Detailed information for compound 555404

Basic information

Technical information
  • TDR Targets ID: 555404
  • Name: Dihydroergocryptine
  • MW: 577.714 | Formula: C32H43N5O5
  • H donors: 3 H acceptors: 4 LogP: 3.07 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 2
  • SMILES: CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C
  • InChi: 1S/C32H43N5O5/c1-17(2)12-25-29(39)36-11-7-10-26(36)32(41)37(25)30(40)31(42-32,18(3)4)34-28(38)20-13-22-21-8-6-9-23-27(21)19(15-33-23)14-24(22)35(5)16-20/h6,8-9,15,17-18,20,22,24-26,33,41H,7,10-14,16H2,1-5H3,(H,34,38)/t20-,22-,24-,25+,26+,31-,32+/m1/s1
  • InChiKey: PBUNVLRHZGSROC-VTIMJTGVSA-N  

Network

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Synonyms

  • 25447-66-9
  • 12'-Hydroxy-2'-(1-methylethyl)-5'alpha-(2-methylpropyl)-9,10alpha-dihydroergotaman-3',6',18-trione
  • Dihydroergokryptine
  • EINECS 246-993-6
  • Ergotaman-3',6',18-trione, 9,10-dihydro-12'-hydroxy-2'-(1-methylethyl)-5'-(2-methylpropyl)-, (5'alpha,10alpha)-
  • PDSP2_001088

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATP-binding cassette, sub-family B (MDR/TAP), member 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Candida albicans potential ABC transporter similar to S. cerevisiae STE6 (YKL209C) involved in peptide pheromone export Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-1 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 Get druggable targets OG5_126596 All targets in OG5_126596
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium falciparum multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Chlamydia trachomatis ABC transporter ATP binding protein/permease Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis taga, putative Get druggable targets OG5_126596 All targets in OG5_126596
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Cryptosporidium parvum ATP-binding cassette transporter Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Onchocerca volvulus Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum ATP-binding cassette sub-family B member 5, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania mexicana p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Neospora caninum ATP-binding cassette, sub-family B (MDR/TAP), member 4, related Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum ko:K05659 ATP-binding cassette, subfamily B (MDR/TAP), member 4, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-2 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 3, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Cryptosporidium hominis ATP-binding cassette protein 3 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Brugia malayi multidrug resistance protein 3 Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) multidrug resistance protein 3 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis abcb9, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania donovani ATP-binding cassette protein subfamily B, member 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Neospora caninum hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 3, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein 5, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni smdr2 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania major p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania mexicana p-glycoprotein-like protein,ABC transporter-like protein,multidrug resistance protein-like protein Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania infantum ATP-binding cassette protein subfamily B, member 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania braziliensis p-glycoprotein-like protein,ABC transporter-like protein,multidrug resistance protein-like protein Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium knowlesi multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-5 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette sub family B Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium vivax multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Brugia malayi ABC transporter family protein Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium berghei multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania donovani p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Bile salt export pump, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, half transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, half transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis abcb9, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-2 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis abcb9, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus 5'partial|ATP binding cassette sub family B Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glyco protein 6, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium yoelii multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania infantum p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596

By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0216 0.0905
Schistosoma mansoni thyroid hormone receptor 0.002 0.0069 0.0069
Echinococcus granulosus GTP binding nuclear protein Ran 0.0045 0.0252 0.0252
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0069 0.0069
Trypanosoma brucei NADPH-dependent diflavin oxidoreductase 1 0.003 0.0144 0.0592
Echinococcus granulosus tumor protein p63 0.0373 0.2676 0.2676
Echinococcus granulosus lactate dehydrogenase a 0.0833 0.6076 0.6076
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0064 0.0197
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.0017 0.0017
Loa Loa (eye worm) flavodoxin family protein 0.0011 0.0007 0.0012
Mycobacterium ulcerans putative regulatory protein 0.0023 0.0091 0.0314
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0216 0.0355
Echinococcus granulosus thioredoxin glutathione reductase 0.0142 0.0971 0.0971
Loa Loa (eye worm) hypothetical protein 0.0236 0.1665 0.274
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.0017 0.0017
Echinococcus granulosus malate dehydrogenase 0.0324 0.2315 0.2315
Schistosoma mansoni malate dehydrogenase 0.0324 0.2315 0.2315
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0045 0.0252 0.0415
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0236 0.1665 0.1665
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0013 0.0019 0.0019
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0063 0.0392 0.0392
Treponema pallidum thioredoxin reductase (trxB) 0.0013 0.0019 0.0051
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0069 0.0069
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0091 0.0362
Entamoeba histolytica malate dehydrogenase, putative 0.0324 0.2315 0.3802
Brugia malayi multidrug resistance protein 3 0.0013 0.0017 0.0027
Echinococcus multilocularis lactate dehydrogenase a 0.0833 0.6076 0.6076
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0049 0.0285 0.1203
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0064 0.0246
Plasmodium falciparum thioredoxin reductase 0.0141 0.0968 0.1582
Loa Loa (eye worm) thioredoxin reductase 0.0141 0.0968 0.1592
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0236 0.1665 0.1665
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.0017 0.0017
Mycobacterium ulcerans glutaminase 0.0272 0.1933 0.834
Loa Loa (eye worm) hypothetical protein 0.002 0.0069 0.0114
Loa Loa (eye worm) TAR-binding protein 0.0062 0.038 0.0625
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0013 0.0017 0.0041
Treponema pallidum fructose-bisphosphate aldolase 0.0318 0.227 1
Leishmania major hypothetical protein, conserved 0.0013 0.0019 0.0019
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0071 0.0451 0.1922
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.018 0.018
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0049 0.0285 0.1159
Schistosoma mansoni thyroid hormone receptor 0.002 0.0069 0.0069
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0023 0.0091 0.0314
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0017 0.0041
Schistosoma mansoni cercarial elastase (S01 family) 0.0236 0.1665 0.1665
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0013 0.0019 0.005
Schistosoma mansoni hypothetical protein 0.0187 0.1303 0.1303
Echinococcus multilocularis jumonji domain containing 1A 0.0017 0.0048 0.0048
Mycobacterium ulcerans formate dehydrogenase H FdhF 0.003 0.0144 0.0545
Mycobacterium ulcerans lipase LipD 0.004 0.0216 0.0859
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0069 0.0069
Echinococcus multilocularis L lactate dehydrogenase 0.0509 0.3684 0.3684
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0064 0.0093
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0071 0.0451 0.1922
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0045 0.0252 0.1063
Loa Loa (eye worm) hypothetical protein 0.0063 0.0392 0.0644
Brugia malayi flavodoxin family protein 0.0011 0.0007 0.0012
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0013 0.0017 0.0041
Brugia malayi FAD binding domain containing protein 0.0018 0.0059 0.0097
Leishmania major p450 reductase, putative 0.003 0.0144 0.0225
Echinococcus multilocularis importin 5 0.0011 0.0007 0.0007
Echinococcus granulosus muscleblind protein 0.0451 0.3257 0.3257
Loa Loa (eye worm) hypothetical protein 0.002 0.0069 0.0114
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0236 0.1665 0.1665
Echinococcus granulosus dnaJ subfamily B 0.0431 0.3108 0.3108
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0069 0.0114
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0451 0.1922
Echinococcus granulosus lactate dehydrogenase a 0.0833 0.6076 0.6076
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0064 0.0251
Trichomonas vaginalis ABC transporter, putative 0.0013 0.0017 0.0041
Trypanosoma cruzi NADPH-dependent FMN/FAD containing oxidoreductase, putative 0.003 0.0144 0.0592
Echinococcus multilocularis lactate dehydrogenase protein 0.0833 0.6076 0.6076
Loa Loa (eye worm) hypothetical protein 0.004 0.0216 0.0355
Trypanosoma brucei trypanothione reductase 0.0141 0.0968 0.4162
Loa Loa (eye worm) hypothetical protein 0.0236 0.1665 0.274
Trypanosoma brucei malate dehydrogenase-related 0.0324 0.2315 1
Trichomonas vaginalis ABC transporter, putative 0.0013 0.0017 0.0041
Loa Loa (eye worm) hypothetical protein 0.0032 0.0156 0.0256
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0013 0.0019 0.0008
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0071 0.0451 0.1922
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0069 0.0114
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0069 0.0069
Schistosoma mansoni cercarial elastase (S01 family) 0.0236 0.1665 0.1665
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0013 0.0019 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0069 0.0114
Plasmodium falciparum importin beta, putative 0.0061 0.0371 0.0599
Schistosoma mansoni microtubule-associated protein tau 0.1363 1 1
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0045 0.0252 0.1063
Brugia malayi nuclear hormone receptor 0.002 0.0069 0.0114
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0397 0.0397
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0216 0.0905
Plasmodium vivax JmjC domain containing protein 0.0017 0.0048 0.0068
Schistosoma mansoni coup transcription factor 0.002 0.0069 0.0069
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0049 0.0285 0.0439
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0013 0.0017 0.0041
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0071 0.0451 0.1922
Plasmodium vivax glutathione reductase, putative 0.0141 0.0968 0.1582
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0071 0.0451 0.1922
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0049 0.0285 0.0285
Echinococcus granulosus JmjC domain containing protein 4 0.0017 0.0048 0.0048
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0069 0.0114
Echinococcus granulosus GPCR family 2 0.0063 0.0392 0.0392
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0045 0.0252 0.1063
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0013 0.0017 0.0041
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.0017 0.0017
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0013 0.0017 0.0017
Schistosoma mansoni disulfide oxidoreductase 0.0013 0.0019 0.0019
Onchocerca volvulus 0.0236 0.1665 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0216 0.0216
Loa Loa (eye worm) hypothetical protein 0.002 0.0069 0.0114
Leishmania major hypothetical protein, conserved 0.0017 0.0048 0.0068
Trypanosoma cruzi cytosolic malate dehydrogenase, putative 0.0324 0.2315 1
Brugia malayi glutaminase DH11.1 0.0272 0.1933 0.3182
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.038 0.0625
Echinococcus multilocularis lysine specific demethylase 5A 0.0064 0.0395 0.0395
Schistosoma mansoni L-lactate dehydrogenase 0.0324 0.2315 0.2315
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0069 0.0114
Trichomonas vaginalis malate dehydrogenase, putative 0.0324 0.2315 1
Brugia malayi kap beta 3 protein 0.0011 0.0007 0.0012
Loa Loa (eye worm) glutathione reductase 0.0141 0.0968 0.1592
Plasmodium vivax hypothetical protein, conserved 0.004 0.0216 0.0344
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0045 0.0252 0.0404
Leishmania major NADH dehydrogenase, putative 0.0013 0.0019 0.0019
Schistosoma mansoni jumonji/arid domain-containing protein 0.0066 0.0408 0.0408
Schistosoma mansoni hypothetical protein 0.0648 0.4708 0.4708
Echinococcus granulosus glycoprotein Antigen 5 0.0236 0.1665 0.1665
Echinococcus multilocularis lactate dehydrogenase a 0.0833 0.6076 0.6076
Brugia malayi nuclear receptor NHR-88 0.002 0.0069 0.0114
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0069 0.0114
Plasmodium falciparum L-lactate dehydrogenase 0.0833 0.6076 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0201 0.1405 0.2312
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0318 0.227 0.9808
Entamoeba histolytica disulphide oxidoreductase, putative 0.0013 0.0019 0.0019
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0069 0.0069
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0386 0.1641
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0013 0.0019 0.005
Echinococcus multilocularis cytosolic malate dehydrogenase 0.0324 0.2315 0.2315
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0013 0.0017 0.0041
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0071 0.0451 0.1922
Echinococcus granulosus lactate dehydrogenase protein 0.0833 0.6076 0.6076
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0071 0.0451 0.1922
Trypanosoma cruzi importin beta-1 subunit, putative 0.0049 0.0286 0.1209
Schistosoma mansoni tar DNA-binding protein 0.0062 0.038 0.038
Brugia malayi Trypsin family protein 0.0236 0.1665 0.274
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0049 0.0285 0.1203
Echinococcus multilocularis multidrug resistance protein 1 0.0013 0.0017 0.0017
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0064 0.0105
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0017 0.0041
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0069 0.0114
Schistosoma mansoni cercarial elastase (S01 family) 0.0236 0.1665 0.1665
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0013 0.0019 0.0019
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.0216 0.078
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.0216 0.078
Onchocerca volvulus 0.0236 0.1665 1
Toxoplasma gondii GAF domain-containing protein 0.0023 0.0091 0.0138
Trichomonas vaginalis abcb9, putative 0.0013 0.0017 0.0041
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0071 0.0451 0.1922
Loa Loa (eye worm) beta-lactamase 0.004 0.0216 0.0355
Loa Loa (eye worm) kap beta 3 protein 0.0011 0.0007 0.0012
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0064 0.0246
Echinococcus multilocularis glutamate synthase 0.0013 0.0019 0.0019
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0049 0.0285 0.0457
Treponema pallidum NADH oxidase 0.0049 0.0285 0.1226
Echinococcus granulosus importin subunit beta 1 0.0061 0.0371 0.0371
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0049 0.0285 0.0457
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0071 0.0451 0.1922
Schistosoma mansoni cercarial elastase (S01 family) 0.0236 0.1665 0.1665
Onchocerca volvulus 0.0236 0.1665 1
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0013 0.0019 0.005
Giardia lamblia NADH oxidase lateral transfer candidate 0.0049 0.0285 0.1159
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0648 0.4708 0.7749
Loa Loa (eye worm) hypothetical protein 0.0017 0.0048 0.008
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0049 0.0286 0.1209
Leishmania major malate dehydrogenase 0.0324 0.2315 0.3802
Schistosoma mansoni multidrug resistance protein 0.0013 0.0017 0.0017
Loa Loa (eye worm) jmjC domain-containing protein 0.0066 0.0408 0.0671
Trypanosoma brucei glycosomal malate dehydrogenase 0.0324 0.2315 1
Trichomonas vaginalis malate dehydrogenase, putative 0.0324 0.2315 1
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0032 0.0156 0.0256
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0071 0.0451 0.0451
Echinococcus multilocularis NADPH dependent diflavin oxidoreductase 1 0.003 0.0144 0.0144
Brugia malayi beta-lactamase family protein 0.004 0.0216 0.0355
Toxoplasma gondii flavodoxin domain-containing protein 0.0015 0.0032 0.0041
Entamoeba histolytica P-glyco protein 6, putative 0.0013 0.0017 0.0016
Echinococcus multilocularis enteropeptidase 0.0236 0.1665 0.1665
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0069 0.0069
Entamoeba histolytica P-glycoprotein-1 0.0013 0.0017 0.0016
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0236 0.1665 0.1665
Toxoplasma gondii malate dehydrogenase MDH 0.0833 0.6076 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0069 0.0114
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.003 0.0144 0.0592
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0236 0.1665 0.1665
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0318 0.227 0.9808
Trichomonas vaginalis ABC transporter, putative 0.0013 0.0017 0.0041
Mycobacterium tuberculosis Probable hydrolase 0.004 0.0216 0.078
Mycobacterium tuberculosis Probable malate dehydrogenase Mdh 0.0324 0.2315 0.8992
Echinococcus granulosus malate dehydrogenase 0.0324 0.2315 0.2315
Mycobacterium tuberculosis Probable reductase 0.0323 0.2306 0.8959
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0064 0.0246
Brugia malayi lactate dehydrogenase. 0.0833 0.6076 1
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0013 0.0019 0.0019
Trichomonas vaginalis ABC transporter, putative 0.0013 0.0017 0.0041
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0048 0.008
Toxoplasma gondii lactate dehydrogenase LDH1 0.0833 0.6076 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0323 0.2306 0.8959
Loa Loa (eye worm) RNA binding protein 0.0062 0.038 0.0625
Schistosoma mansoni glutamate synthase 0.0013 0.0019 0.0019
Brugia malayi jmjC domain containing protein 0.0017 0.0048 0.008
Plasmodium vivax flavodoxin domain containing protein 0.0027 0.0119 0.0184
Trichomonas vaginalis hypothetical protein 0.0011 0.0007 0.0001
Mycobacterium tuberculosis Conserved protein 0.004 0.0216 0.078
Trichomonas vaginalis ran, putative 0.0045 0.0252 0.1063
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0236 0.1665 0.274
Plasmodium falciparum nitric oxide synthase, putative 0.003 0.0144 0.0225
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0091 0.0138
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0013 0.0016 0.0016
Leishmania major glycosomal malate dehydrogenase 0.0324 0.2315 0.3802
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0013 0.0019 0.005
Echinococcus granulosus geminin 0.0187 0.1303 0.1303
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0063 0.0392 0.0392
Giardia lamblia Nitric oxide synthase, inducible 0.0027 0.0119 0.0435
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0069 0.0069
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0049 0.0285 0.1203
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0013 0.0019 0.005
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.003 0.0144 0.0592
Brugia malayi Latrophilin receptor protein 2 0.0063 0.0392 0.0644
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0013 0.0019 0.0008
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0049 0.0285 0.1166
Giardia lamblia Malate dehydrogenase 0.0324 0.2315 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0064 0.0246
Brugia malayi beta-lactamase 0.004 0.0216 0.0355
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.0017 0.0041
Brugia malayi jmjC domain containing protein 0.0017 0.0048 0.008
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0049 0.0285 0.0285
Trichomonas vaginalis malate dehydrogenase, putative 0.0324 0.2315 1
Trichomonas vaginalis esterase, putative 0.004 0.0216 0.0905
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0049 0.0285 0.1203
Schistosoma mansoni importin-beta 2 0.0011 0.0007 0.0007
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0013 0.0019 0.0031
Trichomonas vaginalis glutaminase, putative 0.0272 0.1933 0.8348
Brugia malayi jmjC domain containing protein 0.0017 0.0048 0.008
Plasmodium falciparum glutathione reductase 0.0049 0.0285 0.0457
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0069 0.0114
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0017 0.0048 0.0179
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0071 0.0451 0.1922
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0324 0.2315 1
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0013 0.0019 0.0019
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0013 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.002 0.0069 0.0114
Echinococcus granulosus cpg binding protein 0.0032 0.0159 0.0159
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0069 0.0114
Schistosoma mansoni malate dehydrogenase 0.0324 0.2315 0.2315
Trypanosoma cruzi glycosomal malate dehydrogenase, putative 0.0324 0.2315 1
Brugia malayi Malate dehydrogenase, cytoplasmic 0.0324 0.2315 0.3809
Echinococcus multilocularis transportin 1 0.0011 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0017 0.0048 0.008
Loa Loa (eye worm) multidrug resistance protein 3 0.0013 0.0017 0.0027
Schistosoma mansoni sulfide quinone reductase 0.0013 0.0019 0.0019
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0071 0.0451 0.1922
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0236 0.1665 0.1665
Loa Loa (eye worm) hypothetical protein 0.0013 0.0016 0.0026
Toxoplasma gondii hypothetical protein 0.0023 0.0091 0.0138
Plasmodium falciparum multidrug resistance protein 1 0.0013 0.0017 0.0016
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0069 0.0114
Schistosoma mansoni ap endonuclease 0.0019 0.0064 0.0064
Schistosoma mansoni cercarial elastase (S01 family) 0.0236 0.1665 0.1665
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0069 0.0114
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0146 0.0241
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0323 0.2306 0.8959
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0013 0.0019 0.0008
Echinococcus multilocularis ATP binding cassette sub family B 0.0013 0.0016 0.0016
Brugia malayi hypothetical protein 0.0236 0.1665 0.274
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0216 0.0905
Loa Loa (eye worm) trypsin family protein 0.0236 0.1665 0.274
Loa Loa (eye worm) malate dehydrogenase 0.0324 0.2315 0.3809
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0013 0.0019 0.0019
Echinococcus multilocularis translational activator gcn1 0.0011 0.0007 0.0007
Schistosoma mansoni cytochrome P450 reductase 0.003 0.0144 0.0144
Entamoeba histolytica P-glycoprotein-2 0.0013 0.0017 0.0016
Echinococcus multilocularis thioredoxin glutathione reductase 0.0142 0.0971 0.0971
Loa Loa (eye worm) hypothetical protein 0.002 0.0069 0.0114
Brugia malayi jmjC domain containing protein 0.0017 0.0048 0.008
Schistosoma mansoni multidrug resistance protein 0.0013 0.0017 0.0017
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0064 0.0105
Mycobacterium tuberculosis Probable oxidoreductase 0.0359 0.2572 1
Chlamydia trachomatis malate dehydrogenase 0.0324 0.2315 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0071 0.0451 0.1922
Leishmania major p-glycoprotein 0.0013 0.0017 0.0016
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0013 0.0017 0.0015
Schistosoma mansoni glutamate synthase 0.0013 0.0019 0.0019
Echinococcus granulosus transportin 1 0.0011 0.0007 0.0007
Echinococcus granulosus methionine synthase reductase 0.0018 0.0059 0.0059
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0049 0.0285 0.1203
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.0216 0.078
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0318 0.227 0.9808
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0064 0.0064
Echinococcus multilocularis lactate dehydrogenase a 0.0833 0.6076 0.6076
Toxoplasma gondii lactate dehydrogenase LDH2 0.0833 0.6076 1
Trichomonas vaginalis malate dehydrogenase, putative 0.0324 0.2315 1
Echinococcus multilocularis muscleblind protein 1 0.0451 0.3257 0.3257
Loa Loa (eye worm) hypothetical protein 0.0236 0.1665 0.274
Leishmania major malate dehydrogenase, putative 0.0324 0.2315 0.3802
Schistosoma mansoni cercarial elastase (S01 family) 0.0236 0.1665 0.1665
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0318 0.227 0.9808
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0071 0.0451 0.1922
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0049 0.0285 0.1049
Entamoeba histolytica hypothetical protein 0.0035 0.018 0.0285
Schistosoma mansoni hypothetical protein 0.0236 0.1665 0.1665
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0049 0.0285 0.1159
Loa Loa (eye worm) malate dehydrogenase 0.0324 0.2315 0.3809
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0071 0.0451 0.1922
Mycobacterium leprae PROBABLE MALATE DEHYDROGENASE MDH 0.0324 0.2315 0.8991
Schistosoma mansoni jumonji domain containing protein 0.0064 0.0395 0.0395
Entamoeba histolytica hypothetical protein 0.0035 0.018 0.0285
Loa Loa (eye worm) hypothetical protein 0.0201 0.1405 0.2312
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0013 0.0019 0.0019
Schistosoma mansoni hypothetical protein 0.0236 0.1665 0.1665
Brugia malayi glutathione reductase 0.0141 0.0968 0.1592
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0013 0.0019 0.0019
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0013 0.0019 0.0019
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0013 0.0019 0.005
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0023 0.0091 0.029
Onchocerca volvulus 0.004 0.0216 0.1209
Entamoeba histolytica P-glycoprotein-5 0.0013 0.0017 0.0016
Loa Loa (eye worm) hypothetical protein 0.002 0.0069 0.0114
Plasmodium falciparum ferrodoxin reductase-like protein 0.0013 0.0019 0.0019
Toxoplasma gondii exonuclease III APE 0.0019 0.0064 0.0093
Brugia malayi Thioredoxin reductase 0.0141 0.0968 0.1592
Echinococcus granulosus snurportin 1 0.0648 0.4708 0.4708
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0069 0.0069
Loa Loa (eye worm) glutaminase 0.0272 0.1933 0.3182
Trichomonas vaginalis malate dehydrogenase, putative 0.0324 0.2315 1
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0069 0.0069
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0049 0.0285 0.0457
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0049 0.0285 0.0457
Toxoplasma gondii flavodoxin domain-containing protein 0.0015 0.0032 0.0041
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0013 0.0019 0.0019
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0032 0.0156 0.0156
Trichomonas vaginalis malate dehydrogenase, putative 0.0324 0.2315 1
Plasmodium vivax lactate/malate dehydrogenase, putative 0.0324 0.2315 0.3802
Onchocerca volvulus 0.002 0.0069 0.0319
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0069 0.0114
Onchocerca volvulus 0.0236 0.1665 1
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0069 0.0114
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0049 0.0285 0.1159
Schistosoma mansoni importin beta-1 0.0061 0.0371 0.0371
Trypanosoma cruzi p450 reductase, putative 0.003 0.0144 0.0592
Echinococcus granulosus importin 5 0.0011 0.0007 0.0007
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0013 0.0019 0.0031
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0045 0.0252 0.0404
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0071 0.0451 0.1922
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0071 0.0451 0.1922
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0064 0.0093
Schistosoma mansoni hypothetical protein 0.0035 0.018 0.018
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0386 0.1641
Loa Loa (eye worm) hypothetical protein 0.004 0.0216 0.0355
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0017 0.0041
Schistosoma mansoni jumonji/arid domain-containing protein 0.0066 0.0408 0.0408
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0045 0.0252 0.0252
Entamoeba histolytica malate dehydrogenase, putative 0.0833 0.6076 1
Plasmodium vivax malate dehydrogenase, putative 0.0833 0.6076 1
Onchocerca volvulus 0.004 0.0216 0.1209
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0011 0.0007 0.0001
Echinococcus multilocularis tumor protein p63 0.0373 0.2676 0.2676
Loa Loa (eye worm) hypothetical protein 0.0055 0.0326 0.0536
Schistosoma mansoni malate dehydrogenase 0.0833 0.6076 0.6076
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0069 0.0069
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0049 0.0285 0.0457
Echinococcus granulosus L lactate dehydrogenase B chain 0.0833 0.6076 0.6076
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0854 0.6238 0.6238
Echinococcus granulosus Mastin 0.0236 0.1665 0.1665
Loa Loa (eye worm) hypothetical protein 0.0236 0.1665 0.274
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0013 0.0017 0.0027
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0013 0.0019 0.0031
Trypanosoma cruzi malate dehydrogenase, putative 0.0324 0.2315 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0064 0.0093
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0064 0.0395 0.0395
Plasmodium falciparum thioredoxin reductase 0.0049 0.0285 0.0457
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0013 0.0019 0.005
Echinococcus granulosus NADPH cytochrome P450 reductase 0.003 0.0144 0.0144
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0069 0.0069
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.0061 0.0061
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0013 0.0019 0.005
Trypanosoma brucei mitochondrial malate dehydrogenase 0.0324 0.2315 1
Echinococcus multilocularis GPCR, family 2 0.0063 0.0392 0.0392
Loa Loa (eye worm) hypothetical protein 0.0833 0.6076 1
Brugia malayi Trypsin family protein 0.0236 0.1665 0.274
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0049 0.0285 0.1203
Schistosoma mansoni glutamate synthase 0.0013 0.0019 0.0019
Leishmania major hypothetical protein, conserved 0.0013 0.0019 0.0019
Brugia malayi Trypsin-like protease protein 5 0.0236 0.1665 0.274
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0201 0.1405 0.2312
Schistosoma mansoni cpg binding protein 0.0032 0.0159 0.0159
Echinococcus granulosus phd:f box containing protein 0.0017 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.002 0.0069 0.0114
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0069 0.0069
Toxoplasma gondii thioredoxin reductase 0.0141 0.0968 0.1582
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0017 0.0041
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0324 0.2315 1
Leishmania major importin beta-1 subunit, putative 0.0049 0.0286 0.046
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0069 0.0114
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0069 0.0069
Loa Loa (eye worm) hypothetical protein 0.0451 0.3257 0.536
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0071 0.0451 0.0451
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0045 0.0252 0.0415
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0359 0.2572 1
Trichomonas vaginalis NADPH fad oxidoreductase, putative 0.0027 0.0119 0.0483
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0071 0.0451 0.0451
Brugia malayi FAD binding domain containing protein 0.003 0.0144 0.0237
Entamoeba histolytica P-glycoprotein-2 0.0013 0.0017 0.0016
Plasmodium vivax NADPH-cytochrome p450 reductase, putative 0.003 0.0144 0.0225
Echinococcus granulosus L lactate dehydrogenase 0.0509 0.3684 0.3684
Schistosoma mansoni nuclear hormone receptor 0.002 0.0069 0.0069
Schistosoma mansoni hypothetical protein 0.0063 0.0392 0.0392
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0064 0.0395 0.0395
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0032 0.0156 0.0644
Onchocerca volvulus 0.0236 0.1665 1
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0013 0.0019 0.0019
Echinococcus granulosus lysine specific demethylase 5A 0.0066 0.0408 0.0408
Echinococcus granulosus multidrug resistance protein 1 0.0013 0.0017 0.0017
Mycobacterium leprae Probable lipase LipE 0.004 0.0216 0.0773
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0236 0.1665 0.1665
Trichomonas vaginalis abcb9, putative 0.0013 0.0017 0.0041
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0045 0.0252 0.0404
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0049 0.0285 0.0468
Echinococcus multilocularis glycoprotein Antigen 5 0.0236 0.1665 0.1665
Schistosoma mansoni phosphatidylserine receptor 0.0017 0.0048 0.0048
Trichomonas vaginalis glutamate synthase, putative 0.0013 0.0019 0.005
Leishmania major cytochrome P450 reductase, putative 0.0027 0.0119 0.0184
Entamoeba histolytica hypothetical protein 0.0035 0.018 0.0285
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0155 0.1069 0.4119
Mycobacterium leprae conserved hypothetical protein 0.0023 0.0091 0.0282
Schistosoma mansoni cpg binding protein 0.0032 0.0159 0.0159
Loa Loa (eye worm) glutaminase 2 0.0272 0.1933 0.3182
Schistosoma mansoni cercarial elastase (S01 family) 0.0236 0.1665 0.1665
Echinococcus multilocularis dnaJ subfamily B 0.0431 0.3108 0.3108
Plasmodium vivax thioredoxin reductase, putative 0.0141 0.0968 0.1582
Brugia malayi steroid hormone receptor 0.002 0.0069 0.0114
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0049 0.0282 0.1193
Entamoeba histolytica hypothetical protein 0.0035 0.018 0.0285
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0324 0.2315 1
Toxoplasma gondii hypothetical protein 0.0023 0.0091 0.0138
Entamoeba histolytica thioredoxin reductase, putative 0.0013 0.0019 0.0019
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0045 0.0252 0.1018
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0069 0.0069
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0013 0.0019 0.005
Echinococcus multilocularis methionine synthase reductase 0.0018 0.0059 0.0059
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0069 0.0069
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0049 0.0282 0.1193
Chlamydia trachomatis sulfite reductase 0.0018 0.0059 0.0185
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0236 0.1665 0.1665
Trypanosoma brucei NADH dehydrogenase 0.0013 0.0019 0.005
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0069 0.0069
Brugia malayi hypothetical protein 0.0035 0.018 0.0297
Entamoeba histolytica malate dehydrogenase,cytoplasmic, putative 0.0324 0.2315 0.3802
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0069 0.0114
Leishmania major cytosolic malate dehydrogenase 0.0324 0.2315 0.3802
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0063 0.0392 0.0392
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.0216 0.0859
Loa Loa (eye worm) hypothetical protein 0.004 0.0216 0.0355
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0013 0.0019 0.005
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0017 0.0041
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0155 0.1069 0.4576
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0323 0.2306 0.8959
Brugia malayi ABC transporter family protein 0.0013 0.0017 0.0027
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0013 0.0019 0.0019
Echinococcus multilocularis geminin 0.0187 0.1303 0.1303
Trichomonas vaginalis malate dehydrogenase, putative 0.0324 0.2315 1
Toxoplasma gondii NADPH-glutathione reductase 0.0049 0.0285 0.0457
Brugia malayi Trypsin family protein 0.0236 0.1665 0.274
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0064 0.0075
Toxoplasma gondii ABC1 family protein 0.004 0.0216 0.0344
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.0017 0.0041
Schistosoma mansoni tar DNA-binding protein 0.0062 0.038 0.038
Echinococcus granulosus NADPH dependent diflavin oxidoreductase 1 0.003 0.0144 0.0144
Plasmodium falciparum GAF domain-related protein, putative 0.0023 0.0091 0.0138
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0069 0.0069
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0017 0.0048 0.0068
Trichomonas vaginalis glutathione reductase, putative 0.0049 0.0285 0.1203
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0032 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0013 0.0017 0.0027
Brugia malayi glutamate synthase 0.0013 0.0019 0.0031
Schistosoma mansoni tar DNA-binding protein 0.0062 0.038 0.038
Brugia malayi RNA, U transporter 1 0.0172 0.1197 0.1971
Loa Loa (eye worm) hypothetical protein 0.0013 0.0019 0.0031
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0013 0.0019 0.0019
Onchocerca volvulus 0.003 0.0146 0.0786
Loa Loa (eye worm) hypothetical protein 0.003 0.0144 0.0237
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0064 0.0064
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0071 0.0451 0.1922
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0318 0.227 0.3729
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0013 0.0019 0.005
Trypanosoma brucei cytosolic malate dehydrogenase 0.0324 0.2315 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0049 0.0285 0.0457
Loa Loa (eye worm) hypothetical protein 0.0013 0.0017 0.0027
Leishmania major malate dehydrogenase, putative 0.0833 0.6076 1
Trypanosoma cruzi NADH dehydrogenase, putative 0.0013 0.0019 0.005
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0013 0.0019 0.005
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0071 0.0451 0.1922
Leishmania major hypothetical protein, conserved 0.0013 0.0019 0.0019
Schistosoma mansoni hypothetical protein 0.0063 0.0392 0.0392
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0013 0.0019 0.0019
Echinococcus granulosus FTZ F1 alpha 0.002 0.0069 0.0069
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0216 0.0216
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0141 0.0968 0.3721
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.0017 0.0041
Trypanosoma brucei importin beta-1 subunit, putative 0.0061 0.0371 0.1576
Leishmania major mitochondrial malate dehydrogenase 0.0324 0.2315 0.3802
Onchocerca volvulus 0.0055 0.0326 0.1874
Brugia malayi RNA binding protein 0.0062 0.038 0.0625
Loa Loa (eye worm) FAD binding domain-containing protein 0.003 0.0144 0.0237
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0069 0.0069
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.018 0.018
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0049 0.0285 0.1203
Loa Loa (eye worm) hypothetical protein 0.0451 0.3257 0.536
Echinococcus granulosus lysine specific demethylase 6a 0.0017 0.0048 0.0048
Schistosoma mansoni jumonji domain containing protein 0.0017 0.0048 0.0048
Mycobacterium ulcerans hypothetical protein 0.004 0.0216 0.0859
Schistosoma mansoni hypothetical protein 0.0063 0.0392 0.0392
Echinococcus multilocularis L lactate dehydrogenase B chain 0.0833 0.6076 0.6076
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0019 0.005
Trichomonas vaginalis malate dehydrogenase, putative 0.0324 0.2315 1
Leishmania major NADPH-cytochrome p450 reductase-like protein 0.003 0.0144 0.0225
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.0061 0.0061
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0049 0.0285 0.1203
Plasmodium vivax multidrug resistance protein 1, putative 0.0013 0.0017 0.0016
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0013 0.0019 0.0019
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0236 0.1665 0.1665
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0071 0.0451 0.1922
Trypanosoma cruzi glycosomal malate dehydrogenase, putative 0.0324 0.2315 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0069 0.0069
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.0017 0.0041
Entamoeba histolytica P-glycoprotein-2, putative 0.0013 0.0017 0.0016
Brugia malayi jmjC domain containing protein 0.0066 0.0408 0.0671
Treponema pallidum oxidoreductase 0.0013 0.0019 0.0051
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0069 0.0114
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0323 0.2306 0.8958
Loa Loa (eye worm) hypothetical protein 0.0236 0.1665 0.274
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0069 0.0069
Schistosoma mansoni sulfide quinone reductase 0.0013 0.0019 0.0019
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0071 0.0451 0.1922
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0013 0.0017 0.0041
Echinococcus multilocularis NADPH cytochrome P450 reductase 0.003 0.0144 0.0144
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0049 0.0285 0.0457
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0236 0.1665 0.1665
Loa Loa (eye worm) hypothetical protein 0.0137 0.0936 0.154
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0017 0.0041
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0013 0.0019 0.005
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0254 0.1797 0.6966
Brugia malayi Trypsin family protein 0.0236 0.1665 0.274
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0049 0.0285 0.0457
Wolbachia endosymbiont of Brugia malayi malate dehydrogenase 0.0833 0.6076 1
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0013 0.0019 0.005
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0318 0.227 0.9808
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0071 0.0451 0.1922
Toxoplasma gondii hypothetical protein 0.0063 0.0386 0.0624
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.0048 0.0179
Mycobacterium tuberculosis Probable dehydrogenase 0.0323 0.2306 0.8959
Echinococcus multilocularis phd:f box containing protein 0.0017 0.0048 0.0048
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0013 0.0017 0.0017
Leishmania major hypothetical protein, conserved 0.004 0.0216 0.0344
Schistosoma mansoni cercarial elastase (S01 family) 0.0236 0.1665 0.1665
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0071 0.0451 0.1922
Toxoplasma gondii selenide, water dikinase 0.0013 0.0019 0.0019
Trichomonas vaginalis malate dehydrogenase, putative 0.0324 0.2315 1
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0069 0.0069
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0216 0.0905
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0216 0.0905
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0032 0.0156 0.0644
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0013 0.0017 0.0016
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0236 0.1665 0.1665
Trypanosoma cruzi NADH dehydrogenase, putative 0.0013 0.0019 0.005
Echinococcus multilocularis transmembrane protease serine 3 0.0236 0.1665 0.1665
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0049 0.0285 0.1203
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0013 0.0017 0.0041
Brugia malayi Importin beta-1 subunit 0.0061 0.0371 0.061
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0032 0.0156 0.0156
Schistosoma mansoni L-lactate dehydrogenase 0.0833 0.6076 0.6076
Trichomonas vaginalis abcb9, putative 0.0013 0.0017 0.0041
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0013 0.0019 0.0008
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0069 0.0069
Schistosoma mansoni protein phosphatase 2C 0.0017 0.0048 0.0048
Plasmodium falciparum glutathione reductase 0.0141 0.0968 0.1582
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0359 0.2572 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0017 0.0041
Schistosoma mansoni hypothetical protein 0.0137 0.0936 0.0936
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0069 0.0114
Loa Loa (eye worm) hypothetical protein 0.004 0.0216 0.0355
Trichomonas vaginalis apoptosis inducing factor, putative 0.0013 0.0019 0.005
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0069 0.0114
Trichomonas vaginalis malate dehydrogenase, putative 0.0158 0.1088 0.4684
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.0017 0.0041
Trichomonas vaginalis malate dehydrogenase, putative 0.0324 0.2315 1
Schistosoma mansoni hypothetical protein 0.0431 0.3108 0.3108
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0346 0.0558
Schistosoma mansoni cercarial elastase (S01 family) 0.0236 0.1665 0.1665
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0318 0.227 0.3729
Loa Loa (eye worm) hypothetical protein 0.0023 0.0091 0.0149
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0013 0.0019 0.0019
Schistosoma mansoni tar DNA-binding protein 0.0062 0.038 0.038
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0036 0.0188 0.031
Mycobacterium ulcerans beta-lactamase 0.004 0.0216 0.0859
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0036 0.0188 0.031
Mycobacterium tuberculosis Conserved protein 0.004 0.0216 0.078
Trypanosoma cruzi mitochondrial malate dehydrogenase, putative 0.0324 0.2315 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0216 0.0355
Schistosoma mansoni cercarial elastase (S01 family) 0.0236 0.1665 0.1665
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0318 0.227 0.9808
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0071 0.0451 0.1922
Trypanosoma brucei importin beta-1 subunit, putative 0.0061 0.0371 0.1576
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0019 0.005
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0049 0.0285 0.1203
Echinococcus multilocularis malate dehydrogenase 0.0324 0.2315 0.2315
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0064 0.0093
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0386 0.1641
Mycobacterium leprae conserved hypothetical protein 0.004 0.0216 0.0773
Echinococcus multilocularis microtubule associated protein 2 0.1363 1 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0069 0.0114
Schistosoma mansoni NADPH flavin oxidoreductase 0.0015 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.002 0.0069 0.0114
Trypanosoma cruzi cytochrome P450 reductase, putative 0.003 0.0144 0.0592
Schistosoma mansoni 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase 0.0018 0.0059 0.0059
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0071 0.0451 0.1922
Echinococcus multilocularis cytosolic malate dehydrogenase 0.0324 0.2315 0.2315
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0017 0.0048 0.0048
Trichomonas vaginalis taga, putative 0.0013 0.0017 0.0041
Echinococcus granulosus translational activator gcn1 0.0011 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0236 0.1665 0.274
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0013 0.0019 0.0031
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0049 0.0286 0.1209
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0049 0.0285 0.1203
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0023 0.0091 0.029
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0071 0.0451 0.1922
Chlamydia trachomatis thioredoxin reductase 0.0013 0.0019 0.0009
Schistosoma mansoni hypothetical protein 0.0187 0.1303 0.1303
Brugia malayi Probable malate dehydrogenase, mitochondrial precursor 0.0324 0.2315 0.3809
Echinococcus granulosus multidrug resistance protein 1 0.0013 0.0017 0.0017
Echinococcus multilocularis lysine specific demethylase 6a 0.0017 0.0048 0.0048
Loa Loa (eye worm) FAD binding domain-containing protein 0.0018 0.0059 0.0097
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0013 0.0019 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0069 0.0114
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.0017 0.0041
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0069 0.0069
Plasmodium falciparum JmjC domain-containing protein, putative 0.0017 0.0048 0.0068
Giardia lamblia Fructose-bisphosphate aldolase 0.0318 0.227 0.9807
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0071 0.0451 0.1922
Trypanosoma cruzi cytosolic malate dehydrogenase, putative 0.0324 0.2315 1
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0069 0.0319
Echinococcus multilocularis JmjC domain containing protein 4 0.0017 0.0048 0.0048
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0049 0.0285 0.0285
Plasmodium vivax ferrodoxin reductase, putative 0.0013 0.0019 0.0019
Onchocerca volvulus 0.004 0.0216 0.1209
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0216 0.0905
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0013 0.0019 0.0019
Onchocerca volvulus 0.0013 0.0019 0.0012
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0013 0.0019 0.0019
Trypanosoma brucei NADPH-cytochrome p450 reductase, putative 0.003 0.0144 0.0592
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0049 0.0282 0.1193
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0017 0.0048 0.0068
Entamoeba histolytica Ran family GTPase 0.0045 0.0252 0.0404
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0013 0.0019 0.0019
Schistosoma mansoni malate dehydrogenase 0.0324 0.2315 0.2315
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0013 0.0019 0.005
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0063 0.0392 0.0644
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0236 0.1665 0.1665
Loa Loa (eye worm) latrophilin receptor protein 2 0.0063 0.0392 0.0644
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0048 0.008
Echinococcus multilocularis snurportin 1 0.0648 0.4708 0.4708
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0318 0.227 0.9808
Echinococcus granulosus tar DNA binding protein 0.0062 0.038 0.038
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.0017 0.0041
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0032 0.0156 0.0256
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0064 0.0246
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.0216 0.078
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0071 0.0451 0.1922
Loa Loa (eye worm) hypothetical protein 0.0061 0.0371 0.061
Trypanosoma cruzi malate dehydrogenase, putative 0.0324 0.2315 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0048 0.008
Trypanosoma cruzi cytochrome P450 reductase, putative 0.003 0.0144 0.0592
Plasmodium falciparum lactate dehydrogenase, putative 0.0324 0.2315 0.3802
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0069 0.0319
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0013 0.0019 0.0008
Entamoeba histolytica P-glycoprotein 5, putative 0.0013 0.0017 0.0016
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0049 0.0285 0.0439
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0071 0.0451 0.1922
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0013 0.0019 0.0019
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0323 0.2306 0.8959
Echinococcus multilocularis tar DNA binding protein 0.0062 0.038 0.038
Brugia malayi TAR-binding protein 0.0062 0.038 0.0625
Loa Loa (eye worm) importin-beta domain-containing protein 0.0011 0.0007 0.0012
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0155 0.1069 0.4115
Entamoeba histolytica hypothetical protein 0.0049 0.0286 0.046
Echinococcus granulosus multidrug resistance protein 1 0.0013 0.0017 0.0017
Echinococcus multilocularis Mastin 0.0236 0.1665 0.1665
Trypanosoma cruzi trypanothione reductase, putative 0.0141 0.0968 0.4162
Giardia lamblia Hypothetical protein 0.0027 0.0119 0.0435
Trypanosoma brucei hypothetical protein, conserved 0.0013 0.0019 0.005
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0013 0.0019 0.0019
Schistosoma mansoni ran 0.0045 0.0252 0.0252
Echinococcus granulosus cytosolic malate dehydrogenase 0.0324 0.2315 0.2315
Echinococcus granulosus transmembrane protease serine 3 0.0236 0.1665 0.1665
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0064 0.0197
Echinococcus granulosus jumonji domain containing 1A 0.0017 0.0048 0.0048
Schistosoma mansoni glutaminase 0.0272 0.1933 0.1933
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0069 0.0114
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0069 0.0319
Loa Loa (eye worm) hypothetical protein 0.0017 0.0048 0.008
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0013 0.0019 0.0019
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.0216 0.078
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.0216 0.0859
Toxoplasma gondii HEAT repeat-containing protein 0.0061 0.0371 0.0599
Mycobacterium ulcerans putative regulatory protein 0.0023 0.0091 0.0314
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.038 0.0625
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0013 0.0019 0.0008
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0013 0.0019 0.005
Plasmodium falciparum malate dehydrogenase 0.0833 0.6076 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0216 0.0355
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0071 0.0451 0.1922
Schistosoma mansoni ap endonuclease 0.0019 0.0064 0.0064
Plasmodium vivax importin-beta 2, putative 0.0061 0.0371 0.0599
Trichomonas vaginalis malate dehydrogenase, putative 0.0324 0.2315 1
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0049 0.0285 0.1203
Trichomonas vaginalis mercuric reductase, putative 0.0049 0.0285 0.1203
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0216 0.0216
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0069 0.0114
Schistosoma mansoni smdr2 0.0013 0.0017 0.0017
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0013 0.0017 0.0017
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0071 0.0451 0.1922
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0071 0.0451 0.1922
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0013 0.0017 0.0017
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0069 0.0069
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0017 0.0041
Loa Loa (eye worm) hypothetical protein 0.0236 0.1665 0.274
Brugia malayi Calcitonin receptor-like protein seb-1 0.0201 0.1405 0.2312
Schistosoma mansoni cercarial elastase (S01 family) 0.0236 0.1665 0.1665
Mycobacterium ulcerans malate dehydrogenase 0.0324 0.2315 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0069 0.0114
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0013 0.0019 0.005
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0216 0.0905
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0216 0.0905
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0359 0.2572 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0032 0.0156 0.0644
Schistosoma mansoni cellular tumor antigen P53 0.0055 0.0326 0.0326
Trypanosoma brucei Importin-beta N-terminal domain/HEAT-like repeat, putative 0.0011 0.0007 0.0001
Onchocerca volvulus 0.0236 0.1665 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.0017 0.0017
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0069 0.0069
Loa Loa (eye worm) programmed cell death 8 0.0013 0.0019 0.0031
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0013 0.0019 0.0019
Trichomonas vaginalis glutamate synthase, putative 0.0013 0.0019 0.005
Leishmania major GTP-binding protein, putative 0.0045 0.0252 0.0404
Schistosoma mansoni diflavin oxidoreductase 0.0015 0.0032 0.0032
Echinococcus multilocularis importin subunit beta 1 0.0061 0.0371 0.0371
Plasmodium vivax lactate dehydrogenase 0.0833 0.6076 1
Trichomonas vaginalis importin beta-1, putative 0.0049 0.0286 0.1209
Echinococcus granulosus enteropeptidase 0.0236 0.1665 0.1665
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0216 0.0216
Schistosoma mansoni hypothetical protein 0.0013 0.0019 0.0019
Brugia malayi jmjC domain containing protein 0.0064 0.0395 0.065
Schistosoma mansoni ran 0.0045 0.0252 0.0252
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0013 0.0019 0.0019
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0324 0.2315 1
Brugia malayi CXXC zinc finger family protein 0.003 0.0146 0.0241
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0216 0.0355
Brugia malayi beta-lactamase family protein 0.004 0.0216 0.0355
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0013 0.0019 0.005
Trichomonas vaginalis sulfite reductase, putative 0.003 0.0144 0.0592
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0013 0.0017 0.0015
Brugia malayi flavodoxin family protein 0.003 0.0144 0.0237
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0071 0.0451 0.1922
Echinococcus multilocularis malate dehydrogenase 0.0324 0.2315 0.2315
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0064 0.0185
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.0285 0.1203
Schistosoma mansoni cpg binding protein 0.003 0.0146 0.0146
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.018 0.018
Echinococcus multilocularis muscleblind protein 0.0451 0.3257 0.3257
Schistosoma mansoni phd/f-box containing protein 0.0017 0.0048 0.0048
Leishmania major trypanothione reductase 0.0141 0.0968 0.1582
Echinococcus granulosus glutamate synthase 0.0013 0.0019 0.0019
Schistosoma mansoni tar DNA-binding protein 0.0062 0.038 0.038
Echinococcus multilocularis cpg binding protein 0.0032 0.0159 0.0159
Mycobacterium tuberculosis Conserved protein 0.004 0.0216 0.078
Mycobacterium ulcerans hypothetical protein 0.0236 0.1665 0.7171
Trichomonas vaginalis malate dehydrogenase, putative 0.0158 0.1088 0.4684
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.0216 0.078
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0013 0.0019 0.005
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.0048 0.0179
Brugia malayi Muscleblind-like protein 0.0451 0.3257 0.536
Brugia malayi ecdysteroid receptor 0.002 0.0069 0.0114
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0013 0.0019 0.0019
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0318 0.227 0.9808
Echinococcus multilocularis multidrug resistance protein 1 0.0013 0.0017 0.0017
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0069 0.0069
Schistosoma mansoni hypothetical protein 0.0063 0.0392 0.0392
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0063 0.0392 0.0392
Schistosoma mansoni multidrug resistance protein 0.0013 0.0017 0.0017
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0049 0.0285 0.0457
Brugia malayi latrophilin 2 splice variant baaae 0.0137 0.0936 0.154
Echinococcus granulosus cytosolic malate dehydrogenase 0.0324 0.2315 0.2315
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0013 0.0019 0.0019
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0071 0.0451 0.1922
Trichomonas vaginalis malate dehydrogenase, putative 0.0324 0.2315 1

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) TP_TRANSPORTER: transepithelial transport (basal to apical) in mdr1a-expressing LLC-PK1 cell ChEMBL. 12235267
Activity (ADMET) Clinically relevant substrates of human liver microsomal P450 enzymes, isoform CYP3A4 ChEMBL. No reference
Activity (functional) TP_TRANSPORTER: increase in kidney concentration in mdr1a(-/-) mouse ChEMBL. 12235267
Ki (functional) = 19.82 uM TP_TRANSPORTER: increase in Vinblastine intracellular accumulation in MDR1-expressing LLC-PK1 cells ChEMBL. 11961113
Ki (functional) = 159.9 uM TP_TRANSPORTER: increase in Calcein-AM intracellular accumulation in mdr1b-expressing LLC-PK1 cells ChEMBL. 12235267
Ki (functional) = 333.4 uM TP_TRANSPORTER: increase in Calcein-AM intracellular accumulation in mdr1a-expressing LLC-PK1 cells ChEMBL. 12235267
Ki (functional) = 360.5 uM TP_TRANSPORTER: increase in Calcein-AM intracellular accumulation in MDR1-expressing LLC-PK1 cells ChEMBL. 11961113
Potency (functional) 26.8325 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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