Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | > 50 uM | Inhibition of tubulin polymerization in rat A10 cells after 18 hrs by indirect immunoflourescence technique | ChEMBL. | 18083520 |
IC50 (functional) | = -5.58 | Antiproliferative activity against human MDA-MB-435 cells after 48 hrs by SRB assay | ChEMBL. | 18083520 |
IC50 (functional) | = 5.52 | Cytotoxicity against human MDA-MB-435 cells assessed as growth inhibition | ChEMBL. | 23961916 |
IC50 (functional) | = 2.6 uM | Antiproliferative activity against human MDA-MB-435 cells after 48 hrs by SRB assay | ChEMBL. | 18083520 |
IC50 (functional) | = 2.6 uM | Antiproliferative activity against human MDA-MB-435 cells after 48 hrs by SRB assay | ChEMBL. | 18083520 |
Log IC50 (functional) | = 5.58 | Antiproliferative activity against human MDA-MB-435 cells after 48 hrs by SRB assay | ChEMBL. | 18083520 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 18083520 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.