Detailed information for compound 539767

Basic information

Technical information
  • TDR Targets ID: 539767
  • Name: N-[(E)-2-[(14E)-9-[4-(dimethylamino)-3-hydrox y-6-methyl-tetrahydropyran-2-yl]oxy-3-ethyl-7 -hydroxy-2,8,12,16-tetramethyl-5,13-dioxo-4,1 7-dioxabicyclo[14.1.0]heptadec-14-en-10-yl]et hylideneamino]acetamide
  • MW: 637.804 | Formula: C33H55N3O9
  • H donors: 3 H acceptors: 5 LogP: 2.14 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCC1OC(=O)CC(O)C(C)C(OC2OC(C)CC(C2O)N(C)C)C(CC=NNC(=O)C)CC(C(=O)C=CC2(C(C1C)O2)C)C
  • InChi: 1S/C33H55N3O9/c1-10-27-21(5)31-33(7,45-31)13-11-25(38)18(2)15-23(12-14-34-35-22(6)37)30(20(4)26(39)17-28(40)43-27)44-32-29(41)24(36(8)9)16-19(3)42-32/h11,13-14,18-21,23-24,26-27,29-32,39,41H,10,12,15-17H2,1-9H3,(H,35,37)/b13-11+,34-14+
  • InChiKey: BEYPIGLXIHAEAA-YSGQLIDXSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[(E)-2-[(14E)-9-[[4-(dimethylamino)-3-hydroxy-6-methyl-2-tetrahydropyranyl]oxy]-3-ethyl-7-hydroxy-2,8,12,16-tetramethyl-5,13-dioxo-4,17-dioxabicyclo[14.1.0]heptadec-14-en-10-yl]ethylideneamino]acetamide
  • N-[(E)-2-[(14E)-9-[4-(dimethylamino)-3-hydroxy-6-methyl-oxan-2-yl]oxy-3-ethyl-7-hydroxy-2,8,12,16-tetramethyl-5,13-dioxo-4,17-dioxabicyclo[14.1.0]heptadec-14-en-10-yl]ethylideneamino]ethanamide
  • N-[(E)-2-[(14E)-9-[4-(dimethylamino)-3-hydroxy-6-methyl-tetrahydropyran-2-yl]oxy-3-ethyl-7-hydroxy-5,13-diketo-2,8,12,16-tetramethyl-4,17-dioxabicyclo[14.1.0]heptadec-14-en-10-yl]ethylideneamino]acetamide
  • N-[(E)-2-[(14E)-9-[4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-3-ethyl-7-hydroxy-2,8,12,16-tetramethyl-5,13-dioxo-4,17-dioxabicyclo[14.1.0]heptadec-14-en-10-yl]ethylideneamino]acetamide
  • antibiotic 6108A1
  • N-[2-[(14E)-9-(4-dimethylamino-3-hydroxy-6-methyloxan-2-yl)oxy-3-ethyl-7-hydroxy-2,8,12,16-tetramethyl-5,13-dioxo-4,17-dioxabicyclo[14.1.0]heptadec-14-en-10-yl]ethylideneamino]acetamide
  • N-[2-[(14E)-9-(4-dimethylamino-3-hydroxy-6-methyl-tetrahydropyran-2-yl)oxy-3-ethyl-7-hydroxy-2,8,12,16-tetramethyl-5,13-dioxo-4,17-dioxabicyclo[14.1.0]heptadec-14-en-10-yl]ethylideneamino]acetamide
  • N-[2-[(14E)-9-[(4-dimethylamino-3-hydroxy-6-methyl-2-tetrahydropyranyl)oxy]-3-ethyl-7-hydroxy-2,8,12,16-tetramethyl-5,13-dioxo-4,17-dioxabicyclo[14.1.0]heptadec-14-en-10-yl]ethylideneamino]acetamide
  • N-[2-[(14E)-9-(4-dimethylamino-3-hydroxy-6-methyl-tetrahydropyran-2-yl)oxy-3-ethyl-7-hydroxy-5,13-diketo-2,8,12,16-tetramethyl-4,17-dioxabicyclo[14.1.0]heptadec-14-en-10-yl]ethylideneamino]acetamide
  • N-[2-[(14E)-9-(4-dimethylamino-3-hydroxy-6-methyl-oxan-2-yl)oxy-3-ethyl-7-hydroxy-2,8,12,16-tetramethyl-5,13-dioxo-4,17-dioxabicyclo[14.1.0]heptadec-14-en-10-yl]ethylideneamino]ethanamide
  • 130812-04-3
  • 6108 A(sub 1)
  • Antibiotic 6108 A(sub 1)
  • Cirramycin A(sub 1), 20-(acetylhydrazone)
  • Cirramycin A1, 20-(acetylhydrazone)

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0092 0.0117
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0679 0.0679
Trypanosoma brucei trypanothione reductase 0.0044 0.0916 0.1154
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.059 0.059
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0953 0.0953
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.059 0.0614
Trichomonas vaginalis eukaryotic translation initiation factor 4E type, putative 0.0029 0.0365 0.0275
Leishmania major DNA polymerase eta, putative 0.0021 0.0092 0.0113
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0092 0.0117
Plasmodium vivax hypothetical protein, conserved 0.0035 0.059 0.4192
Mycobacterium tuberculosis Conserved protein 0.0035 0.059 0.0614
Entamoeba histolytica eukaryotic initiation factor 4E, putative 0.0029 0.0365 0.029
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0029 0.0365 0.029
Leishmania major hypothetical protein, conserved 0.0029 0.0365 0.0445
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.949 0.9485
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.059 0.0614
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0092 0.0117
Echinococcus granulosus thioredoxin glutathione reductase 0.0045 0.0937 0.1042
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0029 0.0365 0.0275
Mycobacterium ulcerans aldehyde dehydrogenase 0.0247 0.82 0.82
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0092 0.0117
Brugia malayi Eukaryotic translation initiation factor 4E type 3, putative 0.0029 0.0365 0.0365
Leishmania major DNA polymerase kappa, putative 0.0021 0.0092 0.0113
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0092 0.0117
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.024 0.7937 0.7918
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0393 0.0303
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.949 0.9485
Loa Loa (eye worm) hypothetical protein 0.0035 0.059 0.059
Brugia malayi translation initiation factor 4E 0.024 0.7937 0.7937
Echinococcus granulosus eukaryotic translation initiation factor 4E type 0.0029 0.0365 0.0336
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-4 0.0029 0.0365 0.046
Trypanosoma cruzi Eukaryotic translation initiation factor 4E type 5, putative 0.0029 0.0365 0.046
Loa Loa (eye worm) eukaryotic translation initiation factor 4E type 3 0.0029 0.0365 0.0365
Trichomonas vaginalis eukaryotic translation initiation factor 4E type, putative 0.0029 0.0365 0.0275
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.024 0.7937 0.7918
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0092 0.0117
Echinococcus granulosus lysosomal alpha glucosidase 0.0168 0.5375 0.6515
Giardia lamblia Translation elongation factor 0.0029 0.0365 0.029
Giardia lamblia Hypothetical protein 0.0029 0.0365 0.029
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0092 0.0117
Schistosoma mansoni transcription factor LCR-F1 0.0075 0.2042 0.1968
Plasmodium vivax SET domain protein, putative 0.0029 0.0393 0.0677
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0679 0.0724
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.024 0.7937 0.7918
Loa Loa (eye worm) hypothetical protein 0.0028 0.0355 0.0355
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0679 0.0592
Echinococcus multilocularis lysosomal alpha glucosidase 0.0168 0.5375 0.6515
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.059 0.0614
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0679 0.0624
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0092 0.0117
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0393 0.0371
Schistosoma mansoni alpha-glucosidase 0.0145 0.4535 0.4484
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0029 0.0365 0.0275
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0092 0.0117
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0138 0.4298 0.5187
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.059 0.0614
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0029 0.0365 0.0275
Trypanosoma brucei glucosidase, putative 0.0037 0.0679 0.0856
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0679 0.0592
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.059 0.0502
Brugia malayi beta-lactamase family protein 0.0035 0.059 0.059
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.059 0.0502
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.059 0.0502
Schistosoma mansoni glutaminase 0.0297 1 1
Schistosoma mansoni alpha-glucosidase 0.0145 0.4535 0.4484
Schistosoma mansoni aldehyde dehydrogenase 0.0247 0.82 0.8183
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.059 0.0614
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0953 0.0953
Trichomonas vaginalis hypothetical protein 0.0029 0.0365 0.0275
Trypanosoma brucei unspecified product 0.0021 0.0092 0.0117
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0205 0.6682 0.6682
Leishmania major eukaryotic translation initiation factor 4e, putative 0.0029 0.0365 0.0445
Trichomonas vaginalis glutaminase, putative 0.0297 1 1
Toxoplasma gondii thioredoxin reductase 0.0044 0.0916 0.0716
Echinococcus multilocularis eukaryotic translation initiation factor 4E 0.024 0.7937 0.9676
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-3 0.0029 0.0365 0.046
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.949 0.9485
Mycobacterium ulcerans lipase LipD 0.0035 0.059 0.059
Echinococcus multilocularis lysosomal alpha glucosidase 0.0168 0.5375 0.6515
Mycobacterium ulcerans glutaminase 0.0297 1 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.059 0.0614
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.059 0.0502
Entamoeba histolytica hypothetical protein 0.0029 0.0365 0.029
Trichomonas vaginalis set domain proteins, putative 0.0233 0.7696 0.7674
Plasmodium vivax thioredoxin reductase, putative 0.0044 0.0916 1
Entamoeba histolytica hypothetical protein 0.0075 0.2042 0.2075
Mycobacterium tuberculosis Probable oxidoreductase 0.0111 0.3337 0.4002
Entamoeba histolytica hypothetical protein 0.0075 0.2042 0.2075
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0138 0.4298 0.4298
Schistosoma mansoni aldehyde dehydrogenase 0.0247 0.82 0.8183
Mycobacterium ulcerans aldehyde dehydrogenase 0.0247 0.82 0.82
Trypanosoma brucei Eukaryotic translation initiation factor 4E type 5 0.0029 0.0365 0.046
Mycobacterium ulcerans hypothetical protein 0.0035 0.059 0.059
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0679 0.0592
Echinococcus multilocularis thioredoxin glutathione reductase 0.0045 0.0937 0.1042
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0393 0.0371
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.059 0.0502
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0029 0.0365 0.0275
Leishmania major eukaryotic translation initiation factor eIF-4E, putative 0.024 0.7937 0.9679
Entamoeba histolytica translation initiation factor 4e, putative 0.0029 0.0365 0.029
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.024 0.7937 0.8347
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0029 0.0365 0.0275
Loa Loa (eye worm) hypothetical protein 0.0035 0.059 0.059
Toxoplasma gondii eukaryotic initiation factor-4E, putative 0.024 0.7937 0.9665
Brugia malayi glutaminase DH11.1 0.0297 1 1
Brugia malayi Cytochrome P450 family protein 0.003 0.043 0.043
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.059 0.059
Trichomonas vaginalis eukaryotic translation initiation factor 4E type, putative 0.0029 0.0365 0.0275
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0092 0.0117
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0092 0.0092
Onchocerca volvulus 0.0035 0.059 0.0307
Trichomonas vaginalis esterase, putative 0.0035 0.059 0.0502
Trypanosoma cruzi eukaryotic translation initiation factor 4E (eIF4E) interacting protein, putative 0.0029 0.0365 0.046
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0029 0.0365 0.0275
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.024 0.7937 0.8347
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.059 0.0502
Loa Loa (eye worm) hypothetical protein 0.0035 0.059 0.059
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0092 0.0117
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0365 0.0275
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0035 0.059 0.059
Loa Loa (eye worm) glutaminase 0.0297 1 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0111 0.3337 0.4002
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.01 0.2936 0.3507
Entamoeba histolytica hypothetical protein 0.0029 0.0365 0.029
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0355 0.0447
Brugia malayi MH2 domain containing protein 0.013 0.3995 0.3995
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0075 0.2042 0.2405
Plasmodium falciparum eukaryotic translation initiation factor 4E 0.0029 0.0365 0.0177
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0283 0.949 1
Trichomonas vaginalis eukaryotic translation initiation factor 4E type, putative 0.0029 0.0365 0.0275
Plasmodium vivax glutathione reductase, putative 0.0044 0.0916 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.01 0.2936 0.3507
Loa Loa (eye worm) hypothetical protein 0.0021 0.0092 0.0092
Giardia lamblia hypothetical protein 0.0029 0.0365 0.029
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0354 0.0323
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0092 0.0117
Loa Loa (eye worm) thioredoxin reductase 0.0044 0.0916 0.0916
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0092 0.0117
Leishmania major eukaryotic translation initiation factor-like protein 0.024 0.7937 0.9679
Onchocerca volvulus 0.0097 0.283 0.3363
Trypanosoma brucei Eukaryotic translation initiation factor 4E-1 0.024 0.7937 1
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0355 0.0447
Toxoplasma gondii eukaryotic initiation factor-4E, putative 0.0029 0.0365 0.0013
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.01 0.2936 0.6326
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0393 0.0303
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0365 0.0275
Leishmania major eukaryotic translation initiation factor, putative 0.0029 0.0365 0.0445
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0283 0.949 1
Onchocerca volvulus 0.0035 0.059 0.0307
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-1 0.024 0.7937 1
Mycobacterium tuberculosis Conserved protein 0.0035 0.059 0.0614
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0679 0.0856
Giardia lamblia Hypothetical protein 0.0029 0.0365 0.029
Leishmania major eukaryotic translation initiation factor-like 0.024 0.7937 0.9679
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.059 0.0744
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0168 0.5375 0.5375
Leishmania major hypothetical protein, conserved 0.0035 0.059 0.072
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0679 0.0592
Mycobacterium tuberculosis Probable dehydrogenase 0.01 0.2936 0.3507
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.059 0.0744
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0355 0.0447
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.059 0.0614
Trypanosoma cruzi trypanothione reductase, putative 0.0044 0.0916 0.1154
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0092 0.0117
Mycobacterium ulcerans beta-lactamase 0.0035 0.059 0.059
Entamoeba histolytica hypothetical protein 0.0075 0.2042 0.2075
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.059 0.059
Trypanosoma cruzi Eukaryotic translation initiation factor 4E type 5, putative 0.0029 0.0365 0.046
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0679 0.0856
Treponema pallidum fructose-bisphosphate aldolase 0.0283 0.949 0.5
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.01 0.2936 0.3507
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0679 0.0592
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0953 0.0869
Brugia malayi beta-lactamase 0.0035 0.059 0.059
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.059 0.0502
Plasmodium falciparum glutathione reductase 0.0044 0.0916 1
Toxoplasma gondii hypothetical protein 0.0029 0.0365 0.0013
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.01 0.2936 0.3507
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0679 0.0592
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0029 0.0365 0.029
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0247 0.82 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0092 0.0117
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0223 0.7328 0.8925
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.949 0.9485
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0679 0.0592
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.059 0.0744
Loa Loa (eye worm) MH2 domain-containing protein 0.013 0.3995 0.3995
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.043 0.043
Plasmodium vivax translation initiation factor 4E, putative 0.0029 0.0365 0.0177
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0044 0.0916 0.1016
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0111 0.3337 0.4002
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0138 0.4298 1
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0679 0.0828
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.949 0.9485
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0953 0.1062
Brugia malayi hypothetical protein 0.0028 0.0355 0.0355
Brugia malayi hypothetical protein 0.0075 0.2042 0.2042
Mycobacterium ulcerans aldehyde dehydrogenase 0.0247 0.82 0.82
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0075 0.2042 0.2405
Onchocerca volvulus 0.0233 0.7696 1
Leishmania major hypothetical protein, conserved 0.0029 0.0365 0.0445
Loa Loa (eye worm) hypothetical protein 0.0035 0.059 0.059
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.949 0.9485
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0247 0.82 1
Toxoplasma gondii aldehyde dehydrogenase 0.0247 0.82 1
Brugia malayi Thioredoxin reductase 0.0044 0.0916 0.0916
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0679 0.0679
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0365 0.0275
Loa Loa (eye worm) hypothetical protein 0.0035 0.059 0.059
Brugia malayi Pre-SET motif family protein 0.0029 0.0393 0.0393
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0393 0.0303
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.059 0.0614
Trichomonas vaginalis eukaryotic translation initiation factor 4E type, putative 0.0029 0.0365 0.0275
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0679 0.0624
Entamoeba histolytica eukaryotic initiation factor 4E, putative 0.0029 0.0365 0.029
Loa Loa (eye worm) transcription factor SMAD2 0.013 0.3995 0.3995
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0679 0.0592
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0029 0.0365 0.0275
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0092 0.0117
Leishmania major hypothetical protein, conserved 0.0028 0.0355 0.0433
Brugia malayi beta-lactamase family protein 0.0035 0.059 0.059
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0092 0.0117
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.949 0.9485
Schistosoma mansoni alpha glucosidase 0.0037 0.0679 0.0592
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0092 0.0092
Leishmania major trypanothione reductase 0.0044 0.0916 0.1117
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0953 0.1062
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0247 0.82 1
Schistosoma mansoni eukaryotic translation initiation factor 4e 0.024 0.7937 0.7918
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.059 0.059
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0679 0.0724
Trypanosoma brucei Eukaryotic translation initiation factor 4E-4 0.0029 0.0365 0.046
Brugia malayi glutathione reductase 0.0044 0.0916 0.0916
Mycobacterium tuberculosis Conserved protein 0.0035 0.059 0.0614
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-4 0.0029 0.0365 0.046
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0393 0.0371
Trypanosoma brucei Eukaryotic translation initiation factor 4E-2 0.0029 0.0365 0.046
Onchocerca volvulus 0.0035 0.059 0.0307
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0092 0.0092
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0393 0.0303
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0092 0.0113
Toxoplasma gondii ABC1 family protein 0.0035 0.059 0.03
Onchocerca volvulus 0.0029 0.0393 0.0038
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0365 0.0177
Loa Loa (eye worm) beta-lactamase 0.0035 0.059 0.059
Loa Loa (eye worm) glutathione reductase 0.0044 0.0916 0.0916
Plasmodium falciparum eukaryotic translation initiation factor 4E, putative 0.0029 0.0365 0.0177
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0029 0.0365 0.029
Brugia malayi eukaryotic translation initiation factor 4E-1 0.0029 0.0365 0.0365
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0953 0.0869
Loa Loa (eye worm) translation initiation factor 4E 0.024 0.7937 0.7937
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-1 0.024 0.7937 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0092 0.0117
Entamoeba histolytica hypothetical protein 0.0075 0.2042 0.2075
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.949 0.9485
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0679 0.0413
Trypanosoma brucei Eukaryotic translation initiation factor 4E-3 0.0029 0.0365 0.046
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0111 0.3337 0.7408
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0092 0.0117
Brugia malayi Pre-SET motif family protein 0.0205 0.6682 0.6682
Plasmodium falciparum thioredoxin reductase 0.0044 0.0916 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0679 0.0592
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0953 0.1062
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.024 0.7937 0.7918
Schistosoma mansoni hypothetical protein 0.0075 0.2042 0.1968
Trypanosoma cruzi eukaryotic translation initiation factor 4E (eIF4E) interacting protein, putative 0.0029 0.0365 0.046
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0953 0.1062
Loa Loa (eye worm) eukaryotic translation initiation factor 4E-1 0.0029 0.0365 0.0365
Loa Loa (eye worm) hypothetical protein 0.0029 0.0393 0.0393
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0092 0.0092
Brugia malayi Glycosyl hydrolases family 31 protein 0.0168 0.5375 0.5375
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0029 0.0365 0.0275
Giardia lamblia Fructose-bisphosphate aldolase 0.0283 0.949 1
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.059 0.0614
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0953 0.0869
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0393 0.0048
Mycobacterium tuberculosis Probable reductase 0.01 0.2936 0.3507
Echinococcus granulosus eukaryotic translation initiation factor 4E 0.024 0.7937 0.9676
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0247 0.82 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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