Detailed information for compound 524310

Basic information

Technical information
  • TDR Targets ID: 524310
  • Name: N'-(7-chloroquinolin-4-yl)-N-propan-2-ylpropa ne-1,3-diamine
  • MW: 277.792 | Formula: C15H20ClN3
  • H donors: 2 H acceptors: 1 LogP: 4.08 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(NCCCNc1ccnc2c1ccc(c2)Cl)C
  • InChi: 1S/C15H20ClN3/c1-11(2)17-7-3-8-18-14-6-9-19-15-10-12(16)4-5-13(14)15/h4-6,9-11,17H,3,7-8H2,1-2H3,(H,18,19)
  • InChiKey: XSEQDLPSDCETSK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N'-(7-chloro-4-quinolyl)-N-isopropyl-propane-1,3-diamine
  • N'-(7-chloro-4-quinolyl)-N-isopropylpropane-1,3-diamine
  • N'-(7-chloroquinolin-4-yl)-N-propan-2-yl-propane-1,3-diamine
  • (7-chloro-4-quinolyl)-[3-(isopropylamino)propyl]amine
  • 3-[(7-chloro-4-quinolyl)amino]propyl-isopropyl-amine
  • 5418-54-2
  • NSC10486

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0108215 0.166356 0.487473
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0219196 0.42586 0.423743
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0146914 0.256844 0.578387
Entamoeba histolytica cysteine protease, putative 0.010259 0.153202 0.405405
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.00477541 0.0249796 0.0213836
Brugia malayi hypothetical protein 0.00521854 0.0353413 0.0317836
Echinococcus granulosus hypothetical protein 0.0108215 0.166356 0.152444
Echinococcus granulosus alpha 1A adrenergic receptor 0.0108215 0.166356 0.152444
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0183016 0.341261 0.788967
Echinococcus multilocularis somatostatin receptor 0.0108215 0.166356 0.152444
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.00477541 0.0249796 0.0213836
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0464735 1 1
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0146914 0.256844 0.244442
Onchocerca volvulus Matrix metalloproteinase homolog 0.00857075 0.113726 0.333251
Loa Loa (eye worm) hypothetical protein 0.00521854 0.0353413 0.0353413
Echinococcus granulosus cathepsin L cysteine protease 0.010259 0.153202 0.139071
Leishmania major cathepsin L-like protease 0.0183016 0.341261 0.793382
Loa Loa (eye worm) papain family cysteine protease containing protein 0.00548359 0.041539 0.041539
Echinococcus granulosus tachykinin peptides receptor 99D 0.0457634 0.983397 0.98312
Onchocerca volvulus 0.0108215 0.166356 0.487473
Loa Loa (eye worm) hypothetical protein 0.00386427 0.0036745 0.0036745
Echinococcus granulosus fmrfamide receptor 0.0108215 0.166356 0.152444
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0219196 0.42586 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0183016 0.341261 0.341261
Onchocerca volvulus 0.0108215 0.166356 0.487473
Plasmodium vivax plasmepsin IV, putative 0.0146914 0.256844 0.740132
Echinococcus multilocularis cathepsin L 0.00477541 0.0249796 0.008709
Loa Loa (eye worm) hypothetical protein 0.00477541 0.0249796 0.0249796
Loa Loa (eye worm) hypothetical protein 0.00470648 0.0233679 0.0233679
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0108215 0.166356 0.152444
Plasmodium vivax vivapain-2 0.0183016 0.341261 1
Echinococcus multilocularis sex peptide receptor 0.0108215 0.166356 0.152444
Loa Loa (eye worm) hypothetical protein 0.00477541 0.0249796 0.0249796
Schistosoma mansoni biogenic amine receptor 0.0108215 0.166356 0.163281
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.00477541 0.0249796 0.0263695
Loa Loa (eye worm) hypothetical protein 0.00521854 0.0353413 0.0353413
Entamoeba histolytica cysteine proteinase, putative 0.0183016 0.341261 1
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.00681016 0.072558 0.0691375
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0183016 0.341261 0.689725
Plasmodium vivax vivapain-3 0.010259 0.153202 0.421085
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0183016 0.341261 0.788967
Brugia malayi ORL1-like opioid receptor 0.0108215 0.166356 0.163281
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Brugia malayi hypothetical protein 0.0108215 0.166356 0.163281
Echinococcus multilocularis rhodopsin orphan GPCR 0.0108215 0.166356 0.152444
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0146914 0.256844 0.256844
Schistosoma mansoni neuropeptide receptor 0.0108215 0.166356 0.163281
Entamoeba histolytica cysteine proteinase, putative 0.010259 0.153202 0.405405
Echinococcus granulosus cathepsin l cysteine peptidase 0.0183016 0.341261 0.330268
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0108215 0.166356 0.163281
Onchocerca volvulus 0.0108215 0.166356 0.487473
Brugia malayi Papain family cysteine protease containing protein 0.010259 0.153202 0.150079
Brugia malayi Hemopexin family protein 0.00547919 0.0414359 0.0379007
Loa Loa (eye worm) hypothetical protein 0.00796296 0.0995136 0.0995136
Echinococcus multilocularis cysteine protease 0.0183016 0.341261 0.330268
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0219196 0.42586 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.00477541 0.0249796 0.0213836
Loa Loa (eye worm) hypothetical protein 0.012818 0.213039 0.213039
Echinococcus granulosus neuropeptide receptor A26 0.0108215 0.166356 0.152444
Brugia malayi calpain family protein 1 0.00678035 0.071861 0.068438
Onchocerca volvulus 0.00521854 0.0353413 0.103561
Trypanosoma cruzi cysteine peptidase, putative 0.0183016 0.341261 0.330268
Echinococcus multilocularis cathepsin b 0.0464735 1 1
Plasmodium falciparum serine repeat antigen 7 0.00477541 0.0249796 0.0263695
Schistosoma mansoni opsin-like receptor 0.0108215 0.166356 0.163281
Brugia malayi Dopamine receptor protein 2 0.0108215 0.166356 0.163281
Giardia lamblia Cathepsin B precursor 0.0219196 0.42586 1
Loa Loa (eye worm) calpain family protein 1 0.00678035 0.071861 0.071861
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.010259 0.153202 0.150079
Leishmania major cysteine peptidase A (CPA) 0.0183016 0.341261 0.793382
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.00477541 0.0249796 0.0263695
Echinococcus granulosus serotonin receptor 0.0108215 0.166356 0.152444
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.010259 0.153202 0.319851
Loa Loa (eye worm) matrix metalloproteinase 0.00386427 0.0036745 0.0036745
Loa Loa (eye worm) animal heme peroxidase 0.00521854 0.0353413 0.0353413
Echinococcus granulosus biogenic amine 5HT receptor 0.0108215 0.166356 0.152444
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0108215 0.166356 0.163281
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0108215 0.166356 0.163281
Loa Loa (eye worm) hypothetical protein 0.00477541 0.0249796 0.0249796
Loa Loa (eye worm) hypothetical protein 0.00521854 0.0353413 0.0353413
Toxoplasma gondii cathepsin CPL 0.0183016 0.341261 0.793382
Echinococcus granulosus cathepsin b 0.0464735 1 1
Loa Loa (eye worm) neuropeptide F receptor 0.0108215 0.166356 0.166356
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0108215 0.166356 0.166356
Entamoeba histolytica cysteine protease, putative 0.010259 0.153202 0.405405
Onchocerca volvulus 0.0108215 0.166356 0.487473
Schistosoma mansoni cathepsin C 0.00477541 0.0249796 0.0213836
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Echinococcus granulosus peroxidasin 0.00521854 0.0353413 0.0192436
Echinococcus multilocularis serotonin receptor 0.0108215 0.166356 0.152444
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0108215 0.166356 0.163281
Trypanosoma cruzi cysteine peptidase, putative 0.0183016 0.341261 0.330268
Echinococcus granulosus G protein coupled receptor 139 0.0108215 0.166356 0.152444
Echinococcus multilocularis rhodopsin orphan GPCR 0.0108215 0.166356 0.152444
Mycobacterium leprae PROBABLE HYDROLASE 0.00470648 0.0233679 0.5
Brugia malayi putative neuropeptide receptor 0.0108215 0.166356 0.163281
Schistosoma mansoni growth hormone secretagogue receptor 0.0108215 0.166356 0.163281
Plasmodium falciparum serine repeat antigen 9 0.00477541 0.0249796 0.0263695
Brugia malayi Serotonin receptor 0.0108215 0.166356 0.163281
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.010259 0.153202 0.150079
Echinococcus granulosus tm gpcr rhodopsin 0.0108215 0.166356 0.152444
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0108215 0.166356 0.152444
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.00477541 0.0249796 0.0263695
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0108215 0.166356 0.152444
Echinococcus multilocularis g protein coupled receptor 0.0108215 0.166356 0.152444
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0146914 0.256844 0.254103
Loa Loa (eye worm) hypothetical protein 0.00487067 0.0272071 0.0272071
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0183016 0.341261 0.788967
Echinococcus multilocularis neuropeptides capa receptor 0.0108215 0.166356 0.152444
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.00477541 0.0249796 0.0263695
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0108215 0.166356 0.166356
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0108215 0.166356 0.152444
Echinococcus granulosus neuropeptide FF receptor 2 0.0108215 0.166356 0.152444
Loa Loa (eye worm) hypothetical protein 0.00999484 0.147025 0.147025
Echinococcus granulosus cathepsin L cysteine proteinase 0.0183016 0.341261 0.330268
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.00477541 0.0249796 0.0263695
Entamoeba histolytica cysteine proteinase, putative 0.010259 0.153202 0.405405
Brugia malayi follicle stimulating hormone receptor 0.0108215 0.166356 0.163281
Loa Loa (eye worm) hypothetical protein 0.00555731 0.0432627 0.0432627
Loa Loa (eye worm) TK/ROR protein kinase 0.00440907 0.0164135 0.0164135
Schistosoma mansoni twik family of potassium channels-related 0.03568 0.747619 0.746688
Echinococcus multilocularis allatostatin A receptor 0.0108215 0.166356 0.152444
Plasmodium vivax unspecified product 0.00548359 0.041539 0.0773453
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Schistosoma mansoni peroxidasin 0.00521854 0.0353413 0.0317836
Echinococcus multilocularis cathepsin b 0.0464735 1 1
Brugia malayi Animal haem peroxidase family protein 0.00521854 0.0353413 0.0317836
Brugia malayi GnHR receptor homolog 0.0108215 0.166356 0.163281
Onchocerca volvulus 0.0108215 0.166356 0.487473
Toxoplasma gondii calcium binding egf domain-containing protein 0.00796296 0.0995136 0.202957
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0464735 1 1
Echinococcus granulosus orexin receptor type 2 0.0108215 0.166356 0.152444
Echinococcus granulosus neuropeptides capa receptor 0.0108215 0.166356 0.152444
Brugia malayi putative neuropeptide receptor NPR1 0.0108215 0.166356 0.163281
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0219196 0.42586 0.416279
Schistosoma mansoni amine GPCR 0.0108215 0.166356 0.163281
Schistosoma mansoni biogenic amine (5HT) receptor 0.0108215 0.166356 0.163281
Echinococcus granulosus tm gpcr rhodopsin 0.0108215 0.166356 0.152444
Onchocerca volvulus Dual oxidase homolog 0.00521854 0.0353413 0.103561
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.012818 0.213039 0.199906
Brugia malayi Dopamine receptor 0.0108215 0.166356 0.163281
Schistosoma mansoni hypothetical protein 0.00547919 0.0414359 0.0379007
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0464735 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0183016 0.341261 0.788967
Loa Loa (eye worm) cathepsin B 0.0219196 0.42586 0.42586
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0108215 0.166356 0.163281
Plasmodium falciparum serine repeat antigen 8 0.00477541 0.0249796 0.0263695
Onchocerca volvulus Peroxidasin homolog 0.00521854 0.0353413 0.103561
Brugia malayi Cathepsin L-like precursor 0.0183016 0.341261 0.338832
Schistosoma mansoni cathepsin B (C01 family) 0.00477541 0.0249796 0.0213836
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0183016 0.341261 0.689725
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Echinococcus granulosus cathepsin L 0.010259 0.153202 0.139071
Loa Loa (eye worm) hypothetical protein 0.00386427 0.0036745 0.0036745
Trypanosoma cruzi cysteine peptidase, putative 0.00548359 0.041539 0.0255447
Echinococcus multilocularis neuropeptide Y receptor 0.0108215 0.166356 0.152444
Entamoeba histolytica cysteine protease, putative 0.010259 0.153202 0.405405
Schistosoma mansoni histamine h1 receptor 0.0108215 0.166356 0.163281
Echinococcus granulosus cathepsin b 0.0464735 1 1
Brugia malayi Matrixin family protein 0.00934345 0.131794 0.128592
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0108215 0.166356 0.163281
Plasmodium falciparum plasmepsin I 0.0146914 0.256844 0.740132
Brugia malayi hypothetical protein 0.0108215 0.166356 0.163281
Loa Loa (eye worm) animal heme peroxidase 0.00521854 0.0353413 0.0353413
Brugia malayi Melatonin receptor type 1A 0.0108215 0.166356 0.163281
Brugia malayi hypothetical protein 0.0108215 0.166356 0.163281
Onchocerca volvulus 0.0183016 0.341261 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0108215 0.166356 0.152444
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.00796296 0.0995136 0.0995136
Brugia malayi calpain family protein 1 0.00678035 0.071861 0.068438
Echinococcus multilocularis neuropeptide s receptor 0.0108215 0.166356 0.152444
Loa Loa (eye worm) neuropeptide F receptor 0.0108215 0.166356 0.166356
Loa Loa (eye worm) hypothetical protein 0.00477541 0.0249796 0.0249796
Onchocerca volvulus 0.00440907 0.0164135 0.0480966
Schistosoma mansoni egf-like domain protein 0.00681016 0.072558 0.0691375
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Echinococcus multilocularis neuropeptide receptor 0.0108215 0.166356 0.152444
Schistosoma mansoni hypothetical protein 0.0108215 0.166356 0.163281
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0108215 0.166356 0.152444
Echinococcus multilocularis cathepsin L 0.010259 0.153202 0.139071
Onchocerca volvulus Cathepsin L homolog 0.0183016 0.341261 1
Schistosoma mansoni amine GPCR 0.0108215 0.166356 0.163281
Echinococcus granulosus cysteine protease 0.010259 0.153202 0.139071
Trypanosoma cruzi major cysteine proteinase, putative 0.00477541 0.0249796 0.008709
Brugia malayi Blistered cuticle protein 3 0.00521854 0.0353413 0.0317836
Plasmodium vivax vivapain-1 0.010259 0.153202 0.421085
Schistosoma mansoni cathepsin F (C01 family) 0.0183016 0.341261 0.338832
Loa Loa (eye worm) hypothetical protein 0.00521854 0.0353413 0.0353413
Echinococcus multilocularis calpain family protein 1, d 0.00493017 0.0285983 0.0123881
Plasmodium falciparum serine repeat antigen 2 0.00477541 0.0249796 0.0263695
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0108215 0.166356 0.163281
Brugia malayi Papain family cysteine protease containing protein 0.00477541 0.0249796 0.0213836
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0108215 0.166356 0.152444
Brugia malayi Cathepsin L-like precursor 0.0183016 0.341261 0.338832
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0183016 0.341261 0.788967
Plasmodium falciparum plasmepsin II 0.0146914 0.256844 0.740132
Brugia malayi neuropeptide F receptor 0.0108215 0.166356 0.163281
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0108215 0.166356 0.163281
Onchocerca volvulus 0.0108215 0.166356 0.487473
Leishmania major cathepsin L-like protease 0.0183016 0.341261 0.793382
Echinococcus multilocularis G-protein coupled receptor, putative 0.0108215 0.166356 0.152444
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0183016 0.341261 0.788967
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.00470648 0.0233679 0.019766
Plasmodium vivax serine-repeat antigen (SERA), putative 0.00477541 0.0249796 0.0263695
Loa Loa (eye worm) ctsf protein 0.0183016 0.341261 0.341261
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Schistosoma mansoni neuropeptide receptor 0.0108215 0.166356 0.163281
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.00477541 0.0249796 0.0263695
Loa Loa (eye worm) TYRA-2 protein 0.0108215 0.166356 0.166356
Trypanosoma cruzi cysteine peptidase, putative 0.010259 0.153202 0.139071
Leishmania major cathepsin L-like protease 0.0183016 0.341261 0.793382
Brugia malayi Protein kinase domain containing protein 0.00440907 0.0164135 0.012786
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Onchocerca volvulus 0.0183016 0.341261 1
Trypanosoma cruzi cysteine proteinase, putative 0.010259 0.153202 0.139071
Loa Loa (eye worm) fibroinase 0.0183016 0.341261 0.341261
Loa Loa (eye worm) hypothetical protein 0.012818 0.213039 0.213039
Echinococcus granulosus neuropeptide receptor 0.0108215 0.166356 0.152444
Onchocerca volvulus 0.0183016 0.341261 1
Giardia lamblia Cathepsin B precursor 0.0219196 0.42586 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.00477541 0.0249796 0.0213836
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Brugia malayi cathepsin F-like cysteine proteinase 0.00548359 0.041539 0.0380041
Onchocerca volvulus 0.0183016 0.341261 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0183016 0.341261 0.788967
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0183016 0.341261 0.689725
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0108215 0.166356 0.163281
Leishmania major cathepsin L-like protease 0.0183016 0.341261 0.793382
Loa Loa (eye worm) papain family cysteine protease containing protein 0.00477541 0.0249796 0.0249796
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0108215 0.166356 0.163281
Brugia malayi fibroinase precursor 0.00477541 0.0249796 0.0213836
Echinococcus multilocularis laminin 0.00796296 0.0995136 0.0844869
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Loa Loa (eye worm) hypothetical protein 0.00521854 0.0353413 0.0353413
Loa Loa (eye worm) hypothetical protein 0.0271962 0.549241 0.549241
Brugia malayi Cathepsin L-like precursor 0.012818 0.213039 0.210136
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0108215 0.166356 0.152444
Schistosoma mansoni amine GPCR 0.0108215 0.166356 0.163281
Trypanosoma cruzi cruzipain precursor, putative 0.00548359 0.041539 0.0255447
Echinococcus granulosus 7TM GPCR rhodopsin 0.0108215 0.166356 0.152444
Trypanosoma brucei cysteine peptidase C (CPC) 0.0219196 0.42586 1
Trypanosoma cruzi cysteine peptidase, putative 0.0183016 0.341261 0.330268
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0183016 0.341261 0.788967
Loa Loa (eye worm) blistered cuticle protein 3 0.00521854 0.0353413 0.0353413
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0108215 0.166356 0.152444
Echinococcus multilocularis neuropeptide receptor A26 0.0108215 0.166356 0.152444
Onchocerca volvulus 0.0108215 0.166356 0.487473
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0108215 0.166356 0.163281
Echinococcus granulosus g protein coupled receptor 0.0108215 0.166356 0.152444
Loa Loa (eye worm) matrixin family protein 0.00934345 0.131794 0.131794
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0183016 0.341261 0.788967
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.00692828 0.07532 0.0719097
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0183016 0.341261 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0183016 0.341261 0.788967
Echinococcus granulosus g-protein coupled receptor 0.0108215 0.166356 0.152444
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0457634 0.983397 0.98312
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.00477541 0.0249796 0.0263695
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.00548359 0.041539 0.0380041
Echinococcus multilocularis rhodopsin orphan GPCR 0.0108215 0.166356 0.152444
Leishmania major cathepsin L-like protease 0.0183016 0.341261 0.793382
Toxoplasma gondii calcium binding egf domain-containing protein 0.00796296 0.0995136 0.202957
Schistosoma mansoni cathepsin s 0.00548359 0.041539 0.0380041
Brugia malayi hypothetical protein 0.0108215 0.166356 0.163281
Echinococcus granulosus calpain A 0.00692828 0.07532 0.0598895
Plasmodium falciparum plasmepsin VI 0.0146914 0.256844 0.740132
Echinococcus multilocularis g protein coupled receptor 0.0108215 0.166356 0.152444
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Echinococcus multilocularis neuropeptide receptor 0.0108215 0.166356 0.152444
Plasmodium vivax vivapain-2 0.0183016 0.341261 1
Echinococcus multilocularis orexin receptor type 2 0.0108215 0.166356 0.152444
Brugia malayi Tachykinin-like peptides receptor 99D 0.0108215 0.166356 0.163281
Brugia malayi Animal haem peroxidase family protein 0.00521854 0.0353413 0.0317836
Brugia malayi sulfakinin receptor protein 0.0108215 0.166356 0.163281
Brugia malayi RE15519p 0.0108215 0.166356 0.163281
Toxoplasma gondii cathepsin CPC1 0.00477541 0.0249796 0.0209211
Onchocerca volvulus 0.0108215 0.166356 0.487473
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0183016 0.341261 0.689725
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0146914 0.256844 0.587208
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.00692828 0.07532 0.0598895
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 38. C. elegans sup-9 ortholog 0.03568 0.747619 0.746688
Loa Loa (eye worm) hypothetical protein 0.03568 0.747619 0.747619
Onchocerca volvulus 0.0183016 0.341261 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0108215 0.166356 0.152444
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0183016 0.341261 0.788967
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0108215 0.166356 0.163281
Echinococcus granulosus rhodopsin orphan GPCR 0.0108215 0.166356 0.152444
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Loa Loa (eye worm) hypothetical protein 0.00521854 0.0353413 0.0353413
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0108215 0.166356 0.163281
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0108215 0.166356 0.166356
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0108215 0.166356 0.152444
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0183016 0.341261 0.341261
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.010259 0.153202 0.139071
Brugia malayi Calcium binding EGF domain containing protein 0.00796296 0.0995136 0.0961926
Brugia malayi cathepsin L-like cysteine proteinase 0.00477541 0.0249796 0.0213836
Leishmania major cathepsin L-like protease 0.0183016 0.341261 0.793382
Onchocerca volvulus 0.0183016 0.341261 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0108215 0.166356 0.163281
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0183016 0.341261 0.689725
Onchocerca volvulus 0.00547919 0.0414359 0.12142
Loa Loa (eye worm) hypothetical protein 0.00493017 0.0285983 0.0285983
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0108215 0.166356 0.163281
Schistosoma mansoni neuropeptide receptor 0.0108215 0.166356 0.163281
Brugia malayi cathepsin F-like cysteine proteinase 0.00477541 0.0249796 0.0213836
Echinococcus multilocularis fibrillin 1 0.00796296 0.0995136 0.0844869
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.00477541 0.0249796 0.0213836
Onchocerca volvulus Arrow homolog 0.00681016 0.072558 0.212617
Brugia malayi Cathepsin L-like precursor 0.012818 0.213039 0.210136
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0183016 0.341261 0.689725
Loa Loa (eye worm) hypothetical protein 0.00521854 0.0353413 0.0353413
Onchocerca volvulus Cathepsin L homolog 0.0183016 0.341261 1
Echinococcus granulosus Two pore potassium channel protein sup 9 0.03568 0.747619 0.743408
Echinococcus multilocularis serotonin receptor 0.0108215 0.166356 0.152444
Echinococcus multilocularis cathepsin L cysteine protease 0.0183016 0.341261 0.330268
Loa Loa (eye worm) hypothetical protein 0.00548359 0.041539 0.041539
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0183016 0.341261 0.689725
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.012818 0.213039 0.469116
Entamoeba histolytica cysteine proteinase, putative 0.012818 0.213039 0.594595
Brugia malayi Papain family cysteine protease containing protein 0.00477541 0.0249796 0.0213836
Echinococcus granulosus somatostatin receptor 0.0108215 0.166356 0.152444
Schistosoma mansoni cathepsin D (A01 family) 0.0433167 0.926185 0.925913
Onchocerca volvulus 0.0108215 0.166356 0.487473
Loa Loa (eye worm) hypothetical protein 0.00477541 0.0249796 0.0249796
Entamoeba histolytica cysteine protease, putative 0.010259 0.153202 0.405405
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0464735 1 1
Schistosoma mansoni neuropeptide F-like receptor 0.0108215 0.166356 0.163281
Leishmania major cathepsin L-like protease 0.0183016 0.341261 0.793382
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0183016 0.341261 0.788967
Brugia malayi Animal haem peroxidase family protein 0.00521854 0.0353413 0.0317836
Loa Loa (eye worm) melatonin receptor type 1A 0.0108215 0.166356 0.166356
Entamoeba histolytica cysteine protease, putative 0.010259 0.153202 0.405405
Schistosoma mansoni cathepsin S (C01 family) 0.00477541 0.0249796 0.0213836
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0108215 0.166356 0.166356
Onchocerca volvulus Cathepsin L homolog 0.00477541 0.0249796 0.0731978
Entamoeba histolytica cysteine proteinase, putative 0.0183016 0.341261 1
Loa Loa (eye worm) hypothetical protein 0.00521854 0.0353413 0.0353413
Trypanosoma cruzi cysteine proteinase, putative 0.010259 0.153202 0.139071
Echinococcus multilocularis cathepsin L cysteine protease 0.0183016 0.341261 0.330268
Echinococcus multilocularis fmrfamide receptor 0.0108215 0.166356 0.152444
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Entamoeba histolytica cysteine protease, putative 0.010259 0.153202 0.405405
Onchocerca volvulus Peroxidase homolog 0.00521854 0.0353413 0.103561
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Onchocerca volvulus Matrilysin homolog 0.00857075 0.113726 0.333251
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.00477541 0.0249796 0.0263695
Echinococcus multilocularis neuropeptide FF receptor 2 0.0108215 0.166356 0.152444
Onchocerca volvulus Peroxidase homolog 0.00521854 0.0353413 0.103561
Plasmodium falciparum plasmepsin IV 0.0146914 0.256844 0.740132
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0108215 0.166356 0.152444
Entamoeba histolytica cysteine protease, putative 0.010259 0.153202 0.405405
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.00692828 0.07532 0.0598895
Loa Loa (eye worm) hypothetical protein 0.00521854 0.0353413 0.0353413
Brugia malayi hypothetical protein 0.0108215 0.166356 0.163281
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0183016 0.341261 0.788967
Toxoplasma gondii preprocathepsin c precursor, putative 0.00477541 0.0249796 0.0209211
Echinococcus granulosus g protein coupled receptor 0.0108215 0.166356 0.152444
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.00692828 0.07532 0.0719097
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0108215 0.166356 0.166356
Brugia malayi Cathepsin L-like precursor 0.0183016 0.341261 0.338832
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0108215 0.166356 0.152444
Loa Loa (eye worm) animal heme peroxidase 0.00521854 0.0353413 0.0353413
Echinococcus granulosus neuropeptide s receptor 0.0108215 0.166356 0.152444
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0183016 0.341261 0.788967
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Schistosoma mansoni cathepsin F (C01 family) 0.012818 0.213039 0.210136
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0183016 0.341261 0.788967
Brugia malayi cathepsin L precursor 0.00477541 0.0249796 0.0213836
Onchocerca volvulus 0.0108215 0.166356 0.487473
Schistosoma mansoni amine GPCR 0.0108215 0.166356 0.163281
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0108215 0.166356 0.163281
Schistosoma mansoni neuropeptide receptor 0.0108215 0.166356 0.163281
Brugia malayi Serotonin receptor 0.0108215 0.166356 0.163281
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Plasmodium vivax unspecified product 0.00477541 0.0249796 0.0263695
Brugia malayi G protein-coupled receptor F59B2.13 0.0108215 0.166356 0.163281
Entamoeba histolytica cysteine protease, putative 0.010259 0.153202 0.405405
Schistosoma mansoni opsin-like receptor 0.0108215 0.166356 0.163281
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.012818 0.213039 0.469116
Echinococcus granulosus sex peptide receptor 0.0108215 0.166356 0.152444
Loa Loa (eye worm) hypothetical protein 0.00681016 0.072558 0.072558
Loa Loa (eye worm) animal heme peroxidase 0.00521854 0.0353413 0.0353413
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0108215 0.166356 0.163281
Echinococcus multilocularis rhodopsin orphan GPCR 0.0108215 0.166356 0.152444
Echinococcus granulosus neuropeptides capa receptor 0.0108215 0.166356 0.152444
Loa Loa (eye worm) G-protein coupled receptor 0.0108215 0.166356 0.166356
Entamoeba histolytica cysteine protease, putative 0.010259 0.153202 0.405405
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0183016 0.341261 0.788967
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Plasmodium vivax serine-repeat antigen (SERA) 0.00477541 0.0249796 0.0263695
Brugia malayi hypothetical protein 0.0108215 0.166356 0.163281
Entamoeba histolytica cysteine protease, putative 0.010259 0.153202 0.405405
Brugia malayi Animal haem peroxidase family protein 0.00521854 0.0353413 0.0317836
Echinococcus granulosus neuropeptide Y receptor 0.0108215 0.166356 0.152444
Loa Loa (eye worm) hypothetical protein 0.00521854 0.0353413 0.0353413
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0183016 0.341261 0.788967
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0183016 0.341261 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0108215 0.166356 0.152444
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Plasmodium vivax serine-repeat antigen (SERA) 0.00477541 0.0249796 0.0263695
Toxoplasma gondii cathepsin CPC2 0.00477541 0.0249796 0.0209211
Schistosoma mansoni adenoreceptor 0.0108215 0.166356 0.163281
Echinococcus multilocularis G protein coupled receptor 139 0.0108215 0.166356 0.152444
Entamoeba histolytica cysteine protease, putative 0.010259 0.153202 0.405405
Loa Loa (eye worm) matrixin family protein 0.00857075 0.113726 0.113726
Onchocerca volvulus 0.00386427 0.0036745 0.0107674
Onchocerca volvulus 0.00521854 0.0353413 0.103561
Loa Loa (eye worm) G-protein coupled receptor 0.0108215 0.166356 0.166356
Brugia malayi Kringle domain containing protein 0.00440907 0.0164135 0.012786
Brugia malayi AKH receptor 0.0108215 0.166356 0.163281
Trypanosoma cruzi major cysteine proteinase, putative 0.00477541 0.0249796 0.008709
Echinococcus multilocularis peroxidasin 0.00521854 0.0353413 0.0192436
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.00477541 0.0249796 0.0263695
Echinococcus granulosus laminin 0.00796296 0.0995136 0.0844869
Onchocerca volvulus 0.0108215 0.166356 0.487473
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0108215 0.166356 0.487473
Loa Loa (eye worm) hypothetical protein 0.00521854 0.0353413 0.0353413
Giardia lamblia Cathepsin B precursor 0.0219196 0.42586 1
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.00477541 0.0249796 0.0213836
Schistosoma mansoni opsin-like receptor 0.0108215 0.166356 0.163281
Schistosoma mansoni cathepsin D (A01 family) 0.0433167 0.926185 0.925913
Entamoeba histolytica cysteine proteinase, putative 0.010259 0.153202 0.405405
Brugia malayi G protein-coupled receptor 0.0108215 0.166356 0.163281
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0183016 0.341261 0.788967
Schistosoma mansoni peroxidasin 0.00521854 0.0353413 0.0317836
Loa Loa (eye worm) hypothetical protein 0.00521854 0.0353413 0.0353413
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0140499 0.241845 0.229193
Schistosoma mansoni hypothetical protein 0.0108215 0.166356 0.163281
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0183016 0.341261 0.689725
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.00407895 0.00869437 0.00503839
Schistosoma mansoni hypothetical protein 0.0108215 0.166356 0.163281
Brugia malayi cathepsin B-like cysteine proteinase 0.0464735 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0183016 0.341261 0.689725
Brugia malayi Fibulin-1 precursor 0.00796296 0.0995136 0.0961926
Schistosoma mansoni alpha-1 adrenergic receptor 0.0108215 0.166356 0.163281
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0183016 0.341261 0.788967
Schistosoma mansoni amine GPCR 0.0108215 0.166356 0.163281
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.00477541 0.0249796 0.0213836
Loa Loa (eye worm) hypothetical protein 0.00548359 0.041539 0.041539
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Brugia malayi cathepsin Z-like cysteine proteinase 0.00477541 0.0249796 0.0213836
Echinococcus granulosus rhodopsin orphan GPCR 0.0108215 0.166356 0.152444
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Loa Loa (eye worm) hypothetical protein 0.00477541 0.0249796 0.0249796
Loa Loa (eye worm) AStacin protease 0.0197604 0.375371 0.375371
Loa Loa (eye worm) hypothetical protein 0.00681016 0.072558 0.072558
Echinococcus granulosus cathepsin l1 0.0183016 0.341261 0.330268
Brugia malayi hypothetical protein 0.0108215 0.166356 0.163281
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Echinococcus multilocularis rhodopsin orphan GPCR 0.0108215 0.166356 0.152444
Onchocerca volvulus Chorion peroxidase homolog 0.00521854 0.0353413 0.103561
Plasmodium falciparum serine repeat antigen 6 0.00477541 0.0249796 0.0263695
Echinococcus granulosus biogenic amine 5HT receptor 0.0108215 0.166356 0.152444
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.00477541 0.0249796 0.0263695
Loa Loa (eye worm) hypothetical protein 0.0344678 0.719274 0.719274
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Toxoplasma gondii aspartyl protease ASP1 0.0146914 0.256844 0.587208
Brugia malayi Cathepsin L-like precursor 0.0183016 0.341261 0.338832
Echinococcus granulosus Tolloid protein 1 0.0286024 0.582124 0.575151
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.00477541 0.0249796 0.0213836
Echinococcus granulosus cathepsin L 0.00477541 0.0249796 0.008709
Onchocerca volvulus 0.0108215 0.166356 0.487473
Onchocerca volvulus Matrilysin homolog 0.00386427 0.0036745 0.0107674
Loa Loa (eye worm) calpain family protein 1 0.00493017 0.0285983 0.0285983
Brugia malayi G-protein coupled receptor 0.0108215 0.166356 0.163281
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Plasmodium vivax serine-repeat antigen (SERA), putative 0.00477541 0.0249796 0.0263695
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0108215 0.166356 0.152444
Brugia malayi Papain family cysteine protease containing protein 0.0183016 0.341261 0.338832
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Echinococcus multilocularis fmrfamide receptor 0.0108215 0.166356 0.152444
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Loa Loa (eye worm) cysteine protease 0.0183016 0.341261 0.341261
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Echinococcus multilocularis dro:myosuppressin receptor 0.0108215 0.166356 0.152444
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0108215 0.166356 0.163281
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0183016 0.341261 0.689725
Brugia malayi Peroxidasin 0.00521854 0.0353413 0.0317836
Echinococcus granulosus cathepsin l1 0.012818 0.213039 0.199906
Brugia malayi Dopamine receptor protein 1 0.0108215 0.166356 0.163281
Brugia malayi larval opioid receptor 0.0108215 0.166356 0.163281
Schistosoma mansoni neuropeptide F-like receptor 0.0108215 0.166356 0.163281
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.00681016 0.072558 0.072558
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0108215 0.166356 0.163281
Schistosoma mansoni biogenic amine receptor 0.0108215 0.166356 0.163281
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0108215 0.166356 0.152444
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0108215 0.166356 0.163281
Onchocerca volvulus Putative cubilin 0.00487067 0.0272071 0.0797252
Echinococcus granulosus dro:myosuppressin receptor 0.0108215 0.166356 0.152444
Leishmania major cathepsin L-like protease 0.0183016 0.341261 0.793382
Onchocerca volvulus 0.0108215 0.166356 0.487473
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Entamoeba histolytica cysteine proteinase, putative 0.010259 0.153202 0.405405
Loa Loa (eye worm) hypothetical protein 0.0464735 1 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0183016 0.341261 0.330268
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0183016 0.341261 0.788967
Echinococcus granulosus allatostatin A receptor 0.0108215 0.166356 0.152444
Brugia malayi hypothetical protein 0.0108215 0.166356 0.163281
Echinococcus multilocularis Tolloid protein 1 0.0286024 0.582124 0.575151
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0183016 0.341261 0.330268
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0108215 0.166356 0.163281
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.00470648 0.0233679 0.5
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.00477541 0.0249796 0.0263695
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0286024 0.582124 0.580583
Entamoeba histolytica cysteine proteinase 2 0.010259 0.153202 0.405405
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0108215 0.166356 0.152444
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0108215 0.166356 0.163281
Brugia malayi Papain family cysteine protease containing protein 0.010259 0.153202 0.150079
Brugia malayi Cathepsin L-like precursor 0.0183016 0.341261 0.338832
Onchocerca volvulus 0.0108215 0.166356 0.487473
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.00678035 0.071861 0.068438
Trypanosoma cruzi cruzipain precursor, putative 0.0183016 0.341261 0.330268
Onchocerca volvulus 0.0108215 0.166356 0.487473
Loa Loa (eye worm) hypothetical protein 0.03568 0.747619 0.747619
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0183016 0.341261 0.788967
Loa Loa (eye worm) hypothetical protein 0.00521854 0.0353413 0.0353413
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.00477541 0.0249796 0.0213836
Echinococcus multilocularis neuropeptide Y receptor 0.0108215 0.166356 0.152444
Onchocerca volvulus 0.00521854 0.0353413 0.103561
Onchocerca volvulus 0.00477541 0.0249796 0.0731978
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.00477541 0.0249796 0.0249796
Loa Loa (eye worm) hypothetical protein 0.012818 0.213039 0.213039
Plasmodium falciparum serine repeat antigen 1 0.00477541 0.0249796 0.0263695
Schistosoma mansoni hypothetical protein 0.0108215 0.166356 0.163281
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0140499 0.241845 0.229193
Echinococcus multilocularis g protein coupled receptor 0.0108215 0.166356 0.152444
Brugia malayi Papain family cysteine protease containing protein 0.00477541 0.0249796 0.0213836
Onchocerca volvulus 0.0183016 0.341261 1
Entamoeba histolytica cysteine proteinase 1, putative 0.010259 0.153202 0.405405
Trypanosoma cruzi cysteine protease, putative 0.010259 0.153202 0.139071
Echinococcus multilocularis cysteine protease 0.0183016 0.341261 0.330268
Echinococcus multilocularis g-protein coupled receptor 0.0108215 0.166356 0.152444
Brugia malayi Cathepsin L-like precursor 0.0183016 0.341261 0.338832
Echinococcus multilocularis neuropeptides capa receptor 0.0108215 0.166356 0.152444
Loa Loa (eye worm) hypothetical protein 0.00548359 0.041539 0.041539
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.010259 0.153202 0.150079
Echinococcus multilocularis rhodopsin orphan GPCR 0.0108215 0.166356 0.152444
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0108215 0.166356 0.163281
Mycobacterium ulcerans hydrolase 0.00470648 0.0233679 0.5
Brugia malayi neuropeptide F receptor 0.0108215 0.166356 0.163281
Schistosoma mansoni hypothetical protein 0.00440907 0.0164135 0.012786
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0464735 1 1
Plasmodium falciparum serine repeat antigen 4 0.00477541 0.0249796 0.0263695
Brugia malayi Cathepsin L-like precursor 0.00548359 0.041539 0.0380041
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0183016 0.341261 0.788967
Toxoplasma gondii cathepsin B 0.0219196 0.42586 1
Echinococcus granulosus neuropeptide Y receptor 0.0108215 0.166356 0.152444
Brugia malayi hypothetical protein 0.0108215 0.166356 0.163281
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0108215 0.166356 0.163281
Brugia malayi hypothetical protein 0.0108215 0.166356 0.163281
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0183016 0.341261 0.788967
Brugia malayi cathepsin Z-like cysteine proteinase 0.00477541 0.0249796 0.0213836
Schistosoma mansoni biogenic amine receptor 0.0108215 0.166356 0.163281
Echinococcus granulosus tm gpcr rhodopsin 0.0108215 0.166356 0.152444
Echinococcus granulosus peptide allatostatin:somatostatin 0.0108215 0.166356 0.152444
Plasmodium falciparum cysteine proteinase falcipain 3 0.0183016 0.341261 1
Onchocerca volvulus Peroxidasin homolog 0.00521854 0.0353413 0.103561
Echinococcus granulosus rhodopsin orphan GPCR 0.0108215 0.166356 0.152444
Schistosoma mansoni neuropeptide f receptor 76f 0.0108215 0.166356 0.163281
Echinococcus granulosus rhodopsin orphan GPCR 0.0108215 0.166356 0.152444
Loa Loa (eye worm) hypothetical protein 0.0146914 0.256844 0.256844
Echinococcus multilocularis Two pore potassium channel protein sup 9 0.03568 0.747619 0.743408
Onchocerca volvulus Neuropeptide F receptor homolog 0.0108215 0.166356 0.487473
Echinococcus multilocularis rhodopsin orphan GPCR 0.0108215 0.166356 0.152444
Brugia malayi Animal haem peroxidase family protein 0.00521854 0.0353413 0.0317836
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0183016 0.341261 0.689725
Echinococcus granulosus rhodopsin orphan GPCR 0.0108215 0.166356 0.152444
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0108215 0.166356 0.152444
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0286024 0.582124 0.582124
Schistosoma mansoni myosin xvIII 0.0108215 0.166356 0.163281
Loa Loa (eye worm) hypothetical protein 0.00440907 0.0164135 0.0164135
Echinococcus granulosus rhodopsin orphan GPCR 0.0108215 0.166356 0.152444
Loa Loa (eye worm) hypothetical protein 0.0183016 0.341261 0.341261
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0108215 0.166356 0.163281
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0183016 0.341261 0.788967
Brugia malayi cahepsin L-like non-peptiedase homolog 0.00477541 0.0249796 0.0213836
Schistosoma mansoni cathepsin F (C01 family) 0.0183016 0.341261 0.338832
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0146914 0.256844 0.244442
Echinococcus granulosus g protein coupled receptor 0.0108215 0.166356 0.152444
Entamoeba histolytica cysteine protease, putative 0.010259 0.153202 0.405405
Loa Loa (eye worm) hypothetical protein 0.00521854 0.0353413 0.0353413
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0108215 0.166356 0.152444
Echinococcus granulosus 7tm_1 domain containing protein 0.0108215 0.166356 0.152444
Entamoeba histolytica cysteine protease, putative 0.010259 0.153202 0.405405
Echinococcus multilocularis rhodopsin orphan GPCR 0.0108215 0.166356 0.152444
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Onchocerca volvulus 0.0108215 0.166356 0.487473
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0108215 0.166356 0.163281
Plasmodium vivax unspecified product 0.010259 0.153202 0.421085
Loa Loa (eye worm) hypothetical protein 0.00678035 0.071861 0.071861
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.010259 0.153202 0.319851
Brugia malayi G-protein coupled receptor 0.0108215 0.166356 0.163281
Onchocerca volvulus 0.012818 0.213039 0.624269
Loa Loa (eye worm) papain family cysteine protease containing protein 0.00477541 0.0249796 0.0249796
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Plasmodium falciparum serine repeat antigen 5 0.00477541 0.0249796 0.0263695
Onchocerca volvulus Cathepsin F homolog 0.0183016 0.341261 1
Plasmodium falciparum cysteine proteinase falcipain 1 0.010259 0.153202 0.421085
Brugia malayi cathepsin L-like precursor 0.012818 0.213039 0.210136
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0108215 0.166356 0.163281
Echinococcus multilocularis calpain A 0.00692828 0.07532 0.0598895
Plasmodium falciparum serine repeat antigen 3 0.00477541 0.0249796 0.0263695
Plasmodium vivax aspartyl proteinase, putative 0.0146914 0.256844 0.740132
Trypanosoma cruzi cysteine peptidase, putative 0.0183016 0.341261 0.330268
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0108215 0.166356 0.152444
Brugia malayi Cathepsin L-like cysteine proteinase 0.012818 0.213039 0.210136
Schistosoma mansoni biogenic amine (5HT) receptor 0.0108215 0.166356 0.163281
Echinococcus granulosus neuropeptide receptor 0.0108215 0.166356 0.152444
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0183016 0.341261 0.788967
Entamoeba histolytica cysteine protease, putative 0.0183016 0.341261 1
Loa Loa (eye worm) hypothetical protein 0.00386427 0.0036745 0.0036745
Brugia malayi Calcium binding EGF domain containing protein 0.00487067 0.0272071 0.0236194

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 3.6 nM Antiparasitic activity against chloroquine sensitive Plasmodium falciparum 3D7 ChEMBL. 18260613
IC50 (functional) = 3.6 nM Antiparasitic activity against chloroquine sensitive Plasmodium falciparum 3D7 ChEMBL. 18260613
IC50 (functional) = 144 nM Antiparasitic activity against chloroquine resistant Plasmodium falciparum K1 ChEMBL. 18260613
IC50 (functional) = 144 nM Antiparasitic activity against chloroquine resistant Plasmodium falciparum K1 ChEMBL. 18260613
Ratio IC50 (functional) = 40 Ratio of IC50 for Plasmodium falciparum K1 to IC50 for Plasmodium falciparum 3D7 ChEMBL. 18260613
Ratio IC50 (functional) = 40 Ratio of IC50 for Plasmodium falciparum K1 to IC50 for Plasmodium falciparum 3D7 ChEMBL. 18260613
TD50 (functional) = 47.9 uM Cytotoxicity against human KB cells by alamar blue assay ChEMBL. 18260613
TD50 (functional) = 47.9 uM Cytotoxicity against human KB cells by alamar blue assay ChEMBL. 18260613

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23 18260613

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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