Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Latrophilin receptor protein 2 | 0.0031 | 0.0159 | 0.0212 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0029 | 0.0101 | 0.0085 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0036 | 0.0311 | 0.0461 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0098 | 0.2341 | 0.3452 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.0159 | 0.0143 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0016 | 0.0023 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.2341 | 0.3468 |
Onchocerca volvulus | 0.0048 | 0.07 | 0.1023 | |
Trypanosoma brucei | Mitochondrial ATP synthase subunit c-2 | 0.0106 | 0.2603 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0058 | 0.104 | 0.152 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0161 | 0.4387 | 0.4378 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0028 | 0.0066 | 0.005 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0118 | 0.2987 | 0.4424 |
Echinococcus granulosus | voltage gated sodium channel Nav1 alpha subunit | 0.0111 | 0.2767 | 0.2756 |
Leishmania major | ATPase subunit 9, putative | 0.0106 | 0.2603 | 0.933 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.0296 | 0.0281 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0036 | 0.0311 | 0.0296 |
Trypanosoma cruzi | ATPase subunit 9, putative | 0.0106 | 0.2603 | 1 |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.0039 | 0.0411 | 0.0396 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0098 | 0.2341 | 0.3452 |
Schistosoma mansoni | alpha-glucosidase | 0.0139 | 0.3657 | 0.3647 |
Schistosoma mansoni | survival motor neuron protein | 0.0048 | 0.07 | 0.0685 |
Wolbachia endosymbiont of Brugia malayi | ATP synthase F0F1 subunit C | 0.0106 | 0.2603 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.0296 | 0.0281 |
Loa Loa (eye worm) | hypothetical protein | 0.0234 | 0.6751 | 1 |
Leishmania major | ATPase subunit 9, putative | 0.0106 | 0.2603 | 0.933 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0234 | 0.6751 | 0.6746 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.0411 | 0.0396 |
Brugia malayi | hypothetical protein | 0.0039 | 0.0411 | 0.0587 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0039 | 0.0411 | 0.0396 |
Echinococcus multilocularis | geminin | 0.0333 | 1 | 1 |
Trypanosoma brucei | hypothetical protein | 0.0093 | 0.2165 | 0.8088 |
Brugia malayi | Pre-SET motif family protein | 0.0029 | 0.0101 | 0.0126 |
Loa Loa (eye worm) | doublecortin family protein | 0.0039 | 0.0411 | 0.0609 |
Brugia malayi | MH2 domain containing protein | 0.0118 | 0.2987 | 0.4411 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0296 | 0.0416 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.006 | 0.1101 | 0.3998 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.0159 | 0.0143 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0029 | 0.0101 | 0.0085 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0101 | 0.0149 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.1331 | 0.1972 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0101 | 0.0085 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0036 | 0.0311 | 0.0296 |
Echinococcus multilocularis | GPCR, family 2 | 0.0031 | 0.0159 | 0.0143 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0159 | 0.0143 |
Plasmodium falciparum | ATP synthase subunit C, putative | 0.0106 | 0.2603 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.0159 | 0.0143 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0058 | 0.104 | 0.1025 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0161 | 0.4387 | 0.4378 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0118 | 0.2987 | 0.4424 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0101 | 0.0085 |
Brugia malayi | Doublecortin family protein | 0.0039 | 0.0411 | 0.0587 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0031 | 0.0159 | 0.0235 |
Onchocerca volvulus | 0.0232 | 0.6702 | 1 | |
Echinococcus granulosus | GPCR family 2 | 0.0031 | 0.0159 | 0.0143 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0411 | 0.0609 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0036 | 0.0311 | 1 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0058 | 0.104 | 0.154 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0039 | 0.0411 | 0.0396 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0039 | 0.0411 | 0.1242 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.0296 | 0.0281 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0232 | 0.6701 | 0.6696 |
Onchocerca volvulus | 0.0093 | 0.2178 | 0.3234 | |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.006 | 0.1101 | 0.1087 |
Trypanosoma brucei | Mitochondrial ATP synthase subunit c-1 | 0.0106 | 0.2603 | 1 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0036 | 0.0311 | 0.0438 |
Mycobacterium ulcerans | F0F1 ATP synthase subunit C | 0.0106 | 0.2603 | 1 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0232 | 0.6701 | 0.6696 |
Schistosoma mansoni | alpha-glucosidase | 0.0139 | 0.3657 | 0.3647 |
Schistosoma mansoni | lipoxygenase | 0.0232 | 0.6701 | 0.6696 |
Schistosoma mansoni | rab6-interacting | 0.0039 | 0.0411 | 0.0396 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.0159 | 0.0143 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.1101 | 0.1087 |
Schistosoma mansoni | alpha glucosidase | 0.0036 | 0.0311 | 0.0296 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0039 | 0.0411 | 0.0396 |
Trypanosoma cruzi | ATPase subunit 9, putative | 0.0106 | 0.2603 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0058 | 0.104 | 0.152 |
Schistosoma mansoni | rab6-interacting | 0.0039 | 0.0411 | 0.0396 |
Echinococcus granulosus | sodium channel protein | 0.0111 | 0.2767 | 0.2756 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0159 | 0.0143 |
Schistosoma mansoni | ATP synthase lipid-binding protein-like protein | 0.0106 | 0.2603 | 0.2591 |
Mycobacterium leprae | PROBABLE ATP SYNTHASE C CHAIN ATPE (LIPID-BINDING PROTEIN) (DICYCLOHEXYLCARBODIIMIDE-BINDING PROTEIN) | 0.0106 | 0.2603 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.07 | 0.0685 |
Schistosoma mansoni | hypothetical protein | 0.0067 | 0.1331 | 0.1317 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.006 | 0.1101 | 0.3216 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0058 | 0.104 | 0.1025 |
Schistosoma mansoni | loxhd1 | 0.0039 | 0.0411 | 0.0396 |
Schistosoma mansoni | jumonji domain containing protein | 0.0058 | 0.104 | 0.1025 |
Schistosoma mansoni | lipoxygenase | 0.0162 | 0.4429 | 0.442 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0159 | 0.0143 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.1101 | 0.1087 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0234 | 0.6751 | 0.6746 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.0016 | 0.0023 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0058 | 0.104 | 0.1025 |
Trypanosoma brucei | Mitochondrial ATP synthase subunit c-3 | 0.0106 | 0.2603 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0204 | 0.5785 | 0.8569 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.0016 | 0.0023 |
Schistosoma mansoni | ATP synthase lipid-binding protein-like protein | 0.0106 | 0.2603 | 0.2591 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0058 | 0.104 | 0.1025 |
Schistosoma mansoni | polycystin 1-related | 0.0039 | 0.0411 | 0.0396 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.0812 | 0.0797 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0161 | 0.4387 | 0.6498 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0296 | 0.0281 |
Onchocerca volvulus | 0.0029 | 0.0101 | 0.0127 | |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0098 | 0.2341 | 0.3468 |
Plasmodium vivax | ATP synthase lipid-binding protein, mitochondrial precursor, putative | 0.0106 | 0.2603 | 1 |
Brugia malayi | hypothetical protein | 0.0234 | 0.6751 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0058 | 0.104 | 0.1025 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0036 | 0.0311 | 1 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0039 | 0.0411 | 0.0396 |
Trypanosoma cruzi | ATPase subunit 9, putative | 0.0106 | 0.2603 | 1 |
Echinococcus multilocularis | mitochondrial ATP synthase subunit 9 | 0.0106 | 0.2603 | 0.2591 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0159 | 0.0235 |
Brugia malayi | Pre-SET motif family protein | 0.0204 | 0.5785 | 0.8566 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0411 | 0.0609 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0058 | 0.104 | 0.1025 |
Toxoplasma gondii | ATP synthase F0 subunit 9, putative | 0.0106 | 0.2603 | 1 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0048 | 0.07 | 0.1015 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.006 | 0.1101 | 0.1087 |
Brugia malayi | hypothetical protein | 0.0039 | 0.0411 | 0.0587 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0161 | 0.4387 | 0.6489 |
Leishmania major | calcium channel protein, putative,ion transporter, putative | 0.0111 | 0.2767 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0067 | 0.1331 | 0.1953 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0029 | 0.0101 | 0.0085 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0159 | 0.0143 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.0039 | 0.0411 | 0.0396 |
Trypanosoma cruzi | ATPase subunit 9, putative | 0.0106 | 0.2603 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0031 | 0.0159 | 0.0212 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0036 | 0.0311 | 0.0841 |
Mycobacterium tuberculosis | Probable ATP synthase C chain AtpE (lipid-binding protein) (dicyclohexylcarbodiimide-binding protein) | 0.0106 | 0.2603 | 1 |
Onchocerca volvulus | 0.0039 | 0.0411 | 0.0592 | |
Trichomonas vaginalis | set domain proteins, putative | 0.0232 | 0.6702 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0161 | 0.4387 | 0.4378 |
Brugia malayi | ATP synthase lipid-binding protein, mitochondrial precursor | 0.0106 | 0.2603 | 0.384 |
Schistosoma mansoni | hypothetical protein | 0.0333 | 1 | 1 |
Echinococcus granulosus | mitochondrial ATP synthase subunit 9 | 0.0106 | 0.2603 | 0.2591 |
Echinococcus granulosus | RUN | 0.0039 | 0.0411 | 0.0396 |
Echinococcus multilocularis | sodium channel protein | 0.0111 | 0.2767 | 0.2756 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0101 | 0.0085 |
Onchocerca volvulus | 0.0039 | 0.0411 | 0.0592 | |
Leishmania major | ATPase subunit 9, putative | 0.0106 | 0.2603 | 0.933 |
Schistosoma mansoni | hypothetical protein | 0.0333 | 1 | 1 |
Trypanosoma cruzi | ATPase subunit 9, putative | 0.0106 | 0.2603 | 1 |
Echinococcus multilocularis | RUN | 0.0039 | 0.0411 | 0.0396 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0029 | 0.0101 | 0.0085 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Inhibition of hypoxia-induced HIF1 activation in human U251HRE cells by cell based reporter gene assay | ChEMBL. | 18501601 | |
Activity (binding) | Inhibition of human recombinant PI3Kalpha assessed as formation of PI3P from PI by cell free kinase assay | ChEMBL. | 18501601 | |
Activity (binding) | 0 | Inhibition of mTOR in human H460 cells assessed as p70S6 phosphorylation at Thr 389 upto 30 uM | ChEMBL. | 18501601 |
Activity (binding) | 0 | Inhibition of human recombinant PI3Kalpha assessed as formation of PI3P from PI by cell free kinase assay | ChEMBL. | 18501601 |
Activity (binding) | 0 | Inhibition of hypoxia-induced HIF1 activation in human U251HRE cells by cell based reporter gene assay | ChEMBL. | 18501601 |
Inhibition (binding) | = 43 % | Inhibition of PI3K in human H460 cells assessed as Akt phosphorylation at Ser 473 at 10 uM | ChEMBL. | 18501601 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.