Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | Starlite/ChEMBL | References |
Homo sapiens | integrin, beta 5 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | integrin beta-2 | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Schistosoma japonicum | Integrin beta-3 precursor, putative | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Schistosoma japonicum | Integrin beta-PS precursor, putative | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Schistosoma japonicum | ko:K06464 integrin beta 2, putative | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Brugia malayi | Integrin beta pat-3 precursor | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Schistosoma mansoni | integrin beta subunit | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Echinococcus granulosus | integrin beta 2 | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Echinococcus multilocularis | integrin beta 2 | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | NAD+ synthase, putative | 0.0081 | 0.0649 | 1 |
Mycobacterium tuberculosis | Glutamine-dependent NAD(+) synthetase NadE (NAD(+) synthase [glutamine-hydrolysing]) | 0.0081 | 0.0649 | 0.032 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0063 | 0.0421 | 0.0561 |
Schistosoma mansoni | glutamine-dependent NAD(+) synthetase | 0.0081 | 0.0649 | 0.1125 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0063 | 0.0421 | 0.0721 |
Leishmania major | NAD synthase, putative | 0.0081 | 0.0649 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.0169 | 0.1772 | 0.3116 |
Toxoplasma gondii | bifunctional GMP synthase/glutamine amidotransferase protein | 0.0032 | 0.0032 | 0.0276 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0169 | 0.1772 | 0.2321 |
Loa Loa (eye worm) | kelch domain-containing protein family protein | 0.0126 | 0.1226 | 0.1214 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0032 | 0.0018 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0031 | 0.0014 | 0.002 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0169 | 0.1772 | 0.19 |
Treponema pallidum | NAD synthetase | 0.0081 | 0.0649 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0065 | 0.0444 | 0.6671 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0063 | 0.0421 | 0.0519 |
Giardia lamblia | NH3-dependent NAD+ synthetase | 0.0081 | 0.0649 | 0.5 |
Entamoeba histolytica | NAD synthetase, putative | 0.0081 | 0.0649 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0065 | 0.0444 | 0.6762 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0063 | 0.0421 | 0.6414 |
Echinococcus multilocularis | integrin beta 2 | 0.0602 | 0.7262 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0169 | 0.1772 | 0.176 |
Schistosoma mansoni | glutamine-dependent NAD(+) synthetase | 0.0049 | 0.0238 | 0.0396 |
Brugia malayi | dihydrofolate reductase family protein | 0.0169 | 0.1772 | 0.176 |
Brugia malayi | Kelch motif family protein | 0.0126 | 0.1226 | 0.1214 |
Mycobacterium tuberculosis | Arylamine N-acetyltransferase Nat (arylamine acetylase) | 0.0623 | 0.7531 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0216 | 0.2365 | 0.2353 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0065 | 0.0444 | 0.6671 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0169 | 0.1772 | 0.2425 |
Brugia malayi | GMP synthase | 0.0032 | 0.0032 | 0.0018 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0063 | 0.0421 | 0.0519 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0216 | 0.2365 | 0.2353 |
Brugia malayi | Dihydrofolate reductase | 0.0169 | 0.1772 | 0.176 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0169 | 0.1772 | 0.5 |
Schistosoma mansoni | integrin beta subunit | 0.0475 | 0.5656 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0063 | 0.0421 | 0.0721 |
Trypanosoma brucei | NAD+ synthase, putative | 0.0081 | 0.0649 | 1 |
Plasmodium vivax | glutamine-dependent NAD(+) synthetase, putative | 0.0081 | 0.0649 | 1 |
Mycobacterium ulcerans | NAD synthetase | 0.0081 | 0.0649 | 0.0823 |
Echinococcus granulosus | integrin beta 2 | 0.0602 | 0.7262 | 1 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0063 | 0.0421 | 0.6312 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0063 | 0.0421 | 0.0519 |
Mycobacterium ulcerans | arylamine N-acetyltransferase Nat | 0.0623 | 0.7531 | 1 |
Loa Loa (eye worm) | integrin beta-2 | 0.0817 | 1 | 1 |
Plasmodium vivax | GMP synthetase, putative | 0.0032 | 0.0032 | 0.0276 |
Toxoplasma gondii | glutamine-dependent NAD(+) synthetase protein, putative | 0.0081 | 0.0649 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0126 | 0.1226 | 0.1214 |
Echinococcus granulosus | GMP synthase glutamine hydrolyzing | 0.0032 | 0.0032 | 0.0044 |
Echinococcus multilocularis | GMP synthase (glutamine hydrolyzing) | 0.0032 | 0.0032 | 0.0024 |
Trypanosoma cruzi | NAD+ synthase, putative | 0.0081 | 0.0649 | 1 |
Trichomonas vaginalis | set domain proteins, putative | 0.0246 | 0.2744 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0169 | 0.1772 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0065 | 0.0444 | 0.6762 |
Echinococcus granulosus | dihydrofolate reductase | 0.0169 | 0.1772 | 0.2441 |
Plasmodium falciparum | glutamine-dependent NAD(+) synthetase, putative | 0.0081 | 0.0649 | 1 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0063 | 0.0421 | 0.058 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0065 | 0.0444 | 0.6671 |
Onchocerca volvulus | 0.0246 | 0.2744 | 1 | |
Brugia malayi | hypothetical protein | 0.0126 | 0.1226 | 0.1214 |
Schistosoma mansoni | GMP synthetase | 0.0032 | 0.0032 | 0.0031 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2150 nM | Displacement of [125I]Echistatin from human placental integrin alphaVbeta3 receptor | ChEMBL. | 18343671 |
IC50 (binding) | = 2150 nM | Displacement of [125I]Echistatin from human placental integrin alphaVbeta3 receptor | ChEMBL. | 18343671 |
IC50 (binding) | = 7960 nM | Displacement of [125I]Echistatin from human placental integrin alphaVbeta5 receptor | ChEMBL. | 18343671 |
IC50 (binding) | = 7960 nM | Displacement of [125I]Echistatin from human placental integrin alphaVbeta5 receptor | ChEMBL. | 18343671 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.