Detailed information for compound 518628

Basic information

Technical information
  • TDR Targets ID: 518628
  • Name: 2-amino-6-[4-[[4-(2-oxo-3H-benzimidazol-1-yl) piperidin-1-yl]methyl]phenyl]-5-phenylpyridin e-3-carbonitrile
  • MW: 500.594 | Formula: C31H28N6O
  • H donors: 2 H acceptors: 3 LogP: 4.97 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 2
  • SMILES: N#Cc1cc(c2ccccc2)c(nc1N)c1ccc(cc1)CN1CCC(CC1)n1c(=O)[nH]c2c1cccc2
  • InChi: 1S/C31H28N6O/c32-19-24-18-26(22-6-2-1-3-7-22)29(35-30(24)33)23-12-10-21(11-13-23)20-36-16-14-25(15-17-36)37-28-9-5-4-8-27(28)34-31(37)38/h1-13,18,25H,14-17,20H2,(H2,33,35)(H,34,38)
  • InChiKey: SUBGOBRHJSIFTB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-amino-6-[4-[[4-(2-oxo-3H-benzimidazol-1-yl)-1-piperidyl]methyl]phenyl]-5-phenyl-pyridine-3-carbonitrile
  • 2-amino-6-[4-[[4-(2-oxo-3H-benzimidazol-1-yl)-1-piperidinyl]methyl]phenyl]-5-phenyl-3-pyridinecarbonitrile
  • 2-azanyl-6-[4-[[4-(2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]methyl]phenyl]-5-phenyl-pyridine-3-carbonitrile
  • 2-amino-6-[4-[[4-(2-keto-3H-benzimidazol-1-yl)piperidino]methyl]phenyl]-5-phenyl-nicotinonitrile
  • 2-amino-6-[4-[[4-(2-keto-3H-benzimidazol-1-yl)-1-piperidyl]methyl]phenyl]-5-phenyl-nicotinonitrile
  • 2-amino-6-[4-[[4-(2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]methyl]phenyl]-5-phenyl-pyridine-3-carbonitrile

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens v-akt murine thymoma viral oncogene homolog 1 Starlite/ChEMBL References
Homo sapiens v-akt murine thymoma viral oncogene homolog 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K07390 monothiol glutaredoxin, putative Get druggable targets OG5_126635 All targets in OG5_126635
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126635 All targets in OG5_126635
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma cruzi Protein kinase B Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma japonicum Sodium/potassium-transporting ATPase subunit beta-1, putative Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus serine/threonine protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Brugia malayi p70 ribosomal S6 kinase beta Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma congolense rac serine-threonine kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus sodium:potassium dependent atpase beta subunit Get druggable targets OG5_126635 All targets in OG5_126635
Plasmodium knowlesi RAC-beta serine/threonine protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Plasmodium yoelii kinase Akt/PKB-related Get druggable targets OG5_126635 All targets in OG5_126635
Candida albicans protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Plasmodium berghei rac-beta serine/threonine protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus nervana 2 Get druggable targets OG5_126635 All targets in OG5_126635
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus serine threonine protein kinase nrc Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma mansoni serine/threonine-protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma japonicum ko:K08792 serum/glucocorticoid regulated kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma cruzi rac serine-threonine kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus multilocularis Glutaredoxin protein 5 Get druggable targets OG5_126635 All targets in OG5_126635
Entamoeba histolytica PH domain containing protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Neospora caninum Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1), related Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus multilocularis rac serine:threonine kinase Get druggable targets OG5_126635 All targets in OG5_126635
Giardia lamblia Kinase, AGC PKA Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus multilocularis nervana 2 Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma brucei gambiense rac serine-threonine kinase, putative,protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Plasmodium falciparum RAC-beta serine/threonine protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma japonicum ko:K04456 RAC serine/threonine-protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma japonicum RAC serine/threonine-protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma brucei rac serine-threonine kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Plasmodium vivax rac-beta serine/threonine protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus calcium:calmodulin dependent protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma mansoni serine/threonine-protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Entamoeba histolytica protein kinase 2, putative Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus nervana 2 Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma cruzi rac serine-threonine kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Entamoeba histolytica PH domain containing protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus multilocularis nervana 2 Get druggable targets OG5_126635 All targets in OG5_126635
Candida albicans likely protein kinase similar to S. cerevisiae YPK2 (YMR104C) Get druggable targets OG5_126635 All targets in OG5_126635
Toxoplasma gondii AGC kinase Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus Glutaredoxin protein 5 Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Loa Loa (eye worm) AGC/RSK/P70 protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Loa Loa (eye worm) AGC/AKT protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0101 0.0329 0.1063
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0101 0.0329 0.1063
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0101 0.0329 1
Brugia malayi UDP galactose 4'-epimerase 0.0051 0.0011 0.0049
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0519 0.3 1
Echinococcus granulosus nervana 2 0.0487 0.2796 0.9317
Plasmodium falciparum calcium-transporting ATPase 0.0101 0.0329 1
Entamoeba histolytica PH domain containing protein kinase, putative 0.0061 0.0075 0.2019
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0088 0.0247 0.081
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0091 0.027 0.8131
Giardia lamblia Kinase, AGC PKA 0.0058 0.0059 0.0432
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0058 0.0059 0.0161
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0058 0.0059 0.1074
Echinococcus granulosus nervana 2 0.0487 0.2796 0.9317
Echinococcus multilocularis sodium:potassium transporting ATPase subunit 0.0519 0.3 1
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0519 0.3 1
Echinococcus multilocularis Tetracycline resistance leader peptide, TetL 0.0101 0.0329 0.1063
Echinococcus granulosus Glutaredoxin protein 5 0.0058 0.0055 0.0147
Mycobacterium leprae PROBABLE ISOCITRATE LYASE AceA (ISOCITRASE) (ISOCITRATASE) (ICL) 0.1168 0.7139 0.7131
Echinococcus multilocularis N acetylglucosaminyl phosphatidylinositol 0.0053 0.0027 0.0052
Echinococcus granulosus Na:K ATPase alpha subunit 0.0265 0.1377 0.4569
Entamoeba histolytica protein kinase, putative 0.009 0.0263 0.7931
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0058 0.0059 0.0161
Loa Loa (eye worm) hypothetical protein 0.0206 0.1 0.3321
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0091 0.027 0.8193
Schistosoma mansoni N-acetylglucosaminyl-phosphatidylinositol de-n-acetylase 0.0053 0.0027 0.0052
Trichomonas vaginalis cation-transporting ATPase fungi, putative 0.0091 0.027 0.8167
Loa Loa (eye worm) calcium ATPase 0.0051 0.0011 0.0021
Brugia malayi Na,K-ATPase alpha subunit 0.0265 0.1377 1
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0058 0.0059 0.1686
Mycobacterium tuberculosis Mycothiol conjugate amidase Mca (mycothiol S-conjugate amidase) 0.1562 0.966 1
Trypanosoma cruzi UDP-galactose 4-epimerase, putative 0.0051 0.0011 0.0206
Onchocerca volvulus 0.0429 0.2427 0.6596
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0091 0.027 0.8167
Echinococcus multilocularis nervana 2 0.0487 0.2796 0.9317
Entamoeba histolytica PH domain containing protein kinase, putative 0.0061 0.0075 0.2019
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0101 0.0329 1
Schistosoma mansoni serine/threonine-protein kinase 0.0061 0.0075 0.0214
Loa Loa (eye worm) hypothetical protein 0.0265 0.1377 0.4581
Entamoeba histolytica protein kinase 2, putative 0.0058 0.0059 0.1522
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.0091 0.027 0.1958
Echinococcus granulosus plasma membrane calcium transporting ATPase 2 0.0101 0.0329 0.1063
Echinococcus granulosus Ca2 transporting ATPase plasma membrane 0.0101 0.0329 0.1063
Trypanosoma brucei P-type H+-ATPase, putative 0.005 0.0005 0.0144
Leishmania major P-type ATPase, putative 0.0101 0.0329 1
Trichomonas vaginalis cation-transporting ATPase, putative 0.0091 0.027 0.8167
Toxoplasma gondii sarco/endoplasmic reticulum Ca2+-ATPase 0.0101 0.0329 1
Loa Loa (eye worm) hypothetical protein 0.0519 0.3 1
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0091 0.027 0.8131
Echinococcus granulosus sarco:endoplasmic reticulum calcium ATPase 0.0091 0.027 0.0864
Loa Loa (eye worm) hypothetical protein 0.0164 0.0735 0.2437
Echinococcus multilocularis nervana 2 0.0487 0.2796 0.9317
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.0091 0.027 0.1958
Trypanosoma brucei calcium motive p-type ATPase, putative 0.0101 0.0329 1
Brugia malayi Protein kinase domain containing protein 0.009 0.0263 0.1884
Echinococcus multilocularis Na+:K+ ATPase alpha subunit 0.0265 0.1377 0.4569
Schistosoma mansoni na+/k+ atpase alpha subunit 0.0265 0.1377 0.4569
Trypanosoma brucei calcium-translocating P-type ATPase 0.0101 0.0329 1
Mycobacterium ulcerans cation-transporter ATPase I CtpI 0.0055 0.0036 0.0009
Loa Loa (eye worm) sodium/potassium-transporting ATPase subunit alpha 0.0228 0.1143 0.3801
Schistosoma mansoni transmemberane protein 0.0519 0.3 1
Echinococcus multilocularis Glutaredoxin protein 5 0.0058 0.0055 0.0147
Loa Loa (eye worm) UDP galactose 4'-epimerase 0.0051 0.0011 0.0022
Trichomonas vaginalis AGC family protein kinase 0.009 0.0263 0.7971
Mycobacterium ulcerans isocitrate lyase AceAb 0.1168 0.7139 0.7131
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0101 0.0329 0.1063
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0058 0.0059 0.1074
Leishmania major calcium-transporting ATPase, putative 0.0101 0.0329 1
Trichomonas vaginalis AGC family protein kinase 0.009 0.0263 0.7971
Echinococcus multilocularis rac serine:threonine kinase 0.0061 0.0075 0.0214
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0429 0.2427 0.8084
Trichomonas vaginalis NAD dependent epimerase/dehydratase, putative 0.0051 0.0011 0.0206
Echinococcus multilocularis calcium transporting ATPase type 2C member 0.0101 0.0329 0.1063
Trichomonas vaginalis NAD dependent epimerase/dehydratase, putative 0.0051 0.0011 0.0206
Echinococcus granulosus N acetylglucosaminyl phosphatidylinositol 0.0053 0.0027 0.0052
Mycobacterium tuberculosis Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl) 0.1168 0.7139 0.7383
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0091 0.027 0.8167
Schistosoma mansoni ATPase 0.0091 0.027 0.0864
Toxoplasma gondii plasma membrane-type Ca(2+)-ATPase A1 PMCAA1 0.0101 0.0329 1
Giardia lamblia Glucosamine-6-phosphate isomerase, putative 0.0053 0.0027 0.0196
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0487 0.2796 0.9317
Brugia malayi Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0101 0.0329 0.2364
Toxoplasma gondii calcium-translocating P-type ATPase, PMCA-type protein 0.0091 0.027 0.8167
Echinococcus granulosus serine threonine protein kinase nrc 0.0058 0.0059 0.0161
Entamoeba histolytica N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase, putative 0.0053 0.0027 0.0501
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0101 0.0329 0.1063
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0519 0.3 1
Entamoeba histolytica glucosamine-6-phosphate isomerase, putative 0.0053 0.0027 0.0501
Loa Loa (eye worm) hypothetical protein 0.0091 0.027 0.0884
Plasmodium vivax calcium-transporting ATPase, putative 0.0101 0.0329 1
Echinococcus multilocularis calcium transporting atpase 0.0101 0.0329 0.1063
Giardia lamblia Potassium-transporting ATPase alpha chain 1 0.0265 0.1377 1
Trypanosoma brucei calcium-transporting ATPase, putative 0.0064 0.0095 0.2901
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0519 0.3 1
Toxoplasma gondii AGC kinase 0.0088 0.0247 0.7483
Trichomonas vaginalis UDP-glucose 4-epimerase, putative 0.0051 0.0011 0.0206
Toxoplasma gondii N-acetylglucosaminylphosphatidylinositol deacetylase 0.0053 0.0027 0.0685
Toxoplasma gondii P-type ATPase4, putative 0.0101 0.0329 1
Onchocerca volvulus 0.0519 0.3 1
Echinococcus granulosus nervana 2 0.0519 0.3 1
Trypanosoma cruzi calcium-transporting ATPase, putative 0.0064 0.0095 0.2797
Loa Loa (eye worm) hypothetical protein 0.0177 0.0819 0.2718
Entamoeba histolytica protein kinase, putative 0.0088 0.0247 0.7434
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.0051 0.0011 0.0046
Mycobacterium leprae Isocitrate lyase 0.0547 0.318 0.3161
Brugia malayi p70 ribosomal S6 kinase beta 0.0088 0.0247 0.1769
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0091 0.027 0.8167
Trypanosoma brucei vacuolar-type Ca2+-ATPase, putative 0.0091 0.027 0.8193
Brugia malayi Membrane calcium atpase protein 3 0.0101 0.0329 0.2364
Trypanosoma brucei vacuolar-type Ca2+-ATPase 1 0.0091 0.027 0.8193
Trypanosoma brucei N-acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase 0.0053 0.0027 0.082
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0091 0.027 0.8131
Trypanosoma cruzi N-Acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase, putative 0.0053 0.0027 0.0685
Entamoeba histolytica UDP-glucose 4-epimerase, putative 0.0051 0.0011 0.0012
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0061 0.0075 0.2174
Schistosoma mansoni ATPase 0.0091 0.027 0.0864
Mycobacterium tuberculosis Possible metal cation transporting P-type ATPase CtpH 0.0055 0.0036 0.0009
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase 0.0101 0.0329 1
Echinococcus multilocularis Ca2+ transporting ATPase plasma membrane 0.0101 0.0329 0.1063
Brugia malayi Sodium/potassium-transporting ATPase alpha chain, putative 0.0228 0.1143 0.8297
Trichomonas vaginalis AGC family protein kinase 0.009 0.0263 0.7971
Echinococcus granulosus nervana 2 0.0519 0.3 1
Trypanosoma cruzi UDP-galactose 4-epimerase 0.0051 0.0011 0.0206
Brugia malayi calcium ATPase 0.0051 0.0011 0.0046
Mycobacterium tuberculosis Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl) 0.1168 0.7139 0.7383
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0519 0.3 1
Trichomonas vaginalis cation-transporting ATPase, putative 0.0091 0.027 0.8167
Brugia malayi Uncharacterized LmbE-like protein, COG2120 containing protein 0.0053 0.0027 0.0162
Trichomonas vaginalis AGC family protein kinase 0.009 0.0263 0.7971
Toxoplasma gondii UDP-glucose 4-epimerase 0.0051 0.0011 0.0206
Entamoeba histolytica calcium-transporting P-type ATPase, putative 0.0101 0.0329 1
Trypanosoma brucei vacuolar-type Ca2+-ATPase 2 0.0091 0.027 0.8193
Trypanosoma brucei P-type H+-ATPase, putative 0.005 0.0005 0.0144
Schistosoma mansoni sodium / potassium ATPase beta chain 0.0429 0.2427 0.8084
Loa Loa (eye worm) hypothetical protein 0.0519 0.3 1
Loa Loa (eye worm) hypothetical protein 0.0064 0.0095 0.0303
Trichomonas vaginalis AGC family protein kinase 0.009 0.0263 0.7971
Mycobacterium ulcerans metal cation-transporting p-type ATPase F, CtpF 0.0101 0.0329 0.0303
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0091 0.027 0.8167
Loa Loa (eye worm) calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0064 0.0095 0.0303
Brugia malayi E1-E2 ATPase family protein 0.0059 0.0064 0.0433
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0101 0.0329 1
Leishmania major P-type H -ATPase, putative 0.005 0.0005 0.0144
Loa Loa (eye worm) Na,K-ATPase alpha subunit 0.0265 0.1377 0.4581
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0091 0.027 0.8167
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0101 0.0329 1
Echinococcus multilocularis nervana 2 0.0519 0.3 1
Plasmodium vivax P-type ATPase4, putative 0.0101 0.0329 1
Mycobacterium leprae PROBABLE CATION-TRANSPORTER ATPASE I CTPI 0.0219 0.1084 0.106
Schistosoma mansoni calcium-transporting atpase 2 (atpase 2) 0.0101 0.0329 0.1063
Leishmania major calcium motive p-type ATPase, putative 0.0101 0.0329 1
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0519 0.3 1
Entamoeba histolytica plasma membrane calcium ion-transporting ATPase, putative 0.0059 0.0064 0.1672
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0487 0.2796 0.9317
Echinococcus multilocularis nervana 2 0.0519 0.3 1
Schistosoma mansoni Na+/K+ transporting ATPase subunit alpha 0.0265 0.1377 0.4569
Trypanosoma brucei rac serine-threonine kinase, putative 0.009 0.0263 0.8
Leishmania major calcium-translocating P-type ATPase 0.0091 0.027 0.8193
Mycobacterium ulcerans mycothiol conjugate amidase Mca 0.1616 1 1
Echinococcus multilocularis plasma membrane calcium transporting ATPase 0.0101 0.0329 0.1063
Echinococcus granulosus serine/threonine protein kinase 0.0061 0.0075 0.0214
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0053 0.0027 0.0685
Trypanosoma cruzi Calcium ATPase SERCA-like 0.0091 0.027 0.8167
Leishmania major P-type H -ATPase, putative 0.005 0.0005 0.0144
Echinococcus granulosus sodium:potassium transporting ATPase subunit 0.0519 0.3 1
Leishmania major N-acetyl-D-acetylglucosaminylphosphatidylinositol deacetylase 0.0053 0.0027 0.082
Echinococcus granulosus calcium transporting atpase 0.0101 0.0329 0.1063
Mycobacterium tuberculosis Isocitrate lyase Icl (isocitrase) (isocitratase) 0.1168 0.7139 0.7383
Trichomonas vaginalis AGC family protein kinase 0.009 0.0263 0.7971
Mycobacterium ulcerans metal cation transporter p-type ATPase a 0.0256 0.1318 0.1294
Mycobacterium ulcerans isocitrate lyase Icl 0.1168 0.7139 0.7131
Trichomonas vaginalis cation-transporting ATPase, putative 0.0091 0.027 0.8167
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0091 0.027 0.8167
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0091 0.027 0.8193
Echinococcus granulosus calcium transporting ATPase type 2C member 0.0101 0.0329 0.1063
Brugia malayi Probable calcium-transporting ATPase KIAA0703 0.0064 0.0095 0.0661
Echinococcus multilocularis sarco:endoplasmic reticulum calcium ATPase 0.0091 0.027 0.0864
Entamoeba histolytica protein kinase, putative 0.009 0.0263 0.7931
Loa Loa (eye worm) phosphatidylinositol glycan anchor biosynthesis protein 0.0053 0.0027 0.0074
Trichomonas vaginalis AGC family protein kinase 0.009 0.0263 0.7971
Echinococcus granulosus plasma membrane calcium transporting ATPase 0.0101 0.0329 0.1063
Loa Loa (eye worm) AGC/AKT protein kinase 0.009 0.0263 0.0863
Trypanosoma cruzi N-Acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase, putative 0.0053 0.0027 0.0685
Schistosoma mansoni serine/threonine-protein kinase 0.0061 0.0075 0.0214
Trypanosoma cruzi Protein kinase B 0.0061 0.0075 0.2174

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 495 nM Inhibition of human recombinant Akt1 ChEMBL. 18296048
IC50 (binding) = 495 nM Inhibition of human recombinant Akt1 ChEMBL. 18296048
IC50 (binding) = 2062 nM Inhibition of human recombinant Akt2 ChEMBL. 18296048
IC50 (binding) = 2062 nM Inhibition of human recombinant Akt2 ChEMBL. 18296048

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.