Detailed information for compound 570156

Basic information

Technical information
  • TDR Targets ID: 570156
  • Name: 1-[(2R,4S,5R)-5-(aminomethyl)-4-hydroxy-tetra hydrofuran-2-yl]-5-iodo-pyrimidine-2,4-dione
  • MW: 353.114 | Formula: C9H12IN3O4
  • H donors: 3 H acceptors: 3 LogP: -0.93 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC[C@H]1O[C@H](C[C@@H]1O)n1cc(I)c(=O)[nH]c1=O
  • InChi: 1S/C9H12IN3O4/c10-4-3-13(9(16)12-8(4)15)7-1-5(14)6(2-11)17-7/h3,5-7,14H,1-2,11H2,(H,12,15,16)/t5-,6+,7+/m0/s1
  • InChiKey: UNJJHOQIVSZFDN-RRKCRQDMSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[(2R,4S,5R)-5-(aminomethyl)-4-hydroxy-2-tetrahydrofuranyl]-5-iodopyrimidine-2,4-dione
  • 1-[(2R,4S,5R)-5-(aminomethyl)-4-hydroxy-oxolan-2-yl]-5-iodo-pyrimidine-2,4-dione
  • 1-[(2R,4S,5R)-5-(aminomethyl)-4-hydroxy-tetrahydrofuran-2-yl]-5-iodo-pyrimidine-2,4-quinone
  • 1-[(2R,4S,5R)-5-(aminomethyl)-4-hydroxyoxolan-2-yl]-5-iodopyrimidine-2,4-dione
  • AIdUrd
  • 56045-73-9
  • 5-Iodo-5'-amino-2',5'-dideoxyuridine
  • Uridine, 5'-amino-2',5'-dideoxy-5-iodo-
  • 1-((2R,4S,5R)-5-Aminomethyl-4-hydroxy-tetrahydro-furan-2-yl)-5-iodo-2,4(1H,3H)-pyrimidinedione
  • 5'-Amino-2',5'-dideoxy-5-iodouridine
  • 5'-NH2-IddUrd
  • AIDDU
  • AIDS-072379
  • AIDS072379
  • AIDU
  • 5'-Amino-5-iodo-2',5'-dideoxyuridine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.006 0.0207 0.1582
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0207 0.1582
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0042 0.012 0.0356
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.006 0.0207 0.1582
Echinococcus granulosus dnaJ subfamily B 0.0837 0.3811 0.3811
Trypanosoma brucei cAMP-specific phosphodiesterase 0.006 0.0207 0.367
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.006 0.0207 0.367
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.006 0.0207 0.0207
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.006 0.0207 0.1582
Loa Loa (eye worm) hypothetical protein 0.006 0.0207 0.0273
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0017 0.0017
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.019 0.0809 0.0809
Echinococcus granulosus cpg binding protein 0.0062 0.0215 0.0215
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0207 0.1582
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0434 0.1944 0.1944
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0042 0.012 0.1681
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.006 0.0207 0.0207
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.006 0.0207 0.1582
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.006 0.0207 0.367
Loa Loa (eye worm) hypothetical protein 0.1517 0.6967 1
Trypanosoma cruzi trypanothione reductase, putative 0.012 0.0483 1
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0042 0.012 0.5
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.006 0.0207 0.0207
Loa Loa (eye worm) hypothetical protein 0.006 0.0207 0.0273
Schistosoma mansoni hypothetical protein 0.0837 0.3811 0.3811
Toxoplasma gondii histone lysine methyltransferase SET1 0.0112 0.0449 0.185
Toxoplasma gondii thioredoxin reductase 0.012 0.0483 0.2006
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.006 0.0207 0.367
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0495 0.2223 0.2223
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.006 0.0207 0.1582
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.019 0.0809 0.114
Leishmania major cAMP-specific phosphodiesterase, putative 0.006 0.0207 0.367
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.006 0.0207 0.0207
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0304 0.1337 1
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0434 0.1944 0.2773
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.006 0.0207 0.0207
Giardia lamblia hypothetical protein 0.006 0.0207 0.0413
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0495 0.2223 0.2223
Brugia malayi Pre-SET motif family protein 0.0032 0.0075 0.0203
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0042 0.012 0.1681
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0042 0.012 0.1681
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.006 0.0207 0.0736
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0042 0.012 0.1681
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0207 0.1582
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0207 0.1582
Trypanosoma brucei trypanothione reductase 0.012 0.0483 1
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0042 0.012 0.1681
Loa Loa (eye worm) hypothetical protein 0.006 0.0207 0.0273
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.006 0.0207 0.1582
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0042 0.012 0.5
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0075 0.0132
Schistosoma mansoni hormone-sensitive lipase (S09 family) 0.1517 0.6967 0.6967
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0207 0.1582
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.006 0.0207 0.1582
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.006 0.0207 0.0207
Plasmodium falciparum phosphodiesterase delta, putative 0.006 0.0207 0.239
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0075 0.0075
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.006 0.0207 0.0654
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.003 0.0069 0.0181
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.006 0.0207 0.0736
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.006 0.0207 0.1582
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0214 0.0922 0.1303
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.006 0.0207 0.367
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.006 0.0207 0.0736
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.006 0.0207 0.0207
Loa Loa (eye worm) hypothetical protein 0.0495 0.2223 0.3175
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0042 0.012 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.006 0.0207 0.0736
Loa Loa (eye worm) CXXC zinc finger family protein 0.0059 0.02 0.0263
Plasmodium vivax phosphodiesterase gamma, putative 0.006 0.0207 0.3225
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.006 0.0207 0.367
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0207 0.1582
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.006 0.0207 0.1582
Trichomonas vaginalis mercuric reductase, putative 0.0042 0.012 0.0725
Onchocerca volvulus 0.0059 0.02 0.1516
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.006 0.0207 0.0736
Mycobacterium tuberculosis Probable oxidoreductase 0.0304 0.1337 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.006 0.0207 0.1582
Mycobacterium tuberculosis Probable reductase 0.0273 0.1195 0.8903
Giardia lamblia Hypothetical protein 0.006 0.0207 0.0413
Trichomonas vaginalis glutathione reductase, putative 0.0042 0.012 0.0725
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0042 0.012 0.1681
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0042 0.012 0.1681
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.006 0.0207 0.1582
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.006 0.0207 0.367
Brugia malayi Angiotensin-converting enzyme family protein 0.0648 0.2936 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0207 0.1582
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.006 0.0207 0.1582
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.019 0.0809 0.0809
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.006 0.0207 0.0207
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.006 0.0207 0.0207
Onchocerca volvulus 0.0244 0.1059 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.006 0.0207 0.0207
Loa Loa (eye worm) glutathione reductase 0.012 0.0483 0.0671
Echinococcus multilocularis thioredoxin glutathione reductase 0.0121 0.049 0.049
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.006 0.0207 0.367
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.006 0.0207 0.0207
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.006 0.0207 0.0207
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.006 0.0207 0.0207
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0042 0.012 0.1681
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.006 0.0207 0.1582
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0273 0.1195 0.8903
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0495 0.2223 1
Echinococcus granulosus hormone sensitive lipase 0.1517 0.6967 0.6967
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.006 0.0207 0.0736
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0207 0.1582
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0042 0.012 0.1681
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.006 0.0207 0.0207
Loa Loa (eye worm) aryl-acylamidase 0.0026 0.0046 0.0043
Loa Loa (eye worm) hypothetical protein 0.0032 0.0075 0.0084
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0207 0.1582
Plasmodium falciparum cGMP-specific phosphodiesterase 0.006 0.0207 0.239
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.006 0.0207 0.0654
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.006 0.0207 0.1582
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0207 0.1582
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0042 0.012 0.1681
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.006 0.0207 0.0654
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.006 0.0207 0.0207
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.006 0.0207 0.3225
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0495 0.2223 0.2223
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0075 0.0075
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.003 0.0069 0.0181
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0273 0.1195 0.8903
Schistosoma mansoni cpg binding protein 0.0059 0.02 0.02
Plasmodium falciparum cGMP-specific phosphodiesterase 0.006 0.0207 0.239
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0648 0.2936 0.4201
Treponema pallidum NADH oxidase 0.0042 0.012 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.006 0.0207 0.1582
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0434 0.1944 0.6601
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.006 0.0207 0.0207
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.006 0.0207 0.0207
Brugia malayi CXXC zinc finger family protein 0.0059 0.02 0.0631
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.006 0.0207 0.0654
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.019 0.0809 0.0809
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0042 0.012 0.1681
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0207 0.1582
Loa Loa (eye worm) ammd protein 0.0026 0.0046 0.0043
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.019 0.0809 0.0809
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.006 0.0207 0.1582
Plasmodium vivax thioredoxin reductase, putative 0.012 0.0483 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0042 0.012 0.1681
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0042 0.012 0.1681
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.006 0.0207 0.0207
Trichomonas vaginalis set domain proteins, putative 0.0244 0.1059 1
Trypanosoma brucei cAMP-specific phosphodiesterase 0.006 0.0207 0.367
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0017 0.0017
Onchocerca volvulus 0.0032 0.0075 0.0283
Loa Loa (eye worm) PDE1B protein 0.006 0.0207 0.0273
Plasmodium falciparum thioredoxin reductase 0.012 0.0483 1
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.006 0.0207 0.1582
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0207 0.1582
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.012 0.0483 0.3384
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0042 0.012 0.5
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.006 0.0207 0.3225
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0207 0.1582
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0207 0.1582
Trypanosoma cruzi hypothetical protein, conserved 0.006 0.0207 0.367
Trypanosoma cruzi hypothetical protein, conserved 0.006 0.0207 0.367
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0064 0.0064
Plasmodium falciparum glutathione reductase 0.012 0.0483 1
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.006 0.0207 0.367
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0042 0.012 0.1681
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0207 0.1582
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.006 0.0207 0.1582
Schistosoma mansoni hormone-sensitive lipase (S09 family) 0.1517 0.6967 0.6967
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.019 0.0809 0.0809
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0126 0.0511 0.0511
Leishmania major hypothetical protein, conserved 0.006 0.0207 0.367
Trypanosoma brucei hypothetical protein, conserved 0.006 0.0207 0.367
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0434 0.1944 0.1944
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.006 0.0207 0.239
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.006 0.0207 0.367
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.006 0.0207 0.0736
Echinococcus multilocularis microtubule associated protein 2 0.217 1 1
Plasmodium vivax glutathione reductase, putative 0.012 0.0483 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0042 0.012 0.012
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0207 0.1582
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.006 0.0207 0.239
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.019 0.0809 0.2717
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0042 0.012 0.1681
Echinococcus multilocularis dnaJ subfamily B 0.0837 0.3811 0.3811
Schistosoma mansoni hormone-sensitive lipase (S09 family) 0.1517 0.6967 0.6967
Trypanosoma cruzi hypothetical protein, conserved 0.006 0.0207 0.367
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.006 0.0207 0.0736
Echinococcus granulosus thioredoxin glutathione reductase 0.0121 0.049 0.049
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0042 0.012 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0273 0.1195 0.8903
Trypanosoma cruzi trypanothione reductase, putative 0.0042 0.012 0.1681
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.006 0.0207 0.0736
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.006 0.0207 0.0736
Brugia malayi glutathione reductase 0.012 0.0483 0.16
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0304 0.1337 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0495 0.2223 0.2223
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.006 0.0207 0.0736
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.006 0.0207 0.0207
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.006 0.0207 0.0207
Loa Loa (eye worm) thioredoxin reductase 0.012 0.0483 0.0671
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.006 0.0207 0.0736
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.006 0.0207 0.0207
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.006 0.0207 0.1582
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0042 0.012 0.1097
Brugia malayi Pre-SET motif family protein 0.0214 0.0922 0.3105
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.006 0.0207 0.0736
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0042 0.012 0.012
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.006 0.0207 0.0207
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0273 0.1195 0.8903
Schistosoma mansoni microtubule-associated protein tau 0.217 1 1
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.006 0.0207 0.367
Trypanosoma cruzi hypothetical protein, conserved 0.006 0.0207 0.367
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.006 0.0207 0.0736
Echinococcus multilocularis hormone sensitive lipase 0.1517 0.6967 0.6967
Schistosoma mansoni cpg binding protein 0.0062 0.0215 0.0215
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0042 0.012 0.1097
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0075 0.0075
Echinococcus multilocularis cpg binding protein 0.0062 0.0215 0.0215
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0042 0.012 1
Plasmodium falciparum phosphodiesterase gamma, putative 0.006 0.0207 0.239
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.006 0.0207 0.3225
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.019 0.0809 0.0809
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.006 0.0207 0.0654
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.006 0.0207 0.0736
Trypanosoma cruzi hypothetical protein, conserved 0.006 0.0207 0.367
Brugia malayi aryl-acylamidase 0.0026 0.0046 0.0105
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0304 0.1337 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.006 0.0207 0.1582
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0026 0.0046 0.0046
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.006 0.0207 0.1582
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0273 0.1195 0.8903
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0207 0.1582
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.006 0.0207 0.0736
Leishmania major trypanothione reductase 0.012 0.0483 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0075 0.0075
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0042 0.012 0.012
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0495 0.2223 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0042 0.012 0.0337
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0207 0.1582
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.006 0.0207 0.1582
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0495 0.2223 0.2223
Leishmania major hypothetical protein, conserved 0.006 0.0207 0.367
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.019 0.0809 0.0809
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0207 0.1582
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0042 0.012 0.1681
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0075 0.0075
Schistosoma mansoni cpg binding protein 0.0062 0.0215 0.0215
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0075 0.0075
Toxoplasma gondii NADPH-glutathione reductase 0.0042 0.012 0.0337
Trypanosoma cruzi hypothetical protein, conserved 0.006 0.0207 0.367
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0207 0.1582
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.006 0.0207 0.0736
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0075 0.0075
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.006 0.0207 0.367
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0207 0.1582
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0042 0.012 0.0569
Brugia malayi Thioredoxin reductase 0.012 0.0483 0.16
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0273 0.1195 0.8903
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.006 0.0207 0.0654
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.006 0.0207 0.367
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.006 0.0207 0.1582
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.006 0.0207 0.1582
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.006 0.0207 0.367
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.006 0.0207 0.1582
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.006 0.0207 0.0273

Activities

Activity type Activity value Assay description Source Reference
Activity (ADMET) = 100 % Cytotoxicity against mouse Sarcoma 180 cells assessed as cell viability at 400 uM after 18 to 24 hrs relative to control ChEMBL. 177781
Inhibition (functional) = 0 % Cytotoxicity against mouse S180 cells at 400 uM after 1 day ChEMBL. 229223

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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