Detailed information for compound 56415

Basic information

Technical information
  • TDR Targets ID: 56415
  • Name: 2-(2-methyl-5-nitroimidazol-1-yl)ethyl 3,4,5- trimethoxybenzoate
  • MW: 365.338 | Formula: C16H19N3O7
  • H donors: 0 H acceptors: 4 LogP: 1.97 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(cc(c1OC)OC)C(=O)OCCn1c(C)ncc1[N+](=O)[O-]
  • InChi: 1S/C16H19N3O7/c1-10-17-9-14(19(21)22)18(10)5-6-26-16(20)11-7-12(23-2)15(25-4)13(8-11)24-3/h7-9H,5-6H2,1-4H3
  • InChiKey: SVTLMDWAMSAFIE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-(2-methyl-5-nitro-imidazol-1-yl)ethyl 3,4,5-trimethoxybenzoate
  • 3,4,5-trimethoxybenzoic acid 2-(2-methyl-5-nitro-1-imidazolyl)ethyl ester
  • 3,4,5-trimethoxybenzoic acid 2-(2-methyl-5-nitro-imidazol-1-yl)ethyl ester
  • 104575-36-2
  • 2-(2-Methyl-5-nitro-1H-imidazol-1-yl)ethyl 3,4,5-trimethoxybenzoate
  • Benzoic acid, 3,4,5-trimethoxy-, 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major hypothetical protein, conserved 0.0063 0.0243 0.2496
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0063 0.0244 0.0565
Leishmania major phosphoglycerate kinase B, cytosolic 0.0185 0.0967 1
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0068 0.0274 0.2279
Brugia malayi jmjC domain containing protein 0.0038 0.01 0.0405
Plasmodium falciparum phosphoglycerate kinase 0.0185 0.0967 1
Plasmodium vivax phosphoglycerate kinase, putative 0.0185 0.0967 1
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0185 0.0967 0.1647
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0203 0.1076 0.2227
Plasmodium falciparum phd finger protein, putative 0.0032 0.006 0.0453
Plasmodium vivax small ubiquitin-related modifier, putative 0.0033 0.007 0.0557
Plasmodium falciparum small ubiquitin-related modifier 0.0033 0.007 0.0557
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0623 0.3558 0.7721
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0623 0.3558 1
Plasmodium vivax SET domain protein, putative 0.0063 0.0244 0.2385
Leishmania major small ubiquitin protein, putative 0.0033 0.007 0.0696
Onchocerca volvulus 0.0063 0.0244 0.0865
Onchocerca volvulus 0.0498 0.2817 1
Echinococcus multilocularis peregrin 0.0032 0.006 0.0139
Giardia lamblia PHD finger protein 15 0.0032 0.006 0.0161
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0063 0.0244 0.2385
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0203 0.1076 0.299
Treponema pallidum penicillin-binding protein (pbp-3) 0.1479 0.8619 0.8616
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0043 0.0126 0.0125
Trichomonas vaginalis conserved hypothetical protein 0.0797 0.4587 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0623 0.3558 0.7721
Echinococcus multilocularis dna polymerase kappa 0.0043 0.0126 0.0293
Trypanosoma brucei small ubiquitin-related modifier 0.0033 0.007 0.0696
Loa Loa (eye worm) glutaminase 2 0.0285 0.1561 0.6346
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0117 0.0563 0.5811
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0126 0.0628
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0134 0.0667 0.6657
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0304 0.1673 0.2834
Echinococcus granulosus L aminoadipate semialdehyde 0.0087 0.0386 0.0896
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.0063 0.0243 0.2496
Treponema pallidum penicillin-binding protein (pbp-1) 0.1712 1 1
Mycobacterium ulcerans DNA polymerase IV 0.0043 0.0126 0.0127
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0063 0.0244 0.0565
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0437 0.246 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0065 0.0641
Brugia malayi Phosphoglycerate kinase 0.0185 0.0967 0.3932
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0063 0.0243 0.0384
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0134 0.0667 0.689
Trichomonas vaginalis set domain proteins, putative 0.0498 0.2817 0.6082
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0017 0.0148
Mycobacterium tuberculosis Probable bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 (murein polymerase) [includes: penicillin-insen 0.0549 0.3118 0.532
Trypanosoma cruzi hypothetical protein, conserved 0.0063 0.0243 0.1934
Echinococcus multilocularis PHD finger protein rhinoceros 0.0032 0.006 0.0139
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.006 0.023 0.0533
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0134 0.0667 0.1548
Mycobacterium leprae POSSIBLE PENICILLIN-BINDING LIPOPROTEIN 0.0314 0.1731 0.2934
Schistosoma mansoni hypothetical protein 0.0032 0.006 0.0139
Echinococcus multilocularis microtubule associated protein 2 0.075 0.4311 1
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0134 0.0667 0.2713
Echinococcus multilocularis phosphoglycerate kinase 1 0.0185 0.0967 0.2244
Echinococcus granulosus PHD finger protein rhinoceros 0.0032 0.006 0.0139
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0203 0.1076 0.2227
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.01 0.0405
Treponema pallidum phosphoglycerate kinase 0.0185 0.0967 0.0952
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0185 0.0967 0.1987
Mycobacterium ulcerans penicillin-binding lipoprotein 0.0314 0.1731 0.1993
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0185 0.0967 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.006 0.0453
Brugia malayi Pre-SET motif family protein 0.0437 0.246 1
Mycobacterium tuberculosis Probable bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase 0.0248 0.1341 0.2286
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0117 0.0563 0.1306
Schistosoma mansoni lipoxygenase 0.0123 0.0601 0.1394
Echinococcus granulosus transcription factor Dp 1 0.0078 0.0333 0.0771
Giardia lamblia Phosphoglycerate kinase 0.0185 0.0967 0.2713
Mycobacterium leprae PROBABLE BIFUNCTIONAL MEMBRANE-ASSOCIATED PENICILLIN-BINDING PROTEIN 1A/1B PONA2 (MUREIN POLYMERASE) [INCLUDES: PENICILLIN-INSEN 0.0549 0.3118 0.5309
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0141 0.0705 0.1199
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0126 0.0628
Schistosoma mansoni microtubule-associated protein tau 0.075 0.4311 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0244 0.0565
Echinococcus granulosus jumonji domain containing protein 0.0044 0.0134 0.031
Echinococcus granulosus Small ubiquitin modifier 2 0.0033 0.007 0.0162
Entamoeba histolytica ubiquitin like protein 0.0033 0.007 0.0149
Mycobacterium ulcerans glutaminase 0.0285 0.1561 0.1795
Schistosoma mansoni ubiquitin-like protein sumo/smt3-related 0.0033 0.007 0.0162
Loa Loa (eye worm) hypothetical protein 0.0185 0.0967 0.3932
Loa Loa (eye worm) PHD-finger family protein 0.0032 0.006 0.0244
Loa Loa (eye worm) hypothetical protein 0.0032 0.0065 0.0262
Echinococcus multilocularis transcription factor Dp 1 0.0078 0.0333 0.0771
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0063 0.0244 0.0565
Mycobacterium ulcerans penicillin-binding protein PbpA 0.1012 0.5859 0.6791
Mycobacterium ulcerans phosphoglycerate kinase 0.0185 0.0967 0.1105
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0117 0.0563 0.229
Entamoeba histolytica phosphoglycerate kinase, putative 0.0185 0.0967 0.2684
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0134 0.0667 0.1837
Trichomonas vaginalis DNA polymerase eta, putative 0.0043 0.0126 0.0125
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.026 0.1056
Echinococcus multilocularis L aminoadipate semialdehyde 0.0087 0.0386 0.0896
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0017 0.0148
Echinococcus granulosus dna polymerase kappa 0.0043 0.0126 0.0293
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0203 0.1076 0.4373
Mycobacterium ulcerans DNA polymerase IV 0.0043 0.0126 0.0127
Mycobacterium tuberculosis Probable penicillin-binding protein PbpA 0.1012 0.5859 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0126 0.0628
Mycobacterium tuberculosis Probable penicillin-binding membrane protein PbpB 0.0464 0.2619 0.4468
Leishmania major phosphoglycerate kinase C, glycosomal 0.0185 0.0967 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0126 0.128
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0623 0.3558 0.7721
Echinococcus granulosus phosphoglycerate kinase 1 0.0185 0.0967 0.2244
Mycobacterium ulcerans bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 0.0549 0.3118 0.3605
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0126 0.128
Brugia malayi Pre-SET motif family protein 0.0063 0.0244 0.0991
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0123 0.0601 0.1394
Plasmodium vivax hypothetical protein, conserved 0.0032 0.006 0.0453
Echinococcus multilocularis Small ubiquitin modifier 2 0.0033 0.007 0.0162
Schistosoma mansoni phosphoglycerate kinase 0.0185 0.0967 0.2244
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0134 0.0667 0.689
Brugia malayi Ubiquitin-like protein SMT3 0.0033 0.007 0.0284
Echinococcus granulosus peregrin 0.0032 0.006 0.0139
Echinococcus granulosus microtubule associated protein 2 0.075 0.4311 1
Brugia malayi PHD-finger family protein 0.0032 0.006 0.0244
Onchocerca volvulus 0.0203 0.1076 0.3818
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0304 0.1673 0.2852
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0068 0.0274 0.2279
Loa Loa (eye worm) hypothetical protein 0.0032 0.006 0.0244
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0623 0.3558 0.7721
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0623 0.3558 0.7721
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0126 0.128
Schistosoma mansoni phosphoglycerate kinase 0.0185 0.0967 0.2244
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0126 0.0628
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0068 0.0274 0.2279
Schistosoma mansoni glutaminase 0.0285 0.1561 0.3621
Trypanosoma brucei phosphoglycerate kinase, putative 0.0068 0.0274 0.2817
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0185 0.0967 0.1627
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0117 0.0563 0.0635
Brugia malayi jmjC domain containing protein 0.0104 0.0487 0.1979
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0134 0.0667 0.6657
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0126 0.128
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0126 0.128
Trypanosoma brucei phosphoglycerate kinase 0.0185 0.0967 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.01 0.0231
Brugia malayi Phosphoglycerate kinase 0.0068 0.0274 0.1116
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0068 0.0274 0.2279
Mycobacterium ulcerans bifunctional penicillin-binding protein 1A/1B PonA1 0.0797 0.4587 0.5313
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0126 0.128
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0063 0.0243 0.0384
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0117 0.0563 0.1306
Loa Loa (eye worm) glutaminase 0.0285 0.1561 0.6346
Chlamydia trachomatis phosphoglycerate kinase 0.0185 0.0967 0.0952
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0203 0.1076 0.2227
Loa Loa (eye worm) hypothetical protein 0.0054 0.0194 0.0789
Mycobacterium leprae PROBABLE BIFUNCTIONAL PENICILLIN-BINDING PROTEIN 1A/1B PONA1 (MUREIN POLYMERASE) (PBP1): PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE 0.0797 0.4587 0.7823
Brugia malayi polk-prov protein 0.0032 0.0065 0.0262
Echinococcus multilocularis lysine specific demethylase 5A 0.0038 0.01 0.0231
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.01 0.0231
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0104 0.0487 0.1129
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0203 0.1076 0.3018
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0126 0.128
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0134 0.0667 0.1548
Treponema pallidum penicillin-binding protein (pbp-2) 0.0797 0.4587 0.4578
Giardia lamblia Fructose-bisphosphate aldolase 0.0623 0.3558 1
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0087 0.0386 0.0896
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0126 0.128
Chlamydia trachomatis transglycolase/transpeptidase 0.0778 0.4478 0.4468
Trypanosoma brucei DNA polymerase IV, putative 0.0036 0.0085 0.0858
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0117 0.0563 0.0635
Mycobacterium leprae Probable penicillin-binding membrane protein PbpB 0.0464 0.2619 0.4454
Brugia malayi Bromodomain containing protein 0.0032 0.006 0.0244
Toxoplasma gondii small ubiquitin family modifier, putative 0.0033 0.007 0.0557
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0065 0.0641
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0068 0.0274 0.2279
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0203 0.1076 0.2227
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0244 0.0565
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0203 0.1076 0.299
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0117 0.0563 0.0957
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0068 0.0274 0.2817
Schistosoma mansoni lipoxygenase 0.0086 0.0382 0.0886
Trypanosoma brucei phosphoglycerate kinase 0.0185 0.0967 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0623 0.3558 0.7721
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0032 0.006 0.0139
Mycobacterium tuberculosis Possible penicillin-binding lipoprotein 0.0314 0.1731 0.2951
Echinococcus granulosus lysine specific demethylase 5A 0.0038 0.01 0.0231
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0203 0.1076 0.4373
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0134 0.0667 0.2713
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.006 0.0453
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0104 0.0487 0.1129
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0304 0.1673 0.1925
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0623 0.3558 1
Treponema pallidum fructose-bisphosphate aldolase 0.0623 0.3558 0.3547
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0117 0.0563 0.1306
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0185 0.0967 1
Trichomonas vaginalis glutaminase, putative 0.0285 0.1561 0.3301
Giardia lamblia Sentrin 0.0033 0.007 0.0189
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0185 0.0967 0.0952
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0244 0.0565
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0623 0.3558 0.7721
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0024 0.0017 0.0024
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0126 0.128
Echinococcus granulosus histone lysine methyltransferase setb 0.0063 0.0244 0.0565
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0203 0.1076 0.2227
Wolbachia endosymbiont of Brugia malayi cell division protein FtsI 0.1712 1 1
Trypanosoma brucei unspecified product 0.0036 0.0085 0.0858
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0623 0.3558 0.7721
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0126 0.128
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0185 0.0967 1
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0123 0.0601 0.1394
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0185 0.0967 1
Loa Loa (eye worm) SMO-1 protein 0.0033 0.007 0.0284
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0203 0.1076 0.1231
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0087 0.0386 0.157
Mycobacterium leprae Probable penicillin-binding protein PbpA 0.1012 0.5859 1
Onchocerca volvulus Alhambra homolog 0.0032 0.006 0.0213
Mycobacterium ulcerans penicillin-binding membrane protein PbpB 0.1479 0.8619 1
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0134 0.0667 0.1548
Brugia malayi glutaminase DH11.1 0.0285 0.1561 0.6346
Echinococcus multilocularis jumonji domain containing protein 0.0044 0.0134 0.031
Onchocerca volvulus 0.0087 0.0386 0.1371
Trypanosoma brucei phosphoglycerate kinase 0.0068 0.0274 0.2817
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0203 0.1076 0.2227
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0109 0.0517 0.2101
Trypanosoma cruzi hypothetical protein, conserved 0.0063 0.0243 0.1934
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0126 0.128
Loa Loa (eye worm) hypothetical protein 0.0063 0.0244 0.0991
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0185 0.0967 0.1987
Loa Loa (eye worm) hypothetical protein 0.0087 0.0386 0.157
Schistosoma mansoni jumonji domain containing protein 0.0082 0.036 0.0836

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 1.35 ug ml-1 In vitro anti-trichomonal activity against Trichomonas foetus-Ortho strain-2. ChEMBL. 3543363
Mutagenicity (functional) = 12 % The Mutagenicity against Trichomonas foetus relative to Ronidazole. ChEMBL. 3543363
Safety index (functional) = 2.5 Safety index. ChEMBL. 3543363

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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