human A673 cells ChEMBL. 17568748
Activity (functional) = 71 % Induction of cell death in human MX2 cells ChEMBL. 17568748
Activity (functional) = 73 % Induction of cell death in human U937 cells ChEMBL. 17568748
Activity (functional) = 73 % Induction of cell death in human SKUT cells ChEMBL. 17568748
Activity (functional) = 73 % Induction of cell death in human U937 cells ChEMBL. 17568748
Activity (functional) = 83 % Induction of cell death in human Hs925.T cells ChEMBL. 17568748
Activity (functional) = 88 % Induction of cell death in human TC32 cells ChEMBL. 17568748
Activity (functional) = 88 % Induction of cell death in human Hs51.T cells ChEMBL. 17568748
Activity (functional) = 92 % Induction of cell death in human TC71 cells ChEMBL. 17568748
Activity (functional) = 94 % Induction of cell death in human HeLa cells ChEMBL. 17568748
Activity (functional) = 94 % Induction of cell death in human HeLa cells ChEMBL. 17568748
Activity (functional) = 95 % Induction of cell death in human SK-N-MC cells ChEMBL. 17568748
Activity (functional) = 95 % Induction of cell death in human SK-N-MC cells ChEMBL. 17568748
Activity (functional) = 96 % Induction of cell death in human SK-ES-1 cells ChEMBL. 17568748
Activity (functional) = 96 % Induction of cell death in human U2OS cells ChEMBL. 17568748
Activity (functional) = 96 % Induction of cell death in human U2OS cells ChEMBL. 17568748
Activity (functional) = 98 % Induction of cell death in human HT1080 cells ChEMBL. 17568748
Activity (functional) = 98 % Induction of cell death in human HT1080 cells ChEMBL. 17568748
Activity (functional) = 100 % Induction of cell death in human BJ cells expressing TERT, LT, ST and RAS G12V mutant genes ChEMBL. 17568748
Activity (functional) = 100 % Induction of cell death in human HOS cells ChEMBL. 17568748
Activity (functional) = 100 % Induction of cell death in human SJSA1 cells ChEMBL. 17568748
Activity (functional) = 100 % Induction of cell death in human SKLMS1 cells ChEMBL. 17568748
Activity (functional) = 100 % Induction of cell death in human MES-SA cells ChEMBL. 17568748
Activity (functional) = 100 % Induction of cell death in human BJ cells expressing TERT, LT, ST and RAS G12V mutant genes at 13 uM ChEMBL. 17568748
Activity (functional) = 100 % Induction of cell death in human BJ cells expressing TERT, LT, ST and RAS G12V mutant genes ChEMBL. 17568748
Activity (functional) = 100 % Induction of cell death in human HOS cells ChEMBL. 17568748
Activity (functional) = 100 % Induction of cell death in human SJSA1 cells ChEMBL. 17568748
Activity (functional) = 100 % Induction of cell death in human SKLMS1 cells ChEMBL. 17568748
Activity (functional) = 100 % Induction of cell death in human BJ cells expressing TERT, LT, ST and RAS G12V mutant genes at 13 uM ChEMBL. 17568748
Activity (binding) = 0.05 a.u. Effect on ERK1/2 phosphorylation in human SKNMC cells by western blot ChEMBL. 17568748
Activity (binding) = 0.05 a.u. Effect on ERK1/2 phosphorylation in human SKNMC cells by western blot ChEMBL. 17568748
Activity (binding) = 0.09 a.u. Effect on ERK1/2 phosphorylation in TERT expressing human BJ cells by western blot ChEMBL. 17568748
Activity (binding) = 0.09 a.u. Effect on ERK1/2 phosphorylation in TERT expressing human BJ cells by western blot ChEMBL. 17568748
Activity (binding) = 0.1 a.u. Effect on ERK1/2 phosphorylation in human HL60 cells by western blot ChEMBL. 17568748
Activity (binding) = 0.1 a.u. Effect on ERK1/2 phosphorylation in human HL60 cells by western blot ChEMBL. 17568748
Activity (binding) = 0.12 a.u. Effect on ERK1/2 phosphorylation in human EWS502 cells by western blot ChEMBL. 17568748
Activity (binding) = 0.12 a.u. Effect on ERK1/2 phosphorylation in human SW872 cells by western blot ChEMBL. 17568748
Activity (binding) = 0.12 a.u. Effect on ERK1/2 phosphorylation in human TC32 cells by western blot ChEMBL. 17568748
Activity (binding) = 0.12 a.u. Effect on ERK1/2 phosphorylation in human EWS502 cells by western blot ChEMBL. 17568748
Activity (binding) = 0.12 a.u. Effect on ERK1/2 phosphorylation in human SW872 cells by western blot ChEMBL. 17568748
Activity (binding) = 0.12 a.u. Effect on ERK1/2 phosphorylation in human TC32 cells by western blot ChEMBL. 17568748
Activity (binding) = 0.23 a.u. Effect on ERK1/2 phosphorylation in human TC71 cells by western blot ChEMBL. 17568748
Activity (binding) = 0.23 a.u. Effect on ERK1/2 phosphorylation in human TC71 cells by western blot ChEMBL. 17568748
Activity (binding) = 0.25 a.u. Effect on ERK1/2 phosphorylation in human SKES1 cells by western blot ChEMBL. 17568748
Activity (binding) = 0.25 a.u. Effect on ERK1/2 phosphorylation in human SKES1 cells by western blot ChEMBL. 17568748
Activity (binding) = 0.27 a.u. Effect on ERK1/2 phosphorylation in human U937 cells by western blot ChEMBL. 17568748
Activity (binding) = 0.27 a.u. Effect on ERK1/2 phosphorylation in human U937 cells by western blot ChEMBL. 17568748
Activity (binding) = 0.53 a.u. Effect on ERK1/2 phosphorylation in human HT1080 cells by western blot ChEMBL. 17568748
Activity (binding) = 0.53 a.u. Effect on ERK1/2 phosphorylation in human HT1080 cells by western blot ChEMBL. 17568748
Activity (binding) = 0.66 a.u. Effect on ERK1/2 phosphorylation in human A673 cells by western blot ChEMBL. 17568748
Activity (binding) = 0.66 a.u. Effect on ERK1/2 phosphorylation in human A673 cells by western blot ChEMBL. 17568748
Activity (binding) = 0.92 a.u. Effect on ERK1/2 phosphorylation in human BJ cells expressing TERT, LT, ST and RAS G12V mutant genes cells by western blot ChEMBL. 17568748
Activity (binding) = 0.92 a.u. Effect on ERK1/2 phosphorylation in human BJ cells expressing TERT, LT, ST and RAS G12V mutant genes cells by western blot ChEMBL. 17568748
EC50 (functional) = 0.6 uM Induction of cell death in human HeLa cells ChEMBL. 17568748
EC50 (functional) = 0.6 uM Induction of cell death in human C33A cells ChEMBL. 17568748
EC50 (functional) = 0.6 uM Induction of cell death in human HeLa cells ChEMBL. 17568748
EC50 (functional) = 0.6 uM Induction of cell death in human C33A cells ChEMBL. 17568748
EC50 (functional) = 2 uM Induction of cell death in human HT1080 cells ChEMBL. 17568748
EC50 (functional) = 2 uM Induction of cell death in human HT1080 cells ChEMBL. 17568748
EC50 (functional) = 2.5 uM Induction of cell death in human SVR cells ChEMBL. 17568748
EC50 (functional) = 2.5 uM Induction of cell death in human SVR cells ChEMBL. 17568748
EC50 (functional) = 3 uM Induction of cell death in human MES-SA cells ChEMBL. 17568748
EC50 (functional) = 4 uM Induction of cell death in human SKUT cells ChEMBL. 17568748
EC50 (functional) = 6 uM Induction of cell death in human SKLMS1 cells ChEMBL. 17568748
EC50 (functional) = 6 uM Induction of cell death in human U2OS cells ChEMBL. 17568748
EC50 (functional) = 6 uM Induction of cell death in human LNCaP cells ChEMBL. 17568748
EC50 (functional) = 6 uM Induction of cell death in human BJ cells expressing TERT, LT, ST and RAS G12V mutant genes ChEMBL. 17568748
EC50 (functional) = 6 uM Induction of cell death in human SKLMS1 cells ChEMBL. 17568748
EC50 (functional) = 6 uM Induction of cell death in human U2OS cells ChEMBL. 17568748
EC50 (functional) = 6 uM Induction of cell death in human LNCaP cells ChEMBL. 17568748
EC50 (functional) = 6 uM Induction of cell death in human BJ cells expressing TERT, LT, ST and RAS G12V mutant genes ChEMBL. 17568748
EC50 (functional) = 7 uM Induction of cell death in human SK-ES-1 cells ChEMBL. 17568748
EC50 (functional) = 8 uM Induction of cell death in human TC32 cells ChEMBL. 17568748
EC50 (functional) = 10 uM Induction of cell death in human SK-N-MC cells ChEMBL. 17568748
EC50 (functional) = 10 uM Induction of cell death in human TC71 cells ChEMBL. 17568748
EC50 (functional) = 10 uM Induction of cell death in human U937 cells ChEMBL. 17568748
EC50 (functional) = 10 uM Induction of cell death in human EWS502 cells ChEMBL. 17568748
EC50 (functional) = 10 uM Induction of cell death in TERT expressing human BJ cells ChEMBL. 17568748
EC50 (functional) = 10 uM Induction of cell death in human SK-N-MC cells ChEMBL. 17568748
EC50 (functional) = 10 uM Induction of cell death in human U937 cells ChEMBL. 17568748
EC50 (functional) = 10 uM Induction of cell death in TERT expressing human BJ cells ChEMBL. 17568748
EC50 (functional) = 12 uM Induction of cell death in human SJSA1 cells ChEMBL. 17568748
EC50 (functional) = 12 uM Induction of cell death in human Hs51.T cells ChEMBL. 17568748
EC50 (functional) = 12 uM Induction of cell death in human SJSA1 cells ChEMBL. 17568748
EC50 (functional) = 17 uM Induction of cell death in human HOS cells ChEMBL. 17568748
EC50 (functional) = 17 uM Induction of cell death in human Hs925.T cells ChEMBL. 17568748
EC50 (functional) = 17 uM Induction of cell death in human HOS cells ChEMBL. 17568748
EC50 (functional) = 18 uM Induction of cell death in human MX2 cells ChEMBL. 17568748
EC50 (functional) = 30 uM Induction of cell death in human A673 cells ChEMBL. 17568748
EC50 (functional) = 30 uM Induction of cell death in human A673 cells ChEMBL. 17568748
IC50 (binding) = 200 nM Inhibition of Xct in human CCF-STTG1 cells assessed as glutamate release after 2 hrs by fluorometry ChEMBL. 26231156
IC50 (functional) = 0.9 uM Induction of cell death in human BJ cells expressing TERT, LT, ST and RAS G12V mutant genes cells in presence of PD98059 by trypan blue exclusion method ChEMBL. 17568748
IC50 (functional) = 0.9 uM Induction of cell death in human BJ cells expressing TERT, LT, ST and RAS G12V mutant genes cells in presence of MEK inhibitor 2 by trypan blue exclusion method ChEMBL. 17568748
IC50 (functional) = 0.9 uM Induction of cell death in human BJ cells expressing TERT, LT, ST and RAS G12V mutant genes cells in presence of PD98059 by trypan blue exclusion method ChEMBL. 17568748
IC50 (functional) = 0.9 uM Induction of cell death in human BJ cells expressing TERT, LT, ST and RAS G12V mutant genes cells in presence of MEK inhibitor 2 by trypan blue exclusion method ChEMBL. 17568748
IC50 (functional) = 1 uM Induction of cell death in human HT1080 cells in presence of PD98059 by trypan blue exclusion method ChEMBL. 17568748
IC50 (functional) = 1 uM Induction of cell death in human HT1080 cells in presence of PD98059 by trypan blue exclusion method ChEMBL. 17568748
IC50 (functional) = 1.3 uM Induction of cell death in human HT1080 cells in presence of MEK inhibitor 2 by trypan blue exclusion method ChEMBL. 17568748
IC50 (functional) = 1.3 uM Induction of cell death in human HT1080 cells in presence of MEK inhibitor 2 by trypan blue exclusion method ChEMBL. 17568748
IC50 (functional) = 2 uM Induction of cell death in human BJ cells expressing TERT, LT, ST and RAS G12V mutant genes cells in presence of MEK 1/2 inhibitor by trypan blue exclusion method ChEMBL. 17568748
IC50 (functional) = 2 uM Induction of cell death in human BJ cells expressing TERT, LT, ST and RAS G12V mutant genes cells in presence of MEK 1/2 inhibitor by trypan blue exclusion method ChEMBL. 17568748
IC50 (functional) = 2.5 uM Induction of cell death in human HT1080 cells in presence of MEK inhibitor by trypan blue exclusion method ChEMBL. 17568748
IC50 (functional) = 2.5 uM Induction of cell death in human HT1080 cells in presence of MEK inhibitor by trypan blue exclusion method ChEMBL. 17568748
IC50 (functional) = 2.6 uM Induction of cell death in human BJ cells expressing TERT, LT, ST and RAS G12V mutant genes in presence of MEK inhibitor by trypan blue exclusion method ChEMBL. 17568748
IC50 (functional) = 2.6 uM Induction of cell death in human BJ cells expressing TERT, LT, ST and RAS G12V mutant genes in presence of MEK inhibitor by trypan blue exclusion method ChEMBL. 17568748
IC50 (functional) = 3.4 uM Induction of cell death in human HT1080 cells in presence of U0126 by trypan blue exclusion method ChEMBL. 17568748
IC50 (functional) = 3.4 uM Induction of cell death in human HT1080 cells in presence of U0126 by trypan blue exclusion method ChEMBL. 17568748
IC50 (functional) = 4 uM Inhibition of human Calu1 cells expressing KRAS with activating mutations by trypan blue exclusion assay ChEMBL. 17568748
IC50 (functional) = 4 uM Inhibition of human Calu1 cells expressing KRAS with activating mutations by trypan blue exclusion assay ChEMBL. 17568748
IC50 (functional) = 6 uM Induction of cell death in human HT1080 cells in presence of MEK 1/2 inhibitor by trypan blue exclusion method ChEMBL. 17568748
IC50 (functional) = 6 uM Induction of cell death in human HT1080 cells in presence of MEK 1/2 inhibitor by trypan blue exclusion method ChEMBL. 17568748
IC50 (functional) = 31.2 uM Induction of cell death in human BJ cells expressing TERT, LT, ST and RAS G12V mutant genes in presence of U0126 by trypan blue exclusion method ChEMBL. 17568748
IC50 (functional) = 31.2 uM Induction of cell death in human BJ cells expressing TERT, LT, ST and RAS G12V mutant genes in presence of U0126 by trypan blue exclusion method ChEMBL. 17568748
Kd (binding) = 100 nM Binding affinity to human VDAC2 ChEMBL. 17568748
Kd (binding) = 100 nM Binding affinity to human VDAC2 ChEMBL. 17568748
T1/2 (ADMET) < 5 min Half life in mouse liver microsomes by LC-MS/MS analysis ChEMBL. 26231156

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 17568748
Mus musculus ChEMBL23 17568748

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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