Detailed information for compound 570183

Basic information

Technical information
  • TDR Targets ID: 570183
  • Name: (1,1-dimethylpyrrolidin-1-ium-2-yl)methyl 2-c yclohexyl-2-hydroxy-2-phenyl-acetate bromide
  • MW: 426.388 | Formula: C21H32BrNO3
  • H donors: 1 H acceptors: 2 LogP: 4.93 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C(c1ccccc1)(C1CCCCC1)O)OCC1CCC[N+]1(C)C.[Br-]
  • InChi: 1S/C21H32NO3.BrH/c1-22(2)15-9-14-19(22)16-25-20(23)21(24,17-10-5-3-6-11-17)18-12-7-4-8-13-18;/h3,5-6,10-11,18-19,24H,4,7-9,12-16H2,1-2H3;1H/q+1;/p-1
  • InChiKey: SXGOKQARVJHRML-UHFFFAOYSA-M  


Substructure search Similarity search

Network

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Synonyms

  • 2-cyclohexyl-2-hydroxy-2-phenylacetic acid (1,1-dimethyl-2-pyrrolidin-1-iumyl)methyl ester bromide
  • (1,1-dimethylpyrrolidin-1-ium-2-yl)methyl 2-cyclohexyl-2-hydroxy-2-phenyl-ethanoate bromide
  • 2-cyclohexyl-2-hydroxy-2-phenyl-acetic acid (1,1-dimethylpyrrolidin-1-ium-2-yl)methyl ester bromide
  • (1,1-dimethylpyrrolidin-1-ium-2-yl)methyl 2-cyclohexyl-2-hydroxy-2-phenylacetate bromide
  • oxypyrronium bromide
  • 561-43-3
  • BRL 556
  • Bromure d'oxypyrronium [INN-French]
  • Bromuro de oxipirronio [INN-Spanish]
  • EINECS 209-219-8
  • Imetro
  • Immetropan
  • L.D. 3055
  • Oxypyrronii bromidum [INN-Latin]
  • Oxypyrronium bromide [INN]
  • Pyrrolidinium, 1,1-dimethyl-2-(hydroxymethyl)-, bromide, alpha-phenylcyclohexaneglycolate
  • 1-Methyl-2-(pyrrolid-2-yl)methyl phenylcyclohexyl glycollate methobromide
  • 2-(((Cyclohexylhydroxyphenylacetyl)oxy)methyl)-1,1-dimethylpyrrolidinium, bromide
  • 2-((alpha-Cyclohexylmandeloyloxy)methyl)-1,1-dimethylpyrrolidiniumbromid
  • 2-(2-Hydroxymethyl)-1,1-dimethylpyrrolidinium bromide alpha-phenylcyclohexaneglycolate
  • 2-(Hydroxymethyl)-1,1-dimethylpyrrolidinium bromide alpha-phenylcyclohexaneglycolate
  • BM 3055

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0676 0.5327
Echinococcus multilocularis cysteine protease 0.0018 0.0104 0.0602
Loa Loa (eye worm) hypothetical protein 0.0014 0.0053 0.0053
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.3104 1
Trypanosoma brucei Heat shock protein 83, putative 0.0045 0.0403 0.3159
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0104 0.0067
Brugia malayi Cathepsin L-like precursor 0.0018 0.0104 0.0488
Plasmodium falciparum heat shock protein 90, putative 0.017 0.1804 1
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0104 0.1058 0.8233
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0265 0.1585
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.014 0.1465 0.2043
Trypanosoma cruzi heat shock protein 90, putative 0.0019 0.0111 0.0839
Loa Loa (eye worm) ICD-1 protein 0.0038 0.0325 0.0325
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0104 0.0318
Leishmania major cysteine peptidase A (CPA) 0.0018 0.0104 0.0022
Entamoeba histolytica hypothetical protein 0.0039 0.0338 0.1072
Leishmania major cathepsin L-like protease 0.0018 0.0104 0.0022
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0676 0.5327
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0104 0.0602
Entamoeba histolytica hypothetical protein 0.0038 0.0325 0.1033
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0104 0.0318
Schistosoma mansoni family C54 unassigned peptidase (C54 family) 0.0122 0.1263 0.7676
Trypanosoma brucei cytochrome P450, putative 0.0027 0.0201 0.1554
Plasmodium vivax vivapain-2 0.0018 0.0104 0.0548
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0027 0.0201 0.0149
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.1058 0.3397
Loa Loa (eye worm) hypothetical protein 0.0133 0.1389 0.1389
Schistosoma mansoni hypothetical protein 0.007 0.0688 0.4166
Leishmania major basic transcription factor 3a, putative 0.0038 0.0325 0.1927
Schistosoma mansoni heat shock protein 0.0045 0.0403 0.2425
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0676 0.5327
Echinococcus granulosus Peptidase C54 0.0122 0.1263 0.7676
Trichomonas vaginalis CAMK family protein kinase 0.0052 0.0479 0.1527
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0104 0.0318
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0287 0.3104 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0018 0.0104 0.0104
Onchocerca volvulus Cathepsin F homolog 0.0018 0.0104 0.0067
Onchocerca volvulus 0.0018 0.0104 0.0067
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0104 0.0318
Schistosoma mansoni hypothetical protein 0.0039 0.0338 0.2027
Onchocerca volvulus 0.0018 0.0104 0.0067
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0104 0.0318
Schistosoma mansoni endoplasmin 0.0045 0.0403 0.2425
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0104 0.0318
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0265 0.0265
Onchocerca volvulus 0.0031 0.0249 0.0213
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0038 0.033 0.1982
Onchocerca volvulus 0.0018 0.0104 0.0067
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0676 0.5327
Schistosoma mansoni serine/threonine protein kinase 0.0156 0.1644 1
Loa Loa (eye worm) CYP4Cod1 0.0027 0.0201 0.0201
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0037 0.0101
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.0676 0.5327
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0104 0.0318
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.014 0.1465 1
Schistosoma mansoni cytochrome P450 0.0018 0.0101 0.0586
Loa Loa (eye worm) heat shock protein 90 0.0045 0.0403 0.0403
Schistosoma mansoni heat shock protein 0.003 0.0234 0.1396
Plasmodium vivax basic transcription factor 3b, putative 0.0038 0.0325 0.1779
Trypanosoma cruzi cruzipain precursor, putative 0.0069 0.0676 0.5327
Echinococcus granulosus cathepsin l cysteine peptidase 0.0018 0.0104 0.0602
Trypanosoma brucei heat shock protein, putative 0.0045 0.0403 0.3159
Brugia malayi Cathepsin L-like precursor 0.0018 0.0104 0.0488
Trypanosoma brucei transcription factor BTF3, putative 0.0038 0.0325 0.2543
Trichomonas vaginalis heat shock protein, putative 0.0038 0.033 0.1048
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0018 0.0101 0.0764
Trichomonas vaginalis heat shock protein, putative 0.0042 0.0372 0.1183
Leishmania major heat shock protein 83-1 0.0045 0.0403 0.2594
Leishmania major cytochrome p450-like protein 0.0027 0.0201 0.0856
Brugia malayi cytochrome P450 0.0018 0.0101 0.0475
Echinococcus granulosus lamin dm0 0.0029 0.0228 0.136
Echinococcus granulosus transcription factor btf3 0.0038 0.0325 0.1952
Onchocerca volvulus Phospholipase A2 homolog 0.019 0.2027 0.1997
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.0101 0.0764
Toxoplasma gondii heat shock protein HSP90 0.0045 0.0403 0.177
Entamoeba histolytica hypothetical protein 0.0039 0.0338 0.1072
Trypanosoma cruzi major cysteine proteinase, putative 0.0054 0.051 0.4009
Brugia malayi Endoplasmin precursor 0.0045 0.0403 0.1966
Echinococcus multilocularis heat shock protein 0.0045 0.0403 0.2425
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0122 0.1263 0.406
Brugia malayi Hsp90 protein 0.003 0.0234 0.1132
Trypanosoma cruzi cytochrome P450, putative 0.0027 0.0201 0.1554
Leishmania major heat shock protein 83-1 0.0045 0.0403 0.2594
Echinococcus multilocularis lamin 0.0029 0.0228 0.136
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0338 0.2027
Loa Loa (eye worm) histone methyltransferase 0.001 0.0008 0.0008
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0562 0.2703
Brugia malayi Cathepsin L-like precursor 0.0018 0.0104 0.0488
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0676 0.5327
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0228 0.0228
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.3104 1
Leishmania major AUT2/APG4/ATG4 cysteine peptidase, putative 0.0048 0.0432 0.2845
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0265 0.1585
Trichomonas vaginalis heat shock protein, putative 0.0033 0.0265 0.0838
Trypanosoma cruzi AUT2/APG4/ATG4 cysteine peptidase, putative 0.0048 0.0432 0.3392
Trypanosoma brucei heat shock protein, putative 0.0045 0.0403 0.3159
Trichomonas vaginalis heat shock protein, putative 0.0045 0.0403 0.1283
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.1058 0.3397
Entamoeba histolytica heat shock protein 90, putative 0.0045 0.0403 0.1283
Echinococcus granulosus cytochrome P450 2K1 0.0018 0.0101 0.0586
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0104 0.0318
Echinococcus granulosus heat shock protein 0.0045 0.0403 0.2425
Schistosoma mansoni hypothetical protein 0.0033 0.0265 0.1585
Loa Loa (eye worm) hypothetical protein 0.0012 0.0037 0.0037
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0018 0.0104 0.0548
Entamoeba histolytica cysteine proteinase, putative 0.0012 0.0037 0.0101
Brugia malayi Cathepsin L-like precursor 0.0012 0.0037 0.0155
Echinococcus granulosus cpg binding protein 0.0033 0.0269 0.1611
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0104 0.0067
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0265 0.1285
Toxoplasma gondii Hsp90 domain-containing protein 0.017 0.1804 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0676 0.5327
Trypanosoma cruzi heat shock protein, putative 0.003 0.0234 0.1819
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0059 0.0325
Leishmania major cathepsin L-like protease 0.0069 0.0676 0.4941
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0104 0.0602
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0104 0.0318
Schistosoma mansoni kinase 0.0053 0.0494 0.298
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0156 0.1644 0.1613
Loa Loa (eye worm) hypothetical protein 0.0018 0.0104 0.0104
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0156 0.1644 1
Schistosoma mansoni endoplasmin 0.0045 0.0403 0.2425
Loa Loa (eye worm) hypothetical protein 0.019 0.2027 0.2027
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0103 0.1053 0.1053
Echinococcus multilocularis cysteine protease atg4b 0.0122 0.1263 0.7676
Trypanosoma cruzi heat shock protein 85, putative 0.0038 0.033 0.2582
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0104 0.1058 0.6424
Trypanosoma brucei polo-like protein kinase 0.0104 0.1058 0.8368
Giardia lamblia Fructose-bisphosphate aldolase 0.0287 0.3104 1
Plasmodium falciparum cysteine protease ATG4, putative 0.0048 0.0432 0.2372
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0104 0.1058 0.1058
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0104 0.0318
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0249 0.0249
Giardia lamblia Grp94/Hsp90 0.0042 0.0372 0.015
Trypanosoma cruzi cysteine peptidase, Clan CA, family C54, putative 0.0048 0.0432 0.3392
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0104 0.0318
Leishmania major heat shock protein 83-1 0.0045 0.0403 0.2594
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.3104 1
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0007 0.0009
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0037 0.0101
Trichomonas vaginalis CAMK family protein kinase 0.0052 0.0479 0.1527
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0156 0.1644 0.1644
Schistosoma mansoni hypothetical protein 0.0033 0.0265 0.1585
Plasmodium vivax vivapain-2 0.0018 0.0104 0.0548
Plasmodium falciparum cysteine proteinase falcipain 3 0.0018 0.0104 0.0548
Entamoeba histolytica serine/threonine protein kinase, putative 0.0104 0.1058 0.3397
Schistosoma mansoni heat shock protein 0.0045 0.0403 0.2425
Echinococcus multilocularis 0.0018 0.0101 0.0586
Schistosoma mansoni family C54 unassigned peptidase (C54 family) 0.0122 0.1263 0.7676
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0228 0.1102
Leishmania major heat shock protein 83-1 0.0045 0.0403 0.2594
Giardia lamblia Kinase, PLK 0.0104 0.1058 0.2624
Trypanosoma brucei cysteine peptidase, Clan CA, family C54, putative 0.0048 0.0432 0.3392
Leishmania major cathepsin L-like protease 0.0069 0.0676 0.4941
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0104 0.0602
Trypanosoma brucei heat shock protein, putative 0.0045 0.0403 0.3159
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.3104 1
Trichomonas vaginalis heat shock protein, putative 0.0042 0.0372 0.1183
Toxoplasma gondii heat shock protein 75, putative 0.003 0.0234 0.078
Brugia malayi Cytochrome P450 family protein 0.0057 0.0535 0.2618
Loa Loa (eye worm) hypothetical protein 0.0012 0.0037 0.0037
Trypanosoma brucei heat shock protein, putative 0.0045 0.0403 0.3159
Toxoplasma gondii heat shock protein 90, putative 0.0045 0.0403 0.177
Onchocerca volvulus 0.0018 0.0104 0.0067
Toxoplasma gondii autophagy-related cysteine peptidase atg4, putative 0.0048 0.0432 0.1942
Leishmania major cathepsin L-like protease 0.0018 0.0104 0.0022
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0104 0.1058 0.6424
Loa Loa (eye worm) hypothetical protein 0.0014 0.0059 0.0059
Trichomonas vaginalis endoplasmin, putative 0.0033 0.0265 0.0838
Brugia malayi hypothetical protein 0.0133 0.1389 0.6844
Leishmania major heat shock protein 83-1 0.0045 0.0403 0.2594
Echinococcus granulosus endoplasmin 0.0042 0.0372 0.2237
Loa Loa (eye worm) hypothetical protein 0.0122 0.1263 0.1263
Trypanosoma brucei heat shock protein, putative 0.0045 0.0403 0.3159
Entamoeba histolytica peptidase, C54 family 0.0048 0.0432 0.1377
Leishmania major heat shock protein 83-1 0.0045 0.0403 0.2594
Loa Loa (eye worm) hypothetical protein 0.0103 0.1053 0.1053
Trypanosoma cruzi heat shock protein 85, putative 0.0045 0.0403 0.3159
Brugia malayi intermediate filament protein 0.0029 0.0228 0.1102
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0063 0.0608 0.4793
Trypanosoma cruzi Heat shock protein 83, putative 0.0045 0.0403 0.3159
Leishmania major heat shock protein, putative 0.003 0.0234 0.1143
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0104 0.0784
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0104 0.0318
Echinococcus multilocularis GPCR, family 2 0.0033 0.0265 0.1585
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.003 0.0234 0.1396
Plasmodium vivax heat shock protein 90, putative 0.003 0.0234 0.1272
Onchocerca volvulus Serine\/threonine kinase homolog 0.0104 0.1058 0.1025
Brugia malayi Cathepsin L-like precursor 0.0012 0.0037 0.0155
Trypanosoma cruzi transcription factor btf3, putative 0.0038 0.0325 0.2543
Loa Loa (eye worm) cytochrome P450 0.0018 0.0101 0.0101
Treponema pallidum fructose-bisphosphate aldolase 0.0287 0.3104 1
Loa Loa (eye worm) ctsf protein 0.0018 0.0104 0.0104
Echinococcus granulosus heat shock protein 90 0.0045 0.0403 0.2425
Schistosoma mansoni autophagin-1 (C54 family) 0.0122 0.1263 0.7676
Echinococcus multilocularis heat shock protein 90 0.0038 0.033 0.1982
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0059 0.0325
Brugia malayi Cytochrome P450 family protein 0.0027 0.0201 0.0967
Trypanosoma brucei heat shock protein 84, putative 0.003 0.0234 0.1819
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0265 0.1285
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0104 0.0318
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.3104 1
Onchocerca volvulus 0.0018 0.0104 0.0067
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.0676 0.5327
Schistosoma mansoni serine/threonine protein kinase 0.0104 0.1058 0.6424
Loa Loa (eye worm) heat shock protein 75 0.003 0.0234 0.0234
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0008 0.0019
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0103 0.1053 0.518
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0338 0.2027
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.1058 0.3397
Loa Loa (eye worm) hypothetical protein 0.0133 0.1389 0.1389
Loa Loa (eye worm) hypothetical protein 0.0029 0.0228 0.0228
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0156 0.1644 0.8108
Brugia malayi Calcitonin receptor-like protein seb-1 0.0103 0.1053 0.518
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0104 0.0318
Brugia malayi Cathepsin L-like precursor 0.0018 0.0104 0.0488
Echinococcus multilocularis lamin dm0 0.0029 0.0228 0.136
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.0641 0.3876
Leishmania major heat shock protein 83-1 0.0045 0.0403 0.2594
Leishmania major heat shock protein 83-1 0.0045 0.0403 0.2594
Brugia malayi Cathepsin L-like precursor 0.0018 0.0104 0.0488
Entamoeba histolytica hypothetical protein 0.0039 0.0338 0.1072
Entamoeba histolytica transcription factor BTF3, putative 0.0038 0.0325 0.1033
Echinococcus granulosus cysteine protease atg4b 0.0122 0.1263 0.7676
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0008 0.0019
Leishmania major heat shock protein 83-1 0.0045 0.0403 0.2594
Brugia malayi Cathepsin L-like cysteine proteinase 0.0012 0.0037 0.0155
Entamoeba histolytica 90 kDa heat shock protein, putative 0.003 0.0234 0.0739
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.0104 0.0104
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.1058 0.3397
Echinococcus multilocularis transcription factor btf3 0.0038 0.0325 0.1952
Leishmania major heat shock protein 83-1 0.0045 0.0403 0.2594
Onchocerca volvulus 0.0018 0.0104 0.0067
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.3104 1
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.1058 0.3397
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0104 0.0488
Brugia malayi Cytochrome P450 family protein 0.0027 0.0201 0.0967
Schistosoma mansoni transcription factor btf3 0.0038 0.0325 0.1952
Plasmodium falciparum heat shock protein 90, putative 0.0026 0.0192 0.1041
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0042 0.0372 0.1983
Mycobacterium tuberculosis Arylamine N-acetyltransferase Nat (arylamine acetylase) 0.0615 0.678 1
Brugia malayi heat shock protein 90 0.0045 0.0403 0.1966
Onchocerca volvulus Huntingtin homolog 0.0133 0.1389 0.1357
Loa Loa (eye worm) cysteine protease 0.0018 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0014 0.0053 0.0053
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0201 0.0201
Loa Loa (eye worm) endoplasmin 0.0045 0.0403 0.0403
Schistosoma mansoni hypothetical protein 0.0033 0.0265 0.1585
Schistosoma mansoni lamin 0.0029 0.0228 0.136
Leishmania major cathepsin L-like protease 0.0018 0.0104 0.0022
Echinococcus granulosus cathepsin L cysteine proteinase 0.0018 0.0104 0.0602
Trypanosoma cruzi heat shock protein 85, putative 0.0045 0.0403 0.3159
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0104 0.0318
Plasmodium falciparum endoplasmin, putative 0.0033 0.0265 0.1444
Schistosoma mansoni cathepsin F (C01 family) 0.0012 0.0037 0.0191
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0122 0.1263 0.406
Leishmania major heat shock protein 83-1 0.0045 0.0403 0.2594
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0676 0.5327
Entamoeba histolytica heat shock protein 90, putative 0.0045 0.0403 0.1283
Brugia malayi serine/threonine-protein kinase plk-2 0.0104 0.1058 0.5208
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0104 0.0318
Brugia malayi Protein kinase domain containing protein 0.0156 0.1644 0.8108
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0325 0.1033
Plasmodium vivax heat shock protein, putative 0.017 0.1804 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0676 0.5327
Loa Loa (eye worm) hypothetical protein 0.007 0.0688 0.0688
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.1058 0.3397
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0076 0.035
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.014 0.1465 0.2043
Plasmodium falciparum basic transcription factor 3b, putative 0.0038 0.0325 0.1779
Schistosoma mansoni cpg binding protein 0.0031 0.0249 0.1489
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0104 0.0318
Entamoeba histolytica hypothetical protein 0.0039 0.0338 0.1072
Leishmania major heat shock protein 83-1 0.0045 0.0403 0.2594
Mycobacterium ulcerans arylamine N-acetyltransferase Nat 0.0615 0.678 1
Leishmania major heat shock protein 83-1 0.0045 0.0403 0.2594
Leishmania major heat shock protein 83-1 0.0045 0.0403 0.2594
Echinococcus multilocularis Peptidase C54 0.0122 0.1263 0.7676
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.3104 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0104 0.0318
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0676 0.5327
Plasmodium falciparum heat shock protein 90 0.0045 0.0403 0.221
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0122 0.1263 0.406
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0265 0.1585
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0104 0.0602
Schistosoma mansoni cpg binding protein 0.0033 0.0269 0.1611
Echinococcus granulosus intermediate filament protein 0.0029 0.0228 0.136
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0156 0.1644 0.1644
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0676 0.5327
Trypanosoma cruzi heat shock protein 90, putative 0.0045 0.0403 0.3159
Echinococcus granulosus cathepsin l1 0.0012 0.0037 0.0191
Trypanosoma brucei heat shock protein, putative 0.0045 0.0403 0.3159
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0104 0.0602
Onchocerca volvulus Phospholipase A2 homolog 0.0904 1 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0104 0.1058 0.8368
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0338 0.2027
Toxoplasma gondii cathepsin CPL 0.0018 0.0104 0.0015
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.0676 0.5327
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.3104 1
Trypanosoma cruzi AUT2/APG4/ATG4 cysteine peptidase, putative 0.0122 0.1263 1
Brugia malayi Peptidase family C54 containing protein 0.0122 0.1263 0.6223
Trypanosoma cruzi transcription factor btf3, putative 0.0038 0.0325 0.2543
Leishmania major cathepsin L-like protease 0.0018 0.0104 0.0022
Leishmania major heat shock protein 83-1 0.0045 0.0403 0.2594
Schistosoma mansoni hypothetical protein 0.0033 0.0265 0.1585
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0104 0.0318
Plasmodium vivax endoplasmin, putative 0.0045 0.0403 0.221
Echinococcus multilocularis musashi 0.0029 0.0228 0.136
Trypanosoma cruzi polo-like protein kinase, putative 0.0104 0.1058 0.8368
Trypanosoma brucei heat shock protein, putative 0.0045 0.0403 0.3159
Trypanosoma brucei heat shock protein 90, putative 0.0045 0.0403 0.3159
Leishmania major heat shock protein 83-1 0.0045 0.0403 0.2594
Onchocerca volvulus 0.0018 0.0104 0.0067
Entamoeba histolytica peptidase, C54 family 0.0048 0.0432 0.1377
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.1058 0.3397
Schistosoma mansoni cpg binding protein 0.0033 0.0269 0.1611
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0325 0.1033
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0104 0.0318
Schistosoma mansoni intermediate filament proteins 0.0029 0.0228 0.136
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0122 0.1263 0.406
Entamoeba histolytica peptidase, C54 family 0.0048 0.0432 0.1377
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.003 0.0234 0.1396
Giardia lamblia Heat shock protein HSP 90-alpha 0.0045 0.0403 0.0262
Trypanosoma brucei heat shock protein, putative 0.0045 0.0403 0.3159
Trypanosoma brucei AUT2/APG4/ATG4 cysteine peptidase, putative 0.0122 0.1263 1
Brugia malayi Cathepsin L-like precursor 0.0018 0.0104 0.0488
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0265 0.1585
Toxoplasma gondii NAC domain-containing protein 0.0038 0.0325 0.1315
Trypanosoma cruzi heat shock protein 90, putative 0.0038 0.033 0.2582
Echinococcus granulosus lamin 0.0029 0.0228 0.136
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0042 0.0372 0.0405
Entamoeba histolytica cysteine protease, putative 0.0018 0.0104 0.0318
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0104 0.0318
Entamoeba histolytica peptidase, C54 family 0.0122 0.1263 0.406
Leishmania major AUT2/APG4/ATG4 cysteine peptidase, putative 0.0122 0.1263 1
Entamoeba histolytica peptidase, C54 family 0.0048 0.0432 0.1377
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0104 0.0318
Echinococcus multilocularis cysteine protease 0.0018 0.0104 0.0602
Echinococcus multilocularis cpg binding protein 0.0033 0.0269 0.1611
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0228 0.0228
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.0688 0.3377
Brugia malayi Cytochrome P450 family protein 0.0018 0.0101 0.0475
Echinococcus granulosus cathepsin l1 0.0018 0.0104 0.0602
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0122 0.1263 0.406
Leishmania major heat shock protein 83-1 0.0045 0.0403 0.2594
Schistosoma mansoni hypothetical protein 0.0018 0.0101 0.0586
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0042 0.0372 0.2328
Echinococcus multilocularis endoplasmin 0.0042 0.0372 0.2237
Brugia malayi beta-NAC-like protein 0.0038 0.0325 0.1583
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0104 0.0318
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0076 0.0076
Schistosoma mansoni lamin 0.0029 0.0228 0.136
Loa Loa (eye worm) hypothetical protein 0.0033 0.0265 0.0265
Leishmania major cathepsin L-like protease 0.0069 0.0676 0.4941
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0156 0.1644 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0104 0.0318
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0287 0.3104 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0018 0.0104 0.0548
Onchocerca volvulus 0.0029 0.0228 0.0192
Onchocerca volvulus Huntingtin homolog 0.0133 0.1389 0.1357
Echinococcus granulosus heat shock protein 90 0.0038 0.033 0.1982
Brugia malayi hypothetical protein 0.0039 0.0338 0.1644
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0192 0.0604
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0104 0.0602
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0104 0.0318
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0325 0.1033
Brugia malayi Phospholipase A2 family protein 0.019 0.2027 1
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.003 0.0234 0.0198
Brugia malayi CXXC zinc finger family protein 0.0031 0.0249 0.1208
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.0101 0.0764
Trypanosoma cruzi heat shock protein 85, putative 0.0045 0.0403 0.3159
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0042 0.0372 0.5
Trypanosoma cruzi cytochrome P450, putative 0.0027 0.0201 0.1554
Leishmania major cathepsin L-like protease 0.0018 0.0104 0.0022
Plasmodium vivax heat shock protein 86, putative 0.0045 0.0403 0.221
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0676 0.5327
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0104 0.0318
Trypanosoma brucei heat shock protein 90, putative 0.0045 0.0403 0.3159
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0018 0.0101 0.0764
Loa Loa (eye worm) cytochrome P450 family protein 0.0057 0.0535 0.0535
Loa Loa (eye worm) hypothetical protein 0.0012 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0029 0.0222 0.0222
Echinococcus multilocularis heat shock protein 90 0.0045 0.0403 0.2425
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0201 0.0201
Loa Loa (eye worm) fibroinase 0.0018 0.0104 0.0104
Onchocerca volvulus 0.0029 0.0228 0.0192
Echinococcus granulosus GPCR family 2 0.0033 0.0265 0.1585
Brugia malayi cathepsin L-like precursor 0.0012 0.0037 0.0155
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0104 0.0318
Mycobacterium ulcerans heat shock protein 90 0.0042 0.0372 0.0405

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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