Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | thioredoxin reductase | 0.0046 | 0.0113 | 0.0212 |
Loa Loa (eye worm) | glutaminase 2 | 0.0286 | 0.5315 | 1 |
Trichomonas vaginalis | serine threonine-protein kinase, putative | 0.011 | 0.1502 | 0.2721 |
Echinococcus multilocularis | tumor protein p63 | 0.0395 | 0.7668 | 1 |
Onchocerca volvulus | 0.0058 | 0.0359 | 0.5 | |
Echinococcus multilocularis | geminin | 0.0166 | 0.2714 | 0.3539 |
Mycobacterium ulcerans | L-lysine aminotransferase | 0.0502 | 1 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0046 | 0.0113 | 1 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0118 | 0.1659 | 0.1594 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0106 | 0.1403 | 0.1336 |
Brugia malayi | glutaminase DH11.1 | 0.0286 | 0.5315 | 0.5315 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0046 | 0.0113 | 0.0147 |
Echinococcus granulosus | ornithine aminotransferase | 0.0045 | 0.0077 | 0.01 |
Echinococcus granulosus | serine:threonine protein kinase:endoribonuclease | 0.0217 | 0.3808 | 0.4966 |
Plasmodium vivax | glutathione reductase, putative | 0.0046 | 0.0113 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0359 | 0.0676 |
Echinococcus multilocularis | ornithine aminotransferase | 0.0045 | 0.0077 | 0.01 |
Loa Loa (eye worm) | glutathione reductase | 0.0046 | 0.0113 | 0.0212 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0046 | 0.0113 | 0.0147 |
Trichomonas vaginalis | conserved hypothetical protein | 0.011 | 0.1502 | 0.2721 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0106 | 0.1403 | 0.1336 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0106 | 0.1403 | 0.1336 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0046 | 0.0113 | 1 |
Schistosoma mansoni | ornithine--oxo-acid transaminase | 0.0045 | 0.0077 | 0.0144 |
Echinococcus multilocularis | ornithine aminotransferase | 0.0045 | 0.0077 | 0.01 |
Echinococcus multilocularis | serine:threonine protein kinase:endoribonuclease | 0.0217 | 0.3808 | 0.4966 |
Brugia malayi | glutathione reductase | 0.0046 | 0.0113 | 0.0113 |
Plasmodium falciparum | thioredoxin reductase | 0.0046 | 0.0113 | 1 |
Chlamydia trachomatis | glutamate-1-semialdehyde-2,1-aminomutase | 0.0045 | 0.0077 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0217 | 0.3808 | 0.5 |
Mycobacterium ulcerans | glutaminase | 0.0286 | 0.5315 | 0.5278 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0058 | 0.0359 | 0.0676 |
Brugia malayi | jmjC domain containing protein | 0.0111 | 0.1525 | 0.1525 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0111 | 0.1525 | 0.1989 |
Schistosoma mansoni | jumonji domain containing protein | 0.0089 | 0.1028 | 0.1934 |
Brugia malayi | Thioredoxin reductase | 0.0046 | 0.0113 | 0.0113 |
Echinococcus granulosus | jumonji domain containing protein | 0.0047 | 0.0134 | 0.0175 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0118 | 0.1659 | 1 |
Loa Loa (eye worm) | IRE protein kinase | 0.0217 | 0.3808 | 0.7165 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0106 | 0.1403 | 0.1336 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0111 | 0.1517 | 0.2854 |
Brugia malayi | Ribonuclease 2-5A family protein | 0.0217 | 0.3808 | 0.3808 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0106 | 0.1403 | 0.1336 |
Echinococcus multilocularis | Aminotransferase class III | 0.0045 | 0.0077 | 0.01 |
Trypanosoma brucei | trypanothione reductase | 0.0046 | 0.0113 | 0.5 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0047 | 0.0134 | 0.0175 |
Mycobacterium tuberculosis | Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) | 0.0502 | 1 | 1 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.007 | 0.0631 | 0.1188 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0106 | 0.1403 | 0.838 |
Entamoeba histolytica | protein kinase, putative | 0.0217 | 0.3808 | 0.5 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0118 | 0.1659 | 0.1594 |
Schistosoma mansoni | glutaminase | 0.0286 | 0.5315 | 1 |
Echinococcus granulosus | Aminotransferase class III | 0.0045 | 0.0077 | 0.01 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0046 | 0.0113 | 0.0036 |
Mycobacterium tuberculosis | Probable reductase | 0.0106 | 0.1403 | 0.1336 |
Wolbachia endosymbiont of Brugia malayi | acetylornithine transaminase protein | 0.0045 | 0.0077 | 0.5 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0046 | 0.0113 | 0.5 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0111 | 0.1525 | 0.1989 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.2714 | 0.5107 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0118 | 0.1659 | 0.1594 |
Echinococcus granulosus | geminin | 0.0166 | 0.2714 | 0.3539 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0372 | 0.0701 |
Leishmania major | trypanothione reductase | 0.0046 | 0.0113 | 0.5 |
Loa Loa (eye worm) | glutaminase | 0.0286 | 0.5315 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.2714 | 0.5107 |
Trichomonas vaginalis | glutaminase, putative | 0.0286 | 0.5315 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0046 | 0.0113 | 1 |
Echinococcus granulosus | tumor protein p63 | 0.0395 | 0.7668 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.