Detailed information for compound 539937

Basic information

Technical information
  • TDR Targets ID: 539937
  • Name: 3,6-bis(hydroxymethyl)-2-methyl-pyran-4-one
  • MW: 170.163 | Formula: C8H10O4
  • H donors: 2 H acceptors: 3 LogP: -0.7 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCc1cc(=O)c(c(o1)C)CO
  • InChi: 1S/C8H10O4/c1-5-7(4-10)8(11)2-6(3-9)12-5/h2,9-10H,3-4H2,1H3
  • InChiKey: FEEAMUNPZANTSE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3,6-bis(hydroxymethyl)-2-methyl-4-pyranone
  • 2-methyl-3,6-dimethylol-pyran-4-one
  • 3,6-bis(hydroxymethyl)-2-methylpyran-4-one
  • herierin III
  • 131123-56-3
  • 6-Methyl-2,5-dihydroxymethyl-gamma-pyranone III
  • 4H-Pyran-4-one, 3,6-bis(hydroxymethyl)-2-methyl-
  • 6-Methyl-2,5-dihydroxymethyl-gamma pyranone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0087 0.0145 0.0145
Schistosoma mansoni lozenge 0.0057 0.0064 0.0064
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.3789 1 1
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0116 0.0223 0.0223
Trypanosoma brucei DNA polymerase kappa, putative 0.014 0.0287 0.0234
Trypanosoma brucei DNA polymerase kappa, putative 0.014 0.0287 0.0234
Schistosoma mansoni terminal deoxycytidyl transferase 0.0087 0.0145 0.0145
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.0013 0.0013
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0085 0.0085
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0093 0.0038
Echinococcus granulosus polycomb protein SCMH1 0.0197 0.0438 0.0438
Schistosoma mansoni myelin transcription factor 1 myt1 0.0224 0.051 0.051
Chlamydia trachomatis replicative DNA helicase 0.042 0.1031 0.2449
Schistosoma mansoni caspase-3 (C14 family) 0.0053 0.0055 0.0055
Onchocerca volvulus 0.0148 0.0307 0.2253
Schistosoma mansoni sex comb on midleg homolog 0.0197 0.0438 0.0438
Leishmania major DNA polymerase eta, putative 0.0078 0.0121 0.0067
Schistosoma mansoni bromodomain containing protein 0.0066 0.0089 0.0089
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0085 0.0085
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0077 0.012 0.012
Trypanosoma brucei DNA polymerase kappa, putative 0.014 0.0287 0.0234
Echinococcus multilocularis L aminoadipate semialdehyde 0.009 0.0154 0.0154
Schistosoma mansoni caspase-7 (C14 family) 0.0053 0.0055 0.0055
Treponema pallidum octaprenyl-diphosphate synthase 0.139 0.3613 1
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0064 0.0083 0.0029
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0174 0.0376 0.0323
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0116 0.0223 0.0223
Loa Loa (eye worm) runx1 0.0057 0.0064 0.0064
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.014 0.0287 0.0234
Trypanosoma cruzi DNA polymerase eta, putative 0.0138 0.0281 0.0228
Schistosoma mansoni hypothetical protein 0.0365 0.0886 0.0886
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0099 0.0176 0.0176
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.1648 0.4301 0.427
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.0108 0.0054
Echinococcus multilocularis farnesyl pyrophosphate synthase 0.3789 1 1
Trypanosoma brucei unspecified product 0.006 0.0073 0.0019
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0053 0.0055 0.0055
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0085 0.0085
Echinococcus granulosus dna polymerase eta 0.0138 0.0281 0.0281
Brugia malayi Bromodomain containing protein 0.0078 0.0122 0.0122
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.1648 0.4301 0.4289
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0116 0.0223 0.0223
Loa Loa (eye worm) hypothetical protein 0.0116 0.0223 0.0223
Echinococcus granulosus prenyl decaprenyl diphosphate synthase 0.1179 0.3053 0.3053
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0099 0.0176 0.0176
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0224 0.051 0.051
Mycobacterium tuberculosis Probable multifunctional geranylgeranyl pyrophosphate synthetase IdsA1 (GGPP synthetase) (ggppsase) (geranylgeranyl diphosphate 0.1179 0.3053 0.295
Loa Loa (eye worm) hypothetical protein 0.008 0.0127 0.0127
Onchocerca volvulus 0.0197 0.0438 0.3426
Loa Loa (eye worm) carbonic anhydrase 3 0.0215 0.0485 0.0485
Loa Loa (eye worm) hypothetical protein 0.0074 0.011 0.011
Schistosoma mansoni carbonic anhydrase-related 0.0116 0.0223 0.0223
Loa Loa (eye worm) hypothetical protein 0.0053 0.0055 0.0055
Mycobacterium tuberculosis RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. 0.145 0.3774 0.3682
Echinococcus multilocularis dna polymerase eta 0.0138 0.0281 0.0281
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.0108 0.0054
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.1179 0.3053 0.682
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.0176 0.0176
Plasmodium falciparum carbonic anhydrase 0.0116 0.0223 0.0169
Echinococcus granulosus caspase 2 0.0053 0.0055 0.0055
Leishmania major polyprenyl synthase, putative 0.139 0.3613 0.3578
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0215 0.0485 0.0432
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0057 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0077 0.012 0.012
Echinococcus multilocularis muscleblind protein 1 0.0472 0.1169 0.1169
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0099 0.0176 0.0176
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.01 0.018 0.0127
Schistosoma mansoni hypothetical protein 0.007 0.0101 0.0101
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0085 0.0085
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0174 0.0376 0.0234
Schistosoma mansoni glutathione synthetase 0.1179 0.3053 0.3053
Plasmodium falciparum geranylgeranyl pyrophosphate synthase, putative 0.3789 1 1
Plasmodium vivax octaprenyl pyrophosphate synthase, putative 0.1648 0.4301 0.427
Treponema pallidum replicative DNA helicase (dnaB) 0.042 0.1031 0.2025
Loa Loa (eye worm) hypothetical protein 0.0174 0.0376 0.0376
Trypanosoma brucei phosphoglycerate kinase 0.0064 0.0083 0.0029
Trypanosoma brucei DNA polymerase IV, putative 0.0127 0.0252 0.0198
Mycobacterium tuberculosis Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase) 0.1179 0.3053 0.295
Echinococcus multilocularis carbonic anhydrase 0.0116 0.0223 0.0223
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.3789 1 1
Schistosoma mansoni hypothetical protein 0.0365 0.0886 0.0886
Trypanosoma cruzi polyprenyl synthase, putative 0.139 0.3613 0.3578
Mycobacterium ulcerans phosphoglycerate kinase 0.0174 0.0376 0.0092
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0215 0.0485 0.0485
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.01 0.018 0.0036
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0053 0.0055 0.0055
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0064 0.0083 0.0029
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0078 0.0121 0.0101
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0881 0.2259 0.2259
Plasmodium falciparum phosphoglycerate kinase 0.0174 0.0376 0.0323
Brugia malayi hypothetical protein 0.0148 0.0307 0.0307
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0174 0.0376 0.0323
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0215 0.0485 0.0432
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.006 0.0072 0.0072
Brugia malayi Phosphoglycerate kinase 0.0174 0.0376 0.0376
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0197 0.0438 0.3426
Schistosoma mansoni Replicative DNA helicase 0.042 0.1031 0.1031
Loa Loa (eye worm) hypothetical protein 0.0452 0.1117 0.1117
Mycobacterium tuberculosis Probable polyprenyl-diphosphate synthase GrcC1 (polyprenyl pyrophosphate synthetase) 0.0469 0.1161 0.1031
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0604 0.152 0.1473
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.078 0.199 0.199
Echinococcus multilocularis carbonic anhydrase 0.0116 0.0223 0.0223
Brugia malayi Polyprenyl synthetase family protein 0.1648 0.4301 0.4301
Mycobacterium tuberculosis Probable replicative DNA helicase DnaB 0.187 0.4892 0.4817
Loa Loa (eye worm) twinkle helicase 0.012 0.0233 0.0233
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0174 0.0376 0.0323
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0116 0.0223 0.0223
Mycobacterium ulcerans polyprenyl diphosphate synthetase, GrcC1 0.1648 0.4301 0.4133
Loa Loa (eye worm) hypothetical protein 0.009 0.0154 0.0154
Schistosoma mansoni phosphoglycerate kinase 0.0174 0.0376 0.0376
Echinococcus multilocularis prenyl (decaprenyl) diphosphate synthase 0.1179 0.3053 0.3053
Trypanosoma cruzi farnesyl pyrophosphate synthase 0.3789 1 1
Echinococcus multilocularis dna polymerase kappa 0.014 0.0287 0.0287
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.3789 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.014 0.0287 0.0234
Brugia malayi geranylgeranyl pyrophosphate synthetase 0.139 0.3613 0.3613
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.009 0.0154 0.0154
Loa Loa (eye worm) hypothetical protein 0.0043 0.0027 0.0027
Echinococcus multilocularis geminin 0.0365 0.0886 0.0886
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0053 0.0055 0.0034
Trichomonas vaginalis DNA polymerase eta, putative 0.014 0.0287 0.0234
Mycobacterium tuberculosis Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) 0.3789 1 1
Trypanosoma brucei phosphoglycerate kinase 0.0174 0.0376 0.0323
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.1648 0.4301 1
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0067 0.0093 0.0093
Schistosoma mansoni phosphoglycerate kinase 0.0174 0.0376 0.0376
Leishmania major DNA polymerase kappa, putative 0.01 0.018 0.0127
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0053 0.0055 0.0055
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.0101 0.0101
Plasmodium vivax phosphoglycerate kinase, putative 0.0174 0.0376 0.0323
Echinococcus multilocularis geranylgeranyl pyrophosphate synthase 0.139 0.3613 0.3613
Brugia malayi Calcitonin receptor-like protein seb-1 0.0103 0.0187 0.0187
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.3789 1 1
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0053 0.0055 0.0034
Onchocerca volvulus 0.0473 0.1173 1
Mycobacterium ulcerans hypothetical protein 0.0318 0.076 0.0487
Entamoeba histolytica deoxycytidyl transferase, putative 0.0087 0.0145 0.0125
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0093 0.0038
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0103 0.0189 0.0135
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0085 0.0139 0.0085
Echinococcus granulosus endonuclease exonuclease phosphatase 0.078 0.199 0.199
Trypanosoma brucei DNA polymerase eta, putative 0.0138 0.0281 0.0228
Loa Loa (eye worm) hypothetical protein 0.0472 0.1169 0.1169
Echinococcus granulosus decaprenyl diphosphate synthase subunit 1 0.1648 0.4301 0.4301
Echinococcus multilocularis caspase 2 0.0053 0.0055 0.0055
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0077 0.012 0.012
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0017 0.0017
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0286 0.0674 0.0623
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0077 0.012 0.012
Echinococcus granulosus muscleblind protein 0.0472 0.1169 0.1169
Loa Loa (eye worm) polyprenyl synthetase 0.1648 0.4301 0.4301
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0085 0.0085
Entamoeba histolytica phosphoglycerate kinase, putative 0.0174 0.0376 0.0673
Trypanosoma cruzi DNA polymerase kappa, putative 0.014 0.0287 0.0234
Echinococcus multilocularis phosphoglycerate kinase 1 0.0174 0.0376 0.0376
Brugia malayi ImpB/MucB/SamB family protein 0.0138 0.0281 0.0281
Loa Loa (eye worm) hypothetical protein 0.0116 0.0223 0.0223
Loa Loa (eye worm) geranylgeranyl pyrophosphate synthetase 0.139 0.3613 0.3613
Mycobacterium ulcerans glutaminase 0.0546 0.1367 0.1112
Schistosoma mansoni hypothetical protein 0.0116 0.0223 0.0223
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.0127 0.0073
Plasmodium vivax SET domain protein, putative 0.006 0.0072 0.0018
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0103 0.0187 0.0187
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0067 0.0093 0.0038
Brugia malayi RNA binding protein 0.0065 0.0085 0.0085
Leishmania major phosphoglycerate kinase C, glycosomal 0.0174 0.0376 0.0323
Schistosoma mansoni glutaminase 0.0546 0.1367 0.1367
Echinococcus granulosus caspase 8 0.0053 0.0055 0.0055
Plasmodium vivax geranylgeranyl pyrophosphate synthase 0.3789 1 1
Schistosoma mansoni caspase-7 (C14 family) 0.0053 0.0055 0.0055
Trichomonas vaginalis set domain proteins, putative 0.0473 0.1173 0.1125
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0224 0.051 0.051
Trypanosoma brucei DNA polymerase IV, putative 0.014 0.0287 0.0234
Echinococcus granulosus caspase 0.0053 0.0055 0.0055
Brugia malayi mbt repeat family protein 0.0197 0.0438 0.0438
Leishmania major carbonic anhydrase-like protein 0.0215 0.0485 0.0432
Trypanosoma brucei DNA polymerase kappa, putative 0.01 0.018 0.0127
Mycobacterium leprae PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC1 (POLYPRENYL PYROPHOSPHATE SYNTHETASE) 0.1648 0.4301 1
Entamoeba histolytica bifunctional short chain isoprenyl diphosphate synthase, putative 0.1179 0.3053 0.7034
Echinococcus granulosus dna polymerase kappa 0.014 0.0287 0.0287
Trypanosoma cruzi DNA polymerase kappa, putative 0.014 0.0287 0.0234
Brugia malayi Muscleblind-like protein 0.0472 0.1169 0.1169
Trypanosoma brucei DNA polymerase IV, putative 0.014 0.0287 0.0234
Brugia malayi polk-prov protein 0.008 0.0127 0.0127
Trypanosoma brucei DNA polymerase kappa, putative 0.014 0.0287 0.0234
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0174 0.0376 0.0356
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0286 0.0674 0.0623
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.0108 0.0054
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0099 0.0176 0.0176
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0085 0.0139 0.0085
Loa Loa (eye worm) glutaminase 0.0546 0.1367 0.1367
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0087 0.0145 0.0145
Loa Loa (eye worm) hypothetical protein 0.0103 0.0187 0.0187
Schistosoma mansoni carbonic anhydrase 0.0116 0.0223 0.0223
Echinococcus granulosus farnesyl pyrophosphate synthase 0.3789 1 1
Echinococcus granulosus SAM and MBT domain containing protein 0.0197 0.0438 0.0438
Trypanosoma brucei phosphoglycerate kinase, putative 0.0064 0.0083 0.0029
Trypanosoma cruzi polyprenyl synthase, putative 0.139 0.3613 0.3578
Onchocerca volvulus 0.006 0.0072 0.0157
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0099 0.0176 0.0176
Trypanosoma brucei solanesyl-diphosphate synthase, putative 0.1648 0.4301 0.427
Trichomonas vaginalis glutaminase, putative 0.0546 0.1367 0.132
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0197 0.0438 0.0438
Brugia malayi Phosphoglycerate kinase 0.0064 0.0083 0.0083
Schistosoma mansoni hypothetical protein 0.1202 0.3112 0.3112
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0085 0.0085
Echinococcus granulosus histone lysine methyltransferase setb 0.0077 0.012 0.012
Loa Loa (eye worm) glutaminase 2 0.0546 0.1367 0.1367
Wolbachia endosymbiont of Brugia malayi replicative DNA helicase 0.042 0.1031 0.167
Trypanosoma brucei carbonic anhydrase-like protein 0.0215 0.0485 0.0432
Trypanosoma brucei DNA polymerase kappa, putative 0.014 0.0287 0.0234
Trypanosoma cruzi DNA polymerase kappa, putative 0.014 0.0287 0.0234
Loa Loa (eye worm) mbt repeat family protein 0.0197 0.0438 0.0438
Echinococcus multilocularis caspase 0.0053 0.0055 0.0055
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.3789 1 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0087 0.0145 0.0145
Brugia malayi mbt repeat family protein 0.0197 0.0438 0.0438
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0224 0.051 0.051
Mycobacterium leprae Conserved hypothetical protein 0.055 0.1378 0.2554
Chlamydia trachomatis geranylgeranyl pyrophosphate synthase 0.1179 0.3053 1
Giardia lamblia Farnesyl diphosphate synthase 0.3789 1 1
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0215 0.0485 0.0485
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0017 0.0017
Leishmania major mitochondrial DNA polymerase beta 0.0604 0.152 0.1473
Trypanosoma brucei DNA polymerase kappa, putative 0.014 0.0287 0.0234
Brugia malayi ImpB/MucB/SamB family protein 0.0087 0.0145 0.0145
Schistosoma mansoni farnesyl pyrophosphate synthase 0.3789 1 1
Echinococcus granulosus carbonic anhydrase II 0.0215 0.0485 0.0485
Loa Loa (eye worm) hypothetical protein 0.0148 0.0307 0.0307
Loa Loa (eye worm) hypothetical protein 0.0224 0.051 0.051
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0103 0.0187 0.0187
Echinococcus multilocularis SAM and MBT domain containing protein 0.0197 0.0438 0.0438
Trypanosoma brucei phosphoglycerate kinase 0.0174 0.0376 0.0323
Echinococcus multilocularis Protein lozenge 0.0057 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0045 0.0032 0.0032
Toxoplasma gondii hypothetical protein 0.0097 0.0172 0.0152
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0062 0.0079 0.0079
Onchocerca volvulus 0.009 0.0154 0.0888
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0062 0.0079 0.0079
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0085 0.0139 0.0085
Leishmania major solanesyl-diphosphate synthase, putative 0.1648 0.4301 0.427
Loa Loa (eye worm) hypothetical protein 0.0452 0.1117 0.1117
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0053 0.0055 0.0055
Loa Loa (eye worm) RNA binding protein 0.0065 0.0085 0.0085
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0416 0.102 0.102
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0085 0.0085
Echinococcus multilocularis decaprenyl diphosphate synthase subunit 1 0.1648 0.4301 0.4301
Entamoeba histolytica geranylgeranyl pyrophosphate synthetase, putative 0.1648 0.4301 1
Loa Loa (eye worm) MBCTL1 0.0224 0.051 0.051
Echinococcus multilocularis muscleblind protein 0.0472 0.1169 0.1169
Echinococcus granulosus carbonic anhydrase 0.0116 0.0223 0.0223
Echinococcus granulosus geranylgeranyl pyrophosphate synthase 0.139 0.3613 0.3613
Leishmania major phosphoglycerate kinase B, cytosolic 0.0174 0.0376 0.0323
Trypanosoma cruzi farnesyl pyrophosphate synthase, putative 0.3789 1 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0078 0.0121 0.0067
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0085 0.0139 0.0085
Trypanosoma brucei DNA polymerase kappa, putative 0.014 0.0287 0.0234
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0067 0.0093 0.0093
Schistosoma mansoni DNA polymerase eta 0.0138 0.0281 0.0281
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0286 0.0674 0.0623
Onchocerca volvulus 0.0452 0.1117 0.9495
Brugia malayi TAR-binding protein 0.0065 0.0085 0.0085
Trypanosoma brucei farnesyl pyrophosphate synthase 0.3789 1 1
Echinococcus multilocularis carbonic anhydrase II 0.0215 0.0485 0.0485
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.0127 0.0073
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.009 0.0154 0.0154
Loa Loa (eye worm) hypothetical protein 0.0197 0.0438 0.0438
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.0176 0.0176
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0215 0.0485 0.0485
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0604 0.152 0.1473
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0215 0.0485 0.0485
Echinococcus granulosus phosphoglycerate kinase 1 0.0174 0.0376 0.0376
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0064 0.0083 0.0029
Leishmania major DNA polymerase eta, putative 0.0138 0.0281 0.0228
Schistosoma mansoni carbonic anhydrase-related 0.0116 0.0223 0.0223
Loa Loa (eye worm) hypothetical protein 0.0116 0.0223 0.0223
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0174 0.0376 0.0356
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0064 0.0083 0.0029
Loa Loa (eye worm) hypothetical protein 0.007 0.0101 0.0101
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0116 0.0223 0.0223
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0067 0.0093 0.0093
Loa Loa (eye worm) polyprenyl synthetase 0.3789 1 1
Echinococcus multilocularis caspase 8 0.0053 0.0055 0.0055
Echinococcus granulosus carbonic anhydrase 0.0116 0.0223 0.0223
Echinococcus granulosus histone acetyltransferase MYST2 0.0224 0.051 0.051
Trypanosoma cruzi DNA polymerase kappa, putative 0.014 0.0287 0.0234
Schistosoma mansoni geranylgeranyl pyrophosphate synthase 0.139 0.3613 0.3613
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0215 0.0485 0.0485
Giardia lamblia Phosphoglycerate kinase 0.0174 0.0376 0.0199
Echinococcus granulosus L aminoadipate semialdehyde 0.009 0.0154 0.0154
Brugia malayi Bromodomain containing protein 0.004 0.002 0.002
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.0176 0.0176
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0116 0.0223 0.0223
Loa Loa (eye worm) hypothetical protein 0.0053 0.0055 0.0055
Brugia malayi hypothetical protein 0.0452 0.1117 0.1117
Brugia malayi Pre-SET motif family protein 0.0416 0.102 0.102
Schistosoma mansoni trans-prenyltransferase 0.1648 0.4301 0.4301
Brugia malayi Cell death protein 3 precursor 0.0053 0.0055 0.0055
Plasmodium falciparum octaprenyl pyrophosphate synthase 0.1648 0.4301 0.427
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0093 0.0038
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0174 0.0376 0.0323
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0064 0.0083 0.0029
Echinococcus granulosus carbonic anhydrase 0.0116 0.0223 0.0223
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0087 0.0145 0.0145
Mycobacterium tuberculosis Conserved hypothetical protein 0.0318 0.076 0.0623
Brugia malayi Pre-SET motif family protein 0.006 0.0072 0.0072
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0067 0.0093 0.0093
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0604 0.152 0.1473
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.1648 0.4301 0.427
Loa Loa (eye worm) hypothetical protein 0.0472 0.1169 0.1169
Toxoplasma gondii hypothetical protein 0.0116 0.0223 0.0203
Mycobacterium ulcerans polyprenyl synthetase IdsB 0.1179 0.3053 0.2848
Echinococcus multilocularis histone acetyltransferase MYST2 0.0224 0.051 0.051
Echinococcus multilocularis polycomb protein SCMH1 0.0197 0.0438 0.0438
Mycobacterium leprae PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase 0.042 0.1031 0.167
Leishmania major farnesyl pyrophosphate synthase 0.3789 1 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.006 0.0072 0.0052
Trypanosoma brucei unspecified product 0.006 0.0073 0.0019
Trypanosoma brucei unspecified product 0.0127 0.0252 0.0198
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0072 0.0072
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0053 0.0055 0.0034
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.0013 0.0013
Schistosoma mansoni sex comb on midleg homolog 0.0197 0.0438 0.0438
Echinococcus granulosus geminin 0.0365 0.0886 0.0886
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0085 0.0085
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.006 0.0072 0.0072
Trypanosoma brucei DNA polymerase kappa, putative 0.014 0.0287 0.0234
Trichomonas vaginalis geranylgeranyl diphosphate synthase, putative 0.3789 1 1
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0085 0.0085
Entamoeba histolytica geranylgeranyl pyrophosphate synthase, putative 0.1648 0.4301 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0099 0.0176 0.0176
Brugia malayi glutaminase DH11.1 0.0546 0.1367 0.1367
Trypanosoma cruzi solanesyl-diphosphate synthase 0.1648 0.4301 0.427
Schistosoma mansoni carbonic anhydrase-related 0.0116 0.0223 0.0223
Echinococcus granulosus tar DNA binding protein 0.0065 0.0085 0.0085
Mycobacterium ulcerans replicative DNA helicase DnaB 0.042 0.1031 0.0766
Loa Loa (eye worm) hypothetical protein 0.0138 0.0281 0.0281
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0064 0.0083 0.0029
Echinococcus multilocularis carbonic anhydrase 0.0116 0.0223 0.0223
Loa Loa (eye worm) hypothetical protein 0.004 0.002 0.002
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0067 0.0093 0.0093
Mycobacterium tuberculosis Possible polyprenyl synthetase IdsB (polyprenyl transferase) (polyprenyl diphosphate synthase) 0.1179 0.3053 0.295

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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