Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | vacuolar ATP synthase catalytic subunit A, osteoclast isoform | 0.0013 | 0.1597 | 0.0009 |
Mycobacterium leprae | PROBABLE ATP SYNTHASE BETA CHAIN ATPD | 0.0013 | 0.1597 | 0.5 |
Trypanosoma cruzi | Vacuolar proton pump subunit B, putative | 0.0043 | 1 | 1 |
Schistosoma mansoni | ATP synthase beta subunit | 0.0013 | 0.1597 | 0.0009 |
Echinococcus granulosus | ATP synthase subunit beta mitochondrial | 0.0013 | 0.1597 | 0.0009 |
Wolbachia endosymbiont of Brugia malayi | ATP synthase F0F1 subunit beta | 0.0013 | 0.1597 | 0.5 |
Loa Loa (eye worm) | vacuolar H ATPase family member | 0.0013 | 0.1597 | 0.0009 |
Schistosoma mansoni | ATP synthase subunit beta vacuolar | 0.0043 | 1 | 1 |
Giardia lamblia | Vacuolar ATP synthase subunit B | 0.0043 | 1 | 1 |
Treponema pallidum | V-type ATP synthase subunit B | 0.0043 | 1 | 1 |
Plasmodium falciparum | V-type proton ATPase catalytic subunit A | 0.0013 | 0.1597 | 0.0009 |
Entamoeba histolytica | vacuolar proton ATPase subunit, putative | 0.0013 | 0.159 | 0.159 |
Plasmodium vivax | ATP synthase subunit beta, mitochondrial, putative | 0.0013 | 0.1597 | 0.0009 |
Trichomonas vaginalis | ATP synthase, putative | 0.0043 | 1 | 1 |
Leishmania major | vacuolar ATP synthase subunit b, putative | 0.0043 | 1 | 1 |
Onchocerca volvulus | ATP synthase subunit alpha, mitochondrial homolog | 0.0013 | 0.1597 | 0.5 |
Mycobacterium ulcerans | F0F1 ATP synthase subunit beta | 0.0013 | 0.1597 | 0.5 |
Leishmania major | ATPase beta subunit, putative | 0.0013 | 0.1597 | 0.0009 |
Trichomonas vaginalis | ATP synthase alpha subunit mitochondrial, putative | 0.0043 | 1 | 1 |
Echinococcus granulosus | vacuolar ATP synthase subunit b | 0.0043 | 1 | 1 |
Trypanosoma brucei | V-type ATPase, A subunit, putative | 0.0013 | 0.1597 | 0.0009 |
Trichomonas vaginalis | vacuolar proton ATPase, putative | 0.0013 | 0.159 | 0.159 |
Giardia lamblia | Vacuolar ATP synthase catalytic subunit A | 0.0013 | 0.1597 | 0.0009 |
Mycobacterium tuberculosis | Probable ATP synthase beta chain AtpD | 0.0013 | 0.1597 | 0.5 |
Echinococcus multilocularis | vacuolar ATP synthase subunit b | 0.0043 | 1 | 1 |
Loa Loa (eye worm) | vacuolar ATP synthase subunit B | 0.0043 | 1 | 1 |
Trichomonas vaginalis | vacuolar proton ATPase subunit A4, putative | 0.0013 | 0.159 | 0.159 |
Plasmodium falciparum | V-type proton ATPase subunit B | 0.0043 | 1 | 1 |
Leishmania major | ATPase beta subunit, putative | 0.0013 | 0.1597 | 0.0009 |
Trypanosoma cruzi | V-type proton ATPase subunit B, putative | 0.0043 | 1 | 1 |
Entamoeba histolytica | vacuolar proton ATPase subunit, putative | 0.0013 | 0.159 | 0.159 |
Chlamydia trachomatis | V-type ATP synthase subunit B | 0.0043 | 1 | 1 |
Toxoplasma gondii | vacuolar ATP synthase subunit A, putative | 0.0013 | 0.1597 | 0.0009 |
Trypanosoma cruzi | V-type ATPase, A subunit, putative | 0.0013 | 0.1597 | 0.0009 |
Trypanosoma cruzi | V-type ATPase, A subunit, putative | 0.0013 | 0.1597 | 0.0009 |
Schistosoma mansoni | ATP synthase alpha subunit mitochondrial | 0.0013 | 0.1597 | 0.0009 |
Mycobacterium leprae | PROBABLE ATP SYNTHASE ALPHA CHAIN ATPA | 0.0013 | 0.1597 | 0.5 |
Leishmania major | vacuolar ATP synthase catalytic subunit A, putative | 0.0013 | 0.1597 | 0.0009 |
Mycobacterium tuberculosis | Probable ATP synthase alpha chain AtpA | 0.0013 | 0.1597 | 0.5 |
Plasmodium vivax | vacuolar ATP synthase subunit b, putative | 0.0043 | 1 | 1 |
Brugia malayi | ATP synthase beta chain, mitochondrial precursor, putative | 0.0013 | 0.1597 | 0.0009 |
Mycobacterium ulcerans | F0F1 ATP synthase subunit alpha | 0.0013 | 0.1597 | 0.5 |
Trypanosoma brucei | Vacuolar proton pump subunit B, putative | 0.0043 | 1 | 1 |
Trichomonas vaginalis | vacuolar proton ATPase, putative | 0.0013 | 0.159 | 0.159 |
Plasmodium vivax | vacuolar ATP synthase catalytic subunit A, putative | 0.0013 | 0.1597 | 0.0009 |
Echinococcus multilocularis | ATP synthase subunit beta, mitochondrial | 0.0013 | 0.1597 | 0.0009 |
Wolbachia endosymbiont of Brugia malayi | ATP synthase F0F1 subunit alpha | 0.0013 | 0.1597 | 0.5 |
Plasmodium vivax | ATP synthase alpha chain, putative | 0.0013 | 0.1597 | 0.0009 |
Entamoeba histolytica | V-type ATPase, B subunit, putative | 0.0043 | 1 | 1 |
Trichomonas vaginalis | ATP synthase beta subunit, putative | 0.0013 | 0.1597 | 0.1597 |
Echinococcus multilocularis | ATP synthase subunit alpha, mitochondrial | 0.0013 | 0.1597 | 0.0009 |
Schistosoma mansoni | ATP synthase alpha subunit vacuolar | 0.0013 | 0.1597 | 0.0009 |
Plasmodium falciparum | ATP synthase subunit beta, mitochondrial | 0.0013 | 0.1597 | 0.0009 |
Entamoeba histolytica | V-type ATPase, A subunit, putative | 0.0013 | 0.1597 | 0.1597 |
Toxoplasma gondii | ATP synthase beta subunit ATP-B | 0.0013 | 0.1597 | 0.0009 |
Brugia malayi | ATP synthase alpha chain, mitochondrial precursor, putative | 0.0013 | 0.1597 | 0.0009 |
Toxoplasma gondii | vacuolar ATP synthase subunit b, putative | 0.0043 | 1 | 1 |
Echinococcus granulosus | ATP synthase subunit alpha mitochondrial | 0.0013 | 0.1597 | 0.0009 |
Plasmodium falciparum | ATP synthase F1, alpha subunit | 0.0013 | 0.1597 | 0.0009 |
Echinococcus granulosus | vacuolar H ATPase v1 sector subunit A | 0.0013 | 0.1597 | 0.0009 |
Trypanosoma brucei | ATP synthase subunit beta, mitochondrial | 0.0013 | 0.1597 | 0.0009 |
Echinococcus multilocularis | vacuolar H+ ATPase v1 sector subunit A | 0.0013 | 0.1597 | 0.0009 |
Treponema pallidum | V-type ATP synthase subunit B | 0.0043 | 1 | 1 |
Trypanosoma cruzi | ATP synthase subunit beta, mitochondrial, putative | 0.0013 | 0.1597 | 0.0009 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (ADMET) | = 500 uM | Cytotoxicity against african green monkey Vero cells after 69 hrs by Alamar blue assay | ChEMBL. | 17981031 |
EC50 (functional) | = 79 uM | Antiviral activity against HSV1 KOS in african green monkey Vero cells by plaque reduction assay | ChEMBL. | 17981031 |
LogP | = 2.7 | Partition coefficient, log P of the compound | ChEMBL. | 17981031 |
Ratio CC50/EC50 (functional) | = 6.3 | Ratio of CC50 for african green monkey Vero cells to EC50 for HSV1 KOS | ChEMBL. | 17981031 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.