Detailed information for compound 566641

Basic information

Technical information
  • TDR Targets ID: 566641
  • Name: ammonium 2-amino-4-[hydroxy(methyl)phosphoryl ]butanoate
  • MW: 198.157 | Formula: C5H15N2O4P
  • H donors: 3 H acceptors: 4 LogP: -6.71 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-]C(=O)C(CCP(=O)(O)C)N.[NH4+]
  • InChi: 1S/C5H12NO4P.H3N/c1-11(9,10)3-2-4(6)5(7)8;/h4H,2-3,6H2,1H3,(H,7,8)(H,9,10);1H3
  • InChiKey: ZBMRKNMTMPPMMK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • azanium 2-azanyl-4-[hydroxy(methyl)phosphoryl]butanoate
  • ammonium 2-amino-4-[hydroxy(methyl)phosphoryl]butyrate
  • azanium 2-amino-4-[hydroxy(methyl)phosphoryl]butanoate
  • phosphinothricin
  • azanium 2-amino-4-(hydroxy-methylphosphoryl)butanoate
  • ammonium 2-amino-4-(hydroxy-methyl-phosphoryl)butanoate
  • ammonium 2-amino-4-(hydroxy-methylphosphoryl)butanoate
  • ammonium 2-amino-4-(hydroxy-methyl-phosphoryl)butyrate
  • azanium 2-amino-4-(hydroxy-methyl-phosphoryl)butanoate
  • 51276-47-2
  • 106917-54-8
  • 118336-14-4
  • 82785-28-2
  • 77182-82-2
  • HOE 39866
  • 2-amino-4-[hydroxy(methyl)phosphoryl]butanoic acid ammoniate
  • 2-Amino-4-(hydroxymethylphosphinyl)butanoic acid monoammonium salt
  • Ammonium (3-amino-3-carboxypropyl)methylphosphinate
  • Ammonium (DL-homoalanine-4-yl)methylphosphinate
  • Ammonium 2-amino-4-(hydroxymethylphosphinyl)butanoate
  • Ammonium 2-amino-4-(hydroxymethylphosphinyl)butyrate
  • Ammonium glufusinate
  • Basta
  • Basta F1
  • Basta LS
  • Butanoic acid, 2-amino-4-(hydroxymethylphosphinyl)-, monoammonium salt
  • Caswell No. 580I
  • Dash
  • EINECS 278-636-5
  • EPA Pesticide Chemical Code 128850
  • Finale
  • Finale 14SL
  • GLUFOSINATE AMMONIUM
  • Glufosinate-ammonium
  • Gluphosinate ammonium
  • HOE 00661
  • HSDB 6666
  • Ignite
  • Ignite ISC Herbicide
  • Liberty
  • Liberty (pesticide)
  • Monoammonium 4-(hydroxy(methyl)phosphinoyl)-DL-homoalaninate
  • Monoammonium-2-amino-4-(hydroxymethylphosphinyl)butanoate

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mycobacterium tuberculosis Probable glutamine synthetase GlnA2 (glutamine synthase) (GS-II) Curated by TDR Targets References
Mycobacterium tuberculosis Probable glutamine synthetase GlnA3 (glutamine synthase) (GS-I) Curated by TDR Targets References
Mycobacterium leprae PROBABLE GLUTAMINE SYNTHETASE GLNA2 (GLUTAMINE SYNTHASE) (GS-II) Curated by TDR Targets References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium leprae GLUTAMINE SYNTHETASE GLNA1 (GLUTAMINE SYNTHASE) (Glutamate--ammonia ligase 1) (GS-I) Get druggable targets OG5_127086 All targets in OG5_127086
Neospora caninum Glutamine synthetase (EC 6.3.1.2), related Get druggable targets OG5_127086 All targets in OG5_127086
Schistosoma japonicum Glutamine synthetase, putative Get druggable targets OG5_127086 All targets in OG5_127086
Schistosoma mansoni glutamine synthetase bacteria Get druggable targets OG5_127086 All targets in OG5_127086
Mycobacterium tuberculosis Probable glutamine synthetase GlnA4 (glutamine synthase) (GS-II) Get druggable targets OG5_127086 All targets in OG5_127086
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_127086 All targets in OG5_127086
Mycobacterium tuberculosis Conserved hypothetical protein Get druggable targets OG5_127086 All targets in OG5_127086
Plasmodium yoelii glutamine synthetase, putative Get druggable targets OG5_127086 All targets in OG5_127086
Wolbachia endosymbiont of Brugia malayi glutamine synthetase Get druggable targets OG5_127086 All targets in OG5_127086
Mycobacterium ulcerans glutamine synthetase Get druggable targets OG5_127086 All targets in OG5_127086
Mycobacterium tuberculosis Probable glutamine synthetase GlnA2 (glutamine synthase) (GS-II) Get druggable targets OG5_127086 All targets in OG5_127086
Plasmodium knowlesi glutamine synthetase, putative Get druggable targets OG5_127086 All targets in OG5_127086
Plasmodium berghei glutamine synthetase, putative Get druggable targets OG5_127086 All targets in OG5_127086
Plasmodium falciparum glutamine synthetase, putative Get druggable targets OG5_127086 All targets in OG5_127086
Plasmodium vivax glutamine synthetase, putative Get druggable targets OG5_127086 All targets in OG5_127086
Toxoplasma gondii glutamine synthetase, type I, putative Get druggable targets OG5_127086 All targets in OG5_127086
Cryptosporidium parvum glutamate synthetase, possible bacterial origin, beta-grasp+glutamate synthase catalytic domain Get druggable targets OG5_127086 All targets in OG5_127086
Cryptosporidium hominis glutamine synthetase Get druggable targets OG5_127086 All targets in OG5_127086
Mycobacterium tuberculosis Probable glutamine synthetase GlnA3 (glutamine synthase) (GS-I) Get druggable targets OG5_127086 All targets in OG5_127086
Schistosoma japonicum ko:K01915 glutamine synthetase [EC6.3.1.2], putative Get druggable targets OG5_127086 All targets in OG5_127086
Schistosoma mansoni glutamine synthetase bacteria Get druggable targets OG5_127086 All targets in OG5_127086
Mycobacterium ulcerans glutamine synthetase GlnA1 Get druggable targets OG5_127086 All targets in OG5_127086
Schistosoma japonicum expressed protein Get druggable targets OG5_127086 All targets in OG5_127086
Mycobacterium tuberculosis Glutamine synthetase GlnA1 (glutamine synthase) (GS-I) Get druggable targets OG5_127086 All targets in OG5_127086
Mycobacterium leprae PROBABLE GLUTAMINE SYNTHETASE GLNA2 (GLUTAMINE SYNTHASE) (GS-II) Get druggable targets OG5_127086 All targets in OG5_127086
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis glutamine synthetase-bacteria, putative 0.0122 0.0911 0.5
Loa Loa (eye worm) hypothetical protein 0.0616 0.6392 1
Schistosoma mansoni glutamine synthetase bacteria 0.0364 0.3596 0.4671
Schistosoma mansoni tar DNA-binding protein 0.0067 0.031 0.0402
Brugia malayi Thyroglobulin type-1 repeat family protein 0.0616 0.6392 1
Echinococcus granulosus neuropeptide receptor A26 0.0537 0.5514 0.7143
Loa Loa (eye worm) hypothetical protein 0.0616 0.6392 1
Brugia malayi RNA binding protein 0.0067 0.031 0.0484
Mycobacterium ulcerans hypothetical protein 0.0242 0.2246 0.3441
Plasmodium falciparum glutamine synthetase, putative 0.0472 0.479 0.5
Schistosoma mansoni insulin-like growth factor binding protein-related 0.0734 0.7698 1
Loa Loa (eye worm) RNA binding protein 0.0067 0.031 0.0484
Echinococcus granulosus glutamine synthetase 0.023 0.2106 0.2685
Schistosoma mansoni tar DNA-binding protein 0.0067 0.031 0.0402
Onchocerca volvulus 0.0616 0.6392 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0053 0.0083
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0058 0.0203 0.0318
Mycobacterium tuberculosis Probable glutamine synthetase GlnA3 (glutamine synthase) (GS-I) 0.0364 0.3596 0.5305
Echinococcus multilocularis tar DNA binding protein 0.0067 0.031 0.0258
Schistosoma mansoni glutamine synthetase 1 2 (glutamate-amonia ligase) (gs) 0.023 0.2106 0.2735
Trypanosoma cruzi glutamine synthetase, putative 0.023 0.2106 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0053 0.0069
Brugia malayi Calcitonin receptor-like protein seb-1 0.0058 0.0203 0.0318
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.031 0.0484
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.031 0.0484
Onchocerca volvulus 0.0616 0.6392 1
Onchocerca volvulus 0.0616 0.6392 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0053 0.0069
Loa Loa (eye worm) thyroglobulin type-1 repeat family protein 0.0616 0.6392 1
Echinococcus granulosus tar DNA binding protein 0.0067 0.031 0.0335
Toxoplasma gondii glutamine synthetase, type I, putative 0.0472 0.479 0.5
Plasmodium vivax glutamine synthetase, putative 0.0472 0.479 0.5
Trichomonas vaginalis glutamine synthetase, putative 0.0122 0.0911 0.5
Entamoeba histolytica glutamine synthetase, putative 0.0122 0.0911 0.5
Loa Loa (eye worm) TAR-binding protein 0.0067 0.031 0.0484
Echinococcus multilocularis glutamine synthetase 0.023 0.2106 0.2063
Onchocerca volvulus 0.0616 0.6392 1
Echinococcus granulosus neuropeptide s receptor 0.0537 0.5514 0.7143
Mycobacterium leprae PROBABLE GLUTAMINE SYNTHETASE GLNA2 (GLUTAMINE SYNTHASE) (GS-II) 0.0472 0.479 1
Schistosoma mansoni glutamine synthetase bacteria 0.0364 0.3596 0.4671
Brugia malayi secreted modular calcium-binding protein 1 0.0616 0.6392 1
Brugia malayi TAR-binding protein 0.0067 0.031 0.0484
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0053 0.0083
Trypanosoma cruzi glutamine synthetase, putative 0.023 0.2106 0.5
Entamoeba histolytica glutamine synthetase, putative 0.0122 0.0911 0.5
Echinococcus granulosus insulin growth factor binding 0.0734 0.7698 1
Loa Loa (eye worm) Gln-2 protein 0.023 0.2106 0.3294
Leishmania major glutamine synthetase, putative 0.023 0.2106 0.5
Brugia malayi Thyroglobulin type-1 repeat family protein 0.0616 0.6392 1
Mycobacterium ulcerans glutamine synthetase 0.0472 0.479 1
Loa Loa (eye worm) hypothetical protein 0.0616 0.6392 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0058 0.0203 0.0318
Wolbachia endosymbiont of Brugia malayi glutamine synthetase 0.0364 0.3596 0.5
Schistosoma mansoni tar DNA-binding protein 0.0067 0.031 0.0402
Echinococcus multilocularis neuropeptide s receptor 0.0537 0.5514 0.549
Mycobacterium tuberculosis Probable glutamine synthetase GlnA2 (glutamine synthase) (GS-II) 0.0472 0.479 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.0203 0.0318
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0053 0.0069
Mycobacterium ulcerans glutamine synthetase GlnA1 0.0472 0.479 1
Loa Loa (eye worm) thyroglobulin type-1 repeat family protein 0.0616 0.6392 1
Trypanosoma brucei glutamine synthetase, putative 0.023 0.2106 0.5
Schistosoma mansoni tar DNA-binding protein 0.0067 0.031 0.0402
Loa Loa (eye worm) hypothetical protein 0.0616 0.6392 1
Echinococcus multilocularis neuropeptide receptor A26 0.0537 0.5514 0.549
Brugia malayi Thyroglobulin type-1 repeat family protein 0.0616 0.6392 1
Echinococcus multilocularis insulin growth factor binding 0.0734 0.7698 0.7686
Schistosoma mansoni tar DNA-binding protein 0.0067 0.031 0.0402

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Targets
growth (GO:0040007) decreased (PATO:0000468) inferred from in vitro culture assay (ECO:0000182) Mycobacterium tuberculosis 256476  
Annotator: crowther@u.washington.edu Comment: 2007-12-21 References: 10224282
growth (GO:0040007) decreased (PATO:0000468) inferred from in vitro culture assay (ECO:0000182) Mycobacterium tuberculosis 6149  
Annotator: crowther@u.washington.edu Comment: 2007-12-21 References: 10224282
growth (GO:0040007) decreased (PATO:0000468) inferred from in vitro culture assay (ECO:0000182) Mycobacterium tuberculosis 6150  
Annotator: crowther@u.washington.edu Comment: 2007-12-21 References: 10224282

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.