Detailed information for compound 56594

Basic information

Technical information
  • TDR Targets ID: 56594
  • Name: 7-methyl-4H-indeno[1,2-d][1,3]thiazol-2-amine hydroiodide
  • MW: 330.188 | Formula: C11H11IN2S
  • H donors: 1 H acceptors: 1 LogP: 3.53 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc2c(c1)c1nc(sc1C2)N.I
  • InChi: 1S/C11H10N2S.HI/c1-6-2-3-7-5-9-10(8(7)4-6)13-11(12)14-9;/h2-4H,5H2,1H3,(H2,12,13);1H
  • InChiKey: PREKDQDLYJZGCR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 7-methyl-4H-indeno[1,2-d]thiazol-2-amine hydroiodide
  • (7-methyl-4H-indeno[1,2-d]thiazol-2-yl)amine hydroiodide
  • 7-methyl-4H-indeno[3,2-d][1,3]thiazol-2-amine hydroiodide
  • 7-methyl-4H-indeno[3,2-d]thiazol-2-amine hydroiodide
  • (7-methyl-4H-indeno[3,2-d]thiazol-2-yl)amine hydroiodide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens adenosine A1 receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi hypothetical protein adenosine A1 receptor 326 aa 305 aa 21.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0009
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0253 0.1203 0.1668
Loa Loa (eye worm) PDE1B protein 0.0056 0.0237 0.1038
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0039 0.0138
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0133 0.2435
Trichomonas vaginalis conserved hypothetical protein 0.001 0.001 0.0079
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0056 0.0932
Brugia malayi MH1 domain containing protein 0.0014 0.0031 0.0119
Trypanosoma brucei unspecified product 0.0061 0.0262 0.4958
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0237 0.9028
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0021 0.0065 0.0258
Brugia malayi hypothetical protein 0.0016 0.0041 0.0169
Loa Loa (eye worm) thioredoxin reductase 0.01 0.0452 0.2014
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0056 0.0237 0.9028
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.003 0.0111 0.4052
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0237 0.9028
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0237 0.5154
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0182 0.072
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0015 0.006
Plasmodium vivax glutathione reductase, putative 0.01 0.0452 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0253 0.1203 0.1668
Entamoeba histolytica recQ family helicase, putative 0.001 0.0013 0.016
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0061 0.0262 0.1037
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0009 0.0008 0.0033
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0015 0.0031
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0065 0.111
Schistosoma mansoni DNA polymerase IV / kappa 0.0019 0.0056 0.0222
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0035 0.0133 0.2435
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0065 0.2238
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0056 0.0237 0.094
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0056 0.0237 0.094
Schistosoma mansoni tar DNA-binding protein 0.0065 0.028 0.1108
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0056 0.0237 0.094
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0056 0.0237 0.094
Brugia malayi steroid hormone receptor 0.0011 0.0015 0.0036
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0237 0.9028
Plasmodium falciparum phosphodiesterase delta, putative 0.0056 0.0237 0.5154
Entamoeba histolytica recQ family DNA helicase 0.0011 0.0015 0.0224
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0015 0.006
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0065 0.2238
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0237 0.4476
Schistosoma mansoni glutamate synthase 0.0009 0.0008 0.0033
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0404 0.1939 0.7682
Trichomonas vaginalis mercuric reductase, putative 0.0035 0.0133 0.491
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0133 0.2435
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0015 0.0036
Trichomonas vaginalis C-MYB, putative 0.003 0.0111 0.4052
Entamoeba histolytica hypothetical protein 0.0072 0.0315 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0117 0.0465
Onchocerca volvulus 0.001 0.001 0.0197
Toxoplasma gondii NADPH-glutathione reductase 0.0035 0.0133 0.0447
Echinococcus multilocularis smad 0.0025 0.0086 0.0342
Loa Loa (eye worm) hypothetical protein 0.0056 0.0237 0.1038
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0039 0.0109
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0296 0.1491
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0025 0.0086 0.0342
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0056 0.0237 0.4476
Schistosoma mansoni smad1 5 8 and 0.0025 0.0086 0.0342
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.1473 0.7171 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0237 0.0822
Schistosoma mansoni hypothetical protein 0.0031 0.0117 0.0465
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0035 0.0133 0.2803
Schistosoma mansoni glutamate synthase 0.0009 0.0008 0.0033
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.003 0.0111 0.3352
Giardia lamblia Sgs1 DNA helicase, putative 0.0021 0.0065 0.0257
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0035 0.0133 0.2435
Leishmania major DNA damage repair protein, putative 0.0019 0.0056 0.0932
Echinococcus multilocularis dna polymerase eta 0.0114 0.052 0.2058
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0021 0.0065 0.0257
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0084 0.0271
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0015 0.0134
Mycobacterium ulcerans DNA polymerase IV 0.0061 0.0262 0.0254
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0056 0.0237 0.4476
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0035 0.0133 0.2803
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0035 0.0133 0.2435
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0237 0.9028
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0021 0.0065 0.0258
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0031
Schistosoma mansoni tar DNA-binding protein 0.0065 0.028 0.1108
Brugia malayi isocitrate dehydrogenase 0.0015 0.0039 0.0158
Trypanosoma cruzi DNA polymerase eta, putative 0.0072 0.0314 0.5974
Brugia malayi DKFZp564C0469 protein 0.001 0.001 0.001
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0013 0.0053
Plasmodium falciparum DNA repair protein REV1, putative 0.0019 0.0056 0.1073
Entamoeba histolytica hypothetical protein 0.0072 0.0315 1
Echinococcus granulosus mothers against decapentaplegic 5 0.0025 0.0086 0.0342
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0009
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0262 0.4958
Plasmodium falciparum thioredoxin reductase 0.0035 0.0133 0.2803
Brugia malayi hypothetical protein 0.001 0.001 0.001
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0404 0.1939 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0182 0.072
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0237 0.0822
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0182 0.072
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.001 0.001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0021 0.0065 0.0257
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0084 0.1473
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0025 0.0088 0.0412
Schistosoma mansoni smad 0.0011 0.0018 0.0073
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0015 0.006
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0061 0.0262 0.0354
Schistosoma mansoni sulfide quinone reductase 0.0009 0.0008 0.0033
Schistosoma mansoni DNA ligase IV 0.001 0.001 0.0041
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0056 0.0237 0.094
Trypanosoma brucei trypanothione reductase 0.01 0.0452 0.8684
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0009 0.0008 0.0033
Schistosoma mansoni cpg binding protein 0.0032 0.0119 0.0472
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0056 0.0237 0.094
Schistosoma mansoni disulfide oxidoreductase 0.0009 0.0008 0.0033
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0011 0.0018 0.0974
Giardia lamblia Hypothetical protein 0.0056 0.0237 0.1038
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0237 0.9028
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0035 0.0133 0.0526
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0035 0.0133 0.0125
Trichomonas vaginalis DNA polymerase eta, putative 0.0061 0.0262 1
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.003 0.0111 0.3352
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0056 0.0237 0.9028
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.003 0.0112 0.408
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0015 0.0673
Chlamydia trachomatis DNA ligase 0.001 0.001 0.0002
Schistosoma mansoni sulfide quinone reductase 0.0009 0.0008 0.0033
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0056 0.0237 0.094
Schistosoma mansoni DNA helicase recq5 0.0021 0.0065 0.0258
Schistosoma mansoni tar DNA-binding protein 0.0065 0.028 0.1108
Mycobacterium ulcerans hypothetical protein 0.0019 0.0056 0.0048
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0015 0.0036
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.001 0.0079
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0056 0.0237 0.9028
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0009 0.0008 0.0033
Schistosoma mansoni blooms syndrome DNA helicase 0.0011 0.0015 0.006
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.2051 1 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0035 0.0133 0.2435
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0035 0.0133 0.2435
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0237 0.4476
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0182 0.072
Schistosoma mansoni chromosome transmission fidelity factor 0.001 0.001 0.0041
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0061 0.0262 0.1037
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0111 0.0464
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0039 0.0154
Schistosoma mansoni DNA helicase recq1 0.0021 0.0065 0.0258
Echinococcus multilocularis mothers against decapentaplegic 5 0.0025 0.0086 0.0342
Trichomonas vaginalis conserved hypothetical protein 0.001 0.001 0.0079
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0015 0.006
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0133 0.2435
Echinococcus multilocularis replication factor c subunit 1 0.001 0.001 0.0041
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0237 0.9028
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0031
Trypanosoma cruzi DNA polymerase kappa, putative 0.0061 0.0262 0.4958
Loa Loa (eye worm) hypothetical protein 0.01 0.045 0.2005
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.001 0.001 0.001
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0009 0.0008 0.0033
Brugia malayi hypothetical protein 0.0072 0.0315 0.1587
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0056 0.0237 0.094
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0015 0.006
Toxoplasma gondii ATPase, AAA family protein 0.001 0.001 0.0007
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0237 0.9028
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0009
Brugia malayi mothers against decapentaplegic homolog 3 0.0011 0.0018 0.0052
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0056 0.0237 0.9028
Trypanosoma brucei DNA polymerase eta, putative 0.0114 0.052 1
Trypanosoma brucei chrX additional, unordered contigs 0.0019 0.0056 0.0932
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0035 0.0133 0.2435
Schistosoma mansoni hypothetical protein 0.0523 0.2524 1
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0056 0.0237 0.4476
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.003 0.0111 0.3352
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0237 0.5154
Entamoeba histolytica recQ family helicase, putative 0.0021 0.0065 0.1851
Leishmania major DNA polymerase kappa, putative 0.0019 0.0056 0.0932
Echinococcus granulosus Smad4 0.0025 0.0086 0.0342
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0015 0.0031
Echinococcus multilocularis thioredoxin glutathione reductase 0.01 0.0452 0.1792
Echinococcus multilocularis Smad4 0.0025 0.0086 0.0342
Echinococcus granulosus bloom syndrome protein 0.0021 0.0065 0.0258
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0065 0.0204
Treponema pallidum NADH oxidase 0.0035 0.0133 0.0125
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0015 0.0673
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0237 0.0822
Echinococcus multilocularis dna polymerase kappa 0.0061 0.0262 0.1037
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0021 0.0065 0.0258
Trypanosoma cruzi trypanothione reductase, putative 0.01 0.0452 0.8684
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0065 0.0294
Trypanosoma cruzi DNA polymerase kappa, putative 0.0061 0.0262 0.4958
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0243 0.0841
Plasmodium falciparum thioredoxin reductase 0.01 0.0452 1
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0237 0.4476
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0035 0.0133 0.2435
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0228 0.1079 0.1495
Brugia malayi MH1 domain containing protein 0.0025 0.0086 0.0404
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0015 0.0036
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0017 0.0069
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0056 0.0237 0.4476
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0031
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0262 0.4958
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0015 0.0036
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.003 0.0111 0.3352
Brugia malayi Pax transcription activation domain interacting protein 0.001 0.001 0.001
Echinococcus granulosus thioredoxin glutathione reductase 0.01 0.0452 0.1792
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0237 0.9028
Leishmania major cAMP-specific phosphodiesterase, putative 0.0056 0.0237 0.4476
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.0315 0.1247
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0015 0.0039 0.0685
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0133 0.2435
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0015 0.0036
Trypanosoma cruzi DNA damage repair protein, putative 0.0019 0.0056 0.0932
Echinococcus multilocularis dnaJ subfamily B 0.0429 0.2062 0.817
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0182 0.0898
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.001 0.0079
Brugia malayi hypothetical protein 0.0025 0.0084 0.039
Giardia lamblia Replication factor C, subunit 1 0.001 0.001 0.0009
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0253 0.1203 0.1668
Echinococcus granulosus dna polymerase kappa 0.0061 0.0262 0.1037
Echinococcus multilocularis glutamate synthase 0.0009 0.0008 0.0033
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.001 0.0013 0.011
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0009
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0035 0.0133 0.0125
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0237 0.4476
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0021 0.0065 0.1278
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0237 0.9028
Onchocerca volvulus 0.003 0.0111 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.046 0.2213 0.8766
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0056 0.0237 0.4476
Trypanosoma brucei DNA polymerase IV, putative 0.0061 0.0262 0.4958
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0056 0.0237 0.4476
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0262 0.4958
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0056 0.0237 0.9028
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0237 0.5154
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.003 0.0111 0.4052
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0015 0.006
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0056 0.0237 0.094
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0039 0.0595
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0056 0.0237 0.9028
Loa Loa (eye worm) hypothetical protein 0.0014 0.0031 0.0104
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.028 0.1406
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0262 0.4958
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0056 0.0237 0.9028
Trichomonas vaginalis conserved hypothetical protein 0.001 0.001 0.0079
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0015 0.0039 0.0042
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0019 0.0056 0.0171
Echinococcus granulosus GPCR family 2 0.0031 0.0117 0.0465
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0056 0.0237 0.094
Giardia lamblia NADH oxidase lateral transfer candidate 0.0035 0.0133 0.0565
Schistosoma mansoni Smad4 0.0011 0.0018 0.0073
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.001 0.001 0.0002
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0039 0.0595
Plasmodium falciparum glutathione reductase 0.0035 0.0133 0.2803
Brugia malayi MH2 domain containing protein 0.0025 0.0086 0.0404
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.001 0.001 0.0039
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0015 0.006
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0035 0.0133 0.2435
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0237 0.9028
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0039 0.0154
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0035 0.0133 0.0125
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0035 0.0133 0.2435
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.01 0.045 0.2289
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0182 0.072
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0065 0.0294
Brugia malayi MH2 domain containing protein 0.0011 0.0018 0.0052
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0056 0.0237 0.1185
Toxoplasma gondii Myb family DNA-binding domain-containing protein 0.003 0.0112 0.0371
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0404 0.1939 0.7682
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0015 0.0036
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0237 0.9028
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0228 0.1079 0.1495
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0015 0.0031
Leishmania major DNA polymerase eta, putative 0.0114 0.052 1
Trypanosoma cruzi DNA damage repair protein, putative 0.0019 0.0056 0.0932
Trichomonas vaginalis MYB, putative 0.003 0.0112 0.408
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0031
Loa Loa (eye worm) hypothetical protein 0.0019 0.0056 0.0216
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0056 0.0237 0.4476
Leishmania major DNA polymerase kappa, putative 0.0061 0.0262 0.4958
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0237 0.0822
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0015 0.006
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0009 0.0003
Schistosoma mansoni hypothetical protein 0.0031 0.0117 0.0465
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0237 0.5154
Brugia malayi CXXC zinc finger family protein 0.003 0.0111 0.053
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0056 0.0932
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0056 0.0237 0.4476
Mycobacterium ulcerans DNA polymerase IV 0.0061 0.0262 0.0254
Trypanosoma brucei unspecified product 0.0042 0.0169 0.3146
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0237 0.9028
Trypanosoma brucei DNA damage repair protein, putative 0.0019 0.0056 0.0932
Leishmania major hypothetical protein, conserved 0.0056 0.0237 0.4476
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0065 0.111
Brugia malayi ImpB/MucB/SamB family protein 0.0061 0.0262 0.1313
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0237 0.0822
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0237 0.9028
Trichomonas vaginalis pc-MYB2, putative 0.003 0.0111 0.4052
Brugia malayi Calcitonin receptor-like protein seb-1 0.01 0.045 0.2289
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0056 0.0237 0.4476
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0084 0.1473
Loa Loa (eye worm) TAR-binding protein 0.0065 0.028 0.1231
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0169 0.3146
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0017 0.0069
Schistosoma mansoni smad1 5 8 and 0.0025 0.0086 0.0342
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0056 0.0237 0.094
Trichomonas vaginalis conserved hypothetical protein 0.001 0.001 0.0079
Giardia lamblia Myb 1-like protein 0.003 0.0112 0.0469
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0015 0.006
Schistosoma mansoni hypothetical protein 0.0072 0.0315 0.1247
Trypanosoma brucei hypothetical protein, conserved 0.0019 0.0056 0.0932
Trichomonas vaginalis C-MYB, putative 0.003 0.0111 0.4052
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0015 0.0036
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.001 0.001 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0015 0.0036
Giardia lamblia hypothetical protein 0.0056 0.0237 0.1038
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0056 0.0237 0.094
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0056 0.0932
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0237 0.9028
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0276 0.1093
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0035 0.0133 0.2803
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0056 0.0237 0.094
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0578 0.2793 0.2787
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0039 0.0154
Schistosoma mansoni hypothetical protein 0.0031 0.0117 0.0465
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0237 0.9028
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0009 0.0008 0.0033
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0015 0.006
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0015 0.006
Loa Loa (eye worm) pigment dispersing factor receptor c 0.01 0.045 0.2005
Plasmodium falciparum phosphodiesterase gamma, putative 0.0056 0.0237 0.5154
Plasmodium vivax phosphodiesterase gamma, putative 0.0056 0.0237 0.5154
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0013 0.0018
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0015 0.006
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0039 0.0158
Brugia malayi MH2 domain containing protein 0.0369 0.1768 0.9112
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0237 0.9028
Brugia malayi MH1 domain containing protein 0.0014 0.0031 0.0119
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0056 0.0237 0.4476
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0015 0.0673
Schistosoma mansoni DNA polymerase eta 0.0114 0.052 0.2058
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.0086 0.0354
Schistosoma mansoni coup transcription factor 0.0011 0.0015 0.006
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0117 0.0465
Mycobacterium tuberculosis Probable reductase 0.0228 0.1079 0.1495
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0015 0.006
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0015 0.0036
Onchocerca volvulus 0.0011 0.0015 0.0673
Plasmodium vivax replication factor C subunit 1, putative 0.001 0.001 0.0045
Toxoplasma gondii thioredoxin reductase 0.01 0.0452 0.1595
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0237 0.9028
Giardia lamblia DNA damage repair protein 0.0019 0.0056 0.0216
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0009 0.0008 0.0033
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0015 0.006
Echinococcus multilocularis mothers against decapentaplegic 6 0.0011 0.0018 0.0073
Loa Loa (eye worm) glutathione reductase 0.01 0.0452 0.2014
Brugia malayi TAR-binding protein 0.0065 0.028 0.1406
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.003 0.0111 0.4052
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0011 0.0015 0.0155
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0262 0.4958
Plasmodium vivax thioredoxin reductase, putative 0.01 0.0452 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0133 0.2435
Brugia malayi nuclear receptor NHR-88 0.0011 0.0015 0.0036
Schistosoma mansoni smad1 5 8 and 0.0025 0.0086 0.0342
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0031
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0015 0.006
Loa Loa (eye worm) transcription factor SMAD2 0.0369 0.1768 0.798
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0056 0.0237 0.9028
Echinococcus granulosus nibrin 0.001 0.001 0.0041
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0237 0.0822
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0056 0.0237 0.9028
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0056 0.0237 0.094
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0009 0.0008 0.0033
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0009 0.0036
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0578 0.2793 1
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0035 0.0133 0.2435
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.2051 1 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.046 0.2213 0.8766
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0117 0.0565
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0031
Schistosoma mansoni hypothetical protein 0.0429 0.2062 0.817
Leishmania major hypothetical protein, conserved 0.0025 0.0084 0.1473
Brugia malayi Smad1 0.0025 0.0086 0.0404
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.046 0.2213 0.8766
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0237 0.0822
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0228 0.1079 0.1495
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0056 0.0237 0.1185
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0056 0.0237 0.1185
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0025 0.0086 0.0342
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0009 0.0008 0.0033
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0065 0.0258
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0182 0.072
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0065 0.1278
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0015 0.0036
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0015 0.0036
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0117 0.0565
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0056 0.0237 0.5154
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0015 0.0039 0.0595
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0133 0.2435
Trichomonas vaginalis conserved hypothetical protein 0.001 0.001 0.0079
Echinococcus granulosus mothers against decapentaplegic 2 0.0011 0.0018 0.0073
Loa Loa (eye worm) hypothetical protein 0.0056 0.0237 0.1038
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0056 0.0237 0.9028
Echinococcus granulosus dna polymerase eta 0.0114 0.052 0.2058
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.01 0.0452 0.062
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0015 0.0036
Schistosoma mansoni hypothetical protein 0.0009 0.0008 0.0033
Entamoeba histolytica deoxycytidyl transferase, putative 0.0061 0.0262 0.8272
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0015 0.0134
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0009 0.0008 0.0033
Loa Loa (eye worm) nuclear factor I 0.0014 0.0031 0.0104
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0061 0.0262 1
Schistosoma mansoni hypothetical protein 0.0011 0.0017 0.0069
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0056 0.0237 0.094
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0237 0.0822
Loa Loa (eye worm) Smad1 0.0025 0.0086 0.0354
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0015 0.006
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0237 0.0822
Trypanosoma cruzi FHA domain containing protein, putative 0.001 0.001 0.0039
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0015 0.006
Echinococcus multilocularis GPCR, family 2 0.0031 0.0117 0.0465
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.028 0.1231
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0237 0.0822
Plasmodium vivax DNA repair protein REV1, putative 0.0019 0.0056 0.1073
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0056 0.0932
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0056 0.0237 0.9028
Brugia malayi RNA binding protein 0.0065 0.028 0.1406
Loa Loa (eye worm) hypothetical protein 0.0056 0.0237 0.1038
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0237 0.9028
Giardia lamblia DINP protein human, muc B family 0.0061 0.0262 0.115
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0056 0.0237 0.094
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0035 0.0133 0.0645
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0237 0.9028
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0061 0.0262 0.4958
Echinococcus granulosus dnaJ subfamily B 0.0429 0.2062 0.817
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0009
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0262 0.4958
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0084 0.1473
Plasmodium falciparum glutathione reductase 0.01 0.0452 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0228 0.1079 0.1495
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.046 0.2213 0.8766
Trichomonas vaginalis MYB3r3, putative 0.003 0.0111 0.4052
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.001 0.0079
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.001 0.001 0.0066
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0262 0.4958
Schistosoma mansoni topbp1 0.001 0.001 0.0041
Echinococcus multilocularis tar DNA binding protein 0.0065 0.028 0.1108
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.003 0.0111 0.4052
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0065 0.0204
Loa Loa (eye worm) hypothetical protein 0.0031 0.0117 0.0495
Brugia malayi ImpB/MucB/SamB family protein 0.0114 0.052 0.2648
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0117 0.0495
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.001 0.0079
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0084 0.1697
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0015 0.006
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0015 0.006
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0169 0.3146
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0009 0.0008 0.0033
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0039 0.0154
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0117 0.0465
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0056 0.0237 0.094
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0182 0.0786
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0056 0.0237 0.094
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0262 0.4958
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0039 0.0109
Loa Loa (eye worm) MH2 domain-containing protein 0.0011 0.0018 0.0045
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0237 0.0822
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0237 0.9028
Brugia malayi hypothetical protein 0.001 0.001 0.001
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0072 0.0314 0.1097
Brugia malayi glutathione reductase 0.01 0.0452 0.2299
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.0315 0.1247
Treponema pallidum ATP-dependent DNA helicase 0.0011 0.0015 0.0007
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0015 0.006
Brugia malayi polk-prov protein 0.0019 0.0056 0.0247
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0237 0.9028
Entamoeba histolytica hypothetical protein 0.001 0.001 0.0066
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0015 0.006
Schistosoma mansoni hypothetical protein 0.0031 0.0117 0.0465
Loa Loa (eye worm) hypothetical protein 0.0068 0.0296 0.1306
Entamoeba histolytica hypothetical protein 0.0072 0.0315 1
Loa Loa (eye worm) RNA binding protein 0.0065 0.028 0.1231
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0237 0.4476
Brugia malayi Thioredoxin reductase 0.01 0.0452 0.2299
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0056 0.0237 0.1185
Trypanosoma brucei DNA damage repair protein, putative 0.0019 0.0056 0.0932
Schistosoma mansoni cpg binding protein 0.0032 0.0119 0.0472
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0061 0.0262 0.115
Trichomonas vaginalis pc-MYB2, putative 0.003 0.0111 0.4052
Brugia malayi topoisomerase 0.001 0.001 0.001
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0404 0.1939 0.8758
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0035 0.0133 0.0174
Echinococcus multilocularis cpg binding protein 0.0032 0.0119 0.0472
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0035 0.0133 0.2803
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0056 0.0237 0.9028
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0237 0.9028
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.003 0.0111 0.3352
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0065 0.0294
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0237 0.0822
Loa Loa (eye worm) hypothetical protein 0.0025 0.0084 0.0342
Echinococcus granulosus replication factor c subunit 1 0.001 0.001 0.0041
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0237 0.9028
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0065 0.111
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0015 0.006
Echinococcus multilocularis nibrin 0.001 0.001 0.0041
Schistosoma mansoni cpg binding protein 0.003 0.0111 0.0439
Echinococcus granulosus TGF beta signal transducer SmadC 0.0025 0.0086 0.0342
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0015 0.0031
Echinococcus multilocularis geminin 0.0523 0.2524 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0015 0.0036
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0035 0.0133 0.0526
Schistosoma mansoni terminal deoxycytidyl transferase 0.0061 0.0262 0.1037
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.046 0.2213 0.8766
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0009
Schistosoma mansoni tar DNA-binding protein 0.0065 0.028 0.1108
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0084 0.1697
Trypanosoma brucei DNA polymerase IV, putative 0.0061 0.0262 0.4958
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0039 0.0154
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0237 0.4476
Trypanosoma brucei DNA polymerase IV, putative 0.0061 0.0262 0.4958
Leishmania major trypanothione reductase 0.01 0.0452 0.8684
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0237 0.0822
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0015 0.0031
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0237 0.0822
Schistosoma mansoni glutamate synthase 0.0009 0.0008 0.0033
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0084 0.1697
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0039 0.0154
Echinococcus multilocularis mothers against decapentaplegic 2 0.0011 0.0018 0.0073
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.046 0.2213 1
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0056 0.0237 0.094
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0015 0.006
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.046 0.2213 0.7918
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0056 0.0237 0.9028
Brugia malayi MH2 domain containing protein 0.0025 0.0086 0.0404
Schistosoma mansoni hypothetical protein 0.0068 0.0296 0.1174
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0031
Loa Loa (eye worm) MH2 domain-containing protein 0.0369 0.1768 0.798
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0056 0.0237 0.9028
Echinococcus granulosus smad 0.0025 0.0086 0.0342
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0035 0.0133 0.0526
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.0315 0.1247
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0237 0.9028
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0015 0.006
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0021 0.0065 0.0258
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0056 0.0237 0.4476
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0009 0.0036
Mycobacterium tuberculosis Conserved hypothetical protein 0.0061 0.0262 0.0354
Loa Loa (eye worm) hypothetical protein 0.0114 0.052 0.2319
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.001 0.0039
Treponema pallidum DNA ligase (lig) 0.001 0.001 0.0002
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0009 0.0008 0.0033
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0237 0.0822
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0015 0.006
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0056 0.0237 0.1038
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.003 0.0111 0.4052
Schistosoma mansoni hypothetical protein 0.0523 0.2524 1
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0056 0.0237 0.1185
Echinococcus granulosus tar DNA binding protein 0.0065 0.028 0.1108
Echinococcus granulosus cpg binding protein 0.0032 0.0119 0.0472
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0056 0.0237 0.094
Trichomonas vaginalis glutathione reductase, putative 0.0035 0.0133 0.491
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0237 0.4476
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0015 0.0036
Trypanosoma brucei hypothetical protein, conserved 0.0056 0.0237 0.4476
Loa Loa (eye worm) hypothetical protein 0.046 0.2213 1
Schistosoma mansoni Smad4 0.0011 0.0018 0.0073
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0262 0.4958
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0056 0.0237 0.5154
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0015 0.006
Echinococcus granulosus mothers against decapentaplegic 6 0.0011 0.0018 0.0073
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0045
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0056 0.0237 0.9028
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0578 0.2793 0.3888
Loa Loa (eye worm) RecQ helicase 0.0021 0.0065 0.0257
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0056 0.0237 0.5154
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0056 0.0237 0.1185
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0019 0.0056 0.0171
Schistosoma mansoni tar DNA-binding protein 0.0065 0.028 0.1108
Plasmodium falciparum replication factor C subunit 1, putative 0.001 0.001 0.0045
Echinococcus granulosus geminin 0.0523 0.2524 1
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0056 0.0237 0.4476
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0039 0.0154
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0031
Mycobacterium tuberculosis Probable dehydrogenase 0.0228 0.1079 0.1495
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0015 0.0039 0.0595
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.001 0.001 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0015 0.0036
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0228 0.1079 0.1495
Leishmania major hypothetical protein, conserved 0.0056 0.0237 0.4476
Trichomonas vaginalis replication factor C large subunit, putative 0.001 0.001 0.0079
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0015 0.0025
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.003 0.0112 0.408
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0169 0.3146
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0056 0.0237 0.9028
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0237 0.9028
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0237 0.9028
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0117 0.0465
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0015 0.006
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.001 0.001 0.0039
Schistosoma mansoni smad 0.0025 0.0086 0.0342
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0035 0.0133 0.0125
Schistosoma mansoni Smad4 0.0025 0.0086 0.0342
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.2051 1 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0035 0.0133 0.0447
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0056 0.0237 0.4476
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0015 0.006
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.003 0.0111 0.4052
Leishmania major DNA polymerase eta, putative 0.0072 0.0314 0.5974
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0009 0.0008 0.0033
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0061 0.0262 0.1037
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0056 0.0237 0.094
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0237 0.9028
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0182 0.072
Trypanosoma cruzi DNA polymerase kappa, putative 0.0061 0.0262 0.4958
Echinococcus granulosus glutamate synthase 0.0009 0.0008 0.0033
Brugia malayi nuclear hormone receptor 0.0011 0.0015 0.0036
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.1473 0.7171 1
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0065 0.2238
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0031
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0015 0.0039 0.0685
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0031
Trypanosoma cruzi DNA polymerase eta, putative 0.0114 0.052 1
Brugia malayi MH1 domain containing protein 0.0025 0.0086 0.0404
Trichomonas vaginalis MYB72, putative 0.003 0.0111 0.4052
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0015 0.0031
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0015 0.0036
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0253 0.1203 0.1668
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0025 0.0088 0.0412
Brugia malayi ecdysteroid receptor 0.0011 0.0015 0.0036
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0039 0.0595
Trypanosoma brucei unspecified product 0.0042 0.0169 0.3146
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.0086 0.0354
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0237 0.9028
Trypanosoma cruzi trypanothione reductase, putative 0.0035 0.0133 0.2435
Trypanosoma brucei hypothetical protein, conserved 0.0019 0.0056 0.0932
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0056 0.0237 0.9028
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0056 0.0237 0.094
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.001 0.0039
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0015 0.0031
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0237 0.0822
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0015 0.006
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0237 0.0822
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0262 0.4958
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0035 0.0133 0.0125
Loa Loa (eye worm) MH1 domain-containing protein 0.0011 0.0018 0.0045
Trypanosoma cruzi DNA polymerase kappa, putative 0.0061 0.0262 0.4958
Schistosoma mansoni topbp1 0.001 0.001 0.0041
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0035 0.0133 0.0125
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0015 0.0031
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0578 0.2793 0.2787
Entamoeba histolytica hypothetical protein 0.0072 0.0315 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0015 0.006
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0237 0.9028
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0237 0.4476

Activities

Activity type Activity value Assay description Source Reference
AE activity (binding) = 72 % AE activity is the ratio of specific binding at the end of dissociation to specific binding at the end of 120 min of equilibration at 50 uM concentration to Adenosine A1 receptor ChEMBL. 12039562
AE activity (binding) = 72 % AE activity is the ratio of specific binding at the end of dissociation to specific binding at the end of 120 min of equilibration at 50 uM concentration to Adenosine A1 receptor ChEMBL. 12039562
EC50 (binding) = 4.2 uM Effective concentration against Adenosine A1 receptor ChEMBL. 12039562
EC50 (binding) = 4.2 uM Effective concentration against Adenosine A1 receptor ChEMBL. 12039562

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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