Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | V-type ATPase, A subunit, putative | 0.006 | 0.0837 | 0.0837 |
Treponema pallidum | V-type ATP synthase subunit B | 0.0194 | 1 | 1 |
Schistosoma mansoni | sodium/potassium-dependent atpase beta subunit | 0.0076 | 0.1986 | 0.1986 |
Echinococcus multilocularis | nervana 2 | 0.0076 | 0.1986 | 0.1986 |
Leishmania major | vacuolar ATP synthase catalytic subunit A, putative | 0.006 | 0.0837 | 0.0837 |
Brugia malayi | ATP synthase beta chain, mitochondrial precursor, putative | 0.006 | 0.0837 | 0.0837 |
Trypanosoma cruzi | Vacuolar proton pump subunit B, putative | 0.0194 | 1 | 1 |
Echinococcus granulosus | ATP synthase subunit beta mitochondrial | 0.006 | 0.0837 | 0.0837 |
Schistosoma mansoni | transmemberane protein | 0.0076 | 0.1986 | 0.1986 |
Wolbachia endosymbiont of Brugia malayi | ATP synthase F0F1 subunit alpha | 0.0087 | 0.2689 | 1 |
Trichomonas vaginalis | ATP synthase alpha subunit mitochondrial, putative | 0.0194 | 1 | 1 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.0076 | 0.1986 | 0.1986 |
Toxoplasma gondii | vacuolar ATP synthase subunit A, putative | 0.006 | 0.0837 | 0.0837 |
Mycobacterium leprae | PROBABLE ATP SYNTHASE ALPHA CHAIN ATPA | 0.0087 | 0.2689 | 0.5 |
Echinococcus granulosus | vacuolar ATP synthase subunit b | 0.0194 | 1 | 1 |
Trypanosoma cruzi | V-type ATPase, A subunit, putative | 0.006 | 0.0837 | 0.0837 |
Plasmodium vivax | ATP synthase alpha chain, putative | 0.0087 | 0.2689 | 0.2689 |
Schistosoma mansoni | sodium/potassium-dependent atpase beta subunit | 0.0076 | 0.1986 | 0.1986 |
Trypanosoma cruzi | V-type proton ATPase subunit B, putative | 0.0194 | 1 | 1 |
Echinococcus granulosus | sodium:potassium transporting ATPase subunit | 0.0076 | 0.1986 | 0.1986 |
Plasmodium vivax | vacuolar ATP synthase catalytic subunit A, putative | 0.006 | 0.0837 | 0.0837 |
Toxoplasma gondii | ATP synthase beta subunit ATP-B | 0.006 | 0.0837 | 0.0837 |
Plasmodium falciparum | V-type proton ATPase catalytic subunit A | 0.006 | 0.0837 | 0.0837 |
Echinococcus granulosus | nervana 2 | 0.0076 | 0.1986 | 0.1986 |
Echinococcus multilocularis | vacuolar ATP synthase subunit b | 0.0194 | 1 | 1 |
Plasmodium falciparum | V-type proton ATPase subunit B | 0.0194 | 1 | 1 |
Brugia malayi | vacuolar ATP synthase catalytic subunit A, osteoclast isoform | 0.006 | 0.0837 | 0.0837 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.0076 | 0.1986 | 0.1986 |
Echinococcus granulosus | vacuolar H ATPase v1 sector subunit A | 0.006 | 0.0837 | 0.0837 |
Echinococcus multilocularis | ATP synthase subunit alpha, mitochondrial | 0.0087 | 0.2689 | 0.2689 |
Mycobacterium tuberculosis | Probable ATP synthase beta chain AtpD | 0.0087 | 0.2689 | 0.5 |
Echinococcus multilocularis | nervana 2 | 0.0076 | 0.1986 | 0.1986 |
Echinococcus multilocularis | vacuolar H+ ATPase v1 sector subunit A | 0.006 | 0.0837 | 0.0837 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.1986 | 0.1986 |
Mycobacterium leprae | PROBABLE ATP SYNTHASE BETA CHAIN ATPD | 0.0087 | 0.2689 | 0.5 |
Leishmania major | ATPase alpha subunit | 0.0053 | 0.0363 | 0.0363 |
Entamoeba histolytica | V-type ATPase, B subunit, putative | 0.0194 | 1 | 1 |
Schistosoma mansoni | sodium / potassium ATPase beta chain | 0.0076 | 0.1986 | 0.1986 |
Entamoeba histolytica | V-type ATPase, A subunit, putative | 0.006 | 0.0837 | 0.0837 |
Mycobacterium ulcerans | F0F1 ATP synthase subunit alpha | 0.0087 | 0.2689 | 1 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.0076 | 0.1986 | 0.1986 |
Trichomonas vaginalis | ATP synthase beta subunit, putative | 0.006 | 0.0837 | 0.0837 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.0076 | 0.1986 | 0.1986 |
Schistosoma mansoni | sodium/potassium-dependent atpase beta subunit | 0.0076 | 0.1986 | 0.1986 |
Leishmania major | ATPase beta subunit, putative | 0.006 | 0.0837 | 0.0837 |
Giardia lamblia | Vacuolar ATP synthase catalytic subunit A | 0.006 | 0.0837 | 0.0837 |
Trypanosoma brucei | ATP synthase subunit beta, mitochondrial | 0.006 | 0.0837 | 0.0837 |
Toxoplasma gondii | vacuolar ATP synthase subunit b, putative | 0.0194 | 1 | 1 |
Schistosoma mansoni | ATP synthase alpha subunit vacuolar | 0.006 | 0.0837 | 0.0837 |
Trypanosoma cruzi | V-type ATPase, A subunit, putative | 0.006 | 0.0837 | 0.0837 |
Echinococcus multilocularis | nervana 2 | 0.0076 | 0.1986 | 0.1986 |
Echinococcus granulosus | nervana 2 | 0.0076 | 0.1986 | 0.1986 |
Trypanosoma brucei | Vacuolar proton pump subunit B, putative | 0.0194 | 1 | 1 |
Loa Loa (eye worm) | vacuolar ATP synthase subunit B | 0.0194 | 1 | 1 |
Schistosoma mansoni | ATP synthase alpha subunit mitochondrial | 0.0087 | 0.2689 | 0.2689 |
Leishmania major | ATPase beta subunit, putative | 0.006 | 0.0837 | 0.0837 |
Echinococcus granulosus | nervana 2 | 0.0076 | 0.1986 | 0.1986 |
Onchocerca volvulus | ATP synthase subunit alpha, mitochondrial homolog | 0.0087 | 0.2689 | 1 |
Trypanosoma brucei | ATP synthase F1, alpha subunit | 0.0053 | 0.0363 | 0.0363 |
Plasmodium vivax | vacuolar ATP synthase subunit b, putative | 0.0194 | 1 | 1 |
Echinococcus multilocularis | nervana 2 | 0.0076 | 0.1986 | 0.1986 |
Trypanosoma cruzi | ATP synthase subunit beta, mitochondrial, putative | 0.006 | 0.0837 | 0.0837 |
Loa Loa (eye worm) | vacuolar H ATPase family member | 0.006 | 0.0837 | 0.0837 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.1986 | 0.1986 |
Leishmania major | vacuolar ATP synthase subunit b, putative | 0.0194 | 1 | 1 |
Echinococcus multilocularis | sodium:potassium transporting ATPase subunit | 0.0076 | 0.1986 | 0.1986 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.0076 | 0.1986 | 0.1986 |
Giardia lamblia | Vacuolar ATP synthase subunit B | 0.0194 | 1 | 1 |
Treponema pallidum | V-type ATP synthase subunit B | 0.0194 | 1 | 1 |
Chlamydia trachomatis | V-type ATP synthase subunit B | 0.0194 | 1 | 1 |
Schistosoma mansoni | ATP synthase beta subunit | 0.006 | 0.0837 | 0.0837 |
Echinococcus granulosus | nervana 2 | 0.0076 | 0.1986 | 0.1986 |
Trichomonas vaginalis | ATP synthase, putative | 0.0194 | 1 | 1 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.0076 | 0.1986 | 0.1986 |
Mycobacterium tuberculosis | Probable ATP synthase alpha chain AtpA | 0.0087 | 0.2689 | 0.5 |
Plasmodium vivax | ATP synthase subunit beta, mitochondrial, putative | 0.006 | 0.0837 | 0.0837 |
Trypanosoma brucei | ATP synthase F1, alpha subunit | 0.0053 | 0.0363 | 0.0363 |
Plasmodium falciparum | ATP synthase subunit beta, mitochondrial | 0.006 | 0.0837 | 0.0837 |
Leishmania major | ATPase alpha subunit | 0.0053 | 0.0363 | 0.0363 |
Echinococcus multilocularis | ATP synthase subunit beta, mitochondrial | 0.006 | 0.0837 | 0.0837 |
Echinococcus granulosus | ATP synthase subunit alpha mitochondrial | 0.0087 | 0.2689 | 0.2689 |
Plasmodium falciparum | ATP synthase F1, alpha subunit | 0.0087 | 0.2689 | 0.2689 |
Schistosoma mansoni | ATP synthase subunit beta vacuolar | 0.0194 | 1 | 1 |
Brugia malayi | ATP synthase alpha chain, mitochondrial precursor, putative | 0.0087 | 0.2689 | 0.2689 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 60 % | Inhibition of autotaxin (unknown origin) assessed as residual enzyme activity at 1 uM relative to control | ChEMBL. | 18082408 |
Activity (binding) | = 60 % | Inhibition of autotaxin (unknown origin) assessed as residual enzyme activity at 1 uM relative to control | ChEMBL. | 18082408 |
Activity (binding) | = 67 % | Inhibition of autotaxin (unknown origin) assessed as residual enzyme activity at 10 uM relative to control | ChEMBL. | 18082408 |
Activity (binding) | = 67 % | Inhibition of autotaxin (unknown origin) assessed as residual enzyme activity at 10 uM relative to control | ChEMBL. | 18082408 |
Activity (binding) | = 72 % | Inhibition of autotaxin (unknown origin) assessed as residual enzyme activity at 100 uM relative to control | ChEMBL. | 18082408 |
Activity (binding) | = 72 % | Inhibition of autotaxin (unknown origin) assessed as residual enzyme activity at 100 uM relative to control | ChEMBL. | 18082408 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.