Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.1995 | 0.4186 | 0.4153 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.005 | 0 | 0.5 |
Echinococcus granulosus | bifunctional protein NCOAT | 0.4697 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.0248 | 0.0193 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0076 | 0.0057 | 1 |
Schistosoma mansoni | Hyaluronidase | 0.4697 | 1 | 1 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0076 | 0.0057 | 0.5 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0674 | 0.1343 | 0.1343 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.005 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.0057 | 0.5 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.0057 | 0.5 |
Echinococcus multilocularis | bifunctional protein NCOAT | 0.4697 | 1 | 1 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0076 | 0.0057 | 0.0057 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.0057 | 0.5 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0076 | 0.0057 | 0.0057 |
Schistosoma mansoni | aminopeptidase P homologue (M24 family) | 0.4697 | 1 | 1 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.0057 | 0.5 |
Echinococcus multilocularis | geminin | 0.0166 | 0.0248 | 0.0248 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.0057 | 0.5 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.0057 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.0248 | 0.0193 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0674 | 0.1343 | 0.1294 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0076 | 0.0057 | 0.5 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.0057 | 0.5 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0674 | 0.1343 | 0.1343 |
Echinococcus granulosus | geminin | 0.0166 | 0.0248 | 0.0248 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0076 | 0.0057 | 0.5 |
Loa Loa (eye worm) | hyaluronidase | 0.4697 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | Inhibition of reserpine-induced ptosis in po dosed mouse at 25 mg/kg, po | ChEMBL. | 5607 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.