Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glycogen synthase kinase 3 beta | Starlite/ChEMBL | References |
Homo sapiens | glycogen synthase kinase 3 alpha | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0133 | 1 | 1 |
Echinococcus granulosus | glycogen synthase kinase 3 beta | 0.0116 | 0.8708 | 0.8708 |
Trypanosoma cruzi | glycogen synthase kinase 3, putative | 0.0116 | 0.8708 | 0.8131 |
Giardia lamblia | Kinase, CMGC GSK | 0.0116 | 0.8708 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0116 | 0.8708 | 1 |
Loa Loa (eye worm) | CMGC/GSK protein kinase | 0.0116 | 0.8708 | 0.8708 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0133 | 1 | 1 |
Loa Loa (eye worm) | CMGC/GSK protein kinase | 0.0116 | 0.8708 | 0.8708 |
Loa Loa (eye worm) | cathepsin B | 0.0044 | 0.3089 | 0.3089 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0044 | 0.3089 | 0.3547 |
Echinococcus multilocularis | protein kinase shaggy | 0.0116 | 0.8708 | 0.8708 |
Echinococcus multilocularis | cathepsin b | 0.0133 | 1 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0044 | 0.3089 | 0.3547 |
Brugia malayi | intracellular kinase | 0.0116 | 0.8708 | 0.8708 |
Echinococcus multilocularis | glycogen synthase kinase 3 beta | 0.0116 | 0.8708 | 0.8708 |
Echinococcus granulosus | cathepsin b | 0.0133 | 1 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0116 | 0.8708 | 1 |
Echinococcus granulosus | cathepsin b | 0.0133 | 1 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0044 | 0.3089 | 0.3547 |
Treponema pallidum | cell division protein (ftsJ) | 0.0004 | 0 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0116 | 0.8708 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0044 | 0.3089 | 0.3089 |
Leishmania major | glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 | 0.0116 | 0.8708 | 1 |
Toxoplasma gondii | cathepsin B | 0.0044 | 0.3089 | 0.3547 |
Giardia lamblia | Kinase, CMGC GSK | 0.0116 | 0.8708 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0116 | 0.8708 | 1 |
Trypanosoma brucei | protein kinase, putative | 0.0116 | 0.8708 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0044 | 0.3089 | 0.3547 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0044 | 0.3089 | 0.3547 |
Plasmodium falciparum | glycogen synthase kinase 3 | 0.0116 | 0.8708 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0116 | 0.8708 | 1 |
Onchocerca volvulus | 0.0116 | 0.8708 | 1 | |
Echinococcus multilocularis | cathepsin b | 0.0133 | 1 | 1 |
Schistosoma mansoni | glycogen synthase kinase 3-related (gsk3) (cmgc group III) | 0.0116 | 0.8708 | 0.8708 |
Plasmodium vivax | glycogen synthase kinase 3, putative | 0.0116 | 0.8708 | 1 |
Echinococcus granulosus | protein kinase shaggy | 0.0116 | 0.8708 | 0.8708 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0133 | 1 | 1 |
Toxoplasma gondii | cell-cycle-associated protein kinase GSK, putative | 0.0116 | 0.8708 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 1 | 1 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0133 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0133 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2697 nM | Inhibition of human glycogen synthase kinase-3alpha (hGSK-3) | ChEMBL. | 12699760 |
IC50 (binding) | = 2697 nM | Inhibition of recombinant GSK3beta (unknown origin) | ChEMBL. | 18324764 |
IC50 (binding) | = 2697 nM | Inhibition of human glycogen synthase kinase-3alpha (hGSK-3) | ChEMBL. | 12699760 |
IC50 (binding) | = 2697 nM | Inhibition of recombinant GSK3beta (unknown origin) | ChEMBL. | 18324764 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.