Detailed information for compound 561374

Basic information

Technical information
  • TDR Targets ID: 561374
  • Name: N-[5-[2-[(1,1-dimethyl-2-phenyl-ethyl)amino]- 1-hydroxy-ethyl]-2-hydroxy-phenyl]methanesulf onamide
  • MW: 378.486 | Formula: C19H26N2O4S
  • H donors: 4 H acceptors: 4 LogP: 1.83 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(c1ccc(c(c1)NS(=O)(=O)C)O)CNC(Cc1ccccc1)(C)C
  • InChi: 1S/C19H26N2O4S/c1-19(2,12-14-7-5-4-6-8-14)20-13-18(23)15-9-10-17(22)16(11-15)21-26(3,24)25/h4-11,18,20-23H,12-13H2,1-3H3
  • InChiKey: XJBCFFLVLOPYBV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[5-[2-[(1,1-dimethyl-2-phenylethyl)amino]-1-hydroxyethyl]-2-hydroxyphenyl]methanesulfonamide
  • N-[2-hydroxy-5-[1-hydroxy-2-[(2-methyl-1-phenyl-propan-2-yl)amino]ethyl]phenyl]methanesulfonamide
  • N-[2-hydroxy-5-[1-hydroxy-2-[(2-methyl-1-phenylpropan-2-yl)amino]ethyl]phenyl]methanesulfonamide
  • zinterol
  • 2'-Hydroxy-5'-(l-hydroxy-2-(2-methyl-1-phenyl-2-propylamino)ethyl)methanesulfonanilide
  • Methanesulfonamide, N-(5-(2-((1,1-dimethyl-2-phenylethyl)amino)-1-hydroxyethyl)-2-hydroxyphenyl)-
  • Zinterolum [INN-Latin]
  • MJ-9184
  • MJ-9184-1
  • NSC-284704

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens adrenoceptor beta 2, surface Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0007 0.002
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0007 0.002
Onchocerca volvulus Alhambra homolog 0.0031 0.0245 0.1813
Loa Loa (eye worm) hypothetical protein 0.0019 0.0102 0.0287
Loa Loa (eye worm) hypothetical protein 0.0053 0.0505 0.1416
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0007 0.002
Loa Loa (eye worm) ACC-1 protein 0.0016 0.0074 0.0207
Schistosoma mansoni hypothetical protein 0.0043 0.0389 0.1092
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0585 0.0579
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0016 0.0074 0.0207
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0016 0.0074 0.0207
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.001 0 0.5
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0016 0.0074 0.0207
Loa Loa (eye worm) hypothetical protein 0.0016 0.0074 0.0207
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.002
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0102 0.0244
Schistosoma mansoni hypothetical protein 0.0043 0.0389 0.1092
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0007 0.002
Schistosoma mansoni hypothetical protein 0.0043 0.0389 0.1092
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0016 0.0074 0.0187
Loa Loa (eye worm) hypothetical protein 0.0019 0.0102 0.0287
Loa Loa (eye worm) hypothetical protein 0.0016 0.0074 0.0207
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0016 0.0074 0.0207
Loa Loa (eye worm) hypothetical protein 0.0016 0.0074 0.0207
Schistosoma mansoni hypothetical protein 0.0038 0.033 0.0926
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0007 0.002
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0007 0.002
Loa Loa (eye worm) hypothetical protein 0.0016 0.0074 0.0207
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0016 0.0074 0.0207
Echinococcus multilocularis protein dispatched 1 0.0051 0.0483 0.0476
Schistosoma mansoni aminopeptidase P homologue (M24 family) 0.0311 0.3564 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0177 0.1548
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0016 0.0074 0.0207
Schistosoma mansoni patched 1 0.0045 0.0408 0.1146
Echinococcus granulosus glycine receptor subunit alpha 1 0.0016 0.0074 0.0187
Brugia malayi Cation transporter family protein 0.0016 0.0074 0.0207
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0245 0.4183
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0104 0.111 1
Schistosoma mansoni hypothetical protein 0.0043 0.0389 0.1092
Brugia malayi Hyaluronidase family protein 0.0311 0.3564 1
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0016 0.0074 0.0067
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0007 0.002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0007 0.002
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0016 0.0074 0.0207
Brugia malayi steroid hormone receptor 0.0011 0.0007 0.002
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0007 0.002
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0016 0.0074 0.0207
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0016 0.0074 0.0207
Brugia malayi PHD-finger family protein 0.0031 0.0245 0.0687
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0177 0.0496
Loa Loa (eye worm) hypothetical protein 0.0016 0.0074 0.0207
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.002
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0016 0.0074 0.0207
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0016 0.0074 0.0067
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0016 0.0074 0.0207
Loa Loa (eye worm) hypothetical protein 0.0122 0.1319 0.37
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0007 0.002
Brugia malayi Cation transporter family protein 0.0016 0.0074 0.0207
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0007 0.002
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0585 1
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0016 0.0074 0.0187
Brugia malayi MH2 domain containing protein 0.0126 0.1371 0.3846
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.001 0 0.5
Brugia malayi Niemann-Pick C1 protein precursor 0.0104 0.111 0.3113
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0007 0.002
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0177 0.5
Schistosoma mansoni nAChR subunit 0.0016 0.0074 0.0207
Schistosoma mansoni nAChR subunit 0.0016 0.0074 0.0207
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0016 0.0074 0.0207
Onchocerca volvulus 0.0016 0.0074 0.0507
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0408 0.5
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.033 0.0323
Echinococcus multilocularis bifunctional protein NCOAT 0.0311 0.3564 0.3559
Echinococcus multilocularis nAChR subunit 0.0016 0.0074 0.0067
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0007 0.002
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0007 0.002
Schistosoma mansoni nAChR subunit 0.0016 0.0074 0.0207
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0321 0.0314
Echinococcus granulosus Protein patched homolog 1 0.0045 0.0408 0.1128
Loa Loa (eye worm) hypothetical protein 0.0016 0.0074 0.0207
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0016 0.0074 0.0187
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0016 0.0074 0.0067
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0016 0.0074 0.0067
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0016 0.0074 0.0067
Schistosoma mansoni jumonji domain containing protein 0.008 0.0828 0.2322
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0245 0.0668
Brugia malayi nuclear hormone receptor 0.0011 0.0007 0.002
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0177 0.1548
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0007 0.002
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0585 1
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0016 0.0074 0.0207
Schistosoma mansoni hypothetical protein 0.0031 0.0245 0.0687
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.033 0.0908
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0007 0.002
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0007 0.002
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0177 0.1548
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0007 0.002
Echinococcus granulosus lysine specific demethylase 5A 0.0037 0.0321 0.0883
Onchocerca volvulus Huntingtin homolog 0.0122 0.1319 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0527 0.1478
Loa Loa (eye worm) LGC-31 protein 0.0016 0.0074 0.0207
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0016 0.0074 0.0207
Loa Loa (eye worm) hypothetical protein 0.0122 0.1319 0.37
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0007 0.002
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0321 0.0902
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0007 0.002
Brugia malayi nuclear receptor NHR-88 0.0011 0.0007 0.002
Schistosoma mansoni coup transcription factor 0.0011 0.0007 0.002
Mycobacterium ulcerans hypothetical protein 0.0025 0.0177 0.1548
Onchocerca volvulus 0.0016 0.0074 0.0507
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0016 0.0074 0.0207
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0007 0.002
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0016 0.0074 0.0067
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0245 0.0238
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0585 0.1643
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0016 0.0074 0.0187
Echinococcus granulosus jumonji domain containing protein 0.0043 0.0387 0.1069
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0016 0.0074 0.0207
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0007 0.002
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0102 0.4171
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0016 0.0074 0.0207
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0016 0.0074 0.0067
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0245 0.4183
Loa Loa (eye worm) hypothetical protein 0.0019 0.0102 0.0287
Loa Loa (eye worm) hypothetical protein 0.0025 0.0177 0.0496
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0045 0.0408 0.1146
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0007 0.002
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0016 0.0074 0.0207
Loa Loa (eye worm) MH2 domain-containing protein 0.0126 0.1371 0.3846
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0016 0.0074 0.0067
Echinococcus granulosus bifunctional protein NCOAT 0.0311 0.3564 1
Echinococcus multilocularis sterol regulatory element binding protein 0.0045 0.0408 0.0401
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0016 0.0074 0.0067
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0007 0.002
Loa Loa (eye worm) hypothetical protein 0.0016 0.0074 0.0207
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0585 0.1626
Onchocerca volvulus 0.0016 0.0074 0.0507
Echinococcus granulosus glycine receptor subunit alpha 1 0.0016 0.0074 0.0187
Echinococcus multilocularis expressed conserved protein 0.0098 0.1035 0.1029
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0016 0.0074 0.0187
Loa Loa (eye worm) hypothetical protein 0.0104 0.111 0.3113
Brugia malayi hypothetical protein 0.0038 0.033 0.0926
Giardia lamblia PHD finger protein 15 0.0031 0.0245 0.5
Entamoeba histolytica hypothetical protein 0.0038 0.033 0.1641
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0245 1
Brugia malayi Bromodomain containing protein 0.0031 0.0245 0.0687
Loa Loa (eye worm) hypothetical protein 0.0016 0.0074 0.0207
Onchocerca volvulus 0.0016 0.0074 0.0507
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0007 0.002
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0585 1
Onchocerca volvulus 0.0016 0.0074 0.0507
Brugia malayi ecdysteroid receptor 0.0011 0.0007 0.002
Loa Loa (eye worm) hypothetical protein 0.0016 0.0074 0.0207
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0585 0.1643
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0016 0.0074 0.0067
Schistosoma mansoni Hyaluronidase 0.0311 0.3564 1
Echinococcus granulosus nAChR subunit 0.0016 0.0074 0.0187
Onchocerca volvulus Huntingtin homolog 0.0122 0.1319 1
Brugia malayi excitatory GABA receptor EXP-1A 0.0016 0.0074 0.0207
Brugia malayi CHE-14 protein 0.0045 0.0408 0.1146
Schistosoma mansoni nAChR subunit 0.0016 0.0074 0.0207
Echinococcus granulosus peregrin 0.0031 0.0245 0.0668
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0177 0.1754
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0101 0.1073 0.2995
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0101 0.1073 0.1066
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0177 0.0496
Echinococcus granulosus Niemann Pick C1 protein 0.0104 0.111 0.31
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0245 0.0687
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0007 0.002
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.002
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0007 0.002
Echinococcus multilocularis glycine receptor subunit beta 0.0016 0.0074 0.0067
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0007 0.002
Loa Loa (eye worm) ACC-1 protein 0.0016 0.0074 0.0207
Loa Loa (eye worm) hypothetical protein 0.0016 0.0074 0.0207
Entamoeba histolytica hypothetical protein 0.0038 0.033 0.1641
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.0102 0.5
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0007 0.002
Loa Loa (eye worm) hypothetical protein 0.0016 0.0074 0.0207
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.002
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0007 0.002
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0102 0.4171
Loa Loa (eye worm) hyaluronidase 0.0311 0.3564 1
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0245 0.0687
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0177 0.1548
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0016 0.0074 0.0187
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0016 0.0074 0.0187
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0007 0.002
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.002
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0177 0.1548
Loa Loa (eye worm) hypothetical protein 0.0016 0.0074 0.0207
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0007 0.002
Loa Loa (eye worm) hypothetical protein 0.0132 0.1446 0.4056
Loa Loa (eye worm) hypothetical protein 0.0016 0.0074 0.0207
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0016 0.0074 0.0207
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0016 0.0074 0.0207
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0177 0.5
Loa Loa (eye worm) hypothetical protein 0.0019 0.0102 0.0287
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.0321 0.0902
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0007 0.002
Loa Loa (eye worm) hypothetical protein 0.0045 0.0408 0.1146
Brugia malayi Cation transporter family protein 0.0016 0.0074 0.0207
Brugia malayi jmjC domain containing protein 0.0037 0.0321 0.0902
Brugia malayi jmjC domain containing protein 0.0101 0.1073 0.301
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0007 0.002
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0177 0.1754
Loa Loa (eye worm) hypothetical protein 0.0016 0.0074 0.0207
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0016 0.0074 0.0207
Echinococcus multilocularis Niemann Pick C1 protein 0.0148 0.1637 0.1631
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0007 0.002
Echinococcus granulosus glycine receptor subunit beta 0.0016 0.0074 0.0187
Entamoeba histolytica hypothetical protein 0.0038 0.033 0.1641
Loa Loa (eye worm) hypothetical protein 0.0019 0.0102 0.0287
Loa Loa (eye worm) transcription factor SMAD2 0.0126 0.1371 0.3846
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.0387 0.038
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.033 0.0926
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0016 0.0074 0.0207
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0016 0.0074 0.0207
Brugia malayi hypothetical protein 0.0122 0.1319 0.37
Plasmodium falciparum phd finger protein, putative 0.0031 0.0245 1
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0016 0.0074 0.0207
Onchocerca volvulus 0.0025 0.0177 0.1294
Echinococcus multilocularis protein patched 0.0045 0.0408 0.0401
Schistosoma mansoni nAChR subunit 0.0016 0.0074 0.0207
Echinococcus multilocularis peregrin 0.0031 0.0245 0.0238
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0585 1
Entamoeba histolytica hypothetical protein 0.0038 0.033 0.1641
Echinococcus granulosus sterol regulatory element binding protein 0.0045 0.0408 0.1128
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0016 0.0074 0.0207
Loa Loa (eye worm) hypothetical protein 0.0025 0.0177 0.0496
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0016 0.0074 0.0187
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0016 0.0074 0.0207
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.0632 0.1774
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0321 0.0902
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0007 0.002
Echinococcus multilocularis Niemann Pick C1 protein 0.0104 0.111 0.1103
Echinococcus granulosus Niemann Pick C1 protein 0.0148 0.1637 0.4582
Onchocerca volvulus 0.0016 0.0074 0.0507
Loa Loa (eye worm) hypothetical protein 0.0025 0.0177 0.0496
Loa Loa (eye worm) hypothetical protein 0.0016 0.0074 0.0207
Echinococcus multilocularis glycine receptor subunit beta 0.0016 0.0074 0.0067
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0585 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0074 0.0207
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0177 0.1548
Echinococcus granulosus glycine receptor subunit alpha 1 0.0016 0.0074 0.0187
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0105 0.1129 0.3167
Schistosoma mansoni nAChR subunit 0.0016 0.0074 0.0207
Onchocerca volvulus Putative nachr subunit 0.0016 0.0074 0.0507
Echinococcus granulosus glycine receptor subunit beta 0.0016 0.0074 0.0187
Schistosoma mansoni nAChR subunit 0.0016 0.0074 0.0207
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0016 0.0074 0.0207
Loa Loa (eye worm) hypothetical protein 0.0016 0.0074 0.0207
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0177 0.1548
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.002
Loa Loa (eye worm) hypothetical protein 0.0016 0.0074 0.0207
Loa Loa (eye worm) hypothetical protein 0.0016 0.0074 0.0207
Echinococcus granulosus expressed conserved protein 0.0098 0.1035 0.289
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0585 1
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0177 0.0496
Loa Loa (eye worm) hypothetical protein 0.0031 0.0245 0.0687
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0016 0.0074 0.0207
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.002
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.002

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 0.054 nM Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method ChEMBL. 20804199

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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