Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | coagulation factor X | Starlite/ChEMBL | References |
Homo sapiens | protease, serine, 1 (trypsin 1) | Starlite/ChEMBL | References |
Homo sapiens | coagulation factor II (thrombin) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Trypsin family protein | protease, serine, 1 (trypsin 1) | 247 aa | 287 aa | 21.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hydroxyacylglutathione hydrolase | 0.0181 | 1 | 1 |
Treponema pallidum | ribonuclease Z | 0.0035 | 0 | 0.5 |
Onchocerca volvulus | Hydroxyacylglutathione hydrolase, mitochondrial homolog | 0.0181 | 1 | 1 |
Entamoeba histolytica | metallo-beta-lactamase superfamily protein | 0.0035 | 0 | 0.5 |
Entamoeba histolytica | metallo-beta-lactamase family protein | 0.0035 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.5792 | 0.5792 |
Trypanosoma cruzi | hydroxyacylglutathione hydrolase, putative | 0.0181 | 1 | 1 |
Onchocerca volvulus | 0.0106 | 0.4875 | 0.4875 | |
Echinococcus granulosus | hydroxyacylglutathione hydrolase | 0.0181 | 1 | 1 |
Entamoeba histolytica | metallo-beta-lactamase superfamily protein | 0.0035 | 0 | 0.5 |
Plasmodium falciparum | cytosolic glyoxalase II | 0.0181 | 1 | 0.5 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0035 | 0 | 0.5 |
Echinococcus multilocularis | hydroxyacylglutathione hydrolase | 0.0181 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | metallo-beta-lactamase superfamily hydrolase | 0.0035 | 0 | 0.5 |
Trypanosoma brucei | hydroxyacylglutathione hydrolase, putative | 0.0181 | 1 | 1 |
Entamoeba histolytica | alkyl sulfatase, putative | 0.0035 | 0 | 0.5 |
Trypanosoma cruzi | hydroxyacylglutathione hydrolase, putative | 0.0181 | 1 | 1 |
Brugia malayi | Trypsin family protein | 0.012 | 0.5792 | 0.5792 |
Schistosoma mansoni | hydroxyacylglutathione hydrolase (Glyoxalase II) (Glx II) | 0.0181 | 1 | 1 |
Entamoeba histolytica | alkyl sulfatase, putative | 0.0035 | 0 | 0.5 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0035 | 0 | 0.5 |
Entamoeba histolytica | metallo-beta-lactamase family protein | 0.0035 | 0 | 0.5 |
Entamoeba histolytica | metallo-beta-lactamase family protein | 0.0035 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.5792 | 0.5792 |
Giardia lamblia | Hydroxyacylglutathione hydrolase | 0.0035 | 0 | 0.5 |
Chlamydia trachomatis | ribonuclease Z | 0.0035 | 0 | 0.5 |
Onchocerca volvulus | 0.012 | 0.5792 | 0.5792 | |
Mycobacterium tuberculosis | Possible glyoxalase II (hydroxyacylglutathione hydrolase) (GLX II) | 0.0146 | 0.7576 | 1 |
Trichomonas vaginalis | beta lactamase domain, putative | 0.0181 | 1 | 1 |
Mycobacterium leprae | POSSIBLE GLYOXALASE II (HYDROXYACYLGLUTATHIONE HYDROLASE) (GLX II) | 0.0146 | 0.7576 | 1 |
Giardia lamblia | Hydroxyacylglutathione hydrolase | 0.0035 | 0 | 0.5 |
Giardia lamblia | Metallo-beta-lactamase superfamily protein | 0.0035 | 0 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.012 | 0.5792 | 0.5792 |
Plasmodium vivax | hydroxyacyl glutathione hydrolase, putative | 0.0181 | 1 | 1 |
Toxoplasma gondii | hydroxyacylglutathione hydrolase | 0.0181 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0035 | 0 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.012 | 0.5792 | 0.5792 |
Leishmania major | hydroxyacylglutathione hydrolase, putative,glyoxalase II, putative | 0.0181 | 1 | 1 |
Mycobacterium ulcerans | glyoxalase II, GloB | 0.0181 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.5 nM | Inhibitory activity against factor Xa | ChEMBL. | 12031331 |
IC50 (binding) | = 0.5 nM | Inhibitory activity against factor Xa | ChEMBL. | 12031331 |
IC50 (binding) | = 188 nM | Inhibitory activity of the compound against trypsin was determined | ChEMBL. | 12031331 |
IC50 (binding) | = 188 nM | Inhibitory activity of the compound against trypsin was determined | ChEMBL. | 12031331 |
IC50 (binding) | = 650 nM | Inhibitory activity of the compound against Factor IIa (serine protease) was determined | ChEMBL. | 12031331 |
IC50 (binding) | = 650 nM | Inhibitory activity of the compound against Factor IIa (serine protease) was determined | ChEMBL. | 12031331 |
IC50 (binding) | = 0.0005 uM | Inhibitory concentration to coagulation factor X | ChEMBL. | 12482444 |
IC50 (binding) | = 0.0005 uM | Inhibitory concentration to coagulation factor X | ChEMBL. | 12482444 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.