Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | prenyltransferase alpha subunit, putative | 0.004 | 0.0382 | 0.2755 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0297 | 0.1201 |
Schistosoma mansoni | geranylgeranyl transferase type I beta subunit | 0.0111 | 0.2472 | 0.7059 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0144 | 0.3441 | 0.4838 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.004 | 0.0382 | 0.0321 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0296 | 0.7883 | 1 |
Brugia malayi | Prenyltransferase and squalene oxidase repeat family protein | 0.0111 | 0.2472 | 1 |
Loa Loa (eye worm) | prenyltransferase alpha subunit repeat containing protein | 0.004 | 0.0382 | 0.1543 |
Trichomonas vaginalis | type I geranylgeranyltransferase beta subunit, putative | 0.0069 | 0.1222 | 0.1483 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0296 | 0.7883 | 0.5 |
Trypanosoma cruzi | trypanothione synthetase | 0.0071 | 0.1275 | 0.122 |
Trichomonas vaginalis | geranylgeranyl transferase type I beta subunit, putative | 0.0111 | 0.2472 | 0.3082 |
Echinococcus granulosus | high affinity choline transporter 1 | 0.0037 | 0.0297 | 0.0848 |
Echinococcus granulosus | geranylgeranyl transferase type I beta subunit | 0.0111 | 0.2472 | 0.7059 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0296 | 0.7883 | 1 |
Giardia lamblia | Rab geranylgeranyltransferase | 0.004 | 0.0382 | 0.0408 |
Echinococcus granulosus | geranylgeranyl transferase type 2 subunit alpha | 0.004 | 0.0382 | 0.109 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0296 | 0.7883 | 1 |
Echinococcus multilocularis | solute carrier family 5 | 0.0147 | 0.3502 | 1 |
Schistosoma mansoni | geranylgeranyl transferase type II beta subunit | 0.0029 | 0.0062 | 0.0177 |
Trichomonas vaginalis | geranylgeranyl transferase type I beta subunit, putative | 0.0069 | 0.1222 | 0.1483 |
Echinococcus granulosus | protein farnesyltransferase subunit beta | 0.0069 | 0.1222 | 0.3489 |
Trypanosoma brucei | lanosterol synthase | 0.0119 | 0.2691 | 1 |
Loa Loa (eye worm) | prenyltransferase alpha subunit repeat containing protein | 0.004 | 0.0382 | 0.1543 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.004 | 0.0382 | 0.0321 |
Trypanosoma cruzi | protein farnesyltransferase, putative | 0.0069 | 0.1222 | 0.1167 |
Brugia malayi | Protein prenyltransferase alpha subunit repeat containing protein | 0.004 | 0.0382 | 0.1543 |
Entamoeba histolytica | protein farnesyltransferase beta subunit, putative | 0.0069 | 0.1222 | 0.1483 |
Schistosoma mansoni | inositol transporter | 0.0147 | 0.3502 | 1 |
Echinococcus granulosus | sodium:myo inositol cotransporter | 0.0147 | 0.3502 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0172 | 0.4241 | 1 |
Trypanosoma cruzi | protein farnesyltransferase alpha subunit, putative | 0.004 | 0.0382 | 0.0321 |
Echinococcus multilocularis | sodium:glucose cotransporter 2 | 0.0147 | 0.3502 | 1 |
Leishmania major | lanosterol synthase, putative | 0.009 | 0.1827 | 1 |
Brugia malayi | Probable protein farnesyltransferase beta subunit, putative | 0.0029 | 0.0062 | 0.0251 |
Plasmodium vivax | conserved Plasmodium protein, unknown function | 0.0039 | 0.0358 | 0.2555 |
Trichomonas vaginalis | geranylgeranyl transferase type beta subunit, putative | 0.0069 | 0.1222 | 0.1483 |
Echinococcus multilocularis | high affinity choline transporter 1 | 0.0037 | 0.0297 | 0.0848 |
Entamoeba histolytica | Rab geranylgeranyltransferase alpha subunit, putative | 0.004 | 0.0382 | 0.0408 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0296 | 0.7883 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0172 | 0.4241 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0296 | 0.7883 | 1 |
Echinococcus multilocularis | protein prenyltransferase alpha subunit | 0.004 | 0.0382 | 0.109 |
Brugia malayi | Sodium:solute symporter family protein | 0.0037 | 0.0297 | 0.1201 |
Giardia lamblia | Prenyltransferase | 0.0069 | 0.1222 | 0.1483 |
Plasmodium falciparum | protein farnesyltransferase subunit alpha | 0.004 | 0.0382 | 0.2755 |
Echinococcus granulosus | sodium coupled monocarboxylate transporter 1 | 0.0037 | 0.0297 | 0.0848 |
Trypanosoma cruzi | protein farnesyltransferase alpha subunit, putative | 0.004 | 0.0382 | 0.0321 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0296 | 0.7883 | 1 |
Plasmodium falciparum | protein farnesyltransferase subunit beta | 0.0069 | 0.1222 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0296 | 0.7883 | 1 |
Echinococcus multilocularis | geranylgeranyl transferase type 2 subunit alpha | 0.004 | 0.0382 | 0.109 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0062 | 0.0251 |
Trypanosoma cruzi | lanosterol synthase, putative | 0.0119 | 0.2691 | 0.2645 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0296 | 0.7883 | 1 |
Echinococcus granulosus | protein prenyltransferase alpha subunit | 0.004 | 0.0382 | 0.109 |
Trypanosoma cruzi | trypanothione synthetase | 0.0071 | 0.1275 | 0.122 |
Giardia lamblia | Rab geranylgeranyltransferase | 0.004 | 0.0382 | 0.0408 |
Plasmodium falciparum | geranylgeranyl transferase type-2 subunit alpha, putative | 0.004 | 0.0382 | 0.2755 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.004 | 0.0382 | 0.109 |
Trypanosoma cruzi | Protein prenyltransferase alpha subunit repeat, putative | 0.004 | 0.0382 | 0.0321 |
Schistosoma mansoni | inositol transporter | 0.0147 | 0.3502 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0296 | 0.7883 | 1 |
Onchocerca volvulus | 0.0037 | 0.0297 | 0.778 | |
Toxoplasma gondii | prenyltransferase and squalene oxidase repeat-containing protein | 0.0069 | 0.1222 | 1 |
Echinococcus granulosus | solute carrier family 5 | 0.0147 | 0.3502 | 1 |
Plasmodium vivax | farnesyltransferase beta subunit, putative | 0.0069 | 0.1222 | 1 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0296 | 0.7883 | 1 |
Schistosoma mansoni | geranylgeranyl transferase type I beta subunit | 0.0111 | 0.2472 | 0.7059 |
Leishmania major | protein farnesyltransferase alpha subunit, putative | 0.004 | 0.0382 | 0.181 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative | 0.004 | 0.0382 | 0.0408 |
Echinococcus granulosus | protein farnesyltransferase alpha subunit | 0.004 | 0.0382 | 0.109 |
Toxoplasma gondii | transporter, solute:sodium symporter (SSS) family protein | 0.0037 | 0.0297 | 0.2024 |
Trichomonas vaginalis | geranylgeranyl transferase type II beta subunit, putative | 0.0069 | 0.1222 | 0.1483 |
Echinococcus multilocularis | Rab geranylgeranyltransferase, beta subunit | 0.0029 | 0.0062 | 0.0177 |
Mycobacterium ulcerans | hypothetical protein | 0.0172 | 0.4241 | 1 |
Leishmania major | trypanothione synthetase, putative | 0.0071 | 0.1275 | 0.687 |
Trypanosoma brucei | protein farnesyltransferase beta subunit | 0.0069 | 0.1222 | 0.4412 |
Schistosoma mansoni | protein farnesyltransferase subunit beta | 0.0069 | 0.1222 | 0.3489 |
Onchocerca volvulus | 0.004 | 0.0382 | 1 | |
Trypanosoma brucei | hypothetical protein, conserved | 0.004 | 0.0382 | 0.1215 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0297 | 0.1201 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0062 | 0.0251 |
Leishmania major | farnesyltransferase beta subunit | 0.0069 | 0.1222 | 0.657 |
Schistosoma mansoni | high-affinity choline transporter | 0.0037 | 0.0297 | 0.0848 |
Schistosoma mansoni | protein farnesyltransferase alpha subunit | 0.004 | 0.0382 | 0.109 |
Trypanosoma cruzi | lanosterol synthase, putative | 0.0119 | 0.2691 | 0.2645 |
Trypanosoma brucei | Protein prenyltransferase alpha subunit repeat, putative | 0.004 | 0.0382 | 0.1215 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0382 | 0.1543 |
Toxoplasma gondii | hypothetical protein | 0.004 | 0.0382 | 0.2755 |
Loa Loa (eye worm) | prenyltransferase and squalene oxidase repeat family protein | 0.0111 | 0.2472 | 1 |
Entamoeba histolytica | geranylgeranyl transferase beta subunit | 0.0111 | 0.2472 | 0.3082 |
Schistosoma mansoni | sodium/solute symporter | 0.0037 | 0.0297 | 0.0848 |
Trichomonas vaginalis | geranylgeranyl transferase type II beta subunit, putative | 0.0069 | 0.1222 | 0.1483 |
Loa Loa (eye worm) | prenyltransferase and squalene oxidase repeat family protein | 0.0069 | 0.1222 | 0.4942 |
Echinococcus multilocularis | protein farnesyltransferase alpha subunit | 0.004 | 0.0382 | 0.109 |
Trypanosoma cruzi | protein farnesyltransferase, putative | 0.0069 | 0.1222 | 0.1167 |
Mycobacterium leprae | conserved hypothetical protein | 0.0172 | 0.4241 | 1 |
Entamoeba histolytica | protein farnesyltransferase alpha subunit, putative | 0.004 | 0.0382 | 0.0408 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit, putative | 0.004 | 0.0382 | 0.0408 |
Echinococcus multilocularis | protein farnesyltransferase subunit beta | 0.0069 | 0.1222 | 0.3489 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit, putative | 0.004 | 0.0382 | 0.0408 |
Brugia malayi | Prenyltransferase and squalene oxidase repeat family protein | 0.0069 | 0.1222 | 0.4942 |
Trypanosoma brucei | protein farnesyltransferase alpha subunit, putative | 0.004 | 0.0382 | 0.1215 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit, putative | 0.004 | 0.0382 | 0.0408 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0172 | 0.4241 | 0.5344 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0296 | 0.7883 | 1 |
Brugia malayi | GH02984p | 0.0037 | 0.0297 | 0.1201 |
Trypanosoma brucei | Protein prenyltransferase alpha subunit repeat, putative | 0.004 | 0.0382 | 0.1215 |
Trypanosoma brucei | trypanothione synthetase, putative | 0.0071 | 0.1275 | 0.4613 |
Echinococcus granulosus | sodium:glucose cotransporter 2 | 0.0147 | 0.3502 | 1 |
Echinococcus multilocularis | sodium:myo inositol cotransporter | 0.0147 | 0.3502 | 1 |
Echinococcus multilocularis | sodium coupled monocarboxylate transporter 1 | 0.0037 | 0.0297 | 0.0848 |
Echinococcus multilocularis | geranylgeranyl transferase type I beta subunit | 0.0111 | 0.2472 | 0.7059 |
Trichomonas vaginalis | geranylgeranyl transferase type II beta subunit, putative | 0.0069 | 0.1222 | 0.1483 |
Plasmodium vivax | protein prenyltransferase alpha subunit, putative | 0.004 | 0.0382 | 0.2755 |
Trypanosoma brucei | trypanothione synthetase | 0.0071 | 0.1275 | 0.4613 |
Mycobacterium ulcerans | hypothetical protein | 0.0172 | 0.4241 | 1 |
Echinococcus granulosus | sodium:glucose cotransporter | 0.0147 | 0.3502 | 1 |
Brugia malayi | Protein prenyltransferase alpha subunit repeat containing protein | 0.004 | 0.0382 | 0.1543 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 44.8 % | Antitrypanosomal activity against Trypanosoma cruzi Tulahuen assessed as trypomastigote viability at 20.1 uM by MTT assay relative to control | ChEMBL. | 18029184 |
Activity (functional) | = 44.8 % | Antitrypanosomal activity against Trypanosoma cruzi Tulahuen assessed as trypomastigote viability at 20.1 uM by MTT assay relative to control | ChEMBL. | 18029184 |
Activity (functional) | = 243.3 % | Effect on oxygen uptake per mg of protein in Trypanosoma cruzi Tulahuen epimastigotes relative to control | ChEMBL. | 18029184 |
Activity (functional) | = 243.3 % | Effect on oxygen uptake per mg of protein in Trypanosoma cruzi Tulahuen epimastigotes relative to control | ChEMBL. | 18029184 |
Activity (functional) | = 254 % | Effect on oxygen redox cycling in Trypanosoma cruzi Tulahuen assessed as oxygen consumption per mg of protein relative to control | ChEMBL. | 18029184 |
Activity (functional) | = 254 % | Effect on oxygen redox cycling in Trypanosoma cruzi Tulahuen assessed as oxygen consumption per mg of protein relative to control | ChEMBL. | 18029184 |
IC50 (functional) | = 20.1 uM | Growth inhibition of Trypanosoma cruzi Tulahuen epimastigotes assessed as drug level causing decrease in growth constant | ChEMBL. | 18029184 |
IC50 (functional) | = 20.1 uM | Growth inhibition of Trypanosoma cruzi Tulahuen epimastigotes assessed as drug level causing decrease in growth constant | ChEMBL. | 18029184 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.