TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 199.187 | Formula: C9H14NO2P
H donors: 2 H acceptors: 2 LogP: 0.68 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: NC(P(=O)O)CCc1ccccc1
InChi: 1S/C9H14NO2P/c10-9(13(11)12)7-6-8-4-2-1-3-5-8/h1-5,9,13H,6-7,10H2,(H,11,12)
InChiKey: BFYOJKDRJIERJF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Sus scrofa	Aminopeptidase N	Starlite/ChEMBL	References
Sus scrofa	Cytosol aminopeptidase	Starlite/ChEMBL	References
Homo sapiens	alanyl (membrane) aminopeptidase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania donovani	cytosolic leucyl aminopeptidase	Get druggable targets OG5_127293	All targets in OG5_127293
Plasmodium knowlesi	M17 leucyl aminopeptidase, putative	Get druggable targets OG5_127293	All targets in OG5_127293
Wolbachia endosymbiont of Brugia malayi	leucyl aminopeptidase	Get druggable targets OG5_127293	All targets in OG5_127293
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127217	All targets in OG5_127217
Leishmania major	cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17	Get druggable targets OG5_127293	All targets in OG5_127293
Trypanosoma cruzi	cytosolic leucyl aminopeptidase, putative	Get druggable targets OG5_127293	All targets in OG5_127293
Trypanosoma cruzi	metallo-peptidase, Clan MF, Family M17, putative	Get druggable targets OG5_127293	All targets in OG5_127293
Plasmodium berghei	M17 leucyl aminopeptidase, putative	Get druggable targets OG5_127293	All targets in OG5_127293
Plasmodium falciparum	M17 leucyl aminopeptidase	Get druggable targets OG5_127293	All targets in OG5_127293
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127217	All targets in OG5_127217
Echinococcus multilocularis	leucine aminopeptidase protein	Get druggable targets OG5_127293	All targets in OG5_127293
Leishmania infantum	cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17	Get druggable targets OG5_127293	All targets in OG5_127293
Leishmania braziliensis	cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17	Get druggable targets OG5_127293	All targets in OG5_127293
Trypanosoma brucei gambiense	cytosolic leucyl aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17, putative	Get druggable targets OG5_127293	All targets in OG5_127293
Toxoplasma gondii	leucyl aminopeptidase LAP	Get druggable targets OG5_127293	All targets in OG5_127293
Theileria parva	leucine aminopeptidase, putative	Get druggable targets OG5_127293	All targets in OG5_127293
Echinococcus granulosus	leucine aminopeptidase protein	Get druggable targets OG5_127293	All targets in OG5_127293
Brugia malayi	Peptidase family M1 containing protein	Get druggable targets OG5_127217	All targets in OG5_127217
Chlamydia trachomatis	cytosol aminopeptidase	Get druggable targets OG5_127293	All targets in OG5_127293
Schistosoma japonicum	ko:K01256 membrane alanyl aminopeptidase [EC3.4.11.2], putative	Get druggable targets OG5_127217	All targets in OG5_127217
Echinococcus multilocularis	aminopeptidase N	Get druggable targets OG5_127217	All targets in OG5_127217
Trypanosoma brucei	metallo-peptidase, Clan MF, Family M17	Get druggable targets OG5_127293	All targets in OG5_127293
Leishmania mexicana	cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17	Get druggable targets OG5_127293	All targets in OG5_127293
Plasmodium vivax	M17 leucyl aminopeptidase, putative	Get druggable targets OG5_127293	All targets in OG5_127293
Mycobacterium leprae	Probable cytosol aminopeptidase PepB	Get druggable targets OG5_127293	All targets in OG5_127293
Loa Loa (eye worm)	peptidase family M1 containing protein	Get druggable targets OG5_127217	All targets in OG5_127217
Cryptosporidium hominis	leucine aminopeptidase	Get druggable targets OG5_127293	All targets in OG5_127293
Onchocerca volvulus		Get druggable targets OG5_127217	All targets in OG5_127217
Babesia bovis	leucine aminopeptidase, putative	Get druggable targets OG5_127293	All targets in OG5_127293
Mycobacterium tuberculosis	Probable aminopeptidase PepB	Get druggable targets OG5_127293	All targets in OG5_127293
Neospora caninum	Probable cytosol aminopeptidase, related	Get druggable targets OG5_127293	All targets in OG5_127293
Plasmodium yoelii	putative leucine aminopeptidase	Get druggable targets OG5_127293	All targets in OG5_127293
Cryptosporidium parvum	putative leucine aminopeptidase; of possible plant or bacterial origin	Get druggable targets OG5_127293	All targets in OG5_127293
Mycobacterium ulcerans	leucyl aminopeptidase	Get druggable targets OG5_127293	All targets in OG5_127293
Echinococcus granulosus	aminopeptidase N	Get druggable targets OG5_127217	All targets in OG5_127217
Trypanosoma congolense	metallo-peptidase, Clan MF, Family M17, putative	Get druggable targets OG5_127293	All targets in OG5_127293

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Onchocerca volvulus		Aminopeptidase N	963 aa	893 aa	32.0 %
Echinococcus multilocularis	puromycin sensitive aminopeptidase	Aminopeptidase N	963 aa	988 aa	28.5 %
Echinococcus granulosus	puromycin sensitive aminopeptidase	Aminopeptidase N	963 aa	975 aa	29.1 %
Toxoplasma gondii	hypothetical protein	Cytosol aminopeptidase	36 aa	29 aa	34.5 %
Echinococcus multilocularis	puromycin sensitive aminopeptidase	Aminopeptidase N	963 aa	981 aa	29.2 %
Dictyostelium discoideum	PA14 domain-containing protein	Cytosol aminopeptidase	36 aa	31 aa	35.5 %
Trypanosoma brucei gambiense	haloacid dehalogenase-like hydrolase, putative	Cytosol aminopeptidase	36 aa	35 aa	31.4 %
Wolbachia endosymbiont of Brugia malayi	30S ribosomal protein S20	Cytosol aminopeptidase	36 aa	31 aa	45.2 %
Echinococcus granulosus	puromycin sensitive aminopeptidase	alanyl (membrane) aminopeptidase	967 aa	976 aa	28.8 %
Brugia malayi	Hsp20/alpha crystallin family protein	Cytosol aminopeptidase	36 aa	30 aa	40.0 %
Echinococcus multilocularis	puromycin sensitive aminopeptidase	Aminopeptidase N	963 aa	981 aa	28.8 %
Trypanosoma brucei	haloacid dehalogenase-like hydrolase, putative	Cytosol aminopeptidase	36 aa	35 aa	31.4 %
Plasmodium falciparum	rifin	Cytosol aminopeptidase	36 aa	29 aa	24.1 %
Trichomonas vaginalis	conserved hypothetical protein	Cytosol aminopeptidase	36 aa	33 aa	33.3 %
Brugia malayi	Hsp20/alpha crystallin family protein	Cytosol aminopeptidase	36 aa	30 aa	40.0 %
Plasmodium vivax	proteasome subunit beta type-6, putative	Cytosol aminopeptidase	36 aa	34 aa	41.2 %
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Cytosol aminopeptidase	36 aa	32 aa	37.5 %
Dictyostelium discoideum	PA14 domain-containing protein	Cytosol aminopeptidase	36 aa	31 aa	35.5 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium vivax	vivapain-1	0.0118	0.0624	0.419
Trypanosoma cruzi	aminopeptidase, putative	0.0084	0.0293	0.0293
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0074	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0074	0.0074
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.02	0.1431	0.3992
Plasmodium vivax	serine-repeat antigen (SERA)	0.0062	0.0074	0.0437
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0084	0.0293	0.0711
Entamoeba histolytica	cysteine protease, putative	0.0118	0.0624	0.4054
Loa Loa (eye worm)	ctsf protein	0.02	0.1431	0.1431
Echinococcus multilocularis	cathepsin b	0.1067	1	1
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0084	0.0293	0.0293
Plasmodium falciparum	cysteine proteinase falcipain 3	0.02	0.1431	0.9682
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.02	0.1431	0.4419
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0062	0.0074	0.0437
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0062	0.0074	0.0437
Entamoeba histolytica	cysteine protease, putative	0.0118	0.0624	0.4054
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0062	0.0074	0.0064
Brugia malayi	Papain family cysteine protease containing protein	0.0062	0.0074	0.0064
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0373	0.3144	1
Brugia malayi	Cathepsin L-like precursor	0.02	0.1431	0.1422
Loa Loa (eye worm)	hypothetical protein	0.0056	0.001	0.001
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0144	0.0881	0.2627
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0144	0.0881	0.0881
Entamoeba histolytica	cysteine proteinase, putative	0.0118	0.0624	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.02	0.1431	0.4419
Loa Loa (eye worm)	fibroinase	0.02	0.1431	0.1431
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0118	0.0624	0.0624
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0118	0.0624	0.0624
Echinococcus multilocularis	calpain family protein 1, d	0.0086	0.0311	0.0311
Brugia malayi	fibroinase precursor	0.0062	0.0074	0.0064
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0084	0.0293	0.022
Brugia malayi	calpain family protein 1	0.0117	0.0616	0.0606
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0084	0.0293	0.0293
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0084	0.0293	0.0293
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0062	0.0074	0.0074
Wolbachia endosymbiont of Brugia malayi	leucyl aminopeptidase	0.0204	0.1476	0.5
Schistosoma mansoni	cathepsin S (C01 family)	0.0062	0.0074	0.0074
Onchocerca volvulus		0.0286	0.2287	1
Entamoeba histolytica	cysteine proteinase, putative	0.0144	0.0881	0.5946
Onchocerca volvulus		0.02	0.1431	0.613
Loa Loa (eye worm)	peptidase family M1 containing protein	0.0232	0.1748	0.1748
Loa Loa (eye worm)	hypothetical protein	0.1067	1	1
Leishmania major	cathepsin L-like protease	0.02	0.1431	0.3992
Trypanosoma cruzi	cysteine peptidase, putative	0.02	0.1431	0.1431
Echinococcus granulosus	cathepsin L cysteine proteinase	0.02	0.1431	0.1367
Brugia malayi	Peptidase family M1 containing protein	0.0286	0.2287	0.2279
Trypanosoma brucei	metallo-peptidase, Clan MF, Family M17	0.0204	0.1476	0.4148
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0062	0.0074	0.0437
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0062	0.0074	0.0437
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.02	0.1431	0.4419
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0074	0.0074
Trypanosoma cruzi	cysteine proteinase, putative	0.0118	0.0624	0.0624
Echinococcus granulosus	cathepsin l cysteine peptidase	0.02	0.1431	0.1367
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0062	0.0074	0.0437
Onchocerca volvulus	Cathepsin L homolog	0.02	0.1431	0.613
Giardia lamblia	Cathepsin B precursor	0.0373	0.3144	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.02	0.1431	0.4419
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0056	0.001	0.001
Mycobacterium ulcerans	leucyl aminopeptidase	0.0204	0.1476	1
Plasmodium vivax	unspecified product	0.0062	0.0074	0.0437
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.1067	1	1
Entamoeba histolytica	cysteine protease, putative	0.0118	0.0624	0.4054
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0084	0.0293	0.0293
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1067	1	1
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0485	0.0485
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0062	0.0074	0.0437
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0062	0.0074	0.0437
Toxoplasma gondii	leucyl aminopeptidase LAP	0.0204	0.1476	0.4564
Entamoeba histolytica	cysteine protease, putative	0.0118	0.0624	0.4054
Echinococcus granulosus	cysteine protease	0.0118	0.0624	0.0554
Onchocerca volvulus		0.02	0.1431	0.613
Trypanosoma cruzi	cruzipain precursor, putative	0.02	0.1431	0.1431
Loa Loa (eye worm)	hypothetical protein	0.0144	0.0881	0.0881
Brugia malayi	hypothetical protein	0.0084	0.0293	0.0282
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0144	0.0881	0.0871
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0062	0.0074	0.0074
Onchocerca volvulus	Cathepsin F homolog	0.02	0.1431	0.613
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1067	1	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0144	0.0881	0.0881
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0311	0.0311
Loa Loa (eye worm)	cathepsin B	0.0373	0.3144	0.3144
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0084	0.0293	0.0711
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.02	0.1431	0.9682
Chlamydia trachomatis	cytosol aminopeptidase	0.0204	0.1476	0.5
Leishmania major	cathepsin L-like protease	0.02	0.1431	0.3992
Echinococcus granulosus	cathepsin l1	0.0144	0.0881	0.0813
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0062	0.0074	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0074	0.0074
Brugia malayi	Papain family cysteine protease containing protein	0.0118	0.0624	0.0615
Loa Loa (eye worm)	hypothetical protein	0.02	0.1431	0.1431
Toxoplasma gondii	cathepsin B	0.0373	0.3144	1
Loa Loa (eye worm)	cysteine protease	0.02	0.1431	0.1431
Entamoeba histolytica	cysteine protease, putative	0.02	0.1431	1
Plasmodium vivax	serine-repeat antigen (SERA)	0.0062	0.0074	0.0437
Trypanosoma cruzi	cytosolic leucyl aminopeptidase, putative	0.0204	0.1476	0.1476
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0118	0.0624	0.3925
Loa Loa (eye worm)	hypothetical protein	0.0056	0.001	0.001
Onchocerca volvulus		0.02	0.1431	0.613
Echinococcus granulosus	geminin	0.0165	0.1091	0.1024
Echinococcus granulosus	cathepsin l1	0.02	0.1431	0.1367
Trypanosoma cruzi	cysteine protease, putative	0.0118	0.0624	0.0624
Loa Loa (eye worm)	aminopeptidase N	0.0084	0.0293	0.0293
Echinococcus multilocularis	cathepsin b	0.1067	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.02	0.1431	0.4419
Echinococcus multilocularis	cysteine protease	0.02	0.1431	0.1431
Leishmania major	cysteine peptidase A (CPA)	0.02	0.1431	0.3992
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0062	0.0074	0.0074
Trypanosoma cruzi	Aminopeptidase M1, putative	0.0084	0.0293	0.0293
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0373	0.3144	1
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0074	0.0074
Brugia malayi	Cathepsin L-like precursor	0.02	0.1431	0.1422
Entamoeba histolytica	cysteine proteinase, putative	0.0118	0.0624	0.4054
Brugia malayi	Cathepsin L-like precursor	0.02	0.1431	0.1422
Entamoeba histolytica	cysteine proteinase 2	0.0118	0.0624	0.4054
Onchocerca volvulus		0.0084	0.0293	0.0986
Brugia malayi	Cathepsin L-like precursor	0.0144	0.0881	0.0871
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.02	0.1431	0.4419
Brugia malayi	Cathepsin L-like precursor	0.02	0.1431	0.1422
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0062	0.0074	0.0074
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0062	0.0074	0.0437
Brugia malayi	Papain family cysteine protease containing protein	0.0118	0.0624	0.0615
Trypanosoma cruzi	cysteine peptidase, putative	0.02	0.1431	0.1431
Trypanosoma cruzi	cysteine peptidase, putative	0.0056	0.001	0.001
Echinococcus multilocularis	geminin	0.0165	0.1091	0.1091
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.02	0.1431	0.4419
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.02	0.1431	0.3992
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0062	0.0074	0.0074
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.02	0.1431	0.3992
Trypanosoma cruzi	metallo-peptidase, Clan MF, Family M17, putative	0.0204	0.1476	0.1476
Loa Loa (eye worm)	hypothetical protein	0.0144	0.0881	0.0881
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.02	0.1431	0.4419
Echinococcus granulosus	cathepsin L	0.0118	0.0624	0.0554
Schistosoma mansoni	cathepsin C	0.0062	0.0074	0.0074
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.02	0.1431	0.4419
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0062	0.0074	0.0437
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0084	0.0293	0.022
Brugia malayi	Papain family cysteine protease containing protein	0.0062	0.0074	0.0064
Onchocerca volvulus		0.0144	0.0881	0.3645
Echinococcus multilocularis	cysteine protease	0.02	0.1431	0.1431
Echinococcus multilocularis	cathepsin L cysteine protease	0.02	0.1431	0.1431
Plasmodium vivax	M17 leucyl aminopeptidase, putative	0.0204	0.1476	1
Entamoeba histolytica	cysteine proteinase 1, putative	0.0118	0.0624	0.4054
Echinococcus multilocularis	calpain A	0.0122	0.0668	0.0668
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0084	0.0293	0.022
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.02	0.1431	0.3992
Trypanosoma cruzi	major cysteine proteinase, putative	0.0062	0.0074	0.0074
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.1067	1	1
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.0122	0.0668	0.0668
Echinococcus multilocularis	leucine aminopeptidase protein	0.0204	0.1476	0.1476
Brugia malayi	Cathepsin L-like precursor	0.02	0.1431	0.1422
Trypanosoma cruzi	cysteine peptidase, putative	0.02	0.1431	0.1431
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.02	0.1431	0.4419
Echinococcus granulosus	leucine aminopeptidase protein	0.0204	0.1476	0.1412
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.02	0.1431	0.3992
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0084	0.0293	0.022
Entamoeba histolytica	cysteine proteinase, putative	0.02	0.1431	1
Entamoeba histolytica	cysteine protease, putative	0.0118	0.0624	0.4054
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0062	0.0074	0.0437
Entamoeba histolytica	cysteine proteinase, putative	0.0118	0.0624	0.4054
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0224	0.1674	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1067	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.02	0.1431	0.3992
Trypanosoma cruzi	cysteine peptidase, putative	0.02	0.1431	0.1431
Leishmania major	cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17	0.0204	0.1476	0.4148
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0373	0.3144	0.3144
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0118	0.0624	0.1163
Brugia malayi	calpain family protein 1	0.0117	0.0616	0.0606
Echinococcus multilocularis	aminopeptidase N	0.0286	0.2287	0.2287
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.02	0.1431	0.4419
Loa Loa (eye worm)	calpain family protein 1	0.0117	0.0616	0.0616
Schistosoma mansoni	cathepsin F (C01 family)	0.02	0.1431	0.1431
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0118	0.0624	0.1791
Entamoeba histolytica	cysteine protease, putative	0.0118	0.0624	0.4054
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0084	0.0293	0.0293
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0373	0.3144	1
Plasmodium vivax	vivapain-2	0.02	0.1431	0.9695
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0616	0.0616
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0117	0.0616	0.0616
Echinococcus granulosus	cathepsin L cysteine protease	0.0118	0.0624	0.0554
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.02	0.1431	0.4419
Entamoeba histolytica	cysteine protease, putative	0.0118	0.0624	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.02	0.1431	0.4419
Entamoeba histolytica	cysteine protease, putative	0.0118	0.0624	0.4054
Schistosoma mansoni	hypothetical protein	0.0165	0.1091	0.1091
Giardia lamblia	Cathepsin B precursor	0.0373	0.3144	1
Giardia lamblia	Cathepsin B precursor	0.0373	0.3144	1
Trypanosoma cruzi	metallo-peptidase, clan MA(E), family M1, putative	0.0084	0.0293	0.0293
Brugia malayi	Cathepsin L-like precursor	0.0144	0.0881	0.0871
Loa Loa (eye worm)	hypothetical protein	0.0202	0.1455	0.1455
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0062	0.0074	0.0064
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0118	0.0624	0.0624
Onchocerca volvulus		0.02	0.1431	0.613
Trypanosoma cruzi	major cysteine proteinase, putative	0.0062	0.0074	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0144	0.0881	0.0881
Plasmodium falciparum	M17 leucyl aminopeptidase	0.0204	0.1476	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0118	0.0624	0.1791
Entamoeba histolytica	cysteine protease, putative	0.0118	0.0624	0.4054
Echinococcus granulosus	calpain A	0.0122	0.0668	0.0598
Onchocerca volvulus	Cathepsin L homolog	0.02	0.1431	0.613
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.02	0.1431	0.3992
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.02	0.1431	0.3992
Entamoeba histolytica	cysteine proteinase, putative	0.0118	0.0624	0.4054
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0122	0.0668	0.0668
Plasmodium vivax	vivapain-2	0.02	0.1431	0.9695
Loa Loa (eye worm)	calpain family protein 1	0.0086	0.0311	0.0311
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.02	0.1431	0.3992
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.02	0.1431	0.4419
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.02	0.1431	0.9682
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.02	0.1431	0.4419
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0074	0.0074
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.0122	0.0668	0.0598
Brugia malayi	Papain family cysteine protease containing protein	0.0062	0.0074	0.0064
Onchocerca volvulus		0.02	0.1431	0.613
Loa Loa (eye worm)	hypothetical protein	0.0056	0.001	0.001
Echinococcus multilocularis	cathepsin L	0.0118	0.0624	0.0624
Echinococcus granulosus	cathepsin b	0.1067	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0062	0.0074	0.0074
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0062	0.0074	0.0074
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0062	0.0074	0.0074
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.02	0.1431	0.3992
Schistosoma mansoni	cathepsin B (C01 family)	0.0062	0.0074	0.0074
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.02	0.1431	0.3992
Entamoeba histolytica	aminopeptidase, putative	0.0084	0.0293	0.1608
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.02	0.1431	0.1431
Trypanosoma cruzi	cruzipain precursor, putative	0.0056	0.001	0.001
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.02	0.1431	0.4419
Brugia malayi	cathepsin L-like cysteine proteinase	0.0062	0.0074	0.0064
Onchocerca volvulus		0.0073	0.018	0.0477
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.02	0.1431	0.4419
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0062	0.0074	0.0074
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.02	0.1431	0.1431
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0144	0.0881	0.2627
Echinococcus granulosus	aminopeptidase N	0.0286	0.2287	0.2229
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.02	0.1431	0.1431
Leishmania major	cathepsin L-like protease	0.02	0.1431	0.3992
Loa Loa (eye worm)	hypothetical protein	0.0257	0.1995	0.1995
Plasmodium vivax	unspecified product	0.0118	0.0624	0.419
Brugia malayi	Peptidase family M1 containing protein	0.0084	0.0293	0.0282
Entamoeba histolytica	cysteine protease, putative	0.0118	0.0624	0.4054
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0084	0.0293	0.0293
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0062	0.0074	0.0074
Brugia malayi	cathepsin L precursor	0.0062	0.0074	0.0064
Echinococcus granulosus	cathepsin b	0.1067	1	1
Onchocerca volvulus		0.02	0.1431	0.613
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.02	0.1431	0.4419
Echinococcus multilocularis	Peptidase M1, membrane alanine aminopeptidase, N terminal	0.0084	0.0293	0.0293
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0118	0.0624	0.1163
Plasmodium vivax	vivapain-3	0.0118	0.0624	0.419
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.02	0.1431	0.4419
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.02	0.1431	0.4419
Entamoeba histolytica	cysteine protease, putative	0.0118	0.0624	0.4054
Brugia malayi	Papain family cysteine protease containing protein	0.02	0.1431	0.1422
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0062	0.0074	0.0064
Schistosoma mansoni	cathepsin F (C01 family)	0.02	0.1431	0.1431
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0062	0.0074	0.0074
Brugia malayi	cathepsin F-like cysteine proteinase	0.0062	0.0074	0.0064
Leishmania major	cathepsin L-like protease	0.02	0.1431	0.3992
Loa Loa (eye worm)	hypothetical protein	0.0073	0.018	0.018
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.02	0.1431	0.4419
Trypanosoma cruzi	cysteine proteinase, putative	0.0118	0.0624	0.0624
Echinococcus multilocularis	cathepsin L cysteine protease	0.02	0.1431	0.1431
Brugia malayi	Cathepsin L-like precursor	0.02	0.1431	0.1422
Entamoeba histolytica	cysteine protease, putative	0.0118	0.0624	0.4054
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0118	0.0624	0.0624
Leishmania major	cathepsin L-like protease	0.02	0.1431	0.3992
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.02	0.1431	0.4419
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0373	0.3144	0.3144
Schistosoma mansoni	hypothetical protein	0.0165	0.1091	0.1091
Schistosoma mansoni	cytosol alanyl aminopeptidase (M01 family)	0.0084	0.0293	0.0293
Brugia malayi	cathepsin L-like precursor	0.0144	0.0881	0.0871
Echinococcus multilocularis	cathepsin L	0.0062	0.0074	0.0074
Toxoplasma gondii	cathepsin CPL	0.02	0.1431	0.4419
Entamoeba histolytica	cysteine proteinase, putative	0.02	0.1431	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.02	0.1431	0.4419
Leishmania major	cathepsin L-like protease	0.02	0.1431	0.3992
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.02	0.1431	0.4419
Entamoeba histolytica	cysteine protease, putative	0.0118	0.0624	0.4054
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.02	0.1431	0.1431
Leishmania major	cathepsin L-like protease	0.02	0.1431	0.3992
Trypanosoma cruzi	cysteine peptidase, putative	0.0118	0.0624	0.0624
Schistosoma mansoni	cathepsin s	0.0056	0.001	0.001
Leishmania major	cathepsin L-like protease	0.02	0.1431	0.3992
Onchocerca volvulus		0.02	0.1431	0.613
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0122	0.0668	0.0668
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.02	0.1431	0.4419
Mycobacterium leprae	Probable cytosol aminopeptidase PepB	0.0204	0.1476	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 0.00000013 M	Inhibition of pig kidney Aminopeptidase N	ChEMBL.	10386926
Ki (binding)	= 0.00000013 M	Inhibition of pig kidney Aminopeptidase N	ChEMBL.	10386926
Ki (binding)	= 0.16 nM	Inhibition of human recombinant alanyl aminopeptidase after 30 to 60 mins by morrison's equation	ChEMBL.	25192493
Ki (binding)	= 1.22 nM	Inhibition of pig recombinant alanyl aminopeptidase after 30 to 60 mins by morrison's equation	ChEMBL.	25192493
Ki (binding)	= 7.69 nM	Inhibition of pig recombinant leucine aminopeptidase after 30 to 60 mins by morrison's equation	ChEMBL.	25192493

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL289824

Bibliographic References

2 literature references were collected for this gene.

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Detailed information for compound 51357