Detailed information for compound 513839

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 460.565 | Formula: C28H32N2O4
  • H donors: 3 H acceptors: 3 LogP: 4.83 Rotable bonds: 15
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCC[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1)CCc1ccccc1
  • InChi: 1S/C28H32N2O4/c31-19-18-25(17-16-22-10-4-1-5-11-22)29-27(32)26(20-23-12-6-2-7-13-23)30-28(33)34-21-24-14-8-3-9-15-24/h1-15,25-26,31H,16-21H2,(H,29,32)(H,30,33)/t25-,26-/m0/s1
  • InChiKey: IAAFVVQSQVUBSV-UIOOFZCWSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0342 1 1
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0445 0.0445
Echinococcus multilocularis cysteine protease 0.002 0.0137 0.0137
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.063 0.0927
Trypanosoma cruzi ATPase subunit 9, putative 0.0108 0.2825 1
Leishmania major cathepsin L-like protease 0.002 0.0137 0.0458
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.1373 0.4859
Entamoeba histolytica hypothetical protein 0.0036 0.0635 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.1328 0.1328
Trypanosoma brucei Mitochondrial ATP synthase subunit c-2 0.0108 0.2825 1
Echinococcus multilocularis sodium channel protein 0.0113 0.2983 0.2983
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0137 0.0137
Entamoeba histolytica hypothetical protein 0.0036 0.0635 1
Brugia malayi Cathepsin L-like precursor 0.002 0.0137 0.0201
Schistosoma mansoni hypothetical protein 0.0036 0.0635 0.0635
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.1002 0.1474
Mycobacterium ulcerans F0F1 ATP synthase subunit C 0.0108 0.2825 1
Echinococcus multilocularis cysteine protease 0.002 0.0137 0.0137
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.063 0.0732
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.063 0.2231
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0635 0.0635
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.1387 0.1387
Brugia malayi Pre-SET motif family protein 0.003 0.0445 0.0654
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.1387 0.4649
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.1387 0.1387
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1878 0.6648
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1878 0.6648
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0137 0.0137
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0113 0.2983 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0332 0.0489
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0164 0.4534 0.6669
Schistosoma mansoni lamin 0.0027 0.0347 0.0347
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.063 0.063
Echinococcus multilocularis musashi 0.0027 0.0347 0.0347
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0635 0.0635
Brugia malayi Cathepsin L-like precursor 0.002 0.0137 0.0201
Toxoplasma gondii ATP synthase F0 subunit 9, putative 0.0108 0.2825 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0137 0.0137
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0137 0.0137
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.063 0.0732
Plasmodium falciparum ATP synthase subunit C, putative 0.0108 0.2825 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0493 0.0493
Schistosoma mansoni hypothetical protein 0.0342 1 1
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0238 0.6813 0.6813
Echinococcus multilocularis lysosomal alpha glucosidase 0.0164 0.4534 0.4534
Schistosoma mansoni lamin 0.0027 0.0347 0.0347
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0493 0.0725
Plasmodium vivax vivapain-2 0.002 0.0137 0.0484
Echinococcus granulosus Polycystic kidney disease protein 0.004 0.0737 0.0737
Leishmania major ATPase subunit 9, putative 0.0108 0.2825 0.9471
Loa Loa (eye worm) hypothetical protein 0.003 0.0445 0.0654
Brugia malayi jmjC domain containing protein 0.0059 0.1328 0.1953
Trypanosoma cruzi ATPase subunit 9, putative 0.0108 0.2825 1
Schistosoma mansoni alpha glucosidase 0.0036 0.063 0.063
Echinococcus granulosus lipoxygenase domain containing protein 0.004 0.0737 0.0737
Leishmania major cathepsin L-like protease 0.0077 0.1878 0.6296
Echinococcus granulosus lipoxygenase domain containing protein 0.004 0.0737 0.0737
Echinococcus multilocularis lysine specific demethylase 5A 0.0059 0.1328 0.1328
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0493 0.0725
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.063 0.0732
Brugia malayi hypothetical protein 0.004 0.0737 0.1084
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0137 0.0137
Plasmodium vivax SET domain protein, putative 0.003 0.0445 0.1574
Trypanosoma cruzi ATPase subunit 9, putative 0.0108 0.2825 1
Echinococcus multilocularis GPCR, family 2 0.0032 0.0493 0.0493
Echinococcus granulosus survival motor neuron protein 1 0.0238 0.6798 0.6798
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0445 0.0445
Loa Loa (eye worm) hypothetical protein 0.0101 0.2601 0.3826
Schistosoma mansoni hypothetical protein 0.0069 0.1625 0.1625
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0493 0.0725
Echinococcus multilocularis lysosomal alpha glucosidase 0.0164 0.4534 0.4534
Plasmodium vivax vivapain-2 0.002 0.0137 0.0484
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1878 0.6648
Leishmania major ATPase subunit 9, putative 0.0108 0.2825 0.9471
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0493 0.0493
Schistosoma mansoni survival motor neuron protein 0.0048 0.1002 0.1002
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.063 0.063
Plasmodium falciparum cysteine proteinase falcipain 2b 0.002 0.0137 0.0484
Brugia malayi Cathepsin L-like precursor 0.002 0.0137 0.0201
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1878 0.6648
Schistosoma mansoni intermediate filament proteins 0.0027 0.0347 0.0347
Schistosoma mansoni jumonji domain containing protein 0.0059 0.1328 0.1328
Onchocerca volvulus 0.0027 0.0347 0.0313
Leishmania major cathepsin L-like protease 0.002 0.0137 0.0458
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0211 0.5984 0.8802
Plasmodium falciparum cysteine proteinase falcipain 3 0.002 0.0137 0.0484
Schistosoma mansoni ATP synthase lipid-binding protein-like protein 0.0108 0.2825 0.2825
Echinococcus granulosus mitochondrial ATP synthase subunit 9 0.0108 0.2825 0.2825
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.063 0.0732
Schistosoma mansoni lipoxygenase 0.0166 0.4618 0.4618
Schistosoma mansoni hypothetical protein 0.0052 0.111 0.111
Leishmania major cathepsin L-like protease 0.0077 0.1878 0.6296
Brugia malayi Cathepsin L-like precursor 0.002 0.0137 0.0201
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1878 0.6648
Brugia malayi intermediate filament protein 0.0027 0.0347 0.0511
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.1878 0.6648
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.1878 0.6648
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.1625 0.2391
Trypanosoma cruzi ATPase subunit 9, putative 0.0108 0.2825 1
Leishmania major cathepsin L-like protease 0.002 0.0137 0.0458
Plasmodium vivax ATP synthase lipid-binding protein, mitochondrial precursor, putative 0.0108 0.2825 1
Mycobacterium leprae PROBABLE ATP SYNTHASE C CHAIN ATPE (LIPID-BINDING PROTEIN) (DICYCLOHEXYLCARBODIIMIDE-BINDING PROTEIN) 0.0108 0.2825 0.5
Echinococcus granulosus RUN 0.004 0.0737 0.0737
Schistosoma mansoni hypothetical protein 0.0048 0.1002 0.1002
Echinococcus multilocularis Polycystic kidney disease protein 0.004 0.0737 0.0737
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.1878 0.6648
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0059 0.1328 0.1328
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0113 0.2983 0.2983
Brugia malayi Pre-SET motif family protein 0.0211 0.5984 0.8802
Brugia malayi hypothetical protein 0.0036 0.0635 0.0934
Onchocerca volvulus 0.003 0.0445 0.0457
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.063 0.2231
Echinococcus granulosus lamin dm0 0.0027 0.0347 0.0347
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0347 0.0511
Brugia malayi ATP synthase lipid-binding protein, mitochondrial precursor 0.0108 0.2825 0.4155
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1878 0.6648
Echinococcus multilocularis lamin 0.0027 0.0347 0.0347
Leishmania major cathepsin L-like protease 0.002 0.0137 0.0458
Echinococcus multilocularis lipoxygenase domain containing protein 0.004 0.0737 0.0737
Leishmania major cathepsin L-like protease 0.002 0.0137 0.0458
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0635 0.0635
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1878 0.6648
Trichomonas vaginalis set domain proteins, putative 0.024 0.6878 1
Schistosoma mansoni ATP synthase lipid-binding protein-like protein 0.0108 0.2825 0.2825
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1878 0.6648
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.063 0.2231
Trypanosoma brucei hypothetical protein 0.0094 0.2405 0.8515
Leishmania major cysteine peptidase A (CPA) 0.002 0.0137 0.0458
Brugia malayi hypothetical protein 0.0238 0.6798 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0445 0.0445
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0445 0.1574
Onchocerca volvulus 0.004 0.0737 0.089
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1878 0.6648
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0445 0.0445
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0137 0.0201
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.1328 0.1328
Schistosoma mansoni alpha-glucosidase 0.0141 0.3835 0.3835
Schistosoma mansoni lipoxygenase 0.0238 0.6813 0.6813
Plasmodium vivax multidomain scavenger receptor, putative 0.004 0.0737 0.2608
Schistosoma mansoni hypothetical protein 0.0032 0.0493 0.0493
Echinococcus multilocularis survival motor neuron protein 1 0.0238 0.6798 0.6798
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0347 0.0511
Brugia malayi hypothetical protein 0.004 0.0737 0.1084
Mycobacterium tuberculosis Probable ATP synthase C chain AtpE (lipid-binding protein) (dicyclohexylcarbodiimide-binding protein) 0.0108 0.2825 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.002 0.0137 0.0484
Loa Loa (eye worm) hypothetical protein 0.002 0.0137 0.0201
Loa Loa (eye worm) MH2 domain-containing protein 0.012 0.3193 0.4697
Echinococcus granulosus lysosomal alpha glucosidase 0.0164 0.4534 0.4534
Echinococcus granulosus lamin 0.0027 0.0347 0.0347
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1878 0.6648
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0493 0.0493
Schistosoma mansoni hypothetical protein 0.004 0.0737 0.0737
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0445 0.0445
Echinococcus multilocularis mitochondrial ATP synthase subunit 9 0.0108 0.2825 0.2825
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.063 0.0732
Loa Loa (eye worm) doublecortin family protein 0.004 0.0737 0.1084
Leishmania major cathepsin L-like protease 0.0077 0.1878 0.6296
Echinococcus multilocularis RUN 0.004 0.0737 0.0737
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.1328 0.1953
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0493 0.0493
Schistosoma mansoni hypothetical protein 0.0032 0.0493 0.0493
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.1387 0.4909
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0445 0.0445
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.063 0.2113
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.063 0.0927
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0238 0.6813 0.6813
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.063 0.0732
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0445 0.0445
Schistosoma mansoni loxhd1 0.004 0.0737 0.0737
Brugia malayi Cathepsin L-like precursor 0.002 0.0137 0.0201
Loa Loa (eye worm) fibroinase 0.002 0.0137 0.0201
Schistosoma mansoni hypothetical protein 0.0032 0.0493 0.0493
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.063 0.9904
Echinococcus multilocularis geminin 0.0342 1 1
Onchocerca volvulus 0.0095 0.2419 0.3385
Echinococcus multilocularis lamin dm0 0.0027 0.0347 0.0347
Brugia malayi MH2 domain containing protein 0.012 0.3193 0.4697
Loa Loa (eye worm) hypothetical protein 0.0032 0.0493 0.0725
Echinococcus granulosus lysine specific demethylase 5A 0.0059 0.1328 0.1328
Onchocerca volvulus 0.0048 0.1002 0.1284
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.1387 0.1387
Loa Loa (eye worm) hypothetical protein 0.0027 0.0347 0.0511
Trypanosoma cruzi ATPase subunit 9, putative 0.0108 0.2825 1
Plasmodium falciparum LCCL domain-containing protein 0.004 0.0737 0.2608
Loa Loa (eye worm) hypothetical protein 0.0238 0.6798 1
Onchocerca volvulus 0.0027 0.0347 0.0313
Onchocerca volvulus 0.024 0.6878 1
Brugia malayi jmjC domain containing protein 0.0059 0.1328 0.1953
Trypanosoma brucei Mitochondrial ATP synthase subunit c-3 0.0108 0.2825 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0137 0.0137
Schistosoma mansoni hypothetical protein 0.0032 0.0493 0.0493
Echinococcus granulosus cathepsin l1 0.002 0.0137 0.0137
Loa Loa (eye worm) hypothetical protein 0.004 0.0737 0.1084
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.063 0.0732
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.1878 0.6648
Loa Loa (eye worm) ctsf protein 0.002 0.0137 0.0201
Echinococcus multilocularis lipoxygenase domain containing protein 0.004 0.0737 0.0737
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.063 0.9904
Echinococcus granulosus GPCR family 2 0.0032 0.0493 0.0493
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.063 0.0732
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1878 0.6648
Schistosoma mansoni rab6-interacting 0.004 0.0737 0.0737
Onchocerca volvulus 0.004 0.0737 0.089
Echinococcus granulosus intermediate filament protein 0.0027 0.0347 0.0347
Entamoeba histolytica hypothetical protein 0.0036 0.0635 1
Brugia malayi Cathepsin L-like precursor 0.002 0.0137 0.0201
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.2601 0.3826
Loa Loa (eye worm) cysteine protease 0.002 0.0137 0.0201
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.063 0.0732
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.2601 0.3826
Schistosoma mansoni rab6-interacting 0.004 0.0737 0.0737
Loa Loa (eye worm) hypothetical protein 0.004 0.0737 0.1084
Trypanosoma brucei glucosidase, putative 0.0036 0.063 0.2231
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0137 0.0137
Toxoplasma gondii cathepsin CPL 0.002 0.0137 0.0484
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.1387 0.1387
Schistosoma mansoni alpha-glucosidase 0.0141 0.3835 0.3835
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0137 0.0137
Wolbachia endosymbiont of Brugia malayi ATP synthase F0F1 subunit C 0.0108 0.2825 0.5
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0411 0.0411
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.2601 0.3826
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0137 0.0484
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0059 0.1328 0.1328
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0137 0.0201
Schistosoma mansoni polycystin 1-related 0.004 0.0737 0.0737
Trypanosoma brucei Mitochondrial ATP synthase subunit c-1 0.0108 0.2825 1
Loa Loa (eye worm) transcription factor SMAD2 0.012 0.3193 0.4697
Echinococcus granulosus sodium channel protein 0.0113 0.2983 0.2983
Brugia malayi Doublecortin family protein 0.004 0.0737 0.1084
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.1673 0.5922
Leishmania major ATPase subunit 9, putative 0.0108 0.2825 0.9471
Loa Loa (eye worm) hypothetical protein 0.0069 0.1625 0.2391
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0347 0.0511
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0137 0.0201
Entamoeba histolytica hypothetical protein 0.0036 0.0635 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0164 0.4534 0.6669

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) > -5 Inhibition of Trypanosoma cruzi cruzain ChEMBL. 17996450
Log Ki (binding) > 5 Inhibition of Trypanosoma cruzi cruzain ChEMBL. 17996450

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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