Detailed information for compound 572552

Basic information

Technical information
  • TDR Targets ID: 572552
  • Name: (2-iodophenyl)methyl-trimethyl-ammonium
  • MW: 276.137 | Formula: C10H15IN+
  • H donors: 0 H acceptors: 0 LogP: 2.42 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Ic1ccccc1C[N+](C)(C)C
  • InChi: 1S/C10H15IN/c1-12(2,3)8-9-6-4-5-7-10(9)11/h4-7H,8H2,1-3H3/q+1
  • InChiKey: BWGBWIGMDOMQQR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2-iodophenyl)methyl-trimethylammonium
  • (2-iodophenyl)methyl-trimethyl-azanium
  • (2-iodobenzyl)-trimethyl-ammonium
  • (2-iodophenyl)methyl-trimethylazanium
  • iodobenzyltrimethylammonium
  • 59777-96-7
  • Benzenemethanaminium, 2-iodo-N,N,N-trimethyl-
  • Iodobenzyltrimethylammonium iodide
  • UM-360
  • 2-Iodobenzyl-N,N,N-trimethylammonium chloride

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi cruzipain precursor, putative 0.0063 0.0056 0.3488
Schistosoma mansoni hypothetical protein 0.0034 0.0019 0.0019
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0071 0.0066 0.0066
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0035 0.002 0.002
Echinococcus multilocularis phd:f box containing protein 0.0026 0.0009 0.0008
Schistosoma mansoni jumonji domain containing protein 0.0141 0.0156 0.0156
Trypanosoma cruzi ISWI complex protein 0.0046 0.0034 0.1848
Schistosoma mansoni hormone-sensitive lipase (S09 family) 0.782 1 1
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0151 0.0168 0.0168
Brugia malayi Bromodomain containing protein 0.0118 0.0127 0.2452
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0059 0.0051 0.3112
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0056 0.0047 0.0046
Loa Loa (eye worm) hypothetical protein 0.0069 0.0063 0.0063
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0049 0.0038 0.2178
Loa Loa (eye worm) hypothetical protein 0.0115 0.0122 0.0122
Trypanosoma brucei polo-like protein kinase 0.01 0.0103 0.6961
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0014 0.0401
Loa Loa (eye worm) jmjC domain-containing protein 0.0026 0.0009 0.0009
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.0044 0.0044
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0034 0.0018 0.0728
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0224 0.0262 0.8837
Plasmodium vivax glutathione reductase, putative 0.0098 0.0101 1
Schistosoma mansoni inositol monophosphatase 0.0075 0.0071 0.0071
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0108 0.0113 0.0113
Mycobacterium tuberculosis Probable oxidoreductase 0.0249 0.0294 1
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.0299 0.5108
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0134 0.0147 0.0147
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0056 0.3488
Mycobacterium tuberculosis Probable esterase LipO 0.0132 0.0145 0.458
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0026 0.0009 0.0009
Onchocerca volvulus 0.0047 0.0036 0.0389
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0056 0.3488
Echinococcus multilocularis peregrin 0.0041 0.0028 0.0027
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0061 0.0061
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0064 0.0057 0.102
Brugia malayi Pre-SET motif family protein 0.0059 0.0051 0.0901
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0134 0.0147 0.0147
Mycobacterium tuberculosis Probable acetyl-hydrolase/esterase LipR 0.0132 0.0145 0.458
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0064 0.0057 0.0057
Plasmodium falciparum sentrin-specific protease 1 0.0046 0.0034 0.2776
Schistosoma mansoni hypothetical protein 0.0677 0.0843 0.0843
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0019 0.0792
Plasmodium vivax thioredoxin reductase, putative 0.0098 0.0101 1
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0034 0.0018 0.0728
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0134 0.0147 0.287
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0187 0.3078
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0018 0.0728
Plasmodium falciparum phd finger protein, putative 0.0031 0.0014 0.0592
Loa Loa (eye worm) hypothetical protein 0.0026 0.0009 0.0009
Mycobacterium tuberculosis Probable dehydrogenase 0.0224 0.0262 0.8837
Schistosoma mansoni methyl-cpg binding protein mbd 0.0051 0.004 0.004
Onchocerca volvulus Huntingtin homolog 0.0122 0.0131 0.211
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0075 0.0071 0.4622
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0018 0.0728
Echinococcus multilocularis geminin 0.0677 0.0843 0.0842
Plasmodium falciparum basic transcription factor 3b, putative 0.0035 0.0019 0.117
Echinococcus granulosus fetal alzheimer antigen falz 0.0071 0.0066 0.0066
Toxoplasma gondii NAC domain-containing protein 0.0035 0.0019 0.0792
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0024 0.0024
Brugia malayi RNA binding protein 0.0067 0.0061 0.1107
Schistosoma mansoni hypothetical protein 0.0031 0.0014 0.0014
Brugia malayi acetyltransferase, GNAT family protein 0.0151 0.0168 0.3305
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0057 0.354
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0056 0.3488
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0103 0.1546
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0134 0.0147 0.0147
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.011 0.0117 0.0117
Loa Loa (eye worm) PHD-finger family protein 0.0062 0.0054 0.0054
Leishmania major hypothetical protein, conserved 0.0132 0.0145 1
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0103 0.1546
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0056 0.3488
Schistosoma mansoni hypothetical protein 0.0038 0.0024 0.0024
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0036 0.0035
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.01 0.0103 0.0103
Schistosoma mansoni zinc finger protein 0.0046 0.0034 0.0034
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0134 0.0147 0.0147
Trypanosoma cruzi Isoprenylcysteine alpha-carbonyl methylesterase, putative 0.0132 0.0145 1
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0199 0.3287
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.0299 0.5108
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0103 0.1546
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0103 0.1546
Echinococcus granulosus tar DNA binding protein 0.0067 0.0061 0.0061
Brugia malayi F/Y-rich N-terminus family protein 0.0035 0.002 0.0269
Mycobacterium ulcerans esterase/lipase 0.0132 0.0145 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.012 0.0128 0.0128
Treponema pallidum N-acetylphosphinothricin-tripetide-deacetylase 0.0132 0.0145 1
Schistosoma mansoni hypothetical protein 0.0046 0.0034 0.0034
Echinococcus granulosus zinc finger protein 0.0066 0.0059 0.0059
Schistosoma mansoni bromodomain containing protein 0.0197 0.0227 0.0227
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0103 0.1546
Brugia malayi mbt repeat family protein 0.0047 0.0036 0.0586
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0103 0.1546
Loa Loa (eye worm) hypothetical protein 0.782 1 1
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0199 0.3287
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.011 0.0117 0.0117
Echinococcus multilocularis dnaJ subfamily B 0.0812 0.1015 0.1015
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0064 0.0057 0.0057
Entamoeba histolytica hypothetical protein 0.0038 0.0024 0.0528
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0019 0.0016
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0075 0.0071 0.4622
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0253 0.0299 0.5973
Schistosoma mansoni jumonji/arid domain-containing protein 0.0108 0.0113 0.0113
Brugia malayi glutathione reductase 0.0098 0.0101 0.192
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0014 0.0014
Mycobacterium tuberculosis Probable lipase/esterase LipN 0.0132 0.0145 0.458
Loa Loa (eye worm) hypothetical protein 0.0122 0.0131 0.0131
Loa Loa (eye worm) jmjC domain-containing protein 0.0108 0.0113 0.0113
Echinococcus granulosus jumonji domain containing 1A 0.0026 0.0009 0.0008
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0034 0.0018 0.1075
Echinococcus granulosus neuropeptide s receptor 0.0466 0.0573 0.0573
Leishmania major trypanothione reductase 0.0098 0.0101 0.6771
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.0299 0.5108
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0187 0.3078
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0024 0.0024
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0151 0.0168 0.0168
Loa Loa (eye worm) ammd protein 0.0132 0.0145 0.0145
Mycobacterium tuberculosis Probable non lipolytic carboxylesterase NlhH 0.0132 0.0145 0.458
Giardia lamblia NADH oxidase lateral transfer candidate 0.0034 0.0018 0.0499
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0108 0.0113 0.0113
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0025 0.1738
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0034 0.0018 0.0728
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.0061 0.1107
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0224 0.0262 0.8623
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0034 0.0018 0.0018
Trypanosoma brucei transcription factor BTF3, putative 0.0035 0.0019 0.0792
Plasmodium falciparum glutathione reductase 0.0034 0.0018 0.1075
Echinococcus multilocularis JmjC domain containing protein 4 0.0026 0.0009 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0019 0.0016
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.012 0.0128 0.3985
Brugia malayi beta-NAC-like protein 0.0035 0.0019 0.0255
Schistosoma mansoni cpg binding protein 0.0057 0.0048 0.0048
Echinococcus granulosus phd:f box containing protein 0.0026 0.0009 0.0008
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0051 0.0051
Echinococcus granulosus sentrin specific protease 1 0.0046 0.0034 0.0034
Echinococcus multilocularis tar DNA binding protein 0.0067 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.011 0.0117 0.0117
Schistosoma mansoni hormone-sensitive lipase (S09 family) 0.782 1 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0099 0.0101 0.0101
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0249 0.0294 1
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0036 0.0036
Mycobacterium ulcerans lipase/esterase LipN 0.0132 0.0145 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0224 0.0262 0.8837
Leishmania major hypothetical protein, conserved 0.0046 0.0034 0.1848
Loa Loa (eye worm) TAR-binding protein 0.0067 0.0061 0.0061
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0134 0.0147 0.0147
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0056 0.3488
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0019 0.0792
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0034 0.0018 0.0728
Schistosoma mansoni phosphatidylserine receptor 0.0026 0.0009 0.0009
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0071 0.0066 0.0066
Brugia malayi TAR-binding protein 0.0067 0.0061 0.1107
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0022 0.0022
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0187 0.3078
Brugia malayi Bromodomain containing protein 0.0232 0.0272 0.5426
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0046 0.0034 0.0034
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0056 0.3488
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0035 0.002 0.002
Loa Loa (eye worm) thioredoxin reductase 0.0098 0.0101 0.0101
Echinococcus granulosus inositol monophosphatase 1 0.0075 0.0071 0.0071
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0067 0.0061 0.1556
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0187 0.3078
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0014 0.0401
Echinococcus multilocularis transcription factor btf3 0.0035 0.0019 0.0019
Trichomonas vaginalis inositol monophosphatase, putative 0.0075 0.0071 0.0966
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0056 0.3488
Mycobacterium ulcerans esterase LipC 0.0132 0.0145 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0121 0.013 0.8898
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0187 0.3078
Leishmania major cathepsin L-like protease 0.0063 0.0056 0.3488
Trypanosoma cruzi Isoprenylcysteine alpha-carbonyl methylesterase, putative 0.0132 0.0145 1
Schistosoma mansoni aldehyde dehydrogenase 0.012 0.0128 0.0128
Echinococcus granulosus serine:threonine protein kinase PLK1 0.01 0.0103 0.0103
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.0128 0.87
Echinococcus granulosus histone acetyltransferase KAT2B 0.0049 0.0038 0.0038
Schistosoma mansoni protein phosphatase 2C 0.0026 0.0009 0.0009
Mycobacterium ulcerans lipase LipU 0.0132 0.0145 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0039 0.0039
Mycobacterium ulcerans lipase LipH 0.0132 0.0145 1
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0061 0.0061
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0046 0.0034 0.0558
Schistosoma mansoni jumonji/arid domain-containing protein 0.0108 0.0113 0.0113
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0187 0.3078
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0056 0.3488
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0039 0.0664
Brugia malayi Thioredoxin reductase 0.0098 0.0101 0.192
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0224 0.0262 0.8837
Echinococcus multilocularis hormone sensitive lipase 0.782 1 1
Toxoplasma gondii alpha/beta hydrolase fold domain-containing protein 0.0132 0.0145 1
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0075 0.0071 0.6208
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0186 0.0213 0.0213
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0034 0.0018 0.0728
Plasmodium vivax SET domain protein, putative 0.0059 0.0051 0.4596
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0061 0.0061
Mycobacterium tuberculosis Probable esterase LipM 0.0132 0.0145 0.458
Echinococcus granulosus lysine specific demethylase 5A 0.0108 0.0113 0.0113
Brugia malayi Pre-SET motif family protein 0.0406 0.0496 1
Schistosoma mansoni hormone-sensitive lipase (S09 family) 0.782 1 1
Onchocerca volvulus Glucosylceramidase homolog 0.0166 0.0187 0.3134
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0034 0.0018 0.0237
Schistosoma mansoni aldehyde dehydrogenase 0.012 0.0128 0.0128
Loa Loa (eye worm) hypothetical protein 0.0054 0.0044 0.0044
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0056 0.3488
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0051 0.004 0.004
Onchocerca volvulus 0.0057 0.0048 0.0613
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0046 0.0034 0.1879
Brugia malayi jmjC domain containing protein 0.0026 0.0009 0.0034
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0034 0.0018 0.0728
Schistosoma mansoni zinc finger protein 0.0066 0.0059 0.0059
Trypanosoma cruzi polo-like protein kinase, putative 0.01 0.0103 0.6961
Entamoeba histolytica hypothetical protein 0.0038 0.0024 0.0528
Trypanosoma cruzi ISWI complex protein 0.0046 0.0034 0.1848
Toxoplasma gondii alpha/beta hydrolase fold domain-containing protein 0.0132 0.0145 1
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.01 0.0103 0.0103
Echinococcus multilocularis lysine specific demethylase 6a 0.0026 0.0009 0.0008
Leishmania major ecotin, putative 0.0132 0.0145 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0018 0.0728
Loa Loa (eye worm) hypothetical protein 0.0126 0.0136 0.0136
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0056 0.3488
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0059 0.0051 0.0051
Brugia malayi PHD-finger family protein 0.0031 0.0014 0.0146
Schistosoma mansoni kinase 0.0051 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0122 0.0131 0.0131
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0075 0.0071 0.0966
Echinococcus multilocularis neuropeptide receptor A26 0.0466 0.0573 0.0573
Entamoeba histolytica hypothetical protein 0.0038 0.0024 0.0528
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0036 0.0035
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0057 0.354
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0014 0.0592
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0025 0.1183
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0064 0.0057 0.0057
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0034 0.0018 0.0728
Trypanosoma cruzi polo-like protein kinase, putative 0.01 0.0103 0.6961
Brugia malayi serine/threonine-protein kinase plk-2 0.01 0.0103 0.1973
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0046 0.0034 0.0286
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0036 0.0036
Schistosoma mansoni hypothetical protein 0.0812 0.1015 0.1015
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0075 0.0071 0.4622
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0249 0.0294 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0056 0.3488
Trypanosoma brucei trypanothione reductase 0.0098 0.0101 0.6771
Brugia malayi CXXC zinc finger family protein 0.0057 0.0048 0.084
Loa Loa (eye worm) ICD-1 protein 0.0035 0.0019 0.0019
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0056 0.3488
Trichomonas vaginalis set domain proteins, putative 0.0462 0.0567 1
Mycobacterium tuberculosis Putative acetyl hydrolase MbtJ 0.0132 0.0145 0.458
Echinococcus multilocularis cpg binding protein 0.0066 0.0059 0.0059
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0036 0.0389
Loa Loa (eye worm) glutathione reductase 0.0098 0.0101 0.0101
Plasmodium falciparum thioredoxin reductase 0.0098 0.0101 1
Brugia malayi Inositol-1 0.0075 0.0071 0.1321
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0024 0.0024
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0224 0.0262 0.8837
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0039 0.0039
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0014 0.0014
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0018 0.0728
Brugia malayi jmjC domain containing protein 0.0108 0.0113 0.2166
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0046 0.0034 0.1762
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0036 0.0035
Echinococcus multilocularis thioredoxin glutathione reductase 0.0098 0.0101 0.0101
Toxoplasma gondii NADPH-glutathione reductase 0.0034 0.0018 0.0728
Echinococcus granulosus lysine specific demethylase 6a 0.0026 0.0009 0.0008
Mycobacterium ulcerans lipase LipU 0.0132 0.0145 1
Brugia malayi Bromodomain containing protein 0.0041 0.0028 0.0425
Plasmodium vivax basic transcription factor 3b, putative 0.0035 0.0019 0.117
Brugia malayi hypothetical protein 0.0038 0.0024 0.0345
Schistosoma mansoni hypothetical protein 0.0677 0.0843 0.0843
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0036 0.0035
Brugia malayi mbt repeat family protein 0.0047 0.0036 0.0586
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0034 0.0018 0.0728
Echinococcus multilocularis inositol monophosphatase 1 0.0075 0.0071 0.0071
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0134 0.0147 0.0147
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0249 0.0294 1
Mycobacterium tuberculosis Possible esterase LipW 0.0132 0.0145 0.458
Trypanosoma brucei Isoprenylcysteine alpha-carbonyl methylesterase, putative 0.0132 0.0145 1
Mycobacterium ulcerans lipase LipI 0.0132 0.0145 1
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0187 0.0214 0.0214
Brugia malayi jmjC domain containing protein 0.0162 0.0182 0.3585
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0059 0.0051 0.0051
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0049 0.0038 0.0359
Brugia malayi jmjC domain containing protein 0.0026 0.0009 0.0034
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.0029 0.0029
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0075 0.0071 0.0966
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0018 0.0728
Loa Loa (eye worm) jmjC domain-containing protein 0.0026 0.0009 0.0009
Loa Loa (eye worm) bromodomain containing protein 0.0057 0.0047 0.0047
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0186 0.0213 0.0213
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.0044 0.0044
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0025 0.0623
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0075 0.0071 0.42
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0026 0.0009 0.0009
Schistosoma mansoni transcription factor btf3 0.0035 0.0019 0.0019
Trypanosoma cruzi major cysteine proteinase, putative 0.005 0.0039 0.2212
Toxoplasma gondii thioredoxin reductase 0.0098 0.0101 0.6771
Echinococcus granulosus transcription factor btf3 0.0035 0.0019 0.0019
Mycobacterium tuberculosis Possible lipase LipU 0.0132 0.0145 0.458
Echinococcus granulosus neuropeptide receptor A26 0.0466 0.0573 0.0573
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.0044 0.0044
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.0299 0.5108
Loa Loa (eye worm) hypothetical protein 0.0135 0.0148 0.0148
Loa Loa (eye worm) RNA binding protein 0.0067 0.0061 0.0061
Brugia malayi jmjC domain containing protein 0.0026 0.0009 0.0034
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.0044 0.0758
Trichomonas vaginalis conserved hypothetical protein 0.0132 0.0145 0.2299
Echinococcus multilocularis microtubule associated protein 2 0.2791 0.3553 0.3552
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0103 0.1546
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0019 0.0246
Trichomonas vaginalis bromodomain-containing protein, putative 0.0049 0.0038 0.0359
Giardia lamblia Kinase, PLK 0.01 0.0103 1
Mycobacterium tuberculosis Probable lipase LipH 0.0132 0.0145 0.458
Echinococcus granulosus thioredoxin glutathione reductase 0.0098 0.0101 0.0101
Loa Loa (eye worm) hypothetical protein 0.0031 0.0014 0.0014
Mycobacterium ulcerans hypothetical protein 0.0132 0.0145 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.011 0.0117 0.0116
Mycobacterium tuberculosis Probable reductase 0.0224 0.0262 0.8837
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0046 0.0034 0.0034
Echinococcus multilocularis neuropeptide s receptor 0.0466 0.0573 0.0573
Echinococcus granulosus histone lysine methyltransferase setb 0.011 0.0117 0.0116
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.0048 0.0048
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0075 0.0071 0.4622
Schistosoma mansoni hypothetical protein 0.0062 0.0054 0.0054
Echinococcus granulosus methyl CpG binding domain protein 2 0.0051 0.004 0.004
Leishmania major basic transcription factor 3a, putative 0.0035 0.0019 0.0792
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0022 0.0022
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.0128 0.87
Brugia malayi PHD-finger family protein 0.0082 0.0079 0.1483
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0075 0.0071 0.4622
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0014 0.0014
Trypanosoma cruzi trypanothione reductase, putative 0.0098 0.0101 0.6771
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0038 0.0364
Mycobacterium tuberculosis Probable carboxylesterase LipQ 0.0132 0.0145 0.458
Schistosoma mansoni phd/f-box containing protein 0.0026 0.0009 0.0009
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0039 0.0664
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.012 0.0128 0.8795
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0064 0.0057 0.4455
Schistosoma mansoni inositol monophosphatase 0.0075 0.0071 0.0071
Schistosoma mansoni jumonji domain containing protein 0.0026 0.0009 0.0009
Loa Loa (eye worm) aryl-acylamidase 0.0132 0.0145 0.0145
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0018 0.0728
Onchocerca volvulus 0.0059 0.0051 0.0667
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.0299 0.5108
Plasmodium vivax sentrin-specific protease 1, putative 0.0046 0.0034 0.2776
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0253 0.0299 0.0299
Trichomonas vaginalis Esterase, putative 0.0132 0.0145 0.2299
Echinococcus granulosus cpg binding protein 0.0066 0.0059 0.0059
Echinococcus granulosus jumonji domain containing protein 0.0043 0.0029 0.0029
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0064 0.0057 0.0057
Trypanosoma brucei ISWI complex protein 0.0046 0.0034 0.1848
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0075 0.0071 1
Mycobacterium ulcerans esterase LipW 0.0132 0.0145 1
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.0299 0.5108
Schistosoma mansoni hypothetical protein 0.0288 0.0344 0.0344
Loa Loa (eye worm) MBCTL1 0.0054 0.0044 0.0044
Echinococcus granulosus geminin 0.0677 0.0843 0.0842
Toxoplasma gondii aldehyde dehydrogenase 0.012 0.0128 0.8795
Loa Loa (eye worm) inositol-1 0.0075 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0212 0.0247 0.0247
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0134 0.0147 0.0147
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0034 0.0018 0.1075
Brugia malayi aryl-acylamidase 0.0132 0.0145 0.2819
Onchocerca volvulus 0.0462 0.0567 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.0056 0.0056
Mycobacterium leprae Possible lipase LipU 0.0132 0.0145 0.3581
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0019 0.0016
Echinococcus multilocularis sentrin specific protease 1 0.0046 0.0034 0.0034
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.0044 0.0044
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0034 0.0018 0.0728
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0034 0.0018 0.1075
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0049 0.0038 0.2178
Echinococcus multilocularis zinc finger protein 0.0066 0.0059 0.0059
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0049 0.0038 0.3216
Schistosoma mansoni cpg binding protein 0.0066 0.0059 0.0059
Echinococcus multilocularis jumonji domain containing 1A 0.0026 0.0009 0.0008
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.012 0.0128 0.0128
Loa Loa (eye worm) hypothetical protein 0.0046 0.0034 0.0034
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0036 0.0036
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0061 0.0061
Brugia malayi hypothetical protein 0.0122 0.0131 0.2534
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0034 0.0018 0.0728
Onchocerca volvulus 0.0132 0.0145 0.2361
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0162 0.0182 0.0182
Schistosoma mansoni cpg binding protein 0.0066 0.0059 0.0059
Mycobacterium ulcerans membrane-bound esterase LipM 0.0132 0.0145 1
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0061 0.0061
Onchocerca volvulus Huntingtin homolog 0.0122 0.0131 0.211
Schistosoma mansoni methyl-cpg binding protein mbd 0.0051 0.004 0.004
Mycobacterium tuberculosis Probable esterase LipC 0.0132 0.0145 0.458
Trichomonas vaginalis Esterase, putative 0.0132 0.0145 0.2299
Loa Loa (eye worm) jmjC domain-containing protein 0.0026 0.0009 0.0009
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0056 0.3488
Loa Loa (eye worm) hypothetical protein 0.0026 0.0009 0.0009
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.325 0.4142 0.4141
Trichomonas vaginalis Esterase, putative 0.0132 0.0145 0.2299
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0058 0.0049 0.2971
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.01 0.0103 0.6961
Leishmania major cathepsin L-like protease 0.0063 0.0056 0.3488
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0034 0.0018 0.0728
Leishmania major cathepsin L-like protease 0.0063 0.0056 0.3488
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0098 0.0101 0.2985
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0034 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0034 0.0019 0.0019
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0057 0.354
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0034 0.0018 0.1075
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0132 0.0145 0.0145
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0014 0.0014
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.0128 0.87
Schistosoma mansoni serine/threonine protein kinase 0.01 0.0103 0.0103
Trypanosoma cruzi trypanothione reductase, putative 0.0034 0.0018 0.0728
Mycobacterium tuberculosis Probable esterase/lipase LipF 0.0132 0.0145 0.458
Trypanosoma cruzi Alpha/beta hydrolase domain-containing protein 0.0132 0.0145 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0134 0.0147 0.0147
Echinococcus granulosus microtubule associated protein 2 0.2791 0.3553 0.3552
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0036 0.0036
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0123 0.0133 0.0133
Plasmodium falciparum glutathione reductase 0.0098 0.0101 1
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.0044 0.0044
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0187 0.0214 0.0214
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0056 0.3488
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0406 0.0496 0.0496
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0047 0.0036 0.0036
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0038 0.0364
Trypanosoma cruzi serine peptidase, Clan SC, Family S9D 0.0132 0.0145 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.014 0.0154 0.0154
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0034 0.0018 0.0018
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0034 0.0018 0.5
Mycobacterium ulcerans acetyl hydrolase MbtJ 0.0132 0.0145 1
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0064 0.0057 0.354
Entamoeba histolytica serine/threonine protein kinase, putative 0.01 0.0103 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0162 0.0182 0.0182
Echinococcus granulosus peregrin 0.0041 0.0028 0.0027
Entamoeba histolytica hypothetical protein 0.0038 0.0024 0.0528
Onchocerca volvulus Serine\/threonine kinase homolog 0.01 0.0103 0.1614
Brugia malayi jmjC domain containing protein 0.0026 0.0009 0.0034
Mycobacterium ulcerans carboxylesterase LipQ 0.0132 0.0145 1
Schistosoma mansoni microtubule-associated protein tau 0.2791 0.3553 0.3553
Echinococcus granulosus dnaJ subfamily B 0.0812 0.1015 0.1015
Plasmodium falciparum thioredoxin reductase 0.0034 0.0018 0.1075
Mycobacterium ulcerans esterase LipO 0.0132 0.0145 1
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0187 0.3078
Loa Loa (eye worm) acetyltransferase 0.0151 0.0168 0.0168
Echinococcus granulosus JmjC domain containing protein 4 0.0026 0.0009 0.0008

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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