Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | acetolactate synthase large subunit IlvB | 0.0282 | 0.2722 | 0.4994 |
Leishmania major | putative pyruvate/indole-pyruvate carboxylase, putative | 0.0282 | 0.2722 | 1 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0685 | 0.7263 | 1 |
Trypanosoma brucei | phosphonopyruvate decarboxylase-like protein, putative | 0.0159 | 0.1343 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0685 | 0.7263 | 1 |
Mycobacterium ulcerans | acetolactate synthase | 0.0282 | 0.2722 | 0.4994 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0685 | 0.7263 | 1 |
Mycobacterium leprae | Probable Acetolactate synthase IlvG (Acetohydroxy-acid synthase)(ALS) | 0.0492 | 0.509 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0271 | 0.26 | 0.8947 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0685 | 0.7263 | 1 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0685 | 0.7263 | 1 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0282 | 0.2722 | 0.5 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0335 | 0.332 | 0.6111 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0685 | 0.7263 | 1 |
Mycobacterium ulcerans | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | 0.0087 | 0.0537 | 0.0378 |
Trypanosoma brucei | phosphonopyruvate decarboxylase-like protein, putative | 0.0159 | 0.1343 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0159 | 0.1343 | 0.208 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0271 | 0.26 | 0.26 |
Mycobacterium tuberculosis | Probable oxalyl-CoA decarboxylase OxcA | 0.0492 | 0.509 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0685 | 0.7263 | 1 |
Schistosoma mansoni | acetolactate synthase | 0.042 | 0.4285 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0685 | 0.7263 | 1 |
Mycobacterium ulcerans | pyruvate or indole-3-pyruvate decarboxylase Pdc | 0.0282 | 0.2722 | 0.4994 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0271 | 0.26 | 1 |
Onchocerca volvulus | 0.0055 | 0.0175 | 1 | |
Brugia malayi | hypothetical protein | 0.0271 | 0.26 | 0.5108 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0282 | 0.2722 | 0.5 |
Brugia malayi | Thiamine pyrophosphate enzyme, central domain containing protein | 0.0492 | 0.509 | 1 |
Loa Loa (eye worm) | thiamine pyrophosphate enzyme | 0.0282 | 0.2727 | 0.9385 |
Mycobacterium ulcerans | hypothetical protein | 0.0492 | 0.509 | 1 |
Mycobacterium leprae | PROBABLE ACETOLACTATE SYNTHASE (LARGE SUBUNIT) ILVB (ACETOHYDROXY-ACID SYNTHASE) | 0.0492 | 0.509 | 1 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0335 | 0.332 | 0.6258 |
Trypanosoma cruzi | phosphonopyruvate decarboxylase, putative | 0.0159 | 0.1343 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0055 | 0.0175 | 0.0408 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0685 | 0.7263 | 1 |
Mycobacterium ulcerans | acetolactate synthase 1 catalytic subunit | 0.0492 | 0.509 | 1 |
Loa Loa (eye worm) | ILVBL protein | 0.0298 | 0.2906 | 1 |
Schistosoma mansoni | survival motor neuron protein | 0.0055 | 0.0175 | 0.0408 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0335 | 0.332 | 0.6258 |
Trypanosoma cruzi | phosphonopyruvate decarboxylase, putative | 0.0159 | 0.1343 | 0.5 |
Mycobacterium tuberculosis | Acetolactate synthase (large subunit) IlvB1 (acetohydroxy-acid synthase) | 0.021 | 0.1922 | 0.3304 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0685 | 0.7263 | 1 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0055 | 0.0175 | 0.0343 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0685 | 0.7263 | 1 |
Mycobacterium ulcerans | putative oxalyl-CoA decarboxylase | 0.0492 | 0.509 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0685 | 0.7263 | 1 |
Mycobacterium tuberculosis | Probable acetolactate synthase IlvG (acetohydroxy-acid synthase)(ALS) | 0.0492 | 0.509 | 1 |
Schistosoma mansoni | acetolactate synthase | 0.042 | 0.4285 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | 0 | Increase in IFNgamma stimulated nitric oxide production in C57BL/6 mouse peritoneal macrophages at 100 uM after 24 hrs | ChEMBL. | 17964173 |
Activity (ADMET) | 0 | Cytotoxicity against mouse L929 cells | ChEMBL. | 17964173 |
Activity (ADMET) | 0 | Cytotoxicity against mouse L1210 cells | ChEMBL. | 17964173 |
Activity (ADMET) | 0 | Cytotoxicity against human HeLaS3 cells | ChEMBL. | 17964173 |
Activity (functional) | 0 | Antiviral activity against MSV | ChEMBL. | 17964173 |
Activity (functional) | 0 | Antiviral activity against HIV1 | ChEMBL. | 17964173 |
Activity (functional) | 0 | Antiviral activity against HIV2 | ChEMBL. | 17964173 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.