TDR Targets

Basic information

Technical information

TDR Targets ID: 538650
Name: 3-azido-5-methyl-10,11-dihydro-5H-dibenzo(a,d )cyclohepten-5,10-imine
MW: 263.317 | Formula: C16H15N4
H donors: 1 H acceptors: 0 LogP: 3.75 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: [NH-]=[N+]=Nc1ccc2c(c1)[C@@]1(C)N[C@@H](C2)c2c1cccc2
InChi: 1S/C16H14N4/c1-16-13-5-3-2-4-12(13)15(18-16)8-10-6-7-11(19-20-17)9-14(10)16/h2-7,9,15,18H,8H2,1H3/t15-,16-/m0/s1
InChiKey: ZXRNPVOTFWAJGE-HOTGVXAUSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

127627-58-1
3-Azido-MK 801

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	Na,K-ATPase alpha subunit	0.0609	0.6409	0.6409
Mycobacterium ulcerans	cation transporter p-type ATPase D CtpD	0.0183	0.1664	0.198
Trypanosoma cruzi	copper-transporting ATPase-like protein, putative	0.0183	0.1664	0.2199
Giardia lamblia	Phospholipid-transporting ATPase IA, putative	0.0183	0.1664	0.2216
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0587	0.6168	0.9978
Echinococcus multilocularis	phosphoserine phosphatase	0.0115	0.0901	0.0881
Echinococcus multilocularis	cation transporting atpase worm	0.0183	0.1664	0.1646
Echinococcus multilocularis	phosphoserine phosphatase	0.0115	0.0901	0.0881
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0992	0.0992
Trichomonas vaginalis	ATPase, class VI, type 11C, putative	0.007	0.0394	0.0022
Echinococcus granulosus	nervana 2	0.093	1	1
Trichomonas vaginalis	phospholipid-transporting ATPase, putative	0.007	0.0394	0.0022
Trichomonas vaginalis	set domain proteins, putative	0.0238	0.2275	0.3266
Loa Loa (eye worm)	helix-loop-helix DNA-binding domain-containing protein	0.0037	0.0034	0.0034
Trichomonas vaginalis	cation-transporting ATPase, putative	0.0587	0.6168	0.9978
Toxoplasma gondii	heavy metal translocating P-type ATPase subfamily protein	0.0183	0.1664	0.2212
Schistosoma mansoni	na+/k+ atpase alpha subunit	0.0494	0.5126	0.5126
Echinococcus granulosus	plasma membrane calcium transporting ATPase	0.0473	0.4899	0.4888
Entamoeba histolytica	phospholipid-transporting P-type ATPase, putative	0.0183	0.1664	0.2666
Schistosoma mansoni	ATPase	0.0587	0.6168	0.6168
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0079	0.0495	0.0475
Trypanosoma cruzi	calcium-translocating P-type ATPase, putative	0.0215	0.2011	0.2801
Treponema pallidum	cation-transporting ATPase, P-type	0.0183	0.1664	1
Echinococcus granulosus	lysine specific demethylase 5A	0.0118	0.0937	0.0918
Brugia malayi	hypothetical protein	0.0037	0.0034	0.0053
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0118	0.0937	0.0918
Leishmania major	calcium motive p-type ATPase, putative	0.0473	0.4899	0.7806
Toxoplasma gondii	P-type ATPase PMA1	0.0373	0.3775	0.5851
Echinococcus granulosus	nervana 2	0.093	1	1
Echinococcus multilocularis	phospholipid transporting ATPase VA	0.0116	0.0913	0.0894
Echinococcus granulosus	Na:K ATPase alpha subunit	0.0494	0.5126	0.5116
Brugia malayi	hypothetical protein	0.0036	0.0021	0.0033
Leishmania major	phospholipid-transporting ATPase 1-like protein	0.007	0.0394	0.0022
Echinococcus granulosus	phospholipid transporting ATPase VA	0.0116	0.0913	0.0894
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0052	0.0193	0.0172
Echinococcus multilocularis	microtubule associated protein 2	0.0694	0.736	0.7354
Plasmodium vivax	cation transporting ATPase, putative	0.0183	0.1664	0.2212
Loa Loa (eye worm)	hypothetical protein	0.0284	0.2787	0.2787
Trypanosoma brucei	cation-transporting ATPase, putative	0.0183	0.1664	0.2216
Giardia lamblia	Potassium-transporting ATPase alpha chain 1	0.0494	0.5126	0.8199
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0992	0.0992
Brugia malayi	Sodium/potassium-transporting ATPase alpha-3 chain, putative	0.0258	0.2492	0.3888
Entamoeba histolytica	plasma membrane calcium-transporting ATPase 1, putative	0.0329	0.3294	0.5313
Trypanosoma cruzi	copper-transporting ATPase, putative	0.0115	0.0901	0.0878
Brugia malayi	MH2 domain containing protein	0.012	0.0957	0.1493
Plasmodium falciparum	phospholipid-transporting ATPase, putative	0.007	0.0394	0.0022
Schistosoma mansoni	cation-transporting atpase worm	0.0183	0.1664	0.1664
Entamoeba histolytica	phospholipid-transporting P-type ATPase, putative	0.0183	0.1664	0.2666
Echinococcus multilocularis	phospholipid transporting ATPase IF	0.007	0.0394	0.0373
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0079	0.0495	0.0739
Brugia malayi	calcium ATPase	0.0216	0.2024	0.3159
Brugia malayi	aryl hydrocarbon receptor nuclear translocator protein, putative	0.0037	0.0034	0.0053
Trichomonas vaginalis	phospholipid-transporting ATPase, putative	0.007	0.0394	0.0022
Schistosoma mansoni	copper ABC transporter ATPase	0.0183	0.1664	0.1664
Plasmodium vivax	P-type ATPase4, putative	0.0588	0.6181	1
Trichomonas vaginalis	phospholipid-transporting ATPase, putative	0.0183	0.1664	0.2212
Brugia malayi	Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type	0.0473	0.4899	0.7643
Loa Loa (eye worm)	sodium potassium adenosine triphosphatase	0.0258	0.2492	0.2492
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.093	1	1
Trypanosoma brucei	calcium-transporting ATPase, putative	0.007	0.0394	0.0022
Schistosoma mansoni	sodium/potassium-dependent atpase beta subunit	0.093	1	1
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0079	0.0495	0.5
Trypanosoma cruzi	P-type H+-ATPase, putative	0.0258	0.2492	0.3633
Leishmania major	phospholipid-translocating P-type ATPase (flippase), putative	0.007	0.0394	0.0022
Trypanosoma brucei	copper-transporting ATPase-like protein, putative	0.0183	0.1664	0.2216
Schistosoma mansoni	calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump)	0.0473	0.4899	0.4899
Toxoplasma gondii	sarco/endoplasmic reticulum Ca2+-ATPase	0.0588	0.6181	1
Giardia lamblia	Copper-transporting P-type ATPase	0.0183	0.1664	0.2216
Loa Loa (eye worm)	E1-E2 ATPase	0.0373	0.3775	0.3775
Entamoeba histolytica	plasma membrane calcium-transporting ATPase, putative	0.0068	0.0381	0.0584
Onchocerca volvulus	Huntingtin homolog	0.0123	0.0992	0.0962
Schistosoma mansoni	phospholipid-transporting atpase 1 (aminophospholipid flippase 1)	0.0068	0.0381	0.0381
Onchocerca volvulus		0.0238	0.2275	0.2249
Schistosoma mansoni	peptidase Clp (S14 family)	0.0079	0.0495	0.0495
Mycobacterium ulcerans	cation-transporter ATPase I CtpI	0.0398	0.4057	0.6037
Brugia malayi	hypothetical protein	0.0037	0.0031	0.0048
Echinococcus granulosus	microtubule associated protein 2	0.0694	0.736	0.7354
Brugia malayi	Probable ClpP-like protease	0.0079	0.0495	0.0772
Leishmania major	calcium-transporting ATPase, putative	0.0473	0.4899	0.7806
Entamoeba histolytica	plasma membrane calcium ion-transporting ATPase, putative	0.0331	0.3307	0.5334
Entamoeba histolytica	phospholipid-transporting P-type ATPase, putative	0.007	0.0394	0.0604
Entamoeba histolytica	calcium-transporting P-type ATPase, putative	0.0588	0.6181	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.005	0.0177	0.0276
Loa Loa (eye worm)	hypothetical protein	0.0204	0.1891	0.1891
Trypanosoma brucei	calcium-translocating P-type ATPase	0.0473	0.4899	0.7806
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0079	0.0495	0.0475
Schistosoma mansoni	Na+/K+ transporting ATPase subunit alpha	0.0609	0.6409	0.6409
Trichomonas vaginalis	cation-transporting ATPase, putative	0.007	0.0394	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0183	0.1664	0.1664
Echinococcus granulosus	nervana 2	0.093	1	1
Trichomonas vaginalis	cation-transporting ATPase, putative	0.0587	0.6168	0.9978
Trypanosoma brucei	phospholipid-transporting ATPase 1-like protein, putative	0.007	0.0394	0.0022
Toxoplasma gondii	calcium-translocating P-type ATPase, PMCA-type protein	0.0587	0.6168	0.9978
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0587	0.6168	0.9978
Mycobacterium ulcerans	metal cation transporter p-type ATPase, CtpV	0.0183	0.1664	0.198
Echinococcus granulosus	sodium:potassium transporting ATPase subunit	0.093	1	1
Schistosoma mansoni	phospholipid-transporting atpase	0.007	0.0394	0.0394
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0131	0.011
Entamoeba histolytica	cation-transporting P-typeATPase, putative	0.0183	0.1664	0.2666
Mycobacterium tuberculosis	Probable cation transporter P-type ATPase D CtpD	0.0183	0.1664	0.3806
Entamoeba histolytica	Plasma membrane calcium-transporting ATPase, putative	0.0587	0.6168	0.9979
Echinococcus granulosus	phospholipid transporting ATPase IA	0.007	0.0394	0.0373
Schistosoma mansoni	phospholipid-transporting atpase	0.007	0.0394	0.0394
Echinococcus multilocularis	aryl hydrocarbon receptor	0.0053	0.0211	0.019
Echinococcus granulosus	aryl hydrocarbon receptor	0.0053	0.0211	0.019
Trypanosoma brucei	vacuolar-type Ca2+-ATPase, putative	0.0587	0.6168	1
Entamoeba histolytica	Plasma membrane calcium-transporting ATPase, putative	0.0587	0.6168	0.9979
Brugia malayi	hypothetical protein	0.0116	0.0913	0.1425
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.0021	0.0021
Leishmania major	vacuolar-type Ca2 -ATPase, putative	0.0587	0.6168	1
Schistosoma mansoni	microtubule-associated protein tau	0.0694	0.736	0.736
Echinococcus granulosus	Ca2 transporting ATPase plasma membrane	0.0473	0.4899	0.4888
Schistosoma mansoni	ATPase	0.0587	0.6168	0.6168
Giardia lamblia	Plasma membrane calcium-transporting ATPase 2	0.0587	0.6168	1
Echinococcus granulosus	copper transporting ATPase 1	0.0183	0.1664	0.1646
Brugia malayi	calcium ATPase	0.0258	0.2492	0.3888
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0079	0.0495	0.0197
Echinococcus multilocularis	Na+:K+ ATPase alpha subunit	0.0494	0.5126	0.5116
Chlamydia trachomatis	metal transport ATPase	0.0183	0.1664	1
Plasmodium vivax	phospholipid-transporting ATPase, putative	0.007	0.0394	0.0022
Trypanosoma brucei	vacuolar-type Ca2+-ATPase 2	0.0587	0.6168	1
Echinococcus granulosus	cation transporting atpase worm	0.0183	0.1664	0.1646
Mycobacterium leprae	PROBABLE CATION-TRANSPORTER P-TYPE ATPASE B CTPB	0.0183	0.1664	0.3594
Trypanosoma brucei	calcium-transporting ATPase, putative	0.0284	0.2787	0.4158
Echinococcus multilocularis	phosphoserine phosphatase	0.0115	0.0901	0.0881
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.093	1	1
Trypanosoma cruzi	P-type H+-ATPase, putative	0.0373	0.3775	0.5855
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0046	0.0131	0.0131
Trichomonas vaginalis	cation-transporting ATPase fungi, putative	0.0587	0.6168	0.9978
Leishmania major	P-type ATPase, putative	0.0473	0.4899	0.7806
Echinococcus multilocularis	cation transporting ATPase 13A1	0.0183	0.1664	0.1646
Leishmania major	aminophospholipid translocase, putative	0.007	0.0394	0.0022
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0118	0.0937	0.0937
Mycobacterium leprae	PROBABLE CATION-TRANSPORTER ATPASE I CTPI	0.0418	0.4285	1
Trypanosoma brucei	vacuolar-type Ca2+-ATPase 1	0.0587	0.6168	1
Leishmania major	copper-transporting ATPase-like protein, putative	0.0183	0.1664	0.2216
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0031	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0258	0.2492	0.2492
Trypanosoma cruzi	P-type H+-ATPase, putative	0.0373	0.3775	0.5855
Leishmania major	P-type H -ATPase, putative	0.0373	0.3775	0.5864
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0079	0.0495	0.0197
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0587	0.6168	0.9978
Schistosoma mansoni	calcium-transporting atpase 2 (atpase 2)	0.0473	0.4899	0.4899
Loa Loa (eye worm)	phospholipid-transporting ATPase ID	0.007	0.0394	0.0394
Schistosoma mansoni	sodium/potassium-dependent atpase beta subunit	0.093	1	1
Echinococcus multilocularis	phospholipid transporting ATPase IIB	0.0183	0.1664	0.1646
Brugia malayi	hypothetical protein	0.0123	0.0992	0.1548
Loa Loa (eye worm)	hypothetical protein	0.093	1	1
Leishmania major	P-type H -ATPase, putative	0.0373	0.3775	0.5864
Mycobacterium tuberculosis	Probable metal cation transporter ATPase P-type CtpE	0.0183	0.1664	0.3806
Mycobacterium leprae	Probable metal cation-transporting P-type ATPase C CtpC	0.0183	0.1664	0.3594
Trichomonas vaginalis	ATPase, class I, type 8B, putative	0.0183	0.1664	0.2212
Mycobacterium ulcerans	metal cation-transporting p-type ATPase CtpC	0.0183	0.1664	0.198
Schistosoma mansoni	phosphoserine phosphatase	0.0115	0.0901	0.0901
Echinococcus granulosus	calcium transporting atpase	0.0473	0.4899	0.4888
Schistosoma mansoni	hypothetical protein	0.0036	0.0021	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0031	0.0031
Toxoplasma gondii	plasma membrane-type Ca(2+)-ATPase A1 PMCAA1	0.0473	0.4899	0.7788
Echinococcus multilocularis	Tetracycline resistance leader peptide, TetL	0.0588	0.6181	0.6173
Trichomonas vaginalis	phospholipid-transporting ATPase, putative	0.007	0.0394	0.0022
Trypanosoma cruzi	Calcium ATPase SERCA-like	0.0587	0.6168	1
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0495	0.0495
Echinococcus multilocularis	sodium:potassium transporting ATPase subunit	0.093	1	1
Onchocerca volvulus		0.093	1	1
Brugia malayi	Probable cation-transporting ATPase C10C6.6 in chromosome IV	0.0183	0.1664	0.2596
Echinococcus granulosus	sarco:endoplasmic reticulum calcium ATPase	0.0587	0.6168	0.616
Leishmania major	proton motive ATPase, putative	0.0183	0.1664	0.2216
Schistosoma mansoni	aryl hydrocarbon receptor nuclear translocator homolog (darnt)	0.0037	0.0034	0.0034
Echinococcus granulosus	phospholipid transporting atpase ih	0.007	0.0394	0.0373
Leishmania major	calcium-translocating P-type ATPase	0.0587	0.6168	1
Loa Loa (eye worm)	hypothetical protein	0.0189	0.1729	0.1729
Schistosoma mansoni	cation-transporting ATPase	0.0183	0.1664	0.1664
Echinococcus granulosus	phospholipid transporting ATPase IF	0.007	0.0394	0.0373
Trypanosoma brucei	phospholipid-translocating P-type ATPase (flippase), putative	0.007	0.0394	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0544	0.0544
Brugia malayi	Pre-SET motif family protein	0.0209	0.1953	0.3047
Trypanosoma cruzi	copper-transporting ATPase-like protein, putative	0.0183	0.1664	0.2199
Entamoeba histolytica	phospholipid-transporting ATPase Neo1, putative	0.007	0.0394	0.0604
Entamoeba histolytica	phospholipid-transporting P-type ATPase, putative	0.007	0.0394	0.0604
Mycobacterium ulcerans	metal cation transporter ATPase p-type CtpE	0.0183	0.1664	0.198
Onchocerca volvulus		0.0607	0.6396	0.6384
Mycobacterium tuberculosis	Possible metal cation transporting P-type ATPase CtpH	0.0398	0.4057	1
Toxoplasma gondii	haloacid dehalogenase family hydrolase domain-containing protein	0.0183	0.1664	0.2212
Brugia malayi	E1-E2 ATPase family protein	0.0374	0.3788	0.591
Trichomonas vaginalis	phospholipid-transporting ATPase, putative	0.007	0.0394	0.0022
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0588	0.6181	1
Trichomonas vaginalis	ATPase, class VI, type 11C, putative	0.0183	0.1664	0.2212
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0118	0.0937	0.0937
Brugia malayi	Sodium/potassium-transporting ATPase alpha chain, putative	0.0419	0.4298	0.6706
Toxoplasma gondii	cation-transporting atpase family protein	0.0115	0.0901	0.0896
Entamoeba histolytica	phospholipid-transporting P-type ATPase, putative	0.007	0.0394	0.0604
Brugia malayi	Helix-loop-helix DNA-binding domain containing protein	0.0037	0.0034	0.0053
Echinococcus multilocularis	calcium transporting ATPase type 2C member	0.0588	0.6181	0.6173
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0118	0.0937	0.0918
Brugia malayi	hypothetical protein	0.0053	0.0208	0.0325
Schistosoma mansoni	sodium/potassium-dependent atpase beta subunit	0.093	1	1
Loa Loa (eye worm)	hypothetical protein	0.093	1	1
Toxoplasma gondii	phospholipid-translocating P-type ATPase, flippase subfamily protein	0.0115	0.0901	0.0896
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.093	1	1
Schistosoma mansoni	cation-transporting atpase fly	0.0068	0.0381	0.0381
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0131	0.0131
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0046	0.0131	0.0204
Trypanosoma cruzi	cation-transporting ATPase, putative	0.0183	0.1664	0.2199
Brugia malayi	jmjC domain containing protein	0.0118	0.0937	0.1463
Plasmodium falciparum	non-SERCA-type Ca2+ -transporting P-ATPase	0.0588	0.6181	1
Brugia malayi	potential phospholipid-transporting ATPase IIB, putative	0.0183	0.1664	0.2596
Trypanosoma cruzi	plasma membrane Ca2+ ATPase	0.0587	0.6168	1
Trypanosoma cruzi	copper-transporting ATPase-like protein, putative	0.0115	0.0901	0.0878
Leishmania major	vacuolar-type Ca2 -ATPase, putative	0.0587	0.6168	1
Echinococcus multilocularis	nervana 2	0.093	1	1
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.093	1	1
Toxoplasma gondii	P-type ATPase4, putative	0.0588	0.6181	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0031	0.0031
Trypanosoma cruzi	calcium motive p-type ATPase, putative	0.0473	0.4899	0.7801
Loa Loa (eye worm)	hypothetical protein	0.0183	0.1664	0.1664
Loa Loa (eye worm)	calcium ATPase	0.0068	0.0381	0.0381
Loa Loa (eye worm)	hypothetical protein	0.0587	0.6168	0.6168
Echinococcus granulosus	plasma membrane calcium transporting ATPase 2	0.0588	0.6181	0.6173
Echinococcus multilocularis	sarco:endoplasmic reticulum calcium ATPase	0.0587	0.6168	0.616
Loa Loa (eye worm)	aryl Hydrocarbon receptor Associated protein family member	0.0053	0.0211	0.0211
Trichomonas vaginalis	cation-transporting ATPase, putative	0.0587	0.6168	0.9978
Trypanosoma cruzi	proton motive ATPase 1, putative	0.0115	0.0901	0.0878
Schistosoma mansoni	calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump)	0.0473	0.4899	0.4899
Schistosoma mansoni	transmemberane protein	0.093	1	1
Echinococcus multilocularis	phospholipid transporting atpase ih phospholipid transporting atpase if	0.007	0.0394	0.0373
Echinococcus multilocularis	plasma membrane calcium transporting ATPase	0.0473	0.4899	0.4888
Giardia lamblia	Phospholipid-transporting ATPase IIB, putative	0.007	0.0394	0.0022
Mycobacterium ulcerans	cation-transporter p-type ATPase B CtpB	0.0183	0.1664	0.198
Loa Loa (eye worm)	hypothetical protein	0.0609	0.6409	0.6409
Brugia malayi	phospholipid-translocating P-type ATPase, flippase family protein	0.007	0.0394	0.0614
Echinococcus multilocularis	nervana 2	0.093	1	1
Echinococcus multilocularis	phosphoserine phosphatase	0.0115	0.0901	0.0881
Echinococcus granulosus	cation transporting ATPase 13A1	0.0183	0.1664	0.1646
Mycobacterium tuberculosis	Probable metal cation transporter P-type ATPase CtpV	0.0183	0.1664	0.3806
Brugia malayi	Calcitonin receptor-like protein seb-1	0.005	0.0177	0.0276
Trypanosoma brucei	calcium motive p-type ATPase, putative	0.0473	0.4899	0.7806
Entamoeba histolytica	phospholipid-transporting ATPase IA, putative	0.007	0.0394	0.0604
Entamoeba histolytica	phospholipid-transporting P-type ATPase, putative	0.0068	0.0381	0.0584
Giardia lamblia	Phospholipid-transporting ATPase IIB, putative	0.007	0.0394	0.0022
Echinococcus multilocularis	copper transporting ATPase 1	0.0183	0.1664	0.1646
Entamoeba histolytica	Acid sphingomyelinase-like phosphodiesterase, putative	0.0083	0.0544	0.0849
Trichomonas vaginalis	cation-transporting ATPase, putative	0.007	0.0394	0.0022
Trypanosoma cruzi	plasma membrane Ca2+ ATPase	0.0587	0.6168	1
Mycobacterium ulcerans	metal cation-transporting p-type ATPase F, CtpF	0.0588	0.6181	0.9636
Echinococcus multilocularis	lysine specific demethylase 5A	0.0118	0.0937	0.0918
Onchocerca volvulus		0.0068	0.0381	0.0348
Treponema pallidum	hypothetical protein	0.0115	0.0901	0.347
Schistosoma mansoni	sodium / potassium ATPase beta chain	0.093	1	1
Trypanosoma brucei	P-type H+-ATPase, putative	0.0373	0.3775	0.5864
Mycobacterium tuberculosis	Cation transporter P-type ATPase a CtpA	0.0183	0.1664	0.3806
Trypanosoma brucei	P-type H+-ATPase, putative	0.0373	0.3775	0.5864
Trypanosoma cruzi	plasma-membrane proton-efflux P-type ATPase, putative	0.0258	0.2492	0.3633
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0208	0.0208
Loa Loa (eye worm)	hypothetical protein	0.0189	0.1729	0.1729
Echinococcus multilocularis	calcium transporting atpase	0.0473	0.4899	0.4888
Trypanosoma brucei	phospholipid-translocating ATPase, putative	0.007	0.0394	0.0022
Brugia malayi	Na,K-ATPase alpha subunit	0.0609	0.6409	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0131	0.0131
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.093	1	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0131	0.0131
Plasmodium vivax	calcium-transporting ATPase, putative	0.0588	0.6181	1
Onchocerca volvulus		0.0053	0.0208	0.0175
Loa Loa (eye worm)	calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type	0.0284	0.2787	0.2787
Trichomonas vaginalis	phospholipid-transporting ATPase, putative	0.007	0.0394	0.0022
Toxoplasma gondii	haloacid dehalogenase family hydrolase domain-containing protein	0.0115	0.0901	0.0896
Trichomonas vaginalis	cation-transporting ATPase, putative	0.0373	0.3775	0.5851
Echinococcus multilocularis	Ca2+ transporting ATPase plasma membrane	0.0473	0.4899	0.4888
Loa Loa (eye worm)	jmjC domain-containing protein	0.0118	0.0937	0.0937
Echinococcus multilocularis	nervana 2	0.093	1	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.005	0.0177	0.0177
Loa Loa (eye worm)	sodium/potassium-transporting ATPase subunit alpha	0.0419	0.4298	0.4298
Loa Loa (eye worm)	MH2 domain-containing protein	0.012	0.0957	0.0957
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0473	0.4899	0.7788
Brugia malayi	aryl hydrocarbon receptor AHR-1	0.0037	0.0031	0.0048
Plasmodium falciparum	calcium-transporting ATPase	0.0473	0.4899	0.7788
Echinococcus granulosus	phospholipid transporting ATPase IIB	0.0183	0.1664	0.1646
Schistosoma mansoni	phospholipid-transporting atpase	0.0068	0.0381	0.0381
Plasmodium falciparum	copper-transporting ATPase	0.0183	0.1664	0.2212
Entamoeba histolytica	phospholipid-transporting P-type ATPase, putative	0.007	0.0394	0.0604
Schistosoma mansoni	plasma membrane calcium-transporting atpase	0.0473	0.4899	0.4899
Schistosoma mansoni	cation-transporting atpase 13a1 (G-box binding protein)	0.0183	0.1664	0.1664
Trypanosoma cruzi	phospholipid-transporting ATPase-like protein, putative	0.0115	0.0901	0.0878
Loa Loa (eye worm)	transbilayer Amphipath transporters family member	0.007	0.0394	0.0394
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0209	0.1953	0.1953
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0079	0.0495	0.0197
Schistosoma mansoni	jumonji domain containing protein	0.0118	0.0937	0.0937
Trichomonas vaginalis	cation-transporting ATPase, putative	0.0183	0.1664	0.2212
Onchocerca volvulus	Huntingtin homolog	0.0123	0.0992	0.0962
Loa Loa (eye worm)	calcium ATPase	0.0331	0.3307	0.3307
Loa Loa (eye worm)	transcription factor SMAD2	0.012	0.0957	0.0957
Echinococcus multilocularis	phosphoserine phosphatase	0.0115	0.0901	0.0881
Echinococcus granulosus	nervana 2	0.093	1	1
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0079	0.0495	0.0197
Trypanosoma cruzi	calcium-translocating P-type ATPase, putative	0.0258	0.2492	0.3633
Mycobacterium ulcerans	cation transporter p-type ATPase a CtpA	0.0183	0.1664	0.198
Schistosoma mansoni	cation-transporting atpase worm	0.0183	0.1664	0.1664
Echinococcus granulosus	cation transporting ATPase 13A3	0.0183	0.1664	0.1646
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0131	0.011
Echinococcus granulosus	peptidase Clp S14 family	0.0052	0.0193	0.0172
Schistosoma mansoni	plasma membrane calcium-transporting atpase	0.0473	0.4899	0.4899
Trichomonas vaginalis	cation-transporting ATPase, putative	0.007	0.0394	0.0022
Onchocerca volvulus		0.093	1	1
Schistosoma mansoni	cation-transporting atpase worm	0.0068	0.0381	0.0381
Brugia malayi	haloacid dehalogenase-like hydrolase family protein	0.0331	0.3307	0.516
Entamoeba histolytica	plasma membrane calcium ion-transporting ATPase, putative	0.0259	0.2505	0.4032
Entamoeba histolytica	phospholipid-transporting P-type ATPase, putative	0.0185	0.1676	0.2687
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0031	0.0031
Brugia malayi	jmjC domain containing protein	0.0118	0.0937	0.1463
Giardia lamblia	Plasma membrane calcium-transporting ATPase 2	0.0472	0.4886	0.7784
Entamoeba histolytica	Plasma membrane calcium-transporting ATPase, putative	0.0587	0.6168	0.9979
Toxoplasma gondii	E1-E2 ATPase subfamily protein	0.0258	0.2492	0.364
Trichomonas vaginalis	ATPase, class VI, type 11C, putative	0.007	0.0394	0.0022
Mycobacterium ulcerans	metal cation transporter p-type ATPase a	0.0607	0.6396	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0131	0.011
Schistosoma mansoni	atpase class VI type 11c	0.0116	0.0913	0.0913
Brugia malayi	Probable calcium-transporting ATPase KIAA0703	0.0284	0.2787	0.4349
Echinococcus multilocularis	cation transporting ATPase 13A3	0.0183	0.1664	0.1646
Plasmodium vivax	copper-transporting ATPase, putative	0.0183	0.1664	0.2212
Schistosoma mansoni	type V p-type atpase isoform	0.007	0.0394	0.0394
Loa Loa (eye worm)	hypothetical protein	0.005	0.0177	0.0177
Brugia malayi	Potential phospholipid-transporting ATPase IA	0.0068	0.0381	0.0594
Trypanosoma cruzi	calcium-transporting ATPase, putative	0.0284	0.2787	0.4145
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0587	0.6168	0.9978
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0131	0.011
Loa Loa (eye worm)	hypothetical protein	0.0235	0.2239	0.2239
Brugia malayi	Membrane calcium atpase protein 3	0.0473	0.4899	0.7643
Echinococcus multilocularis	nervana 2	0.093	1	1
Trypanosoma cruzi	calcium motive p-type ATPase, putative	0.0473	0.4899	0.7801
Brugia malayi	E1-E2 ATPase family protein	0.0183	0.1664	0.2596
Entamoeba histolytica	Acid sphingomyelinase-like phosphodiesterase, putative	0.0083	0.0544	0.0849
Echinococcus multilocularis	phosphoserine phosphatase	0.0115	0.0901	0.0881
Echinococcus multilocularis	phospholipid transporting ATPase IA	0.007	0.0394	0.0373
Schistosoma mansoni	type V p-type atpase isoform	0.0183	0.1664	0.1664
Toxoplasma gondii	phospholipid-translocating P-type ATPase, flippase subfamily protein	0.0116	0.0913	0.0918
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0381	0.0381
Echinococcus granulosus	calcium transporting ATPase type 2C member	0.0588	0.6181	0.6173

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Search by CAS
PubChem: 195533

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 538650