Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cytochrome P450, family 2, subfamily C, polypeptide 9 | Starlite/ChEMBL | References |
Homo sapiens | peroxisome proliferator-activated receptor alpha | Starlite/ChEMBL | References |
Homo sapiens | peroxisome proliferator-activated receptor gamma | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | Cytochrome P450 family protein | Get druggable targets OG5_126582 | All targets in OG5_126582 |
Schistosoma japonicum | ko:K08701 nuclear receptor, subfamily 1, invertebrate, putative | Get druggable targets OG5_137778 | All targets in OG5_137778 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | Get druggable targets OG5_137778 | All targets in OG5_137778 |
Loa Loa (eye worm) | cytochrome P450 family protein | Get druggable targets OG5_126582 | All targets in OG5_126582 |
Schistosoma japonicum | IPR008946,Nuclear receptor, ligand-binding,domain-containing | Get druggable targets OG5_137778 | All targets in OG5_137778 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | ecdysone induced protein 78C | peroxisome proliferator-activated receptor gamma | 477 aa | 447 aa | 28.2 % |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | cytochrome P450, family 2, subfamily C, polypeptide 9 | 490 aa | 441 aa | 21.8 % |
Brugia malayi | ecdysteroid receptor | peroxisome proliferator-activated receptor alpha | 468 aa | 397 aa | 25.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0037 | 0.0239 | 0.088 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0037 | 0.0239 | 0.0486 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0037 | 0.0239 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0074 | 0.1138 | 0.208 |
Mycobacterium ulcerans | acetolactate synthase | 0.013 | 0.2531 | 0.4994 |
Entamoeba histolytica | pyruvate:ferredoxin oxidoreductase | 0.0033 | 0.0143 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0239 | 0.088 |
Mycobacterium leprae | PROBABLE ACETOLACTATE SYNTHASE (LARGE SUBUNIT) ILVB (ACETOHYDROXY-ACID SYNTHASE) | 0.0228 | 0.4926 | 1 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.013 | 0.2531 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0037 | 0.0239 | 0.088 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0037 | 0.0239 | 0.088 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0037 | 0.0239 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0049 | 0.0524 | 0.0292 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0049 | 0.0524 | 0.0292 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0037 | 0.0239 | 0.0486 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0037 | 0.0239 | 0.0486 |
Giardia lamblia | Pyruvate-flavodoxin oxidoreductase | 0.0033 | 0.0143 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0037 | 0.0239 | 0.0486 |
Mycobacterium ulcerans | acetolactate synthase large subunit IlvB | 0.013 | 0.2531 | 0.4994 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0037 | 0.0239 | 0.0486 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0037 | 0.0239 | 0.0486 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0037 | 0.0239 | 0.088 |
Treponema pallidum | pyruvate oxidoreductase | 0.0033 | 0.0143 | 0.5 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0045 | 0.0423 | 0.086 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0239 | 0.088 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0037 | 0.0239 | 0.088 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0239 | 0.088 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0037 | 0.0239 | 0.0486 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0037 | 0.0239 | 0.0486 |
Plasmodium falciparum | acyl-CoA synthetase | 0.013 | 0.2531 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0239 | 0.088 |
Brugia malayi | ecdysteroid receptor | 0.0037 | 0.0239 | 0.0486 |
Brugia malayi | nuclear receptor NHR-88 | 0.0037 | 0.0239 | 0.0486 |
Mycobacterium ulcerans | putative oxalyl-CoA decarboxylase | 0.0228 | 0.4926 | 1 |
Trypanosoma cruzi | phosphonopyruvate decarboxylase, putative | 0.0074 | 0.1138 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0037 | 0.0239 | 0.0486 |
Mycobacterium ulcerans | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | 0.004 | 0.0323 | 0.0378 |
Mycobacterium ulcerans | acetolactate synthase 1 catalytic subunit | 0.0228 | 0.4926 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0037 | 0.0239 | 0.0486 |
Brugia malayi | Thiamine pyrophosphate enzyme, central domain containing protein | 0.0228 | 0.4926 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0239 | 0.088 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0037 | 0.0239 | 0.0486 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0045 | 0.0423 | 0.1558 |
Mycobacterium ulcerans | hypothetical protein | 0.0228 | 0.4926 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0037 | 0.0239 | 0.0486 |
Trypanosoma brucei | phosphonopyruvate decarboxylase-like protein, putative | 0.0074 | 0.1138 | 0.5 |
Schistosoma mansoni | acetolactate synthase | 0.0195 | 0.4111 | 0.3967 |
Mycobacterium ulcerans | pyruvate or indole-3-pyruvate decarboxylase Pdc | 0.013 | 0.2531 | 0.4994 |
Schistosoma mansoni | acetolactate synthase | 0.0195 | 0.4111 | 0.3967 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0037 | 0.0239 | 0.0486 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0037 | 0.0239 | 0.0486 |
Mycobacterium tuberculosis | Probable oxalyl-CoA decarboxylase OxcA | 0.0228 | 0.4926 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0037 | 0.0239 | 0.088 |
Onchocerca volvulus | 0.0037 | 0.0239 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0239 | 0.088 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0037 | 0.0239 | 0.0486 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0037 | 0.0239 | 0.0486 |
Mycobacterium tuberculosis | Acetolactate synthase (large subunit) IlvB1 (acetohydroxy-acid synthase) | 0.0097 | 0.1723 | 0.3304 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0045 | 0.0423 | 1 |
Leishmania major | putative pyruvate/indole-pyruvate carboxylase, putative | 0.013 | 0.2531 | 1 |
Trypanosoma cruzi | phosphonopyruvate decarboxylase, putative | 0.0074 | 0.1138 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0239 | 0.088 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0.0351 | 1 |
Mycobacterium leprae | Probable Acetolactate synthase IlvG (Acetohydroxy-acid synthase)(ALS) | 0.0228 | 0.4926 | 1 |
Trypanosoma brucei | phosphonopyruvate decarboxylase-like protein, putative | 0.0074 | 0.1138 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0037 | 0.0239 | 0.0486 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0037 | 0.0239 | 0.088 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0279 | 0.1026 |
Loa Loa (eye worm) | thiamine pyrophosphate enzyme | 0.0131 | 0.2537 | 0.9335 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0037 | 0.0239 | 0.088 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0239 | 0.088 |
Brugia malayi | nuclear hormone receptor | 0.0037 | 0.0239 | 0.0486 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0037 | 0.0239 | 0.5 |
Mycobacterium tuberculosis | Probable acetolactate synthase IlvG (acetohydroxy-acid synthase)(ALS) | 0.0228 | 0.4926 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0.0351 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0045 | 0.0423 | 1 |
Loa Loa (eye worm) | ILVBL protein | 0.0138 | 0.2718 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 0.5 uM | Agonist activity at PPARgamma (unknown origin) in HEK293 cells by GAL4 transactivation assay | ChEMBL. | 18291645 |
EC50 (functional) | = 0.5 uM | Agonist activity at PPARgamma (unknown origin) in HEK293 cells by GAL4 transactivation assay | ChEMBL. | 18291645 |
EC50 (functional) | = 0.97 uM | Agonist activity at PPARalpha (unknown origin) in HEK293 cells by GAL4 transactivation assay | ChEMBL. | 18291645 |
EC50 (functional) | = 0.97 uM | Agonist activity at PPARalpha (unknown origin) in HEK293 cells by GAL4 transactivation assay | ChEMBL. | 18291645 |
IC50 (ADMET) | Inhibition of CYP2C19 (unknown origin) | ChEMBL. | 18291645 | |
IC50 (binding) | 0 | Inhibition of human ERG by FLIPR assay | ChEMBL. | 18291645 |
IC50 (ADMET) | 0 | Inhibition of CYP2C19 (unknown origin) | ChEMBL. | 18291645 |
IC50 (ADMET) | = 3 uM | Inhibition of CYP2C9 (unknown origin) | ChEMBL. | 18291645 |
IC50 (ADMET) | = 3 uM | Inhibition of CYP2C9 (unknown origin) | ChEMBL. | 18291645 |
IC50 (binding) | = 4.24 uM | Inhibition of PPARgamma (unknown origin) | ChEMBL. | 18291645 |
IC50 (binding) | = 4.24 uM | Inhibition of PPARgamma (unknown origin) | ChEMBL. | 18291645 |
IC50 (binding) | > 15 uM | Inhibition of PPARalpha (unknown origin) | ChEMBL. | 18291645 |
IC50 (binding) | > 15 uM | Inhibition of PPARalpha (unknown origin) | ChEMBL. | 18291645 |
IC50 (ADMET) | > 40 uM | Inhibition of CYP3A4 (unknown origin) in presence of 7-benzyloxy-4-trifluoromethyl coumarin substrate | ChEMBL. | 18291645 |
IC50 (ADMET) | > 40 uM | Inhibition of CYP3A4 (unknown origin) in presence of 7-benzyloxyresorufin substrate | ChEMBL. | 18291645 |
IC50 (ADMET) | > 40 uM | Inhibition of CYP3A4 (unknown origin) in presence of 7-benzyloxy-4-trifluoromethyl coumarin substrate | ChEMBL. | 18291645 |
IC50 (ADMET) | > 40 uM | Inhibition of CYP3A4 (unknown origin) in presence of 7-benzyloxyresorufin substrate | ChEMBL. | 18291645 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.