Detailed information for compound 561370

Basic information

Technical information
  • TDR Targets ID: 561370
  • Name: 4-[2-(methylamino)propyl]phenol; sulfuric aci d
  • MW: 428.543 | Formula: C20H32N2O6S
  • H donors: 6 H acceptors: 6 LogP: 0 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 2
  • SMILES: OS(=O)(=O)O.CNC(Cc1ccc(cc1)O)C.CNC(Cc1ccc(cc1)O)C
  • InChi: 1S/2C10H15NO.H2O4S/c2*1-8(11-2)7-9-3-5-10(12)6-4-9;1-5(2,3)4/h2*3-6,8,11-12H,7H2,1-2H3;(H2,1,2,3,4)
  • InChiKey: WUORSSYNZWHFQY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-(4-hydroxyphenyl)propan-2-yl-methylazanium sulfate
  • [2-(4-hydroxyphenyl)-1-methyl-ethyl]-methyl-ammonium sulfate
  • [2-(4-hydroxyphenyl)-1-methylethyl]-methylammonium sulfate
  • 1-(4-hydroxyphenyl)propan-2-yl-methyl-azanium sulfate
  • Phenol, 4-(2-aminopropyl), n-methyl-, hydrogen sulfate
  • 370-14-9
  • 6114-26-7
  • 953-38-8
  • Pholedrinium sulfate
  • p-Hydroxy-N-methylamphetamine hydrogen sulfate
  • EINECS 228-083-0
  • NSC 96983
  • Phenol, 4-(2-(methylamino)propyl)-, sulfate (2:1)
  • Phenol, 4-(2-(methylamino)propyl)-, sulfate (2:1) (salt) (9CI)
  • Phenol, p-(2-(methylamino)propyl)-, sulfate (2:1) (salt) (8CI)
  • Phenol, p-(2-(methylamino)propyl)-, sulfate (salt)
  • Pholedrine sulphate
  • Propane, 1-(p-hydroxyphenyl)-2-methylamino-, sulfate
  • p-(2-Methylaminopropyl)phenol sulfate
  • 1-(4-Hydroxyphenyl)-2-methylaminopropane sulfate
  • Paredrinol sulfate
  • Pholedrine sulfate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0068 0.0067
Schistosoma mansoni hypothetical protein 0.0016 0.0016 0.0015
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0128 0.0128
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0063 0.0063
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0011 0 0.0069
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0094 0.0297 0.0296
Loa Loa (eye worm) hyaluronidase 0.2804 1 1
Plasmodium vivax importin-beta 2, putative 0.0028 0.0062 0.9143
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0068 0.0067
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0013 0.0154
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0124 0.0404 0.0403
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.014 0.8968
Loa Loa (eye worm) hypothetical protein 0.003 0.0068 0.0067
Loa Loa (eye worm) hypothetical protein 0.0149 0.0493 0.0492
Plasmodium falciparum heterochromatin protein 1 0.0011 0 0.0069
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0128 0.0128
Schistosoma mansoni thyroid hormone receptor 0.0134 0.0439 0.0439
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0061 0.0061
Schistosoma mansoni aminopeptidase P homologue (M24 family) 0.2804 1 1
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0068 0.0067
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0179 0.0178
Onchocerca volvulus 0.0234 0.0797 1
Echinococcus granulosus dnaJ subfamily B 0.0402 0.1401 0.1401
Schistosoma mansoni importin beta-1 0.0028 0.0062 0.0061
Brugia malayi mbt repeat family protein 0.0047 0.0128 0.0128
Schistosoma mansoni hypothetical protein 0.0029 0.0063 0.0063
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0023 0.0288
Echinococcus granulosus chromobox protein 1 0.0069 0.0206 0.0205
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0103 0.0103
Schistosoma mansoni hypothetical protein 0.0034 0.008 0.008
Schistosoma mansoni cpg binding protein 0.003 0.0067 0.0067
Brugia malayi RNA, U transporter 1 0.0081 0.0249 0.0249
Plasmodium falciparum phd finger protein, putative 0.0029 0.0063 1
Trichomonas vaginalis rotamase, putative 0.0032 0.0075 0.0938
Loa Loa (eye worm) hypothetical protein 0.0049 0.0136 0.0136
Plasmodium vivax SET domain protein, putative 0.003 0.0068 1
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0152 0.0151
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0016 0.0015
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0166 0.0556 0.0556
Trichomonas vaginalis set domain proteins, putative 0.0234 0.0797 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0023 0.0288
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0023 0.0288
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0043 0.053
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0136 0.0135
Schistosoma mansoni serine/threonine protein kinase 0.005 0.014 0.0139
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.014 1
Brugia malayi SET domain containing protein 0.0013 0.0007 0.0006
Schistosoma mansoni thyroid hormone receptor 0.0134 0.0439 0.0439
Echinococcus granulosus cpg binding protein 0.003 0.0067 0.0067
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0023 0.0288
Loa Loa (eye worm) hypothetical protein 0.0029 0.0063 0.0063
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0011 0.0133
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.0015
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0023 0.0288
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.014 1
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0128 0.0128
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0016 0.0015
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0016 0.0015
Echinococcus granulosus snurportin 1 0.0303 0.1045 0.1044
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0032 0.0075 1
Schistosoma mansoni jumonji domain containing protein 0.0075 0.0227 0.0227
Brugia malayi Heterochromatin protein 1 0.0069 0.0206 0.0205
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0013 0.0006 0.0006
Brugia malayi CXXC zinc finger family protein 0.0028 0.0061 0.0061
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0128 0.0128
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0098 0.1223
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.014 1
Plasmodium vivax hypothetical protein, conserved 0.0011 0 0.0064
Echinococcus multilocularis thyroid hormone receptor alpha 0.0134 0.0439 0.0439
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0172 0.0172
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0062 0.0061
Onchocerca volvulus 0.0028 0.0061 0.0766
Echinococcus granulosus microtubule associated protein 2 0.0679 0.2391 0.2391
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0063 0.4025
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0075 0.3349
Brugia malayi jmjC domain containing protein 0.0036 0.009 0.009
Brugia malayi Importin beta-1 subunit 0.0028 0.0062 0.0061
Brugia malayi Pre-SET motif family protein 0.0205 0.0696 0.0695
Trichomonas vaginalis CMGC family protein kinase 0.005 0.014 0.1749
Schistosoma mansoni cpg binding protein 0.0028 0.0061 0.0061
Onchocerca volvulus 0.0041 0.0108 0.1348
Brugia malayi Pre-SET motif family protein 0.003 0.0068 0.0067
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.014 0.0139
Onchocerca volvulus 0.0149 0.0493 0.6179
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0303 0.1045 0.1044
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0068 0.0067
Echinococcus granulosus importin subunit beta 1 0.0028 0.0062 0.0061
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0023 0.0288
Echinococcus multilocularis GPCR, family 2 0.0016 0.0016 0.0015
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0206 0.2577
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0063 0.4025
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0023 0.0288
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.014 1
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0013 0.0006 0.0006
Echinococcus multilocularis cpg binding protein 0.003 0.0067 0.0067
Echinococcus granulosus bifunctional protein NCOAT 0.2804 1 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.014 1
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0013 0.0006 0.0006
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0033 0.0078 0.0077
Loa Loa (eye worm) CHromoDomain protein family member 0.0013 0.0006 0.0006
Schistosoma mansoni hypothetical protein 0.0303 0.1045 0.1044
Trypanosoma brucei protein kinase, putative 0.005 0.014 1
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0128 0.0128
Trichomonas vaginalis CMGC family protein kinase 0.005 0.014 0.1749
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0043 0.053
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.014 1
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0152 0.0151
Brugia malayi jmjC domain containing protein 0.0094 0.0297 0.0296
Trichomonas vaginalis CMGC family protein kinase 0.005 0.014 0.1749
Schistosoma mansoni hypothetical protein 0.0016 0.0016 0.0015
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0124 0.0404 0.0403
Echinococcus multilocularis expressed protein 0.0033 0.0078 0.0077
Loa Loa (eye worm) hypothetical protein 0.0047 0.0128 0.0128
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.014 0.0139
Brugia malayi hypothetical protein 0.0149 0.0493 0.0492
Echinococcus multilocularis chromobox protein 1 0.0069 0.0206 0.0205
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0098 0.1223
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0108 0.1354
Loa Loa (eye worm) hypothetical protein 0.0053 0.0152 0.0151
Loa Loa (eye worm) hypothetical protein 0.0028 0.0062 0.0061
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.008 0.008
Brugia malayi PHD-finger family protein 0.0029 0.0063 0.0063
Brugia malayi mbt repeat family protein 0.0047 0.0128 0.0128
Schistosoma mansoni microtubule-associated protein tau 0.0679 0.2391 0.2391
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.02 0.0676 0.0676
Schistosoma mansoni hypothetical protein 0.0402 0.1401 0.1401
Schistosoma mansoni hypothetical protein 0.0124 0.0404 0.0403
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0013 0.0154
Entamoeba histolytica hypothetical protein 0.0023 0.0043 0.5647
Loa Loa (eye worm) hypothetical protein 0.0038 0.0098 0.0097
Echinococcus granulosus chromobox protein 1 0.0069 0.0206 0.0205
Giardia lamblia Kinase, CMGC MAPK 0.005 0.014 1
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0152 0.0151
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0063 0.931
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0058 0.0719
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0058 0.0719
Schistosoma mansoni hypothetical protein 0.0016 0.0016 0.0015
Echinococcus multilocularis dnaJ subfamily B 0.0402 0.1401 0.1401
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.009 0.009
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0063 0.0063
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0128 0.0128
Onchocerca volvulus Alhambra homolog 0.0029 0.0063 0.0785
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0041 0.0108 0.0107
Echinococcus granulosus mitogen activated protein kinase 0.005 0.014 0.0139
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0128 0.1605
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.009 0.009
Schistosoma mansoni rotamase 0.0033 0.0078 0.0077
Echinococcus multilocularis microtubule associated protein 2 0.0679 0.2391 0.2391
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0062 0.0061
Echinococcus granulosus expressed protein 0.0033 0.0078 0.0077
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0108 0.1354
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0068 0.0067
Plasmodium falciparum importin beta, putative 0.0028 0.0062 0.9821
Echinococcus granulosus GPCR family 2 0.0016 0.0016 0.0015
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0185 0.0622 0.0622
Schistosoma mansoni hypothetical protein 0.0285 0.0982 0.0981
Echinococcus multilocularis Chromobox protein 3 0.0011 0 0.0000000044044
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0063 0.0063
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.014 1
Trichomonas vaginalis rotamase, putative 0.0033 0.0078 0.0973
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0062 0.3952
Schistosoma mansoni chromobox protein 0.0069 0.0206 0.0205
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0075 0.3349
Brugia malayi Bromodomain containing protein 0.0029 0.0063 0.0063
Plasmodium vivax hypothetical protein, conserved 0.0011 0 0.0064
Loa Loa (eye worm) hypothetical protein 0.0034 0.008 0.008
Brugia malayi chromobox protein homolog 3 0.0038 0.0098 0.0097
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0032 0.0075 0.3349
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0152 0.0151
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0068 0.4325
Loa Loa (eye worm) hypothetical protein 0.003 0.0068 0.0068
Echinococcus multilocularis peregrin 0.0029 0.0063 0.0063
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0078 0.0973
Brugia malayi MAP kinase sur-1 0.005 0.014 0.0139
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.009 0.009
Onchocerca volvulus 0.0011 0 0.000000055302
Echinococcus granulosus peregrin 0.0029 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.02 0.0676 0.0676
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0029 0.0028
Onchocerca volvulus 0.0047 0.0128 0.1605
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0063 0.0063
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0068 0.0067
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0152 0.0151
Echinococcus multilocularis bifunctional protein NCOAT 0.2804 1 1
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0108 0.1354
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0023 0.0288
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0136 0.0135
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0128 0.0128
Schistosoma mansoni Hyaluronidase 0.2804 1 1
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0206 0.2577
Loa Loa (eye worm) hypothetical protein 0.1191 0.4225 0.4225
Echinococcus multilocularis chromobox protein 1 0.0069 0.0206 0.0205
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0085 0.0084
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0016 0.0015
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.014 0.0139
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0205 0.0696 0.0695
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0152 0.0151
Brugia malayi CHD4 protein 0.0013 0.0006 0.0006
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0128 0.0128
Plasmodium vivax heterochromatin protein 1, putative 0.0011 0 0.0064
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0016 0.0015
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0094 0.0297 0.0296
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0043 0.053
Echinococcus granulosus jumonji domain containing protein 0.004 0.0103 0.0103
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.009 0.009
Schistosoma mansoni chromobox protein 0.0069 0.0206 0.0205
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0166 0.0556 0.0556
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0185 0.0622 0.0622
Schistosoma mansoni cpg binding protein 0.003 0.0067 0.0067
Echinococcus multilocularis snurportin 1 0.0303 0.1045 0.1044
Trichomonas vaginalis CMGC family protein kinase 0.005 0.014 0.1749
Loa Loa (eye worm) heterochromatin protein 1 0.0069 0.0206 0.0205
Schistosoma mansoni hypothetical protein 0.0016 0.0016 0.0015
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.014 0.0139
Loa Loa (eye worm) MBCTL1 0.0053 0.0152 0.0151
Echinococcus granulosus Chromobox protein 3 0.0011 0 0.0000000044044
Onchocerca volvulus 0.003 0.0068 0.085
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0023 0.0022
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0032 0.0075 0.1709
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0011 0 0.0069
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0156 1
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0098 0.1223
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0033 0.0078 0.0077
Toxoplasma gondii peptidylprolyl isomerase 0.0032 0.0075 0.4809

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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