Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | cysteine proteinase, putative | 0.1278 | 0.2616 | 1 |
Onchocerca volvulus | 0.1278 | 0.2616 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1278 | 0.2616 | 0.8526 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1372 | 0.2904 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0757 | 0.1008 | 0.1008 |
Giardia lamblia | Cathepsin B precursor | 0.1368 | 0.2894 | 0.5 |
Brugia malayi | Cathepsin L-like precursor | 0.1278 | 0.2616 | 0.2561 |
Entamoeba histolytica | cysteine protease, putative | 0.0757 | 0.1008 | 0.3676 |
Loa Loa (eye worm) | cysteine protease | 0.1278 | 0.2616 | 0.2561 |
Brugia malayi | Cathepsin L-like precursor | 0.1278 | 0.2616 | 0.2561 |
Entamoeba histolytica | cysteine protease, putative | 0.0757 | 0.1008 | 0.3676 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0757 | 0.1008 | 0.3676 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.1278 | 0.2616 | 0.2127 |
Echinococcus multilocularis | cysteine protease | 0.1278 | 0.2616 | 0.2127 |
Brugia malayi | Cathepsin L-like precursor | 0.1278 | 0.2616 | 0.2561 |
Trypanosoma cruzi | calpain cysteine peptidase, putative | 0.0632 | 0.0622 | 0.0622 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1372 | 0.2904 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1278 | 0.2616 | 0.8526 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0757 | 0.1008 | 0.3676 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1368 | 0.2894 | 0.2837 |
Entamoeba histolytica | cysteine protease, putative | 0.0757 | 0.1008 | 0.3676 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1372 | 0.2904 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1278 | 0.2616 | 0.8526 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.3671 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0757 | 0.1008 | 0.3676 |
Leishmania major | cathepsin L-like protease | 0.1278 | 0.2616 | 0.8983 |
Onchocerca volvulus | 0.1278 | 0.2616 | 1 | |
Trypanosoma cruzi | kinesin, putative | 0.0455 | 0.0074 | 0.0074 |
Plasmodium vivax | unspecified product | 0.0757 | 0.1008 | 0.1938 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0858 | 0.132 | 0.4902 |
Entamoeba histolytica | cysteine protease, putative | 0.0757 | 0.1008 | 0.3676 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.1278 | 0.2616 | 0.2557 |
Brugia malayi | Cathepsin L-like precursor | 0.1278 | 0.2616 | 0.2561 |
Leishmania major | calpain, putative,cysteine peptidase, Clan CA, family C2, putative | 0.0632 | 0.0622 | 0.1936 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.1278 | 0.2616 | 0.8526 |
Plasmodium vivax | vivapain-1 | 0.0757 | 0.1008 | 0.1938 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.1368 | 0.2894 | 0.9965 |
Brugia malayi | Papain family cysteine protease containing protein | 0.1278 | 0.2616 | 0.2561 |
Leishmania major | cysteine peptidase A (CPA) | 0.1278 | 0.2616 | 0.8983 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.1278 | 0.2616 | 0.8526 |
Onchocerca volvulus | Cathepsin F homolog | 0.1278 | 0.2616 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0858 | 0.132 | 0.1255 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0952 | 0.1608 | 0.1608 |
Brugia malayi | Cathepsin L-like precursor | 0.1278 | 0.2616 | 0.2561 |
Entamoeba histolytica | cysteine protease, putative | 0.0757 | 0.1008 | 0.3676 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1278 | 0.2616 | 0.8526 |
Echinococcus multilocularis | cathepsin L | 0.0757 | 0.1008 | 0.0412 |
Loa Loa (eye worm) | ctsf protein | 0.1278 | 0.2616 | 0.2561 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.1278 | 0.2616 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0858 | 0.132 | 0.1255 |
Brugia malayi | calpain family protein 1 | 0.1705 | 0.3934 | 0.3889 |
Loa Loa (eye worm) | hypothetical protein | 0.1251 | 0.2531 | 0.2476 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1278 | 0.2616 | 0.8526 |
Loa Loa (eye worm) | fibroinase | 0.1278 | 0.2616 | 0.2561 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0757 | 0.1008 | 0.0941 |
Brugia malayi | Cathepsin L-like precursor | 0.1278 | 0.2616 | 0.2561 |
Trypanosoma brucei | antigen, putative | 0.0632 | 0.0622 | 0.1936 |
Brugia malayi | Cathepsin L-like precursor | 0.0858 | 0.132 | 0.1255 |
Entamoeba histolytica | cysteine proteinase 2 | 0.0757 | 0.1008 | 0.3676 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1278 | 0.2616 | 0.8526 |
Giardia lamblia | Cathepsin B precursor | 0.1368 | 0.2894 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1372 | 0.2904 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1528 | 0.3386 | 0.3337 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.1368 | 0.2894 | 0.9965 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1372 | 0.2904 | 1 |
Schistosoma mansoni | calpain (C02 family) | 0.0632 | 0.0622 | 0.0546 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0757 | 0.1008 | 0.3302 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.1278 | 0.2616 | 0.2127 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.1278 | 0.2616 | 0.2616 |
Onchocerca volvulus | Cathepsin L homolog | 0.1278 | 0.2616 | 1 |
Onchocerca volvulus | 0.1278 | 0.2616 | 1 | |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.3671 | 1 | 1 |
Echinococcus multilocularis | cathepsin b | 0.3671 | 1 | 1 |
Brugia malayi | calpain 7 | 0.0632 | 0.0622 | 0.0552 |
Trypanosoma brucei | calpain-like cysteine peptidase, putative | 0.0632 | 0.0622 | 0.1936 |
Leishmania major | cathepsin L-like protease | 0.1278 | 0.2616 | 0.8983 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0757 | 0.1008 | 0.3676 |
Echinococcus multilocularis | calpain A | 0.1832 | 0.4326 | 0.395 |
Toxoplasma gondii | cathepsin B | 0.1368 | 0.2894 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.1278 | 0.2616 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.1368 | 0.2894 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1278 | 0.2616 | 0.8526 |
Trypanosoma cruzi | cysteine protease, putative | 0.0757 | 0.1008 | 0.1008 |
Entamoeba histolytica | cysteine protease, putative | 0.0757 | 0.1008 | 0.3676 |
Loa Loa (eye worm) | hypothetical protein | 0.3671 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1278 | 0.2616 | 0.8526 |
Trypanosoma cruzi | calpain-like cysteine peptidase, putative | 0.0632 | 0.0622 | 0.0622 |
Schistosoma mansoni | Mername-AA248 (C02 family) | 0.0632 | 0.0622 | 0.0546 |
Entamoeba histolytica | cysteine proteinase, putative | 0.1278 | 0.2616 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0757 | 0.1008 | 0.0941 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.1278 | 0.2616 | 0.2127 |
Echinococcus multilocularis | family C2 unassigned peptidase (C02 family) | 0.183 | 0.4319 | 0.3943 |
Leishmania major | cathepsin L-like protease | 0.1278 | 0.2616 | 0.8983 |
Trypanosoma brucei | calpain-like protein, putative | 0.0632 | 0.0622 | 0.1936 |
Brugia malayi | cathepsin L-like precursor | 0.0858 | 0.132 | 0.1255 |
Brugia malayi | Cathepsin L-like precursor | 0.0858 | 0.132 | 0.1255 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.3671 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1278 | 0.2616 | 0.8526 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.1278 | 0.2616 | 0.2561 |
Trypanosoma cruzi | cysteine peptidase (N-terminal), putative | 0.0757 | 0.1008 | 0.1008 |
Plasmodium vivax | vivapain-2 | 0.1278 | 0.2616 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.1372 | 0.2904 | 0.2904 |
Leishmania major | cathepsin L-like protease | 0.1278 | 0.2616 | 0.8983 |
Loa Loa (eye worm) | hypothetical protein | 0.1705 | 0.3934 | 0.3889 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1278 | 0.2616 | 0.8526 |
Echinococcus multilocularis | cysteine protease | 0.1278 | 0.2616 | 0.2127 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0757 | 0.1008 | 0.0936 |
Entamoeba histolytica | cysteine protease, putative | 0.0757 | 0.1008 | 0.3676 |
Onchocerca volvulus | 0.1278 | 0.2616 | 1 | |
Entamoeba histolytica | cysteine protease, putative | 0.0757 | 0.1008 | 0.3676 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1278 | 0.2616 | 0.8526 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0757 | 0.1008 | 0.1008 |
Loa Loa (eye worm) | calpain | 0.0632 | 0.0622 | 0.0552 |
Onchocerca volvulus | 0.1073 | 0.1983 | 0.5117 | |
Echinococcus granulosus | cathepsin l1 | 0.0858 | 0.132 | 0.0745 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1278 | 0.2616 | 0.8526 |
Leishmania major | calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative | 0.0632 | 0.0622 | 0.1936 |
Echinococcus granulosus | cathepsin L | 0.0757 | 0.1008 | 0.0412 |
Leishmania major | cathepsin L-like protease | 0.1372 | 0.2904 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1278 | 0.2616 | 0.8526 |
Onchocerca volvulus | 0.1278 | 0.2616 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1278 | 0.2616 | 0.8526 |
Schistosoma mansoni | intracisternal A-particle retropepsin (A02 family) | 0.2511 | 0.6422 | 0.6393 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.1278 | 0.2616 | 1 |
Trypanosoma cruzi | calpain-like cysteine peptidase, putative | 0.0632 | 0.0622 | 0.0622 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1278 | 0.2616 | 0.8526 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1278 | 0.2616 | 0.8526 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.1368 | 0.2894 | 0.2894 |
Trypanosoma cruzi | cysteine peptidase, Clan CA, family C2, putative | 0.0632 | 0.0622 | 0.0622 |
Echinococcus granulosus | cathepsin b | 0.3671 | 1 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.1278 | 0.2616 | 0.2127 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.1372 | 0.2904 | 0.2904 |
Echinococcus granulosus | cathepsin L cysteine protease | 0.0757 | 0.1008 | 0.0412 |
Echinococcus granulosus | cathepsin b | 0.3671 | 1 | 1 |
Trypanosoma cruzi | calpain-like cysteine peptidase, putative | 0.0632 | 0.0622 | 0.0622 |
Loa Loa (eye worm) | calpain family protein 1 | 0.1705 | 0.3934 | 0.3889 |
Brugia malayi | calpain family protein 1 | 0.1705 | 0.3934 | 0.3889 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.183 | 0.4319 | 0.4274 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1372 | 0.2904 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0858 | 0.132 | 0.1255 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.1278 | 0.2616 | 0.2127 |
Plasmodium vivax | vivapain-3 | 0.0757 | 0.1008 | 0.1938 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0858 | 0.132 | 0.125 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1278 | 0.2616 | 0.8526 |
Leishmania major | calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative | 0.0632 | 0.0622 | 0.1936 |
Schistosoma mansoni | calpain-7 (C02 family) | 0.0632 | 0.0622 | 0.0546 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1372 | 0.2904 | 1 |
Loa Loa (eye worm) | cathepsin B | 0.1368 | 0.2894 | 0.2841 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1278 | 0.2616 | 0.8526 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0757 | 0.1008 | 0.0936 |
Echinococcus granulosus | cathepsin l1 | 0.1278 | 0.2616 | 0.2127 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.3671 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1278 | 0.2616 | 0.8526 |
Leishmania major | cathepsin L-like protease | 0.1372 | 0.2904 | 1 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.1705 | 0.3934 | 0.3886 |
Entamoeba histolytica | cysteine proteinase 1, putative | 0.0757 | 0.1008 | 0.3676 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.1372 | 0.2904 | 0.2904 |
Loa Loa (eye worm) | hypothetical protein | 0.0858 | 0.132 | 0.1255 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1278 | 0.2616 | 0.8526 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0858 | 0.132 | 0.1653 |
Entamoeba histolytica | cysteine protease, putative | 0.0757 | 0.1008 | 0.3676 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0757 | 0.1008 | 0.3676 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1372 | 0.2904 | 1 |
Schistosoma mansoni | calpain-7 (C02 family) | 0.0632 | 0.0622 | 0.0546 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.1278 | 0.2616 | 0.2557 |
Echinococcus granulosus | cysteine protease | 0.0757 | 0.1008 | 0.0412 |
Echinococcus granulosus | family C2 unassigned peptidase C02 family | 0.183 | 0.4319 | 0.3943 |
Leishmania major | cathepsin L-like protease | 0.1372 | 0.2904 | 1 |
Echinococcus granulosus | calpain A | 0.1832 | 0.4326 | 0.395 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1278 | 0.2616 | 0.8526 |
Loa Loa (eye worm) | calpain family protein 1 | 0.1251 | 0.2531 | 0.2476 |
Trypanosoma brucei | calpain-like protein, putative | 0.0632 | 0.0622 | 0.1936 |
Trypanosoma cruzi | cysteine peptidase, Clan CA, family C2, putative | 0.0632 | 0.0622 | 0.0622 |
Onchocerca volvulus | 0.1278 | 0.2616 | 1 | |
Trypanosoma brucei | calpain-like protein, putative | 0.0632 | 0.0622 | 0.1936 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.1278 | 0.2616 | 0.2127 |
Trypanosoma cruzi | cysteine peptidase, Clan CA, family C2, putative | 0.0632 | 0.0622 | 0.0622 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1278 | 0.2616 | 0.8526 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.1278 | 0.2616 | 0.2561 |
Trypanosoma cruzi | calpain-like cysteine peptidase, putative | 0.0632 | 0.0622 | 0.0622 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0757 | 0.1008 | 0.0936 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1372 | 0.2904 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1278 | 0.2616 | 0.2561 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C2, putative | 0.0632 | 0.0622 | 0.1936 |
Trypanosoma cruzi | cysteine peptidase, Clan CA, family C2, putative | 0.0632 | 0.0622 | 0.0622 |
Trypanosoma cruzi | calpain-like cysteine peptidase, putative | 0.0632 | 0.0622 | 0.0622 |
Trypanosoma cruzi | kinesin, putative | 0.0455 | 0.0074 | 0.0074 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0858 | 0.132 | 0.1653 |
Schistosoma mansoni | calpain C (C02 family) | 0.0632 | 0.0622 | 0.0546 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.183 | 0.4319 | 0.4274 |
Plasmodium vivax | vivapain-2 | 0.1278 | 0.2616 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.1278 | 0.2616 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1372 | 0.2904 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0757 | 0.1008 | 0.3302 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0757 | 0.1008 | 0.1008 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.1368 | 0.2894 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1073 | 0.1983 | 0.1924 |
Entamoeba histolytica | cysteine protease, putative | 0.0757 | 0.1008 | 0.3676 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.1372 | 0.2904 | 0.2904 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1278 | 0.2616 | 0.8526 |
Echinococcus multilocularis | calpain family protein 1, d | 0.1251 | 0.2531 | 0.2036 |
Trypanosoma brucei | calpain-like protein, putative | 0.0632 | 0.0622 | 0.1936 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.3671 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1372 | 0.2904 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0757 | 0.1008 | 0.3676 |
Onchocerca volvulus | 0.1278 | 0.2616 | 1 | |
Leishmania major | cathepsin L-like protease | 0.1278 | 0.2616 | 0.8983 |
Entamoeba histolytica | cysteine protease, putative | 0.0757 | 0.1008 | 0.3676 |
Echinococcus multilocularis | cathepsin b | 0.3671 | 1 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.1278 | 0.2616 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED30 (functional) | = 22 ug kg-1 | Beta agonistic activity as the dose required to increase heart rate by 30 beats/min in anesthetized rats upon intravenous administration | ChEMBL. | 6138435 |
ED30 (functional) | = 22 ug kg-1 | Beta agonistic activity as the dose required to increase heart rate by 30 beats/min in anesthetized rats upon intravenous administration | ChEMBL. | 6138435 |
ED50 (functional) | = 18 ug kg-1 | Beta-1 adrenoceptor blocking activity as the dose required to inhibit 50% of tachycardia in anesthetized rats | ChEMBL. | 6138435 |
ED50 (functional) | = 18 ug kg-1 | Beta-1 adrenoceptor blocking activity as the dose required to inhibit 50% of tachycardia in anesthetized rats | ChEMBL. | 6138435 |
ED50 (functional) | = 979 ug kg-1 | Beta-2 adrenergic receptor antagonist activity as the dose required to inhibit 50% of vasodepressor response in anesthetized rats | ChEMBL. | 6138435 |
ED50 (functional) | = 979 ug kg-1 | Beta-2 adrenergic receptor antagonist activity as the dose required to inhibit 50% of vasodepressor response in anesthetized rats | ChEMBL. | 6138435 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.