Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | beta-NAC-like protein | 0.0036 | 0.1097 | 0.1097 |
Loa Loa (eye worm) | cysteine protease | 0.006 | 0.2989 | 0.2989 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.006 | 0.2989 | 1 |
Echinococcus multilocularis | transient receptor potential ion channel A | 0.0096 | 0.5866 | 0.5357 |
Echinococcus multilocularis | cathepsin L | 0.0038 | 0.1292 | 0.0219 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0038 | 0.1292 | 0.1292 |
Trypanosoma cruzi | transcription factor btf3, putative | 0.0036 | 0.1097 | 0.1097 |
Loa Loa (eye worm) | ctsf protein | 0.006 | 0.2989 | 0.2989 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1189 | 0.1189 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.006 | 0.2989 | 0.2989 |
Brugia malayi | Cathepsin L-like precursor | 0.006 | 0.2989 | 0.2989 |
Leishmania major | cathepsin L-like protease | 0.006 | 0.2989 | 1 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0057 | 0.2786 | 0.8926 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.3203 | 0.3203 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1253 | 0.1253 |
Entamoeba histolytica | cysteine proteinase 1, putative | 0.0038 | 0.1292 | 0.1031 |
Entamoeba histolytica | cysteine protease, putative | 0.0038 | 0.1292 | 0.1031 |
Giardia lamblia | Cathepsin B precursor | 0.0057 | 0.2786 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.6128 | 0.6128 |
Echinococcus multilocularis | transient receptor potential gamma protein | 0.01 | 0.6128 | 0.5651 |
Plasmodium vivax | vivapain-2 | 0.006 | 0.2989 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.006 | 0.2989 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0038 | 0.1253 | 0.0827 |
Leishmania major | cathepsin L-like protease | 0.006 | 0.2989 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0038 | 0.1292 | 0.1292 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.006 | 0.2989 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0149 | 1 | 1 |
Onchocerca volvulus | 0.006 | 0.2989 | 1 | |
Echinococcus multilocularis | cathepsin b | 0.0149 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0038 | 0.1292 | 0.1031 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0057 | 0.2786 | 0.8926 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0927 | 0.0927 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0038 | 0.1292 | 0.1031 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0038 | 0.1292 | 0.1031 |
Echinococcus multilocularis | cysteine protease | 0.006 | 0.2989 | 0.2126 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0038 | 0.1292 | 0.1292 |
Brugia malayi | Cathepsin L-like precursor | 0.006 | 0.2989 | 0.2989 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.006 | 0.2989 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.006 | 0.2989 | 1 |
Onchocerca volvulus | 0.006 | 0.2989 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.006 | 0.2989 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0038 | 0.1253 | 0.0827 |
Entamoeba histolytica | cysteine proteinase 2 | 0.0038 | 0.1292 | 0.1031 |
Echinococcus granulosus | cysteine protease | 0.0038 | 0.1292 | 0.0219 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.006 | 0.2989 | 0.2989 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.006 | 0.2989 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0149 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.006 | 0.2989 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.006 | 0.2989 | 0.2126 |
Onchocerca volvulus | Cathepsin F homolog | 0.006 | 0.2989 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.006 | 0.2989 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0057 | 0.2786 | 0.5 |
Onchocerca volvulus | 0.006 | 0.2989 | 1 | |
Onchocerca volvulus | Cathepsin L homolog | 0.006 | 0.2989 | 1 |
Echinococcus granulosus | transient receptor potential gamma protein | 0.01 | 0.6128 | 0.5651 |
Leishmania major | cysteine peptidase A (CPA) | 0.006 | 0.2989 | 1 |
Onchocerca volvulus | 0.006 | 0.2989 | 1 | |
Echinococcus granulosus | cathepsin l1 | 0.0038 | 0.1253 | 0.0176 |
Entamoeba histolytica | cysteine protease, putative | 0.0038 | 0.1292 | 0.1031 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0038 | 0.1253 | 0.1253 |
Plasmodium vivax | basic transcription factor 3b, putative | 0.0036 | 0.1097 | 0.3669 |
Onchocerca volvulus | Cathepsin L homolog | 0.006 | 0.2989 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0038 | 0.1253 | 0.1253 |
Trypanosoma cruzi | cysteine protease, putative | 0.0038 | 0.1292 | 0.1292 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0066 | 0.3466 | 0.2661 |
Entamoeba histolytica | cysteine proteinase, putative | 0.006 | 0.2989 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.006 | 0.2989 | 0.2989 |
Onchocerca volvulus | 0.006 | 0.2989 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0038 | 0.1292 | 0.1031 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.006 | 0.2989 | 0.2126 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0038 | 0.1292 | 0.1292 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.006 | 0.2989 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.006 | 0.2989 | 1 |
Trypanosoma cruzi | transcription factor btf3, putative | 0.0036 | 0.1097 | 0.1097 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0149 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.006 | 0.2989 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0038 | 0.1292 | 0.1031 |
Toxoplasma gondii | cathepsin CPL | 0.006 | 0.2989 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0038 | 0.1292 | 0.1031 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.2989 | 0.2989 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1253 | 0.1253 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.006 | 0.2989 | 1 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0066 | 0.3466 | 0.2661 |
Echinococcus granulosus | transient receptor potential ion channel A | 0.0096 | 0.5866 | 0.5357 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.006 | 0.2989 | 0.2989 |
Entamoeba histolytica | cysteine protease, putative | 0.0038 | 0.1292 | 0.1031 |
Schistosoma mansoni | transient receptor potential channel | 0.0066 | 0.3466 | 0.3466 |
Giardia lamblia | Cathepsin B precursor | 0.0057 | 0.2786 | 0.5 |
Loa Loa (eye worm) | ICD-1 protein | 0.0036 | 0.1097 | 0.1097 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.006 | 0.2989 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.006 | 0.2989 | 0.2989 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.006 | 0.2989 | 0.2126 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0038 | 0.1253 | 0.1253 |
Schistosoma mansoni | transient receptor potential channel | 0.01 | 0.6128 | 0.6128 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0149 | 1 | 1 |
Echinococcus granulosus | cathepsin b | 0.0149 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.006 | 0.2989 | 1 |
Leishmania major | cathepsin L-like protease | 0.006 | 0.2989 | 1 |
Echinococcus granulosus | TRP transient receptor potential channel | 0.0037 | 0.1189 | 0.0103 |
Brugia malayi | cathepsin L-like precursor | 0.0038 | 0.1253 | 0.1253 |
Brugia malayi | Transient-receptor-potential like protein | 0.0037 | 0.1189 | 0.1189 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.006 | 0.2989 | 0.2126 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.006 | 0.2989 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.006 | 0.2989 | 1 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0066 | 0.3466 | 0.2661 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.006 | 0.2989 | 1 |
Onchocerca volvulus | 0.006 | 0.2989 | 1 | |
Plasmodium vivax | vivapain-1 | 0.0038 | 0.1292 | 0.4322 |
Echinococcus granulosus | cathepsin l1 | 0.006 | 0.2989 | 0.2126 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1253 | 0.1253 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.006 | 0.2989 | 0.2126 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0038 | 0.1292 | 0.1292 |
Entamoeba histolytica | cysteine protease, putative | 0.0038 | 0.1292 | 0.1031 |
Leishmania major | cathepsin L-like protease | 0.006 | 0.2989 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.006 | 0.2989 | 0.2989 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0066 | 0.3466 | 0.2661 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.006 | 0.2989 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.006 | 0.2989 | 0.2989 |
Toxoplasma gondii | cathepsin B | 0.0057 | 0.2786 | 0.8926 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.006 | 0.2989 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.006 | 0.2989 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.006 | 0.2989 | 1 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0038 | 0.1292 | 0.1292 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0057 | 0.2786 | 0.8926 |
Schistosoma mansoni | transient receptor potential channel 4 | 0.01 | 0.6128 | 0.6128 |
Leishmania major | cathepsin L-like protease | 0.006 | 0.2989 | 1 |
Echinococcus granulosus | cathepsin b | 0.0149 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0038 | 0.1292 | 0.1031 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0038 | 0.1292 | 0.1292 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0038 | 0.1292 | 0.1031 |
Entamoeba histolytica | cysteine protease, putative | 0.0038 | 0.1292 | 0.1031 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.006 | 0.2989 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0038 | 0.1253 | 0.1253 |
Schistosoma mansoni | transcription factor btf3 | 0.0036 | 0.1097 | 0.1097 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.006 | 0.2989 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.006 | 0.2989 | 0.2989 |
Echinococcus multilocularis | cathepsin b | 0.0149 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0038 | 0.1292 | 0.1031 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0149 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.006 | 0.2989 | 0.2989 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.006 | 0.2989 | 1 |
Plasmodium vivax | unspecified product | 0.0038 | 0.1292 | 0.4322 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.006 | 0.2989 | 1 |
Loa Loa (eye worm) | cathepsin B | 0.0057 | 0.2786 | 0.2786 |
Onchocerca volvulus | 0.006 | 0.2989 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.006 | 0.2989 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.006 | 0.2989 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0038 | 0.1292 | 0.1031 |
Echinococcus granulosus | cathepsin L cysteine protease | 0.0038 | 0.1292 | 0.0219 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.006 | 0.2989 | 0.2126 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.006 | 0.2989 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.006 | 0.2989 | 1 |
Leishmania major | cathepsin L-like protease | 0.006 | 0.2989 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0038 | 0.1292 | 0.1031 |
Leishmania major | cathepsin L-like protease | 0.006 | 0.2989 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0038 | 0.1292 | 0.1031 |
Entamoeba histolytica | cysteine protease, putative | 0.0038 | 0.1292 | 0.1031 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.006 | 0.2989 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.006 | 0.2989 | 0.2989 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.006 | 0.2989 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.006 | 0.2989 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0038 | 0.1253 | 0.0827 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.006 | 0.2989 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.006 | 0.2989 | 1 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0038 | 0.1292 | 0.1292 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.006 | 0.2989 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0038 | 0.1253 | 0.1253 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.006 | 0.2989 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.006 | 0.2989 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.006 | 0.2989 | 0.2989 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0057 | 0.2786 | 0.2786 |
Schistosoma mansoni | transient receptor potential channel | 0.0066 | 0.3466 | 0.3466 |
Plasmodium vivax | vivapain-3 | 0.0038 | 0.1292 | 0.4322 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.006 | 0.2989 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.006 | 0.2989 | 1 |
Trypanosoma cruzi | cysteine peptidase (N-terminal), putative | 0.0038 | 0.1292 | 0.1292 |
Plasmodium falciparum | cysteine proteinase falcipain 1 | 0.0038 | 0.1292 | 0.1031 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.006 | 0.2989 | 0.2989 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0038 | 0.1292 | 0.1031 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.006 | 0.2989 | 1 |
Plasmodium vivax | vivapain-2 | 0.006 | 0.2989 | 1 |
Loa Loa (eye worm) | fibroinase | 0.006 | 0.2989 | 0.2989 |
Brugia malayi | Cathepsin L-like precursor | 0.006 | 0.2989 | 0.2989 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0038 | 0.1292 | 0.1031 |
Echinococcus multilocularis | cysteine protease | 0.006 | 0.2989 | 0.2126 |
Echinococcus granulosus | cathepsin L | 0.0038 | 0.1292 | 0.0219 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.006 | 0.2989 | 0.2989 |
Echinococcus multilocularis | TRP (transient receptor potential) channel | 0.0037 | 0.1189 | 0.0103 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0057 | 0.2786 | 0.2786 |
Entamoeba histolytica | cysteine protease, putative | 0.0038 | 0.1292 | 0.1031 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.006 | 0.2989 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 3.9 ug ml-1 | In vitro anti-trichomonal activity against Trichomonas foetus-Ortho strain-2. | ChEMBL. | 3543363 |
Mutagenicity (functional) | = 17 % | The Mutagenicity against Trichomonas foetus relative to Ronidazole. | ChEMBL. | 3543363 |
Safety index (functional) | = 0.6 | Safety index. | ChEMBL. | 3543363 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.