Detailed information for compound 517690

Basic information

Technical information
  • TDR Targets ID: 517690
  • Name: N-[1-[2-fluoro-4-(2-methylsulfonylphenyl)phen yl]-2-oxopiperidin-3-yl]-4-methoxybenzenesulf onamide
  • MW: 532.604 | Formula: C25H25FN2O6S2
  • H donors: 1 H acceptors: 5 LogP: 3.43 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1ccc(cc1)S(=O)(=O)NC1CCCN(C1=O)c1ccc(cc1F)c1ccccc1S(=O)(=O)C
  • InChi: 1S/C25H25FN2O6S2/c1-34-18-10-12-19(13-11-18)36(32,33)27-22-7-5-15-28(25(22)29)23-14-9-17(16-21(23)26)20-6-3-4-8-24(20)35(2,30)31/h3-4,6,8-14,16,22,27H,5,7,15H2,1-2H3
  • InChiKey: ZNGOCHGZXJBAMM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[1-[2-fluoro-4-(2-methylsulfonylphenyl)phenyl]-2-oxo-3-piperidyl]-4-methoxy-benzenesulfonamide
  • N-[1-[2-fluoro-4-(2-methylsulfonylphenyl)phenyl]-2-oxo-3-piperidinyl]-4-methoxybenzenesulfonamide
  • N-[1-[2-fluoro-4-(2-methylsulfonylphenyl)phenyl]-2-oxo-piperidin-3-yl]-4-methoxy-benzenesulfonamide
  • N-[1-[2-fluoro-4-(2-mesylphenyl)phenyl]-2-keto-3-piperidyl]-4-methoxy-benzenesulfonamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens coagulation factor X Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0016 0 0.0002
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0016 0.0003 0.0011
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0196 0.1458 0.1316
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0198 0.0221
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0198 0.099
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0198 0.0222
Trypanosoma cruzi hypothetical protein, conserved 0.0196 0.1458 1
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0016 0.0003 0.0011
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.004 0.0198 0.0766
Echinococcus multilocularis musashi 0.0029 0.011 0.0425
Entamoeba histolytica myo-inositol monophosphatase, putative 0.004 0.0198 0.9972
Brugia malayi Calcium binding EGF domain containing protein 0.0016 0.0003 0.002
Echinococcus granulosus laminin 0.0016 0.0003 0.001
Echinococcus granulosus inositol monophosphatase 1 0.004 0.0198 0.0765
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0336 0.2583 1
Echinococcus granulosus geminin 0.0185 0.1365 0.5283
Schistosoma mansoni lamin 0.0029 0.011 0.0425
Loa Loa (eye worm) beta-lactamase 0.0196 0.1458 0.5644
Echinococcus multilocularis geminin 0.0185 0.1365 0.5283
Mycobacterium ulcerans lipoprotein LpqF 0.007 0.0434 0.0365
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.004 0.0198 0.0766
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0196 0.1458 0.5644
Mycobacterium ulcerans multidrug-transport integral membrane protein Mmr 0.0212 0.1583 0.2142
Loa Loa (eye worm) hypothetical protein 0.0196 0.1458 0.5644
Mycobacterium tuberculosis Probable lipase LipD 0.0196 0.1458 0.1316
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0096 0.0644 0.0936
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.006 0.0409
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.011 0.0427
Trichomonas vaginalis esterase, putative 0.0196 0.1458 0.2237
Echinococcus granulosus importin subunit beta 1 0.0031 0.0127 0.0489
Mycobacterium tuberculosis Class a beta-lactamase BlaC 0.0145 0.1041 0.0892
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.032 0.2454 0.3831
Trichomonas vaginalis conserved hypothetical protein 0.0096 0.0644 0.0936
Treponema pallidum penicillin-binding protein (pbp-2) 0.0798 0.6309 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0196 0.1458 0.5643
Wolbachia endosymbiont of Brugia malayi cell division protein FtsI 0.0747 0.59 1
Loa Loa (eye worm) inositol-1 0.004 0.0198 0.0767
Brugia malayi beta-lactamase 0.0196 0.1458 1
Echinococcus granulosus lamin 0.0029 0.011 0.0425
Brugia malayi RNA, U transporter 1 0.0089 0.0595 0.408
Schistosoma mansoni lamin 0.0029 0.011 0.0425
Trichomonas vaginalis conserved hypothetical protein 0.0096 0.0644 0.0936
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0127 0.0479
Mycobacterium tuberculosis Probable penicillin-binding membrane protein PbpB 0.0248 0.1878 0.1743
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0181 0.0195
Trichomonas vaginalis conserved hypothetical protein 0.0096 0.0644 0.0936
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.004 0.0198 0.0766
Mycobacterium ulcerans multidrugs-transport integral membrane protein Mmr-like 0.0841 0.6662 1
Mycobacterium tuberculosis Conserved protein 0.0196 0.1458 0.1316
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0016 0.0003 0.0011
Trichomonas vaginalis FMN-dependent NADH-azoreductase, putative 0.0038 0.0181 0.0195
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.004 0.0198 0.0766
Mycobacterium tuberculosis Conserved protein 0.0196 0.1458 0.1316
Loa Loa (eye worm) hypothetical protein 0.004 0.0198 0.0768
Schistosoma mansoni inositol monophosphatase 0.004 0.0198 0.0765
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.004 0.0198 0.0766
Trichomonas vaginalis modulator of drug activity B, putative 0.0038 0.0181 0.0195
Echinococcus multilocularis Tolloid protein 1 0.0016 0.0003 0.001
Echinococcus multilocularis inositol monophosphatase 1 0.004 0.0198 0.0765
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0198 0.0992
Leishmania major hypothetical protein, conserved 0.0196 0.1458 1
Echinococcus multilocularis fibrillin 1 0.0016 0.0003 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0181 0.0195
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0016 0.0003 0.001
Trichomonas vaginalis inositol monophosphatase, putative 0.004 0.0198 0.0221
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0198 0.0992
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0196 0.1458 0.1949
Trichomonas vaginalis modulator of drug activity B, putative 0.0038 0.0181 0.0195
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0196 0.1458 0.1316
Trichomonas vaginalis modulator of drug activity B, putative 0.0038 0.0181 0.0195
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0198 0.099
Echinococcus granulosus snurportin 1 0.0336 0.2583 1
Mycobacterium leprae Probable penicillin-binding membrane protein PbpB 0.0248 0.1878 0.2789
Echinococcus granulosus intermediate filament protein 0.0029 0.011 0.0425
Brugia malayi Fibulin-1 precursor 0.0016 0.0003 0.002
Echinococcus multilocularis nuclear factor of activated T cells 5 0.008 0.0521 0.2016
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0011
Trichomonas vaginalis modulator of drug activity B, putative 0.0038 0.0181 0.0195
Brugia malayi Inositol-1 0.004 0.0198 0.1358
Echinococcus granulosus ubiquitin specific protease 41 0.004 0.0198 0.0766
Mycobacterium ulcerans penicillin-binding membrane protein PbpB 0.0744 0.588 0.879
Plasmodium falciparum importin beta, putative 0.0031 0.0127 1
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.004 0.0198 0.0992
Trichomonas vaginalis modulator of drug activity B, putative 0.0038 0.0181 0.0195
Giardia lamblia NADPH oxidoreductase, putative 0.0096 0.0644 1
Trichomonas vaginalis modulator of drug activity B, putative 0.0038 0.0181 0.0195
Echinococcus granulosus nuclear factor of activated T cells 5 0.008 0.0521 0.2016
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0196 0.1458 0.1316
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0198 0.0222
Trichomonas vaginalis conserved hypothetical protein 0.0096 0.0644 0.0936
Echinococcus multilocularis ubiquitin specific protease 41 0.004 0.0198 0.0766
Plasmodium vivax importin-beta 2, putative 0.0031 0.0127 0.0479
Schistosoma mansoni importin beta-1 0.0031 0.0127 0.0489
Mycobacterium ulcerans bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 0.0488 0.3807 0.5583
Entamoeba histolytica hypothetical protein 0.0026 0.0079 0.137
Mycobacterium leprae conserved hypothetical protein 0.0196 0.1458 0.2106
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0181 0.0195
Mycobacterium tuberculosis Probable esterase LipL 0.0196 0.1458 0.1316
Loa Loa (eye worm) hypothetical protein 0.0196 0.1458 0.5644
Mycobacterium ulcerans beta-lactamase 0.0196 0.1458 0.1949
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0079 0.003
Brugia malayi Importin beta-1 subunit 0.0031 0.0127 0.0869
Mycobacterium leprae PROBABLE CONSERVED LIPOPROTEIN LPQF 0.007 0.0434 0.0439
Mycobacterium leprae PROBABLE BIFUNCTIONAL MEMBRANE-ASSOCIATED PENICILLIN-BINDING PROTEIN 1A/1B PONA2 (MUREIN POLYMERASE) [INCLUDES: PENICILLIN-INSEN 0.0488 0.3807 0.5929
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0198 0.0221
Trichomonas vaginalis modulator of drug activity B, putative 0.0038 0.0181 0.0195
Giardia lamblia NADPH oxidoreductase, putative 0.0096 0.0644 1
Echinococcus granulosus Tolloid protein 1 0.0016 0.0003 0.001
Mycobacterium tuberculosis Probable bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase 0.031 0.2375 0.2248
Treponema pallidum penicillin-binding protein (pbp-1) 0.0747 0.59 0.0472
Onchocerca volvulus 0.0196 0.1458 1
Trichomonas vaginalis modulator of drug activity B, putative 0.0038 0.0181 0.0195
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0198 0.099
Plasmodium vivax hypothetical protein, conserved 0.0196 0.1458 1
Trichomonas vaginalis conserved hypothetical protein 0.0096 0.0644 0.0936
Mycobacterium ulcerans penicillin-binding lipoprotein 0.0195 0.1444 0.1928
Trypanosoma brucei hypothetical protein, conserved 0.0196 0.1458 1
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0096 0.0644 0.0936
Trypanosoma brucei beta lactamase 0.007 0.0434 0.2675
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0196 0.1458 0.5643
Schistosoma mansoni hypothetical protein 0.0185 0.1365 0.5283
Trichomonas vaginalis penicillin-binding protein, putative 0.0196 0.1458 0.2237
Loa Loa (eye worm) intermediate filament protein 0.0029 0.011 0.0427
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0127 0.0489
Mycobacterium tuberculosis Possible penicillin-binding lipoprotein 0.0195 0.1444 0.1302
Mycobacterium tuberculosis Probable lipase LipE 0.0196 0.1458 0.1316
Onchocerca volvulus 0.0196 0.1458 1
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.006 0.0231
Mycobacterium tuberculosis Probable penicillin-binding protein PbpA 0.0446 0.347 0.3361
Trichomonas vaginalis conserved hypothetical protein 0.0096 0.0644 0.0936
Brugia malayi beta-lactamase family protein 0.0196 0.1458 1
Trichomonas vaginalis modulator of drug activity B, putative 0.0038 0.0181 0.0195
Mycobacterium leprae Probable lipase LipE 0.0196 0.1458 0.2106
Mycobacterium leprae PROBABLE BIFUNCTIONAL PENICILLIN-BINDING PROTEIN 1A/1B PONA1 (MUREIN POLYMERASE) (PBP1): PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE 0.0798 0.6309 1
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0198 0.0992
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.006 0.039
Schistosoma mansoni intermediate filament proteins 0.0029 0.011 0.0425
Mycobacterium ulcerans hypothetical protein 0.0196 0.1458 0.1949
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.006 0.0229
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.011 0.0756
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0127 0.0479
Loa Loa (eye worm) hypothetical protein 0.0196 0.1458 0.5644
Trichomonas vaginalis modulator of drug activity B, putative 0.0038 0.0181 0.0195
Mycobacterium ulcerans penicillin-binding protein PbpA 0.0446 0.347 0.5061
Trichomonas vaginalis modulator of drug activity B, putative 0.0038 0.0181 0.0195
Trichomonas vaginalis modulator of drug activity B, putative 0.0038 0.0181 0.0195
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0181 0.0195
Trichomonas vaginalis conserved hypothetical protein 0.0096 0.0644 0.0936
Entamoeba histolytica hypothetical protein 0.0038 0.0181 0.8765
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0011
Brugia malayi beta-lactamase family protein 0.0196 0.1458 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0196 0.1458 0.5643
Trichomonas vaginalis modulator of drug activity B, putative 0.0038 0.0181 0.0195
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.032 0.2454 0.3831
Schistosoma mansoni hypothetical protein 0.0185 0.1365 0.5283
Schistosoma mansoni egf-like domain protein 0.0016 0.0003 0.001
Trichomonas vaginalis D-aminoacylase, putative 0.0196 0.1458 0.2237
Trypanosoma cruzi hypothetical protein, conserved 0.0196 0.1458 1
Chlamydia trachomatis transglycolase/transpeptidase 0.0747 0.59 1
Trichomonas vaginalis modulator of drug activity B, putative 0.0038 0.0181 0.0195
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0181 0.0195
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0181 0.0195
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.004 0.0198 0.1341
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.004 0.0198 0.0766
Entamoeba histolytica modulator of drug activity B homolog, putative 0.0038 0.0181 0.8765
Mycobacterium leprae POSSIBLE PENICILLIN-BINDING LIPOPROTEIN 0.0195 0.1444 0.2083
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0336 0.0442
Trichomonas vaginalis conserved hypothetical protein 0.0096 0.0644 0.0936
Echinococcus granulosus lamin dm0 0.0029 0.011 0.0425
Mycobacterium leprae Probable penicillin-binding protein PbpA 0.0446 0.347 0.5379
Mycobacterium tuberculosis Probable hydrolase 0.0196 0.1458 0.1316
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.004 0.0198 0.2373
Loa Loa (eye worm) hypothetical protein 0.0196 0.1458 0.5644
Schistosoma mansoni ran 0.0023 0.006 0.0229
Echinococcus multilocularis lamin 0.0029 0.011 0.0425
Onchocerca volvulus 0.0196 0.1458 1
Onchocerca volvulus 0.0029 0.011 0.0737
Trichomonas vaginalis conserved hypothetical protein 0.0096 0.0644 0.0936
Loa Loa (eye worm) hypothetical protein 0.0029 0.011 0.0427
Echinococcus multilocularis laminin 0.0016 0.0003 0.001
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0079 0.003
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.006 0.0229
Toxoplasma gondii ABC1 family protein 0.0196 0.1458 1
Trichomonas vaginalis modulator of drug activity B, putative 0.0038 0.0181 0.0195
Brugia malayi intermediate filament protein 0.0029 0.011 0.0756
Trichomonas vaginalis modulator of drug activity B, putative 0.0038 0.0181 0.0195
Mycobacterium tuberculosis Conserved protein 0.0196 0.1458 0.1316
Leishmania major importin beta-1 subunit, putative 0.0026 0.0079 0.0136
Schistosoma mansoni hypothetical protein 0.0336 0.2583 1
Trichomonas vaginalis D-aminoacylase, putative 0.0196 0.1458 0.2237
Loa Loa (eye worm) hypothetical protein 0.0029 0.0106 0.041
Echinococcus multilocularis lamin dm0 0.0029 0.011 0.0425
Loa Loa (eye worm) hypothetical protein 0.0031 0.0127 0.049
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0096 0.0644 0.0936
Mycobacterium ulcerans class a beta-lactamase, BlaC 0.0145 0.1041 0.1305
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0196 0.1458 1
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0181 0.0195
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0198 0.099
Trichomonas vaginalis conserved hypothetical protein 0.0096 0.0644 0.0936
Schistosoma mansoni inositol monophosphatase 0.004 0.0198 0.0765
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0198 0.0222
Trichomonas vaginalis modulator of drug activity B, putative 0.0038 0.0181 0.0195
Loa Loa (eye worm) hypothetical protein 0.0196 0.1458 0.5644
Trichomonas vaginalis modulator of drug activity B, putative 0.0038 0.0181 0.0195
Giardia lamblia NADPH oxidoreductase, putative 0.0096 0.0644 1
Trichomonas vaginalis modulator of drug activity B, putative 0.0038 0.0181 0.0195
Onchocerca volvulus 0.0029 0.011 0.0737
Mycobacterium tuberculosis Probable conserved lipoprotein LpqF 0.007 0.0434 0.0274
Mycobacterium ulcerans esterase/lipase LipP 0.0196 0.1458 0.1949
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0011
Echinococcus multilocularis snurportin 1 0.0336 0.2583 1
Mycobacterium tuberculosis Probable bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 (murein polymerase) [includes: penicillin-insen 0.0488 0.3807 0.3704
Trichomonas vaginalis conserved hypothetical protein 0.0798 0.6309 1
Trichomonas vaginalis modulator of drug activity B, putative 0.0038 0.0181 0.0195
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0181 0.0195
Echinococcus multilocularis beta LACTamase domain containing family member 0.0196 0.1458 0.5643
Trichomonas vaginalis penicillin-binding protein, putative 0.0196 0.1458 0.2237
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0096 0.0644 0.0936
Trichomonas vaginalis D-aminoacylase, putative 0.0196 0.1458 0.2237
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0096 0.0644 0.0936
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.004 0.0198 0.1361
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0079 0.003
Mycobacterium ulcerans lipase LipD 0.0196 0.1458 0.1949
Mycobacterium ulcerans bifunctional penicillin-binding protein 1A/1B PonA1 0.0798 0.6309 0.9454
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0127 0.085
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0016 0.0003 0.002
Entamoeba histolytica iron-sulfur flavoprotein, putative 0.0038 0.0181 0.8765
Schistosoma mansoni ran 0.0023 0.006 0.0229
Loa Loa (eye worm) hypothetical protein 0.0196 0.1458 0.5644
Trichomonas vaginalis conserved hypothetical protein 0.0096 0.0644 0.0936
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0181 0.0195
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0079 0.0136
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.004 0.0198 1

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 53 nM Inhibition of human factor 10a ChEMBL. 18329876
Ki (binding) = 53 nM Inhibition of human factor 10a ChEMBL. 18329876
Selectivity ratio (binding) > 1000 Selectivity for human factor 10a over thrombin (unknown origin) ChEMBL. 18329876
Selectivity ratio (binding) > 1000 Selectivity for human factor 10a over trypsin (unknown origin) ChEMBL. 18329876

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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