Detailed information for compound 549373
Basic information
Technical information
- TDR Targets ID: 549373
- Name: (2S,3S,4R,5S)-2-(6-amino-2-methyl-purin-9-yl) -5-(hydroxymethyl)tetrahydrofuran-3,4-diol
- MW: 281.268 | Formula: C11H15N5O4
-
H donors: 4
H acceptors: 6
LogP: -1.5
Rotable bonds: 2
Rule of 5 violations (Lipinski): 1 - SMILES: OC[C@@H]1O[C@@H]([C@H]([C@H]1O)O)n1cnc2c1nc(C)nc2N
- InChi: 1S/C11H15N5O4/c1-4-14-9(12)6-10(15-4)16(3-13-6)11-8(19)7(18)5(2-17)20-11/h3,5,7-8,11,17-19H,2H2,1H3,(H2,12,14,15)/t5-,7-,8-,11-/m0/s1
- InChiKey: IQZWKGWOBPJWMX-RYVZHVEOSA-N
Network
Hover on a compound node to display the structore
Synonyms
- (2S,3S,4R,5S)-2-(6-amino-2-methyl-9-purinyl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
- (2S,3S,4R,5S)-2-(6-azanyl-2-methyl-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
- (2S,3S,4R,5S)-2-(6-amino-2-methyl-purin-9-yl)-5-methylol-tetrahydrofuran-3,4-diol
- (2S,3S,4R,5S)-2-(6-amino-2-methylpurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
- 2-methyladenosine
- (2S,3S,4R,5S)-2-(6-amino-2-methyl-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
- Adenosine, 2-methyl- (8CI)(9CI)
- NSC 93499
Targets
Known targets for this compound
| Species | Target name | Source | Bibliographic reference |
|---|---|---|---|
| Leishmania major | glyceraldehyde 3-phosphate dehydrogenase, glycosomal | Curated by TDR Targets | References |
| Leishmania major | glyceraldehyde 3-phosphate dehydrogenase, glycosomal | Curated by TDR Targets | References |
Predicted pathogen targets for this compound
By orthology
By sequence similarity to non orthologous known druggable targets
| Species | Potential target | Known druggable target | Length | Alignment span | Identity |
|---|---|---|---|---|---|
| Giardia lamblia | Glyceraldehyde 3-phosphate dehydrogenase | glyceraldehyde 3-phosphate dehydrogenase, glycosomal | 361 aa | 371 aa | 39.6 % |
| Giardia lamblia | Glyceraldehyde 3-phosphate dehydrogenase | glyceraldehyde 3-phosphate dehydrogenase, glycosomal | 361 aa | 371 aa | 39.6 % |
Obtained from network model
Ranking Plot
Putative Targets List
Activities
No activities found for this compound.
Phenotypes
Whole-cell/tissue/organism interactions
We have no records of whole-cell/tissue assays done with this compound
What does this mean?
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
Annotated phenotypes:
| Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Targets |
|---|---|---|---|---|---|---|
| catalytic activity (GO:0003824) | decreased (PATO:0000468) | in vitro (MI:0492) | inferred from in-silico analysis (ECO:0000043) | Leishmania mexicana | 28592 | |
| Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 73340-78-0P; Drug: 158555-06-7; Drug: 158555-07-8; Drug: 158555-08-9; Drug: 158555-09-0. chemical inhibition with designed inhibitors leads to reduced enzyme activity in vitro; | References: | 7932587 | |
| catalytic activity (GO:0003824) | decreased (PATO:0000468) | in vitro (MI:0492) | inferred from in-silico analysis (ECO:0000043) | Leishmania mexicana | 26942 | |
| Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 73340-78-0P; Drug: 158555-06-7; Drug: 158555-07-8; Drug: 158555-08-9; Drug: 158555-09-0. chemical inhibition with designed inhibitors leads to reduced enzyme activity in vitro; | References: | 7932587 | |
| catalytic activity (GO:0003824) | decreased (PATO:0000468) | in vitro (MI:0492) | inferred from specific protein inhibition (ECO:0000020) | Leishmania mexicana | 28592 | |
| Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 73340-78-0P; Drug: 158555-06-7; Drug: 158555-07-8; Drug: 158555-08-9; Drug: 158555-09-0. chemical inhibition with designed inhibitors leads to reduced enzyme activity in vitro; | References: | 7932587 | |
| catalytic activity (GO:0003824) | decreased (PATO:0000468) | in vitro (MI:0492) | inferred from specific protein inhibition (ECO:0000020) | Leishmania mexicana | 26942 | |
| Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 73340-78-0P; Drug: 158555-06-7; Drug: 158555-07-8; Drug: 158555-08-9; Drug: 158555-09-0. chemical inhibition with designed inhibitors leads to reduced enzyme activity in vitro; | References: | 7932587 | |
In TDR Targets, information about phenotypes that are caused by
drugs, or by genetic manipulation of cells (e.g. gene knockouts or
knockdowns) is manually curated from the literature. These
descriptions help to describe the potential of the target for drug
development. If no information is available for this gene or if the
information is incomplete, this may mean that i) the papers
containing this information either appeared after the curation
effort for this organism was carried out or they were inadvertently
missed by curators; or that ii) the curation effort for this
organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.
Bibliographic References
5 literature references were collected for this gene.
If you have references for this compound, please enter them in a user comment (below) or Contact us.