Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | vacuolar proton-ATPase-like protein, putative | 0.0047 | 0.1301 | 0.1301 |
Echinococcus multilocularis | nervana 2 | 0.0075 | 0.2992 | 0.1944 |
Entamoeba histolytica | vacuolar proton ATPase subunit, putative | 0.0047 | 0.1301 | 0.0835 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.2992 | 0.2992 |
Treponema pallidum | V-type ATP synthase subunit B | 0.0191 | 1 | 1 |
Giardia lamblia | Vacuolar ATP synthase catalytic subunit A | 0.0059 | 0.2025 | 0.0832 |
Schistosoma mansoni | sodium/potassium-dependent atpase beta subunit | 0.0075 | 0.2992 | 0.1944 |
Leishmania major | ATPase alpha subunit | 0.0052 | 0.16 | 0.0344 |
Wolbachia endosymbiont of Brugia malayi | ATP synthase F0F1 subunit beta | 0.0059 | 0.2025 | 0.5586 |
Trichomonas vaginalis | vacuolar proton ATPase subunit A4, putative | 0.0047 | 0.1301 | 0.0835 |
Trichomonas vaginalis | ATP synthase, putative | 0.0191 | 1 | 1 |
Trypanosoma brucei | Vacuolar proton pump subunit B, putative | 0.0191 | 1 | 1 |
Trichomonas vaginalis | ATP synthase alpha subunit mitochondrial, putative | 0.0191 | 1 | 1 |
Mycobacterium tuberculosis | Probable ATP synthase alpha chain AtpA | 0.0085 | 0.3625 | 1 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.0075 | 0.2992 | 0.1944 |
Schistosoma mansoni | ATP synthase subunit beta vacuolar | 0.0191 | 1 | 1 |
Brugia malayi | vacuolar ATP synthase catalytic subunit A, osteoclast isoform | 0.0059 | 0.2025 | 0.0832 |
Mycobacterium leprae | PROBABLE ATP SYNTHASE BETA CHAIN ATPD | 0.0085 | 0.3625 | 1 |
Wolbachia endosymbiont of Brugia malayi | ATP synthase F0F1 subunit alpha | 0.0085 | 0.3625 | 1 |
Brugia malayi | ATP synthase alpha chain, mitochondrial precursor, putative | 0.0085 | 0.3625 | 0.2671 |
Leishmania major | ATPase beta subunit, putative | 0.0059 | 0.2025 | 0.0832 |
Echinococcus multilocularis | vacuolar H+ ATPase v1 sector subunit A | 0.0059 | 0.2025 | 0.0832 |
Echinococcus granulosus | ATP synthase subunit beta mitochondrial | 0.0059 | 0.2025 | 0.0832 |
Schistosoma mansoni | ATP synthase beta subunit | 0.0059 | 0.2025 | 0.0832 |
Plasmodium falciparum | ATP synthase subunit beta, mitochondrial | 0.0059 | 0.2025 | 0.0832 |
Trypanosoma cruzi | vacuolar proton translocating ATPase subunit A, putative | 0.0047 | 0.1301 | 0.1301 |
Treponema pallidum | V-type ATP synthase subunit B | 0.0191 | 1 | 1 |
Echinococcus granulosus | sodium:potassium transporting ATPase subunit | 0.0075 | 0.2992 | 0.1944 |
Echinococcus granulosus | nervana 2 | 0.0075 | 0.2992 | 0.1944 |
Mycobacterium ulcerans | F0F1 ATP synthase subunit beta | 0.0059 | 0.2025 | 0.5586 |
Loa Loa (eye worm) | vacuolar ATP synthase subunit B | 0.0191 | 1 | 1 |
Mycobacterium leprae | PROBABLE ATP SYNTHASE ALPHA CHAIN ATPA | 0.0085 | 0.3625 | 1 |
Trichomonas vaginalis | vacuolar proton ATPase, putative | 0.0047 | 0.1301 | 0.0835 |
Toxoplasma gondii | vacuolar ATP synthase subunit b, putative | 0.0191 | 1 | 1 |
Plasmodium vivax | vacuolar ATP synthase catalytic subunit A, putative | 0.0059 | 0.2025 | 0.0832 |
Mycobacterium tuberculosis | Probable ATP synthase beta chain AtpD | 0.0085 | 0.3625 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.2992 | 0.2992 |
Leishmania major | ATPase alpha subunit | 0.0052 | 0.16 | 0.0344 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.0075 | 0.2992 | 0.1944 |
Chlamydia trachomatis | V-type ATP synthase subunit B | 0.0191 | 1 | 1 |
Chlamydia trachomatis | type III secretion system ATPase | 0.0059 | 0.2025 | 0.2025 |
Leishmania major | vacuolar ATP synthase catalytic subunit A, putative | 0.0059 | 0.2025 | 0.0832 |
Echinococcus granulosus | nervana 2 | 0.0075 | 0.2992 | 0.1944 |
Onchocerca volvulus | ATP synthase subunit alpha, mitochondrial homolog | 0.0085 | 0.3625 | 1 |
Plasmodium falciparum | ATP synthase F1, alpha subunit | 0.0085 | 0.3625 | 0.2671 |
Trypanosoma brucei | ATP synthase subunit beta, mitochondrial | 0.0059 | 0.2025 | 0.0832 |
Echinococcus multilocularis | sodium:potassium transporting ATPase subunit | 0.0075 | 0.2992 | 0.1944 |
Echinococcus multilocularis | ATP synthase subunit beta, mitochondrial | 0.0059 | 0.2025 | 0.0832 |
Echinococcus multilocularis | vacuolar ATP synthase subunit b | 0.0191 | 1 | 1 |
Plasmodium vivax | vacuolar ATP synthase subunit b, putative | 0.0191 | 1 | 1 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.0075 | 0.2992 | 0.1944 |
Toxoplasma gondii | ATP synthase beta subunit ATP-B | 0.0059 | 0.2025 | 0.0832 |
Treponema pallidum | V-type ATP synthase subunit A | 0.0059 | 0.2025 | 0.2025 |
Plasmodium falciparum | V-type proton ATPase subunit B | 0.0191 | 1 | 1 |
Plasmodium vivax | ATP synthase subunit beta, mitochondrial, putative | 0.0059 | 0.2025 | 0.0832 |
Plasmodium vivax | ATP synthase alpha chain, putative | 0.0085 | 0.3625 | 0.2671 |
Echinococcus multilocularis | nervana 2 | 0.0075 | 0.2992 | 0.1944 |
Trichomonas vaginalis | vacuolar proton ATPase, putative | 0.0047 | 0.1301 | 0.0835 |
Loa Loa (eye worm) | vacuolar H ATPase family member | 0.0059 | 0.2025 | 0.2025 |
Echinococcus multilocularis | nervana 2 | 0.0075 | 0.2992 | 0.1944 |
Echinococcus granulosus | nervana 2 | 0.0075 | 0.2992 | 0.1944 |
Toxoplasma gondii | vacuolar ATP synthase subunit A, putative | 0.0059 | 0.2025 | 0.0832 |
Echinococcus granulosus | nervana 2 | 0.0075 | 0.2992 | 0.1944 |
Echinococcus multilocularis | ATP synthase subunit alpha, mitochondrial | 0.0085 | 0.3625 | 0.2671 |
Trypanosoma brucei | ATP synthase F1, alpha subunit | 0.0052 | 0.16 | 0.0344 |
Brugia malayi | ATP synthase beta chain, mitochondrial precursor, putative | 0.0059 | 0.2025 | 0.0832 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.1301 | 0.1301 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.0075 | 0.2992 | 0.1944 |
Trypanosoma cruzi | V-type ATPase, A subunit, putative | 0.0059 | 0.2025 | 0.2025 |
Plasmodium falciparum | V-type proton ATPase catalytic subunit A | 0.0059 | 0.2025 | 0.0832 |
Entamoeba histolytica | vacuolar proton ATPase subunit, putative | 0.0047 | 0.1301 | 0.0835 |
Entamoeba histolytica | V-type ATPase, B subunit, putative | 0.0191 | 1 | 1 |
Trypanosoma cruzi | V-type ATPase, A subunit, putative | 0.0059 | 0.2025 | 0.2025 |
Treponema pallidum | flagellum-specific ATP synthase (fliI) | 0.0059 | 0.2025 | 0.2025 |
Trichomonas vaginalis | ATP synthase beta subunit, putative | 0.0059 | 0.2025 | 0.1597 |
Schistosoma mansoni | sodium/potassium-dependent atpase beta subunit | 0.0075 | 0.2992 | 0.1944 |
Schistosoma mansoni | transmemberane protein | 0.0075 | 0.2992 | 0.1944 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.0075 | 0.2992 | 0.1944 |
Echinococcus granulosus | vacuolar ATP synthase subunit b | 0.0191 | 1 | 1 |
Leishmania major | ATPase beta subunit, putative | 0.0059 | 0.2025 | 0.0832 |
Trypanosoma brucei | ATP synthase F1, alpha subunit | 0.0052 | 0.16 | 0.0344 |
Chlamydia trachomatis | V-type ATP synthase subunit A | 0.0059 | 0.2025 | 0.2025 |
Trypanosoma brucei | V-type ATPase, A subunit, putative | 0.0059 | 0.2025 | 0.0832 |
Schistosoma mansoni | ATP synthase alpha subunit mitochondrial | 0.0085 | 0.3625 | 0.2671 |
Schistosoma mansoni | ATP synthase alpha subunit vacuolar | 0.0059 | 0.2025 | 0.0832 |
Loa Loa (eye worm) | V-type ATPase 116kDa subunit family protein | 0.0047 | 0.1301 | 0.1301 |
Treponema pallidum | V-type ATP synthase subunit A | 0.0059 | 0.2025 | 0.2025 |
Loa Loa (eye worm) | vacuolar proton pump | 0.0047 | 0.1301 | 0.1301 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.0075 | 0.2992 | 0.1944 |
Giardia lamblia | Vacuolar ATP synthase subunit B | 0.0191 | 1 | 1 |
Trypanosoma cruzi | V-type proton ATPase subunit a, putative | 0.0047 | 0.1301 | 0.1301 |
Mycobacterium ulcerans | F0F1 ATP synthase subunit alpha | 0.0085 | 0.3625 | 1 |
Chlamydia trachomatis | type III secretion system ATP synthase | 0.0059 | 0.2025 | 0.2025 |
Schistosoma mansoni | sodium / potassium ATPase beta chain | 0.0075 | 0.2992 | 0.1944 |
Trypanosoma cruzi | Vacuolar proton pump subunit B, putative | 0.0191 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.1301 | 0.1301 |
Echinococcus granulosus | vacuolar H ATPase v1 sector subunit A | 0.0059 | 0.2025 | 0.0832 |
Echinococcus multilocularis | nervana 2 | 0.0075 | 0.2992 | 0.1944 |
Schistosoma mansoni | sodium/potassium-dependent atpase beta subunit | 0.0075 | 0.2992 | 0.1944 |
Entamoeba histolytica | V-type ATPase, A subunit, putative | 0.0059 | 0.2025 | 0.1597 |
Trypanosoma cruzi | V-type proton ATPase subunit B, putative | 0.0191 | 1 | 1 |
Echinococcus granulosus | ATP synthase subunit alpha mitochondrial | 0.0085 | 0.3625 | 0.2671 |
Trypanosoma cruzi | ATP synthase subunit beta, mitochondrial, putative | 0.0059 | 0.2025 | 0.2025 |
Leishmania major | vacuolar ATP synthase subunit b, putative | 0.0191 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 1995 nM | Displacement of [3H]cytisine from alpha4beta2 nAChR in rat brain membrane | ChEMBL. | 18006307 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.