Detailed information for compound 53704

Basic information

Technical information
  • TDR Targets ID: 53704
  • Name: (2R,4S)-1-benzylazetidine-2,4-dicarboxylic ac id
  • MW: 235.236 | Formula: C12H13NO4
  • H donors: 2 H acceptors: 4 LogP: -1.13 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)[C@@H]1C[C@@H](N1Cc1ccccc1)C(=O)O
  • InChi: 1S/C12H13NO4/c14-11(15)9-6-10(12(16)17)13(9)7-8-4-2-1-3-5-8/h1-5,9-10H,6-7H2,(H,14,15)(H,16,17)/t9-,10+
  • InChiKey: WQTWXFKDRIXPMZ-AOOOYVTPSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2R,4S)-1-(phenylmethyl)azetidine-2,4-dicarboxylic acid
  • (2R,4S)-1-(benzyl)azetidine-2,4-dicarboxylic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis DNA polymerase eta, putative 0.004 0.0089 0.0022
Echinococcus granulosus neuropeptide s receptor 0.0025 0.0022 0.001
Echinococcus granulosus neuropeptide receptor 0.0025 0.0022 0.001
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0022 0.0003
Brugia malayi Immunoglobulin I-set domain containing protein 0.0028 0.0037 0.0052
Schistosoma mansoni biogenic amine (5HT) receptor 0.0025 0.0022 0.0003
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0025 0.0022 0.001
Loa Loa (eye worm) hypothetical protein 0.0025 0.0022 0.0079
Echinococcus granulosus peptide allatostatin:somatostatin 0.0025 0.0022 0.001
Loa Loa (eye worm) hypothetical protein 0.0025 0.0022 0.0079
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0025 0.0022 0.0003
Brugia malayi ribonucleoside-diphosphate reductase large chain, putative 0.0632 0.2804 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0116 0.0413
Schistosoma mansoni ribonucleoside-diphosphate reductase small chain 0.0132 0.0512 0.0494
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0121 0.0464 0.0445
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0089 0.0316
Schistosoma mansoni netrin receptor unc5 0.0028 0.0037 0.0018
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0121 0.0464 0.0445
Plasmodium falciparum plasmepsin I 0.0232 0.0971 0.3263
Leishmania major ribonucleoside-diphosphate reductase small chain, putative 0.0132 0.0512 0.1824
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0022 0.001
Schistosoma mansoni biogenic amine (5HT) receptor 0.0025 0.0022 0.0003
Echinococcus multilocularis orexin receptor type 2 0.0025 0.0022 0.001
Chlamydia trachomatis ribonucleoside-diphosphate reductase subunit beta 0.0132 0.0512 0.1447
Schistosoma mansoni histamine h1 receptor 0.0025 0.0022 0.0003
Echinococcus multilocularis netrin receptor unc 5 0.0028 0.0037 0.0059
Schistosoma mansoni neuropeptide F-like receptor 0.0025 0.0022 0.0003
Schistosoma mansoni neuropeptide receptor 0.0025 0.0022 0.0003
Brugia malayi aspartic protease BmAsp-1, identical 0.0121 0.0464 0.1587
Brugia malayi polk-prov protein 0.003 0.0045 0.0081
Loa Loa (eye worm) hypothetical protein 0.0025 0.0022 0.0079
Loa Loa (eye worm) hypothetical protein 0.0025 0.0022 0.0079
Schistosoma mansoni amine GPCR 0.0025 0.0022 0.0003
Schistosoma mansoni hypothetical protein 0.0028 0.0037 0.0018
Schistosoma mansoni amine GPCR 0.0025 0.0022 0.0003
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0232 0.0971 0.3263
Echinococcus multilocularis neuropeptide Y receptor 0.0025 0.0022 0.001
Plasmodium falciparum plasmepsin IX 0.0121 0.0464 0.1397
Trichomonas vaginalis ribonucleoside-diphosphate reductase alpha chain, putative 0.0585 0.2587 1
Echinococcus multilocularis fmrfamide receptor 0.0025 0.0022 0.001
Echinococcus granulosus g protein coupled receptor 0.0025 0.0022 0.001
Echinococcus multilocularis ribonucleoside diphosphate reductase large 0.0632 0.2804 0.9383
Brugia malayi celfurPC protein 0.0038 0.0084 0.0221
Loa Loa (eye worm) hypothetical protein 0.0025 0.0022 0.0079
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0022 0.001
Brugia malayi hypothetical protein 0.0121 0.0464 0.1587
Plasmodium falciparum plasmepsin IV 0.0232 0.0971 0.3263
Echinococcus multilocularis tumor necrosis factor receptor superfamily 0.0043 0.0105 0.0288
Echinococcus multilocularis membrane bound transcription factor site 1 0.0038 0.0084 0.0217
Mycobacterium ulcerans transcriptional regulator NrdR 0.0047 0.0124 0.0162
Brugia malayi Uncoordinated protein 44 0.0028 0.0037 0.0052
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0038 0.0084 0.0221
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0025 0.0022 0.0003
Plasmodium vivax ribonucleoside-diphosphate reductase large chain, putative 0.0632 0.2804 1
Brugia malayi ADAM-TS Spacer 1 family protein 0.0027 0.0029 0.0025
Echinococcus multilocularis G-protein coupled receptor, putative 0.0025 0.0022 0.001
Echinococcus multilocularis allatostatin A receptor 0.0025 0.0022 0.001
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0025 0.0022 0.001
Loa Loa (eye worm) subtilase 0.0038 0.0084 0.0298
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0038 0.0084 0.0065
Loa Loa (eye worm) hypothetical protein 0.0025 0.0022 0.0079
Brugia malayi Death domain containing protein 0.0028 0.0037 0.0052
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0028 0.0037 0.0059
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0089 0.0316
Loa Loa (eye worm) hypothetical protein 0.0025 0.0022 0.0079
Loa Loa (eye worm) hypothetical protein 0.0025 0.0022 0.0079
Brugia malayi hypothetical protein 0.006 0.018 0.0568
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0028 0.0037 0.0018
Schistosoma mansoni growth hormone secretagogue receptor 0.0025 0.0022 0.0003
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0089 0.0316
Echinococcus granulosus serotonin receptor 0.0025 0.0022 0.001
Schistosoma mansoni amine GPCR 0.0025 0.0022 0.0003
Plasmodium vivax aspartyl proteinase, putative 0.0232 0.0971 0.3263
Plasmodium falciparum plasmepsin VII 0.0121 0.0464 0.1397
Loa Loa (eye worm) hypothetical protein 0.0025 0.0022 0.0079
Echinococcus multilocularis somatostatin receptor 0.0025 0.0022 0.001
Schistosoma mansoni cathepsin D (A01 family) 0.0515 0.2267 0.2252
Plasmodium vivax aspartyl protease, putative 0.0121 0.0464 0.1397
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0025 0.0022 0.0003
Brugia malayi angiogenesis inhibito 0.0027 0.0029 0.0025
Loa Loa (eye worm) G-protein coupled receptor 0.0025 0.0022 0.0079
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0022 0.0003
Schistosoma mansoni hypothetical protein 0.0025 0.0022 0.0003
Echinococcus granulosus ribonucleoside diphosphate reductase subunit 0.0132 0.0512 0.1661
Loa Loa (eye worm) hypothetical protein 0.0028 0.0037 0.0131
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0121 0.0464 0.0445
Toxoplasma gondii ribonucleoside-diphosphate reductase large chain 0.0632 0.2804 1
Echinococcus multilocularis dna polymerase kappa 0.004 0.0089 0.0236
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0022 0.001
Plasmodium vivax subtilisin-like protease 1 0.0551 0.2431 0.8629
Plasmodium falciparum subtilisin-like protease 1 0.0551 0.2431 0.8629
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0046 0.0116 0.0326
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.0022 0.001
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0025 0.0022 0.001
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0121 0.0464 0.0445
Loa Loa (eye worm) hypothetical protein 0.0025 0.0022 0.0079
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0025 0.0022 0.001
Plasmodium vivax aspartyl protease, putative 0.0121 0.0464 0.1397
Wolbachia endosymbiont of Brugia malayi ribonucleotide-diphosphate reductase subunit alpha 0.0585 0.2587 1
Schistosoma mansoni hypothetical protein 0.0025 0.0022 0.0003
Schistosoma mansoni neuropeptide receptor 0.0025 0.0022 0.0003
Loa Loa (eye worm) hypothetical protein 0.0025 0.0022 0.0079
Loa Loa (eye worm) neuropeptide F receptor 0.0025 0.0022 0.0079
Loa Loa (eye worm) hypothetical protein 0.0025 0.0022 0.0079
Schistosoma mansoni biogenic amine receptor 0.0025 0.0022 0.0003
Echinococcus granulosus neuropeptide Y receptor 0.0025 0.0022 0.001
Loa Loa (eye worm) hypothetical protein 0.0025 0.0022 0.0079
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0022 0.0003
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0089 0.0316
Schistosoma mansoni hypothetical protein 0.0025 0.0022 0.0003
Echinococcus multilocularis 0.0038 0.0084 0.0217
Echinococcus granulosus allatostatin A receptor 0.0025 0.0022 0.001
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (beta chain) NrdB (ribonucleotide reductase small chain) 0.0132 0.0512 0.1977
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.004 0.0089 0.0022
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0089 0.0022
Loa Loa (eye worm) reprolysin 0.0046 0.0116 0.0413
Echinococcus multilocularis neuropeptide receptor A26 0.0025 0.0022 0.001
Loa Loa (eye worm) hypothetical protein 0.0025 0.0022 0.0079
Loa Loa (eye worm) ribonucleoside-diphosphate reductase large subunit 0.0632 0.2804 1
Echinococcus multilocularis TNFR CD27 30 40 95 cysteine rich region 0.0043 0.0105 0.0288
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0025 0.0022 0.001
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0121 0.0464 0.0445
Echinococcus multilocularis serotonin receptor 0.0025 0.0022 0.001
Echinococcus granulosus adam 0.006 0.018 0.0543
Echinococcus granulosus neuropeptide receptor A26 0.0025 0.0022 0.001
Loa Loa (eye worm) hypothetical protein 0.003 0.0045 0.016
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.0022 0.001
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0025 0.0022 0.001
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0025 0.0022 0.001
Leishmania major subtilisin-like serine peptidase 0.0038 0.0084 0.0296
Schistosoma mansoni neuropeptide F-like receptor 0.0025 0.0022 0.0003
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0089 0.0316
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.0022 0.001
Mycobacterium leprae conserved hypothetical protein 0.0047 0.0124 0.0162
Loa Loa (eye worm) hypothetical protein 0.0025 0.0022 0.0079
Echinococcus granulosus g protein coupled receptor 0.0025 0.0022 0.001
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0038 0.0084 0.0321
Treponema pallidum ribonucleotide-diphosphate reductase subunit alpha 0.0632 0.2804 1
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0089 0.0316
Echinococcus granulosus dro:myosuppressin receptor 0.0025 0.0022 0.001
Schistosoma mansoni myosin xvIII 0.0025 0.0022 0.0003
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain 0.0045 0.0112 0.0398
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0121 0.0464 0.0445
Loa Loa (eye worm) aspartyl protease 6 0.0121 0.0464 0.1653
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0038 0.0084 0.0065
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0022 0.001
Brugia malayi ribonucleotide reductase 2 0.0132 0.0512 0.1761
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0025 0.0022 0.0079
Echinococcus granulosus dna polymerase kappa 0.004 0.0089 0.0236
Toxoplasma gondii aspartyl protease ASP3 0.0121 0.0464 0.1397
Echinococcus granulosus tachykinin peptides receptor 99D 0.0025 0.0022 0.001
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0025 0.0022 0.0003
Echinococcus multilocularis neuropeptide receptor 0.0025 0.0022 0.001
Toxoplasma gondii subtilisin SUB1 0.0551 0.2431 0.8629
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0046 0.0116 0.0326
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0025 0.0022 0.0003
Echinococcus granulosus hypothetical protein 0.0025 0.0022 0.001
Trypanosoma brucei ribonucleoside-diphosphate reductase large chain 0.0632 0.2804 1
Echinococcus multilocularis Furin 1 0.0038 0.0084 0.0217
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0025 0.0022 0.001
Schistosoma mansoni tumor necrosis factor receptor related 0.0043 0.0105 0.0086
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0025 0.0022 0.0079
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0038 0.0084 0.0065
Leishmania major ribonucleoside-diphosphate reductase small chain, putative 0.0132 0.0512 0.1824
Echinococcus granulosus 7TM GPCR rhodopsin 0.0025 0.0022 0.001
Mycobacterium ulcerans ribonucleotide-diphosphate reductase subunit beta 0.0045 0.0112 0.0114
Schistosoma mansoni hypothetical protein 0.0025 0.0022 0.0003
Plasmodium falciparum ribonucleoside-diphosphate reductase large subunit, putative 0.0632 0.2804 1
Plasmodium falciparum ribonucleoside-diphosphate reductase small chain, putative 0.0132 0.0512 0.1575
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0121 0.0464 0.1397
Loa Loa (eye worm) hypothetical protein 0.0025 0.0022 0.0079
Echinococcus multilocularis neuropeptide FF receptor 2 0.0025 0.0022 0.001
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0025 0.0022 0.001
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0025 0.0022 0.0003
Echinococcus granulosus tm gpcr rhodopsin 0.0025 0.0022 0.001
Schistosoma mansoni neuropeptide receptor 0.0672 0.2987 0.2973
Plasmodium falciparum plasmepsin III 0.0121 0.0464 0.1397
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0038 0.0084 0.0217
Brugia malayi ADAMTS-like protease 0.0027 0.0029 0.0025
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0121 0.0464 0.0445
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0025 0.0022 0.0079
Loa Loa (eye worm) hypothetical protein 0.0025 0.0022 0.0079
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0025 0.0022 0.0079
Loa Loa (eye worm) endoprotease bli-4 0.0038 0.0084 0.0298
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.0022 0.001
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.0179 0.0729 0.2374
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0045 0.0158
Echinococcus granulosus Ankyrin 0.0028 0.0037 0.0059
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0025 0.0022 0.001
Brugia malayi proprotein convertase 2 0.0038 0.0084 0.0221
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0038 0.0084 0.0217
Echinococcus multilocularis adam 0.006 0.018 0.0543
Echinococcus granulosus neuropeptide Y receptor 0.0025 0.0022 0.001
Echinococcus multilocularis neuropeptide Y receptor 0.0025 0.0022 0.001
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0022 0.0003
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0121 0.0464 0.1653
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.025 0.1051 0.1034
Echinococcus multilocularis g-protein coupled receptor 0.0025 0.0022 0.001
Plasmodium falciparum plasmepsin II 0.0232 0.0971 0.3263
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain 0.0132 0.0512 0.1824
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0025 0.0022 0.0003
Trypanosoma brucei DNA polymerase IV, putative 0.0033 0.006 0.0211
Onchocerca volvulus 0.0121 0.0464 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0025 0.0022 0.001
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0121 0.0464 0.0445
Plasmodium vivax aspartyl protease, putative 0.0121 0.0464 0.1397
Loa Loa (eye worm) hypothetical protein 0.0025 0.0022 0.0079
Echinococcus granulosus ribonucleoside diphosphate reductase large 0.0632 0.2804 0.9383
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0025 0.0022 0.001
Loa Loa (eye worm) melatonin receptor type 1A 0.0025 0.0022 0.0079
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0022 0.001
Loa Loa (eye worm) hypothetical protein 0.0025 0.0022 0.0079
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0022 0.001
Brugia malayi Reprolysin 0.0027 0.0029 0.0026
Loa Loa (eye worm) hypothetical protein 0.0025 0.0022 0.0079
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0089 0.0316
Loa Loa (eye worm) hypothetical protein 0.0232 0.0971 0.3464
Echinococcus multilocularis sex peptide receptor 0.0025 0.0022 0.001
Loa Loa (eye worm) hypothetical protein 0.0025 0.0022 0.0079
Schistosoma mansoni ankyrin 23/unc44 0.0028 0.0037 0.0018
Schistosoma mansoni biogenic amine receptor 0.0025 0.0022 0.0003
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.0632 0.2804 1
Schistosoma mansoni opsin-like receptor 0.0025 0.0022 0.0003
Plasmodium falciparum plasmepsin V 0.0121 0.0464 0.1397
Loa Loa (eye worm) hypothetical protein 0.0025 0.0022 0.0079
Giardia lamblia DINP protein human, muc B family 0.002 0.0001 0.5
Loa Loa (eye worm) hypothetical protein 0.0025 0.0022 0.0079
Echinococcus granulosus neuropeptides capa receptor 0.0025 0.0022 0.001
Loa Loa (eye worm) hypothetical protein 0.0025 0.0022 0.0079
Echinococcus granulosus neuropeptides capa receptor 0.0025 0.0022 0.001
Loa Loa (eye worm) hypothetical protein 0.0038 0.0084 0.0298
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0025 0.0022 0.001
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.006 0.018 0.0161
Brugia malayi neuroendocrine convertase 1 precursor 0.0038 0.0084 0.0221
Onchocerca volvulus 0.0121 0.0464 1
Schistosoma mansoni furin-1 (S08 family) 0.0038 0.0084 0.0065
Mycobacterium leprae RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (BETA CHAIN) NRDF (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R2F PROTEIN) 0.0045 0.0112 0.0114
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0089 0.0022
Schistosoma mansoni site-1 peptidase (S08 family) 0.0038 0.0084 0.0065
Toxoplasma gondii ribonucleoside-diphosphate reductase small subunit 0.0132 0.0512 0.1575
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0038 0.0084 0.0296
Plasmodium vivax plasmepsin IV, putative 0.0232 0.0971 0.3263
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0025 0.0022 0.0079
Loa Loa (eye worm) hypothetical protein 0.0025 0.0022 0.0079
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0046 0.0116 0.0097
Loa Loa (eye worm) hypothetical protein 0.0121 0.0464 0.1653
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0022 0.0003
Echinococcus granulosus orexin receptor type 2 0.0025 0.0022 0.001
Schistosoma mansoni site-1 peptidase (S08 family) 0.0038 0.0084 0.0065
Echinococcus granulosus biogenic amine 5HT receptor 0.0025 0.0022 0.001
Plasmodium vivax ribonucleoside-diphosphate reductase small chain, putative 0.0132 0.0512 0.1575
Loa Loa (eye worm) hypothetical protein 0.0025 0.0022 0.0079
Trypanosoma brucei subtilisin peptidase 0.0038 0.0084 0.0296
Brugia malayi Eukaryotic aspartyl protease family protein 0.0121 0.0464 0.1587
Schistosoma mansoni neuropeptide receptor 0.0025 0.0022 0.0003
Leishmania major ribonucleoside-diphosphate reductase large chain, putative 0.0632 0.2804 1
Loa Loa (eye worm) ribonucleotide reductase M2 B 0.0132 0.0512 0.1826
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0038 0.0084 0.0217
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0038 0.0084 0.0221
Echinococcus granulosus neuropeptide receptor 0.0672 0.2987 1
Loa Loa (eye worm) lethal(1)discs large-1 tumor suppressor 0.0023 0.0013 0.0046
Echinococcus granulosus Furin 1 0.0038 0.0084 0.0217
Brugia malayi Protein kinase domain containing protein 0.0028 0.0037 0.0052
Loa Loa (eye worm) hypothetical protein 0.0025 0.0022 0.0079
Echinococcus granulosus sex peptide receptor 0.0025 0.0022 0.001
Brugia malayi Guanylate kinase family protein 0.0027 0.0031 0.003
Toxoplasma gondii aspartyl protease ASP1 0.0232 0.0971 0.3263
Loa Loa (eye worm) hypothetical protein 0.0025 0.0022 0.0079
Loa Loa (eye worm) hypothetical protein 0.0121 0.0464 0.1653
Plasmodium vivax aspartyl proteinase, putative 0.0121 0.0464 0.1397
Plasmodium vivax plasmepsin V, putative 0.0121 0.0464 0.1397
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0025 0.0022 0.0003
Echinococcus granulosus death domain containing protein 0.0028 0.0037 0.0059
Schistosoma mansoni cathepsin D (A01 family) 0.0515 0.2267 0.2252
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein) 0.0585 0.2587 1
Trypanosoma cruzi ribonucleoside-diphosphate reductase small chain, putative 0.0132 0.0512 0.1575
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0025 0.0022 0.0003
Schistosoma mansoni neuropeptide f receptor 76f 0.0025 0.0022 0.0003
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0089 0.0316
Toxoplasma gondii aspartyl protease 0.0121 0.0464 0.1397
Loa Loa (eye worm) proprotein convertase 2 0.0038 0.0084 0.0298
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0232 0.0971 0.3208
Echinococcus granulosus G protein coupled receptor 139 0.0025 0.0022 0.001
Loa Loa (eye worm) hypothetical protein 0.0025 0.0022 0.0079
Onchocerca volvulus 0.0038 0.0084 0.1391
Echinococcus granulosus g protein coupled receptor 0.0025 0.0022 0.001
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0025 0.0022 0.0003
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0025 0.0022 0.001
Schistosoma mansoni biogenic amine receptor 0.0025 0.0022 0.0003
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0022 0.0003
Echinococcus multilocularis serotonin receptor 0.0025 0.0022 0.001
Loa Loa (eye worm) hypothetical protein 0.0025 0.0022 0.0079
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0089 0.002
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0025 0.0022 0.001
Loa Loa (eye worm) hypothetical protein 0.0025 0.0022 0.0079
Loa Loa (eye worm) hypothetical protein 0.0025 0.0022 0.0079
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0232 0.0971 0.3208
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0038 0.0084 0.0217
Echinococcus multilocularis neuropeptide receptor 0.0672 0.2987 1
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0038 0.0084 0.0321
Loa Loa (eye worm) hypothetical protein 0.0025 0.0022 0.0079
Plasmodium falciparum plasmepsin VIII, putative 0.0121 0.0464 0.1397
Echinococcus multilocularis neuropeptides capa receptor 0.0025 0.0022 0.001
Loa Loa (eye worm) G-protein coupled receptor 0.0025 0.0022 0.0079
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.0022 0.001
Plasmodium vivax ribonucleotide reductase small subunit, putative 0.0045 0.0112 0.0105
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.0022 0.001
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0232 0.0971 0.0954
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0232 0.0971 0.3464
Schistosoma mansoni adenoreceptor 0.0025 0.0022 0.0003
Loa Loa (eye worm) hypothetical protein 0.0025 0.0022 0.0079
Trypanosoma brucei unspecified product 0.0033 0.006 0.0211
Echinococcus multilocularis g protein coupled receptor 0.0025 0.0022 0.001
Echinococcus multilocularis Ankyrin 0.0028 0.0037 0.0059
Loa Loa (eye worm) hypothetical protein 0.0025 0.0022 0.0079
Loa Loa (eye worm) hypothetical protein 0.0027 0.0029 0.0105
Loa Loa (eye worm) hypothetical protein 0.0025 0.0022 0.0079
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain 0.0132 0.0512 0.1824
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0025 0.0022 0.001
Echinococcus granulosus tumor necrosis factor receptor superfamily 0.0043 0.0105 0.0288
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0089 0.002
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0046 0.0116 0.0097
Loa Loa (eye worm) hypothetical protein 0.0025 0.0022 0.0079
Echinococcus multilocularis ribonucleoside diphosphate reductase subunit 0.0132 0.0512 0.1661
Echinococcus multilocularis g protein coupled receptor 0.0025 0.0022 0.001
Loa Loa (eye worm) hypothetical protein 0.0025 0.0022 0.0079
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0028 0.0037 0.0131
Loa Loa (eye worm) hypothetical protein 0.0025 0.0022 0.0079
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain 0.0132 0.0512 0.1824
Plasmodium falciparum ribonucleoside-diphosphate reductase small chain, putative 0.0045 0.0112 0.0105
Echinococcus granulosus fmrfamide receptor 0.0025 0.0022 0.001
Echinococcus granulosus neuroendocrine convertase 2 0.0038 0.0084 0.0217
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0089 0.0316
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0089 0.0316
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain, putative 0.0132 0.0512 0.1824
Echinococcus multilocularis g protein coupled receptor 0.0025 0.0022 0.001
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0022 0.0003
Schistosoma mansoni opsin-like receptor 0.0025 0.0022 0.0003
Echinococcus granulosus TNFR CD27 30 40 95 cysteine rich region 0.0043 0.0105 0.0288
Loa Loa (eye worm) hypothetical protein 0.0038 0.0084 0.0298
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0025 0.0022 0.0003
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0028 0.0037 0.0059
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (beta chain) NrdF1 (ribonucleotide reductase small subunit) (R2F protein) 0.0132 0.0512 0.1977
Plasmodium falciparum plasmepsin VI 0.0232 0.0971 0.3263
Brugia malayi Pepsin A precursor 0.0121 0.0464 0.1587
Echinococcus multilocularis G protein coupled receptor 139 0.0672 0.2987 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0037 0.0131
Echinococcus granulosus tm gpcr rhodopsin 0.0025 0.0022 0.001
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1373 0.6197 0.619
Trypanosoma cruzi ribonucleoside-diphosphate reductase small chain, putative 0.0132 0.0512 0.1575
Loa Loa (eye worm) hypothetical protein 0.0025 0.0022 0.0079
Echinococcus multilocularis fmrfamide receptor 0.0025 0.0022 0.001
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0089 0.002
Echinococcus multilocularis neuroendocrine convertase 2 0.0038 0.0084 0.0217
Plasmodium falciparum plasmepsin X 0.0121 0.0464 0.1397
Mycobacterium leprae RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN) 0.0585 0.2587 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0025 0.0022 0.001
Schistosoma mansoni alpha-1 adrenergic receptor 0.0025 0.0022 0.0003
Loa Loa (eye worm) hypothetical protein 0.0025 0.0022 0.0079
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0038 0.0084 0.0321
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0022 0.0003
Echinococcus granulosus alpha 1A adrenergic receptor 0.0025 0.0022 0.001
Loa Loa (eye worm) hypothetical protein 0.0025 0.0022 0.0079
Echinococcus multilocularis dro:myosuppressin receptor 0.0025 0.0022 0.001
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0025 0.0022 0.001
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0025 0.0022 0.001
Echinococcus multilocularis neuropeptides capa receptor 0.0025 0.0022 0.001
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0089 0.0316
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0022 0.0003
Mycobacterium tuberculosis Probable transcriptional regulatory protein NrdR 0.0047 0.0124 0.0478
Loa Loa (eye worm) hypothetical protein 0.0025 0.0022 0.0079
Schistosoma mansoni amine GPCR 0.0025 0.0022 0.0003
Echinococcus granulosus membrane bound transcription factor site 1 0.0038 0.0084 0.0217
Brugia malayi aspartic protease BmAsp-2, identical 0.0121 0.0464 0.1587
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0089 0.002
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0022 0.001
Echinococcus multilocularis neuropeptide s receptor 0.0025 0.0022 0.001
Brugia malayi Subtilase family protein 0.0038 0.0084 0.0221
Echinococcus granulosus tm gpcr rhodopsin 0.0025 0.0022 0.001
Brugia malayi endoprotease bli-4 precursor 0.0038 0.0084 0.0221
Schistosoma mansoni opsin-like receptor 0.0025 0.0022 0.0003
Loa Loa (eye worm) hypothetical protein 0.0025 0.0022 0.0079
Loa Loa (eye worm) hypothetical protein 0.0025 0.0022 0.0079
Echinococcus granulosus netrin receptor unc 5 0.0028 0.0037 0.0059
Schistosoma mansoni ribonucleoside-diphosphate reductase alpha subunit 0.0632 0.2804 0.279
Echinococcus granulosus biogenic amine 5HT receptor 0.0025 0.0022 0.001
Echinococcus granulosus 7tm_1 domain containing protein 0.0025 0.0022 0.001
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0045 0.0158
Loa Loa (eye worm) neuropeptide F receptor 0.0025 0.0022 0.0079
Loa Loa (eye worm) hypothetical protein 0.0027 0.0029 0.0105
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0232 0.0971 0.3546
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0025 0.0022 0.001
Echinococcus granulosus neuropeptide FF receptor 2 0.0025 0.0022 0.001
Chlamydia trachomatis ribonucleoside-diphosphate reductase subunit alpha 0.0632 0.2804 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0025 0.0022 0.0003
Mycobacterium ulcerans ribonucleotide-diphosphate reductase subunit alpha 0.0585 0.2587 1
Loa Loa (eye worm) TYRA-2 protein 0.0025 0.0022 0.0079
Brugia malayi hypothetical protein 0.0121 0.0464 0.1587
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0022 0.001
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0025 0.0022 0.0003
Echinococcus granulosus g-protein coupled receptor 0.0025 0.0022 0.001
Onchocerca volvulus Netrin receptor homolog 0.0028 0.0037 0.0327
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0038 0.0084 0.0321
Echinococcus granulosus somatostatin receptor 0.0025 0.0022 0.001
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0038 0.0084 0.0065
Echinococcus granulosus furin 0.0038 0.0084 0.0217
Schistosoma mansoni amine GPCR 0.0025 0.0022 0.0003
Mycobacterium tuberculosis Probable ribonucleoside-diphosphate reductase (large subunit) NrdZ (ribonucleotide reductase) 0.021 0.0871 0.3364
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.0022 0.001

Activities

Activity type Activity value Assay description Source Reference
Influx (functional) = 15 nM mg-1 Influx of calcium in Cerebellar Granule Cells of rat after 10 min of incubation with compound ChEMBL. 2160533
Influx (functional) = 47 nM mg-1 Influx of calcium in Cerebellar Granule Cells of rat after 10 min of incubation with compound and 10 microM glutamate ChEMBL. 2160533
Stimulation (functional) = 119 % Stimulation caused by Glutamate in Cerebellar Granule Cells over basal stimulation ChEMBL. 2160533

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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