Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.0079 | 0.9918 | 1 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.0079 | 0.9918 | 1 |
Loa Loa (eye worm) | haspin protein kinase | 0.0079 | 0.9918 | 0.9918 |
Echinococcus granulosus | dual specificity | 0.0061 | 0.7243 | 0.7302 |
Echinococcus multilocularis | serine:threonine protein kinase haspin | 0.0079 | 0.9918 | 1 |
Echinococcus granulosus | dual specificity | 0.0061 | 0.7243 | 0.7302 |
Echinococcus granulosus | dual specificity | 0.0061 | 0.7243 | 0.7302 |
Trypanosoma cruzi | dual specificity tyrosine-phosphorylation-regulated kinase 2, putative | 0.0061 | 0.7243 | 1 |
Brugia malayi | GSG2 | 0.0079 | 0.9918 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0061 | 0.7243 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0061 | 0.7243 | 1 |
Plasmodium falciparum | MO15-related protein kinase | 0.0014 | 0 | 0.5 |
Plasmodium vivax | serine/threonine protein kinase KIN, putative | 0.0014 | 0 | 0.5 |
Brugia malayi | Dual-specificity tyrosine-phosphorylation regulated kinase 2 | 0.0061 | 0.7243 | 0.7302 |
Toxoplasma gondii | cell-cycle-associated protein kinase DYRK2, putative | 0.0061 | 0.7243 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0061 | 0.7243 | 1 |
Echinococcus multilocularis | dual specificity | 0.0061 | 0.7243 | 0.7302 |
Leishmania major | protein kinase, putative,dual-specificity protein kinase, putative | 0.0061 | 0.7243 | 1 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK2 protein kinase | 0.0061 | 0.7243 | 0.7243 |
Plasmodium vivax | cyclin dependent kinase 7 (cdk7), putative | 0.0014 | 0 | 0.5 |
Loa Loa (eye worm) | haspin protein kinase | 0.0079 | 0.9918 | 0.9918 |
Giardia lamblia | Kinase, CMGC DYRK | 0.0061 | 0.7243 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0061 | 0.7243 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0079 | 0.9918 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0061 | 0.7243 | 0.7302 |
Echinococcus multilocularis | serine:threonine protein kinase haspin | 0.0079 | 0.9918 | 1 |
Echinococcus multilocularis | dual specificity | 0.0061 | 0.7243 | 0.7302 |
Entamoeba histolytica | protein kinase, putative | 0.0061 | 0.7243 | 1 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.0079 | 0.9918 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0061 | 0.7243 | 1 |
Echinococcus multilocularis | dual specificity | 0.0061 | 0.7243 | 0.7302 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0061 | 0.7243 | 1 |
Trypanosoma brucei | dual specificity tyrosine-phosphorylation-regulated kinase 2, putative | 0.0061 | 0.7243 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0061 | 0.7243 | 1 |
Brugia malayi | hypothetical protein | 0.0079 | 0.9918 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Antimicrobial activity against Escherichia coli SPA27 upto 100 ug/ml by broth dilution technique | ChEMBL. | 18299196 | |
Activity (functional) | Antimicrobial activity against Saccharomyces cerevisiae ATCC 9763 upto 100 ug/ml by broth dilution technique | ChEMBL. | 18299196 | |
Activity (functional) | 0 | Antimicrobial activity against Escherichia coli SPA27 upto 100 ug/ml by broth dilution technique | ChEMBL. | 18299196 |
Activity (functional) | 0 | Antimicrobial activity against Candida tropicalis ATCC 1369 upto 100 ug/ml by broth dilution technique | ChEMBL. | 18299196 |
Activity (functional) | 0 | Antimicrobial activity against Aspergillus niger ATCC 6275 upto 100 ug/ml by broth dilution technique | ChEMBL. | 18299196 |
Activity (functional) | 0 | Antimicrobial activity against Saccharomyces cerevisiae ATCC 9763 upto 100 ug/ml by broth dilution technique | ChEMBL. | 18299196 |
MIC (functional) | = 0.15 ug ml-1 | Antimicrobial activity against Haemophilus influenzae by broth dilution technique | ChEMBL. | 18299196 |
MIC (functional) | = 0.3 ug ml-1 | Antimicrobial activity against Bacillus megaterium by broth dilution technique | ChEMBL. | 18299196 |
MIC (functional) | = 0.7 ug ml-1 | Antimicrobial activity against Bacillus subtilis ATCC 6633 by broth dilution technique | ChEMBL. | 18299196 |
MIC (functional) | = 0.7 ug ml-1 | Antimicrobial activity against penicillin-resistant Staphylococcus aureus by broth dilution technique | ChEMBL. | 18299196 |
MIC (functional) | = 0.7 ug ml-1 | Antimicrobial activity against Bacillus thuringiensis var. kurstaki BGSC 4D1 by broth dilution technique | ChEMBL. | 18299196 |
MIC (functional) | = 1.5 ug ml-1 | Antimicrobial activity against Staphylococcus aureus ATCC 25923 by broth dilution technique | ChEMBL. | 18299196 |
MIC (functional) | = 3 ug ml-1 | Antimicrobial activity against Sarcina lutea by broth dilution technique | ChEMBL. | 18299196 |
MIC (functional) | = 3 ug ml-1 | Antimicrobial activity against penicillin-resistant Staphylococcus epidermidis ATCC 12228 by broth dilution technique | ChEMBL. | 18299196 |
MIC (functional) | = 3 ug ml-1 | Antimicrobial activity against penicillin-resistant Staphylococcus epidermidis by broth dilution technique | ChEMBL. | 18299196 |
MIC (functional) | = 3 ug ml-1 | Antimicrobial activity against Staphylococcus haemolyticus by broth dilution technique | ChEMBL. | 18299196 |
MIC (functional) | = 3 ug ml-1 | Antimicrobial activity against Streptococcus agalactiae by broth dilution technique | ChEMBL. | 18299196 |
MIC (functional) | = 3 ug ml-1 | Antimicrobial activity against Streptococcus faecium by broth dilution technique | ChEMBL. | 18299196 |
MIC (functional) | = 12 ug ml-1 | Antimicrobial activity against Streptococcus faecalis by broth dilution technique | ChEMBL. | 18299196 |
MIC (functional) | = 12 ug ml-1 | Antimicrobial activity against Streptococcus pyogenes by broth dilution technique | ChEMBL. | 18299196 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.