Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | AMP deaminase 2 | 0.117722 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.117722 | 1 | 1 |
Trypanosoma cruzi | adenosine monophosphate deaminase, putative | 0.117722 | 1 | 1 |
Echinococcus granulosus | AMP deaminase 2 | 0.117722 | 1 | 1 |
Leishmania major | adenosine monophosphate deaminase, putative,AMP deaminase, putative | 0.117722 | 1 | 1 |
Loa Loa (eye worm) | AMP deaminase | 0.117722 | 1 | 1 |
Brugia malayi | adenosine monophosphate deaminase | 0.117722 | 1 | 1 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0419704 | 0 | 0.5 |
Treponema pallidum | adenosine deaminase | 0.0419704 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.0419704 | 0 | 0.5 |
Plasmodium vivax | adenosine/AMP deaminase, putative | 0.117722 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.117722 | 1 | 1 |
Schistosoma mansoni | AMP deaminase | 0.117722 | 1 | 1 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0419704 | 0 | 0.5 |
Trypanosoma cruzi | AMP deaminase, putative | 0.117722 | 1 | 1 |
Plasmodium falciparum | AMP deaminase, putative | 0.117722 | 1 | 1 |
Trypanosoma cruzi | adenosine monophosphate deaminase-like protein, putative | 0.117722 | 1 | 1 |
Leishmania major | AMP deaminase, putative,amp deaminase-like protein | 0.117722 | 1 | 1 |
Trypanosoma brucei | AMP deaminase, putative | 0.117722 | 1 | 0.5 |
Toxoplasma gondii | AMP deaminase | 0.117722 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.117722 | 1 | 1 |
Leishmania major | AMP deaminase, putative | 0.117722 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.117722 | 1 | 1 |
Entamoeba histolytica | AMP deaminase, putative | 0.117722 | 1 | 1 |
Trypanosoma brucei | AMP deaminase, putative | 0.117722 | 1 | 0.5 |
Entamoeba histolytica | AMP deaminase, putative | 0.117722 | 1 | 1 |
Mycobacterium ulcerans | adenosine deaminase | 0.0419704 | 0 | 0.5 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.0419704 | 0 | 0.5 |
Trypanosoma brucei | adenosine monophosphate deaminase, putative | 0.117722 | 1 | 0.5 |
Onchocerca volvulus | AMP deaminase 2 homolog | 0.117722 | 1 | 1 |
Trypanosoma brucei | AMP deaminase, putative | 0.117722 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0757515 | 0.445946 | 0.445946 |
Leishmania major | AMP deaminase, putative,adenosine monophosphate deaminase-like protein | 0.117722 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.59 uM | Antitrypanosomal activity against Trypanosoma brucei 427 at pH 7.4 | ChEMBL. | 18281929 |
IC50 (functional) | = 0.59 uM | Antitrypanosomal activity against Trypanosoma brucei 427 at pH 7.4 | ChEMBL. | 18281929 |
IC90 (functional) | = 1.06 uM | Antitrypanosomal activity against Trypanosoma brucei 427 at pH 7.4 | ChEMBL. | 18281929 |
IC90 (functional) | = 1.06 uM | Antitrypanosomal activity against Trypanosoma brucei 427 at pH 7.4 | ChEMBL. | 18281929 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Trypanosoma brucei | ChEMBL23 | 18281929 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.