Detailed information for compound 557783

Basic information

Technical information
  • TDR Targets ID: 557783
  • Name: (2-Ethylthiomethyl-phenyl)-N-methylcarbamate
  • MW: 225.307 | Formula: C11H15NO2S
  • H donors: 1 H acceptors: 1 LogP: 2.32 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCSCc1ccccc1OC(=O)NC
  • InChi: 1S/C11H15NO2S/c1-3-15-8-9-6-4-5-7-10(9)14-11(13)12-2/h4-7H,3,8H2,1-2H3,(H,12,13)
  • InChiKey: HEZNVIYQEUHLNI-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 2-((Ethylthio)methyl)phenol methylcarbamate
  • 2-((Ethylthio)methyl)phenyl methylcarbamate
  • 2-Ethyl-mercaptomethyl-phenyl-N-methylcarbamate
  • 2-Ethylthiomethylphenyl N-methylcarbamate
  • 2-[(ethylsulfanyl)methyl]phenyl methylcarbamate
  • 29973-13-5
  • 45475_RIEDEL
  • 56729-20-5
  • 56730-58-6
  • AI3-29007
  • alpha-(Ethylthio)-o-tolyl methylcarbamate
  • alpha-(Ethylthio)-o-tolyl methylcarbamate [ISO:BSI]
  • alpha-Ethylthio-o-tolyl methylcarbamate
  • Arylmate
  • BAY-HOX-1901
  • BRN 2973224
  • Carbamic acid, methyl-, 2-(ethylthiomethyl)phenyl ester
  • Carbamic acid, methyl-, alpha-(ethylthio)-o-tolyl ester (8CI)
  • Caswell No. 263AA
  • CHEBI:38483
  • CHOX 1901
  • croneton
  • Croneton 500
  • EINECS 249-981-9
  • EPA Pesticide Chemical Code 112101
  • Ethiofencarb
  • Ethiofencarb [BSI:ISO]
  • Ethiophencarbe [ISO-French]
  • Hox 1901
  • HSDB 7140
  • Kronetone
  • N-methylcarbamic acid [2-[(ethylthio)methyl]phenyl] ester
  • NCGC00163882-01
  • Phenol, 2-[(ethylthio)methyl]-, methylcarbamate
  • Phenol, 2-((ethylthio)methyl)-, methylcarbamate (9CI)
  • PS2058_SUPELCO
  • [2-(ethylsulfanylmethyl)phenyl] N-methylcarbamate

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Hormone-sensitive lipase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K07188 hormone-sensitive lipase [EC3.1.1.79], putative Get druggable targets OG5_132840 All targets in OG5_132840
Schistosoma japonicum Hormone-sensitive lipase, putative Get druggable targets OG5_132840 All targets in OG5_132840
Schistosoma japonicum Hormone-sensitive lipase, putative Get druggable targets OG5_132840 All targets in OG5_132840
Echinococcus granulosus hormone sensitive lipase Get druggable targets OG5_132840 All targets in OG5_132840
Schistosoma mansoni hormone-sensitive lipase (S09 family) Get druggable targets OG5_132840 All targets in OG5_132840
Schistosoma mansoni hormone-sensitive lipase (S09 family) Get druggable targets OG5_132840 All targets in OG5_132840
Schistosoma mansoni hormone-sensitive lipase (S09 family) Get druggable targets OG5_132840 All targets in OG5_132840
Echinococcus multilocularis hormone sensitive lipase Get druggable targets OG5_132840 All targets in OG5_132840
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132840 All targets in OG5_132840
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis short-chain dehydrogenases/reductase, putative 0.0024 0.0254 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0024 0.0254 1
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0024 0.0254 0.5
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0024 0.0254 0.5
Loa Loa (eye worm) hypothetical protein 0.0024 0.0254 0.0265
Trypanosoma brucei 3-keto-dihydrosphingosine reductase 0.0024 0.0254 0.5
Schistosoma mansoni steroid dehydrogenase 0.0024 0.0254 0.0265
Brugia malayi hypothetical protein 0.0024 0.0254 1
Leishmania major quinonoid dihydropteridine reductase 0.0024 0.0254 0.5
Leishmania major short chain dehydrogenase/reductase, putative 0.0024 0.0254 0.5
Loa Loa (eye worm) oxidoreductase 0.0024 0.0254 0.0265
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.0024 0.0254 0.0265
Schistosoma mansoni short chain dehydrogenase 0.0024 0.0254 0.0265
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0024 0.0254 0.5
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0024 0.0254 1
Echinococcus granulosus retinol dehydrogenase 11 0.0024 0.0254 0.0265
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0254 0.5
Schistosoma mansoni short chain dehydrogenase 0.0024 0.0254 0.0265
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.0024 0.0254 0.0265
Schistosoma mansoni steroid dehydrogenase 0.0024 0.0254 0.0265
Entamoeba histolytica hypothetical protein, conserved 0.0024 0.0254 0.5
Leishmania major short chain dehydrogenase-like protein 0.0024 0.0254 0.5
Leishmania major quinonoid dihydropteridine reductase 0.0024 0.0254 0.5
Leishmania major hypothetical protein, conserved 0.0024 0.0254 0.5
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.0024 0.0254 0.5
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0024 0.0254 0.5
Entamoeba histolytica 3-ketodihydrosphingosine reductase protein, putative 0.0024 0.0254 0.5
Echinococcus multilocularis carbonyl reductase 1 0.0024 0.0254 0.0265
Loa Loa (eye worm) hypothetical protein 0.0024 0.0254 0.0265
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0024 0.0254 1
Echinococcus multilocularis retinol dehydrogenase 11 0.0024 0.0254 0.0265
Trypanosoma brucei oxidoreductase-like protein 0.0024 0.0254 0.5
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 1 homolog 0.0024 0.0254 1
Trypanosoma brucei short-chain dehydrogenase, putative 0.0024 0.0254 0.5
Leishmania major quinonoid dihydropteridine reductase 0.0024 0.0254 0.5
Leishmania major short chain dehydrogenase, putative 0.0024 0.0254 0.5
Loa Loa (eye worm) oxidoreductase 0.0024 0.0254 0.0265
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0024 0.0254 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0024 0.0254 1
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.0024 0.0254 0.0265
Trypanosoma brucei short-chain dehydrogenase, putative 0.0024 0.0254 0.5
Schistosoma mansoni steroid dehydrogenase 0.0024 0.0254 0.0265
Leishmania major quinonoid dihydropteridine reductase 0.0024 0.0254 0.5
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0024 0.0254 1
Brugia malayi Dehydrogenases, short chain protein 2 0.0024 0.0254 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0024 0.0254 1
Echinococcus granulosus hypothetical protein 0.0024 0.0254 0.0265
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0024 0.0254 0.5
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0024 0.0254 0.5
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0024 0.0254 0.5
Schistosoma mansoni short chain dehydrogenase 0.0024 0.0254 0.0265
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0254 0.5
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0024 0.0254 0.0265
Brugia malayi oxidoreductase 0.0024 0.0254 1
Echinococcus multilocularis steroid dehydrogenase 0.0024 0.0254 0.0265
Mycobacterium leprae ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE 0.0024 0.0254 0.5
Leishmania major hypothetical protein, conserved 0.0024 0.0254 0.5
Loa Loa (eye worm) hypothetical protein 0.0024 0.0254 0.0265
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0024 0.0254 1
Schistosoma mansoni steroid dehydrogenase 0.0024 0.0254 0.0265
Loa Loa (eye worm) hypothetical protein 0.0024 0.0254 0.0265
Loa Loa (eye worm) oxidoreductase 0.0024 0.0254 0.0265
Leishmania major quinonoid dihydropteridine reductase 0.0024 0.0254 0.5
Trypanosoma brucei beta-ketoacyl-ACP reductase 3, putative 0.0024 0.0254 0.5
Leishmania major oxidoreductase-like protein 0.0024 0.0254 0.5
Trypanosoma cruzi short chain dehydrogenase, putative 0.0024 0.0254 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0263 1 1
Echinococcus granulosus carbonyl reductase 1 0.0024 0.0254 0.0265
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0024 0.0254 0.5
Trichomonas vaginalis steroid dehydrogenase, putative 0.0024 0.0254 0.5
Trypanosoma brucei short-chain dehydrogenase, putative 0.0024 0.0254 0.5
Onchocerca volvulus 0.0024 0.0254 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0024 0.0254 1
Trypanosoma brucei beta-D-hydroxybutyrate dehydrogenase 0.0024 0.0254 0.5
Schistosoma mansoni short chain dehydrogenase 0.0024 0.0254 0.0265
Loa Loa (eye worm) dehydrogenase 0.0024 0.0254 0.0265
Schistosoma mansoni hormone-sensitive lipase (S09 family) 0.0253 0.9591 1
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.0024 0.0254 0.5
Echinococcus granulosus hormone sensitive lipase 0.0253 0.9591 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0254 0.0265
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0024 0.0254 0.0265
Loa Loa (eye worm) oxidoreductase 0.0024 0.0254 0.0265
Onchocerca volvulus 0.0024 0.0254 1
Plasmodium vivax hypothetical protein, conserved 0.0024 0.0254 0.5
Plasmodium vivax steroid dehydrogenase, putative 0.0024 0.0254 0.5
Schistosoma mansoni short chain dehydrogenase 0.0024 0.0254 0.0265
Leishmania major 3-keto-dihydrosphingosine reductase 0.0024 0.0254 0.5
Echinococcus granulosus carbonyl reductase 1 0.0024 0.0254 0.0265
Onchocerca volvulus 0.0024 0.0254 1
Schistosoma mansoni short chain dehydrogenase 0.0024 0.0254 0.0265
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0024 0.0254 1
Trichomonas vaginalis hydroxyacyl dehydrogenase, putative 0.0024 0.0254 0.5
Onchocerca volvulus 0.0024 0.0254 1
Echinococcus multilocularis oxidoreductase 0.0024 0.0254 0.0265
Schistosoma mansoni steroid dehydrogenase 0.0024 0.0254 0.0265
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0024 0.0254 0.5
Onchocerca volvulus 0.0024 0.0254 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0024 0.0254 1
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0024 0.0254 0.5
Echinococcus granulosus retinol dehydrogenase 11 0.0024 0.0254 0.0265
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0024 0.0254 0.0265
Echinococcus multilocularis retinol dehydrogenase 13 0.0024 0.0254 0.0265
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0024 0.0254 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0024 0.0254 0.5
Loa Loa (eye worm) dehydrogenase 0.0024 0.0254 0.0265
Loa Loa (eye worm) hypothetical protein 0.0024 0.0254 0.0265
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.0024 0.0254 0.0265
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0024 0.0254 0.5
Loa Loa (eye worm) oxidoreductase 0.0024 0.0254 0.0265
Toxoplasma gondii carbonyl reductase 1, putative 0.0024 0.0254 0.5
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0024 0.0254 0.5
Mycobacterium leprae Probable oxidoreductase 0.0024 0.0254 0.5
Echinococcus granulosus carbonyl reductase 1 0.0024 0.0254 0.0265
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0254 0.5
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0024 0.0254 1
Brugia malayi Retinol dehydrogenase 12 0.0024 0.0254 1
Brugia malayi Dehydrogenases, short chain protein 30 0.0024 0.0254 1
Schistosoma mansoni steroid dehydrogenase 0.0024 0.0254 0.0265
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0024 0.0254 1
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0254 0.5
Schistosoma mansoni short chain dehydrogenase 0.0024 0.0254 0.0265
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0024 0.0254 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0254 0.5
Loa Loa (eye worm) oxidoreductase 0.0024 0.0254 0.0265
Schistosoma mansoni short chain dehydrogenase 0.0024 0.0254 0.0265
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0024 0.0254 0.0265
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0024 0.0254 1
Schistosoma mansoni hormone-sensitive lipase (S09 family) 0.0253 0.9591 1
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0024 0.0254 0.5
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0024 0.0254 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0024 0.0254 1
Onchocerca volvulus 0.0024 0.0254 1
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0024 0.0254 0.5
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0024 0.0254 1
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0024 0.0254 0.5
Onchocerca volvulus 0.0024 0.0254 1
Leishmania major hypothetical protein, conserved 0.0024 0.0254 0.5
Entamoeba histolytica hypothetical protein 0.0024 0.0254 0.5
Entamoeba histolytica oxidoreductase, short chain dehydrogenase/reductase family 0.0024 0.0254 0.5
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0024 0.0254 0.5
Echinococcus granulosus hypothetical protein 0.0024 0.0254 0.0265
Echinococcus multilocularis hormone sensitive lipase 0.0253 0.9591 1
Plasmodium falciparum steroid dehydrogenase, putative 0.0024 0.0254 0.5
Schistosoma mansoni carbonyl reductase 0.0024 0.0254 0.0265
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0024 0.0254 0.5
Loa Loa (eye worm) oxidoreductase 0.0024 0.0254 0.0265
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0024 0.0254 0.5
Trypanosoma brucei short-chain dehydrogenase, putative 0.0024 0.0254 0.5
Schistosoma mansoni short chain dehydrogenase 0.0024 0.0254 0.0265
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0024 0.0254 0.0265
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0024 0.0254 1
Leishmania major quinonoid dihydropteridine reductase 0.0024 0.0254 0.5
Loa Loa (eye worm) oxidoreductase 0.0024 0.0254 0.0265
Leishmania major short chain dehydrogenase, putative 0.0024 0.0254 0.5
Onchocerca volvulus 0.0024 0.0254 1
Onchocerca volvulus 0.0024 0.0254 1
Onchocerca volvulus Sepiapterin reductase homolog 0.0024 0.0254 1
Echinococcus granulosus WW domain containing oxidoreductase 0.0024 0.0254 0.0265
Schistosoma mansoni short chain dehydrogenase 0.0024 0.0254 0.0265
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0024 0.0254 0.5
Toxoplasma gondii oxidoreductase, putative 0.0024 0.0254 0.5
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0024 0.0254 0.5
Toxoplasma gondii 3-ketoacyl-CoA reductase, putative 0.0024 0.0254 0.5
Leishmania major short chain dehydrogenase/reductase, putative 0.0024 0.0254 0.5
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0024 0.0254 0.5
Trypanosoma cruzi quinonoid dihydropteridine reductase, putative 0.0024 0.0254 0.5
Onchocerca volvulus 0.0024 0.0254 1
Schistosoma mansoni steroid dehydrogenase 0.0024 0.0254 0.0265
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0024 0.0254 0.5
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0024 0.0254 0.5
Trypanosoma cruzi short chain dehydrogenase, putative 0.0024 0.0254 0.5
Schistosoma mansoni retinal dehydrogenase 0.0024 0.0254 0.0265
Giardia lamblia Reductase, putative 0.0024 0.0254 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0024 0.0254 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0024 0.0254 1
Echinococcus multilocularis carbonyl reductase 1 0.0024 0.0254 0.0265
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0024 0.0254 1
Onchocerca volvulus 0.0024 0.0254 1
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0024 0.0254 0.0265
Schistosoma mansoni steroid dehydrogenase 0.0024 0.0254 0.0265
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0024 0.0254 1
Schistosoma mansoni steroid dehydrogenase 0.0024 0.0254 0.0265
Entamoeba histolytica hypothetical protein, conserved 0.0024 0.0254 0.5
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0024 0.0254 0.5
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0024 0.0254 0.5
Mycobacterium leprae PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE 0.0024 0.0254 0.5
Schistosoma mansoni short chain dehydrogenase 0.0024 0.0254 0.0265
Toxoplasma gondii sterol carrier protein-2 HAD-2SCP-2 0.0024 0.0254 0.5
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0024 0.0254 0.5
Loa Loa (eye worm) hypothetical protein 0.0024 0.0254 0.0265
Brugia malayi dehydrogenases, short chain protein 2 0.0024 0.0254 1
Leishmania major hypothetical protein, conserved 0.0024 0.0254 0.5
Echinococcus granulosus steroid dehydrogenase 0.0024 0.0254 0.0265
Leishmania major hypothetical protein, conserved 0.0024 0.0254 0.5
Echinococcus granulosus carbonyl reductase 1 0.0024 0.0254 0.0265
Trypanosoma brucei short-chain dehydrogenase, putative 0.0024 0.0254 0.5
Loa Loa (eye worm) hypothetical protein 0.0253 0.9591 1
Echinococcus multilocularis conserved hypothetical protein 0.0024 0.0254 0.0265
Loa Loa (eye worm) oxidoreductase 0.0024 0.0254 0.0265
Echinococcus multilocularis steroid dehydrogenase 0.0024 0.0254 0.0265
Plasmodium falciparum oxidoreductase, short-chain dehydrogenase family, putative 0.0024 0.0254 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0024 0.0254 1
Echinococcus multilocularis carbonyl reductase 1 0.0024 0.0254 0.0265
Giardia lamblia Oxidoreductase, short chain dehydrogenase/reductase family 0.0024 0.0254 0.5
Trypanosoma brucei beta-ketoacyl-ACP reductase 2 0.0024 0.0254 0.5
Loa Loa (eye worm) hypothetical protein 0.0024 0.0254 0.0265
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0254 0.5
Echinococcus multilocularis carbonyl reductase 1 0.0024 0.0254 0.0265
Trypanosoma brucei 3-ketoacyl-CoA reductase, putative 0.0024 0.0254 0.5
Giardia lamblia Hypothetical protein 0.0024 0.0254 0.5
Leishmania major dehydrogenase-like protein 0.0024 0.0254 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0024 0.0254 1
Toxoplasma gondii oxidoreductase, putative 0.0024 0.0254 0.5
Schistosoma mansoni carbonyl reductase 0.0024 0.0254 0.0265
Leishmania major quinonoid dihydropteridine reductase 0.0024 0.0254 0.5
Entamoeba histolytica short chain dehydrogenase family protein 0.0024 0.0254 0.5
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0024 0.0254 0.5
Schistosoma mansoni short chain dehydrogenase 0.0024 0.0254 0.0265
Loa Loa (eye worm) hypothetical protein 0.0024 0.0254 0.0265
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0024 0.0254 0.5
Schistosoma mansoni hormone-sensitive lipase (S09 family) 0.0253 0.9591 1
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0024 0.0254 0.0265
Echinococcus multilocularis transient receptor potential cation channel 0.0024 0.0254 0.0265
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0024 0.0254 0.5
Schistosoma mansoni carbonyl reductase 0.0024 0.0254 0.0265
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.0024 0.0254 0.0265
Leishmania major pteridine reductase 1 0.0024 0.0254 0.5
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.0024 0.0254 0.0265
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0024 0.0254 0.5
Entamoeba histolytica short chain dehydrogenase family protein 0.0024 0.0254 0.5
Brugia malayi dehydrogenases, short chain protein 9 0.0024 0.0254 1
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.0024 0.0254 0.0265
Loa Loa (eye worm) hypothetical protein 0.0024 0.0254 0.0265
Brugia malayi hypothetical protein 0.0024 0.0254 1
Schistosoma mansoni short chain dehydrogenase 0.0024 0.0254 0.0265
Schistosoma mansoni steroid dehydrogenase 0.0024 0.0254 0.0265
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0024 0.0254 0.5
Loa Loa (eye worm) hypothetical protein 0.0024 0.0254 0.0265
Trichomonas vaginalis estradiol 17 beta-dehydrogenase, putative 0.0024 0.0254 0.5
Onchocerca volvulus 0.0024 0.0254 1
Echinococcus multilocularis retinol dehydrogenase 11 0.0024 0.0254 0.0265
Giardia lamblia Short-chain dehydrogenase, putative 0.0024 0.0254 0.5
Onchocerca volvulus 0.0024 0.0254 1
Schistosoma mansoni short chain dehydrogenase 0.0024 0.0254 0.0265
Schistosoma mansoni short chain dehydrogenase 0.0024 0.0254 0.0265
Echinococcus granulosus oxidoreductase 0.0024 0.0254 0.0265

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.37 uM Inhibition of HSL in Wistar rat isolated fat cells by spectrophotometric assay ChEMBL. 18808096
Inhibition (binding) = 52 % Inhibition of HSL in Wistar rat isolated fat cells at 10 uM by spectrophotometric assay ChEMBL. 18808096
Potency (functional) 34.3762 uM PubChem BioAssay. qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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