Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adenosine A2b receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A2a receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | follicle stimulating hormone receptor | adenosine A2a receptor | 412 aa | 336 aa | 22.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | CMGC family protein kinase | 0.0061 | 0.7243 | 1 |
Echinococcus multilocularis | dual specificity | 0.0061 | 0.7243 | 0.7302 |
Brugia malayi | Dual-specificity tyrosine-phosphorylation regulated kinase 2 | 0.0061 | 0.7243 | 0.7302 |
Plasmodium falciparum | MO15-related protein kinase | 0.0014 | 0 | 0.5 |
Plasmodium vivax | serine/threonine protein kinase KIN, putative | 0.0014 | 0 | 0.5 |
Toxoplasma gondii | cell-cycle-associated protein kinase DYRK2, putative | 0.0061 | 0.7243 | 0.5 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK2 protein kinase | 0.0061 | 0.7243 | 0.7243 |
Leishmania major | protein kinase, putative,dual-specificity protein kinase, putative | 0.0061 | 0.7243 | 1 |
Loa Loa (eye worm) | haspin protein kinase | 0.0079 | 0.9918 | 0.9918 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.0079 | 0.9918 | 1 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.0079 | 0.9918 | 1 |
Echinococcus granulosus | dual specificity | 0.0061 | 0.7243 | 0.7302 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0061 | 0.7243 | 1 |
Brugia malayi | GSG2 | 0.0079 | 0.9918 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0061 | 0.7243 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase haspin | 0.0079 | 0.9918 | 1 |
Echinococcus granulosus | dual specificity | 0.0061 | 0.7243 | 0.7302 |
Echinococcus granulosus | dual specificity | 0.0061 | 0.7243 | 0.7302 |
Trypanosoma cruzi | dual specificity tyrosine-phosphorylation-regulated kinase 2, putative | 0.0061 | 0.7243 | 1 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.0079 | 0.9918 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0061 | 0.7243 | 1 |
Brugia malayi | hypothetical protein | 0.0079 | 0.9918 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0061 | 0.7243 | 1 |
Trypanosoma brucei | dual specificity tyrosine-phosphorylation-regulated kinase 2, putative | 0.0061 | 0.7243 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0061 | 0.7243 | 1 |
Echinococcus multilocularis | dual specificity | 0.0061 | 0.7243 | 0.7302 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0061 | 0.7243 | 1 |
Loa Loa (eye worm) | haspin protein kinase | 0.0079 | 0.9918 | 0.9918 |
Plasmodium vivax | cyclin dependent kinase 7 (cdk7), putative | 0.0014 | 0 | 0.5 |
Echinococcus multilocularis | serine:threonine protein kinase haspin | 0.0079 | 0.9918 | 1 |
Echinococcus multilocularis | dual specificity | 0.0061 | 0.7243 | 0.7302 |
Giardia lamblia | Kinase, CMGC DYRK | 0.0061 | 0.7243 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0061 | 0.7243 | 0.7302 |
Schistosoma mansoni | hypothetical protein | 0.0079 | 0.9918 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0061 | 0.7243 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = -8.09 | Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells | ChEMBL. | 18226909 |
Ki (binding) | = -6.57 | Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in CHO cells | ChEMBL. | 18226909 |
Log Ki (binding) | Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cells | ChEMBL. | 18226909 | |
Log Ki (binding) | Displacement of [3H]NECA from human adenosine A3 receptor expressed in CHO cells | ChEMBL. | 18226909 | |
Log Ki (binding) | 0 | Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cells | ChEMBL. | 18226909 |
Log Ki (binding) | 0 | Displacement of [3H]NECA from human adenosine A3 receptor expressed in CHO cells | ChEMBL. | 18226909 |
Log Ki (binding) | = 6.57 | Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in CHO cells | ChEMBL. | 18226909 |
Log Ki (binding) | = 8.09 | Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells | ChEMBL. | 18226909 |
Ratio (binding) | = 26 | Selectivity index, ratio for human adenosine A2A receptor to human adenosine A2B receptor | ChEMBL. | 18226909 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.