Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | purine nucleoside phosphorylase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | methylthioadenosine phosphorylase, putative | purine nucleoside phosphorylase | 289 aa | 255 aa | 23.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | conserved hypothetical protein | 0.0197 | 0.3295 | 1 |
Trichomonas vaginalis | endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative | 0.0197 | 0.3295 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0154 | 0.1395 | 0.1395 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0154 | 0.1395 | 0.1395 |
Trichomonas vaginalis | endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative | 0.0197 | 0.3295 | 1 |
Mycobacterium tuberculosis | Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP) | 0.0154 | 0.1395 | 0.5 |
Trichomonas vaginalis | mannosyl-oligosaccharide alpha-1,2-mannosidase, putative | 0.0197 | 0.3295 | 1 |
Giardia lamblia | Purine nucleoside phosphorylase lateral transfer candidate | 0.0154 | 0.1395 | 0.5 |
Onchocerca volvulus | 0.0235 | 0.4967 | 1 | |
Trichomonas vaginalis | mannosyl-oligosaccharide alpha-1,2-mannosidase, putative | 0.0197 | 0.3295 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0154 | 0.1395 | 0.1395 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.035 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0154 | 0.1395 | 0.1395 |
Schistosoma mansoni | alpha-glucosidase | 0.035 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0154 | 0.1395 | 0.1395 |
Trichomonas vaginalis | mannosyl-oligosaccharide alpha-1,2-mannosidase, putative | 0.0197 | 0.3295 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.035 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 0.2104 | 0.2104 |
Trichomonas vaginalis | endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative | 0.0197 | 0.3295 | 1 |
Mycobacterium ulcerans | purine nucleoside phosphorylase | 0.0154 | 0.1395 | 0.5 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.035 | 1 | 1 |
Echinococcus granulosus | endoplasmic reticulum mannosyl oligosaccharide | 0.0197 | 0.3295 | 0.3295 |
Trichomonas vaginalis | endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative | 0.0197 | 0.3295 | 1 |
Trichomonas vaginalis | mannosyl-oligosaccharide alpha-1,2-mannosidase, putative | 0.0197 | 0.3295 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0154 | 0.1395 | 0.1395 |
Loa Loa (eye worm) | mannosidase | 0.0197 | 0.3295 | 0.3295 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0154 | 0.1395 | 0.1395 |
Echinococcus multilocularis | mannosyl oligosaccharide 1,2 alpha mannosidase | 0.0197 | 0.3295 | 0.3295 |
Schistosoma mansoni | alpha-glucosidase | 0.035 | 1 | 1 |
Trichomonas vaginalis | mannosyl-oligosaccharide alpha-1,2-mannosidase, putative | 0.0197 | 0.3295 | 1 |
Echinococcus multilocularis | transfer RNA-Trp | 0.0197 | 0.3295 | 0.3295 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.035 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.3295 | 0.3295 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0154 | 0.1395 | 0.1395 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0154 | 0.1395 | 0.1395 |
Brugia malayi | Mannosyl-oligosaccharide alpha-1,2-mannosidase isoform 1 | 0.0197 | 0.3295 | 0.2207 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0154 | 0.1395 | 0.1395 |
Schistosoma mansoni | mannosyl-oligosaccharide alpha-12-mannosidase | 0.0197 | 0.3295 | 0.2207 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0154 | 0.1395 | 0.1395 |
Echinococcus multilocularis | endoplasmic reticulum mannosyl oligosaccharide | 0.0197 | 0.3295 | 0.3295 |
Echinococcus granulosus | mannosyl oligosaccharide 12 alpha mannosidase | 0.0197 | 0.3295 | 0.3295 |
Trichomonas vaginalis | endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative | 0.0197 | 0.3295 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.3295 | 0.3295 |
Trichomonas vaginalis | mannosyl-oligosaccharide alpha-1,2-mannosidase, putative | 0.0197 | 0.3295 | 1 |
Trichomonas vaginalis | endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative | 0.0197 | 0.3295 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0154 | 0.1395 | 0.1395 |
Trichomonas vaginalis | endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative | 0.0197 | 0.3295 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0154 | 0.1395 | 0.1395 |
Mycobacterium leprae | Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) | 0.0154 | 0.1395 | 0.5 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0154 | 0.1395 | 0.1395 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5.4 uM | Compound was tested for the inhibitory activity against purine nucleoside phosphorylase (PNP) | ChEMBL. | 1578487 |
IC50 (binding) | = 5.4 uM | Compound was tested for the inhibitory activity against purine nucleoside phosphorylase (PNP) | ChEMBL. | 1578487 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.