TDR Targets

Basic information

Technical information

TDR Targets ID: 57339
Name: 1-[4-(2-phenethyloxyethoxy)phenoxy]-3-(propan -2-ylamino)propan-2-ol
MW: 373.486 | Formula: C22H31NO4
H donors: 2 H acceptors: 1 LogP: 3.42 Rotable bonds: 13
Rule of 5 violations (Lipinski): 1
SMILES: OC(COc1ccc(cc1)OCCOCCc1ccccc1)CNC(C)C
InChi: 1S/C22H31NO4/c1-18(2)23-16-20(24)17-27-22-10-8-21(9-11-22)26-15-14-25-13-12-19-6-4-3-5-7-19/h3-11,18,20,23-24H,12-17H2,1-2H3
InChiKey: FKOFOQSLZJGJHP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-(isopropylamino)-3-[4-(2-phenethyloxyethoxy)phenoxy]propan-2-ol
1-(isopropylamino)-3-[4-(2-phenethyloxyethoxy)phenoxy]-2-propanol
1-[4-[2-(2-phenylethoxy)ethoxy]phenoxy]-3-(propan-2-ylamino)propan-2-ol
1-(isopropylamino)-3-[4-[2-(2-phenylethoxy)ethoxy]phenoxy]propan-2-ol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	cathepsin L-like protease	0.1278	0.2616	0.8983
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0632	0.0622	0.1936
Entamoeba histolytica	cysteine proteinase, putative	0.0757	0.1008	0.3676
Echinococcus multilocularis	calpain A	0.1832	0.4326	0.395
Giardia lamblia	Cathepsin B precursor	0.1368	0.2894	0.5
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.1278	0.2616	1
Toxoplasma gondii	cathepsin B	0.1368	0.2894	1
Onchocerca volvulus		0.1278	0.2616	1
Onchocerca volvulus	Cathepsin L homolog	0.1278	0.2616	1
Echinococcus multilocularis	cathepsin b	0.3671	1	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.3671	1	1
Brugia malayi	calpain 7	0.0632	0.0622	0.0552
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0757	0.1008	0.3302
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1372	0.2904	1
Schistosoma mansoni	calpain (C02 family)	0.0632	0.0622	0.0546
Echinococcus granulosus	cathepsin L cysteine proteinase	0.1278	0.2616	0.2127
Trypanosoma cruzi	cysteine peptidase, putative	0.1278	0.2616	0.2616
Brugia malayi	Cathepsin L-like precursor	0.0858	0.132	0.1255
Loa Loa (eye worm)	hypothetical protein	0.1528	0.3386	0.3337
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1372	0.2904	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1278	0.2616	0.8526
Giardia lamblia	Cathepsin B precursor	0.1368	0.2894	0.5
Entamoeba histolytica	cysteine proteinase 2	0.0757	0.1008	0.3676
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.1368	0.2894	0.9965
Echinococcus multilocularis	cysteine protease	0.1278	0.2616	0.2127
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1278	0.2616	0.8526
Loa Loa (eye worm)	hypothetical protein	0.1705	0.3934	0.3889
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0757	0.1008	0.0936
Entamoeba histolytica	cysteine protease, putative	0.0757	0.1008	0.3676
Onchocerca volvulus		0.1278	0.2616	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1278	0.2616	0.8526
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0757	0.1008	0.1008
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.1278	0.2616	0.2561
Leishmania major	cathepsin L-like protease	0.1278	0.2616	0.8983
Trypanosoma cruzi	cysteine peptidase, putative	0.1372	0.2904	0.2904
Plasmodium vivax	vivapain-2	0.1278	0.2616	1
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.183	0.4319	0.3943
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.1278	0.2616	0.2127
Trypanosoma brucei	calpain-like protein, putative	0.0632	0.0622	0.1936
Leishmania major	cathepsin L-like protease	0.1278	0.2616	0.8983
Brugia malayi	Cathepsin L-like precursor	0.0858	0.132	0.1255
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.3671	1	1
Brugia malayi	cathepsin L-like precursor	0.0858	0.132	0.1255
Trypanosoma cruzi	cysteine protease, putative	0.0757	0.1008	0.1008
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1278	0.2616	0.8526
Entamoeba histolytica	cysteine protease, putative	0.0757	0.1008	0.3676
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1278	0.2616	0.8526
Loa Loa (eye worm)	hypothetical protein	0.3671	1	1
Schistosoma mansoni	Mername-AA248 (C02 family)	0.0632	0.0622	0.0546
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0632	0.0622	0.0622
Brugia malayi	Papain family cysteine protease containing protein	0.0757	0.1008	0.0941
Entamoeba histolytica	cysteine proteinase, putative	0.1278	0.2616	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1278	0.2616	0.8526
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1372	0.2904	1
Entamoeba histolytica	cysteine protease, putative	0.0757	0.1008	0.3676
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.3671	1	1
Onchocerca volvulus		0.1278	0.2616	1
Leishmania major	cathepsin L-like protease	0.1278	0.2616	0.8983
Plasmodium vivax	unspecified product	0.0757	0.1008	0.1938
Trypanosoma cruzi	kinesin, putative	0.0455	0.0074	0.0074
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.0632	0.0622	0.0622
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1372	0.2904	1
Brugia malayi	Cathepsin L-like precursor	0.1278	0.2616	0.2561
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1278	0.2616	0.8526
Entamoeba histolytica	cysteine protease, putative	0.0757	0.1008	0.3676
Entamoeba histolytica	cysteine proteinase, putative	0.0757	0.1008	0.3676
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1368	0.2894	0.2837
Loa Loa (eye worm)	cysteine protease	0.1278	0.2616	0.2561
Brugia malayi	Cathepsin L-like precursor	0.1278	0.2616	0.2561
Entamoeba histolytica	cysteine proteinase, putative	0.0757	0.1008	0.3676
Echinococcus multilocularis	cysteine protease	0.1278	0.2616	0.2127
Echinococcus multilocularis	cathepsin L cysteine protease	0.1278	0.2616	0.2127
Entamoeba histolytica	cysteine protease, putative	0.0757	0.1008	0.3676
Onchocerca volvulus		0.1278	0.2616	1
Entamoeba histolytica	cysteine proteinase, putative	0.1278	0.2616	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1278	0.2616	0.8526
Trypanosoma cruzi	cysteine peptidase, putative	0.0757	0.1008	0.1008
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1372	0.2904	1
Giardia lamblia	Cathepsin B precursor	0.1368	0.2894	0.5
Entamoeba histolytica	cysteine protease, putative	0.0757	0.1008	0.3676
Brugia malayi	Cathepsin L-like precursor	0.1278	0.2616	0.2561
Loa Loa (eye worm)	hypothetical protein	0.0858	0.132	0.1255
Plasmodium falciparum	cysteine proteinase falcipain 3	0.1278	0.2616	1
Loa Loa (eye worm)	hypothetical protein	0.1251	0.2531	0.2476
Brugia malayi	calpain family protein 1	0.1705	0.3934	0.3889
Brugia malayi	Cathepsin L-like precursor	0.1278	0.2616	0.2561
Brugia malayi	Papain family cysteine protease containing protein	0.0757	0.1008	0.0941
Trypanosoma brucei	antigen, putative	0.0632	0.0622	0.1936
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1278	0.2616	0.8526
Loa Loa (eye worm)	fibroinase	0.1278	0.2616	0.2561
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0952	0.1608	0.1608
Loa Loa (eye worm)	hypothetical protein	0.0858	0.132	0.1255
Entamoeba histolytica	cysteine protease, putative	0.0757	0.1008	0.3676
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1278	0.2616	0.8526
Brugia malayi	Cathepsin L-like precursor	0.1278	0.2616	0.2561
Loa Loa (eye worm)	ctsf protein	0.1278	0.2616	0.2561
Echinococcus multilocularis	cathepsin L	0.0757	0.1008	0.0412
Brugia malayi	Papain family cysteine protease containing protein	0.1278	0.2616	0.2561
Leishmania major	cysteine peptidase A (CPA)	0.1278	0.2616	0.8983
Onchocerca volvulus	Cathepsin F homolog	0.1278	0.2616	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.1278	0.2616	0.8526
Entamoeba histolytica	cysteine proteinase, putative	0.0858	0.132	0.4902
Leishmania major	calpain, putative,cysteine peptidase, Clan CA, family C2, putative	0.0632	0.0622	0.1936
Entamoeba histolytica	cysteine protease, putative	0.0757	0.1008	0.3676
Schistosoma mansoni	cathepsin F (C01 family)	0.1278	0.2616	0.2557
Brugia malayi	Cathepsin L-like precursor	0.1278	0.2616	0.2561
Trypanosoma brucei	cysteine peptidase C (CPC)	0.1368	0.2894	0.9965
Plasmodium vivax	vivapain-1	0.0757	0.1008	0.1938
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.1278	0.2616	0.8526
Loa Loa (eye worm)	hypothetical protein	0.1278	0.2616	0.2561
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0632	0.0622	0.1936
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1372	0.2904	1
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0632	0.0622	0.0622
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0632	0.0622	0.0622
Trypanosoma cruzi	kinesin, putative	0.0455	0.0074	0.0074
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.183	0.4319	0.4274
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0858	0.132	0.1653
Schistosoma mansoni	calpain C (C02 family)	0.0632	0.0622	0.0546
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0632	0.0622	0.0622
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0757	0.1008	0.0936
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0632	0.0622	0.0622
Trypanosoma brucei	calpain-like protein, putative	0.0632	0.0622	0.1936
Trypanosoma brucei	calpain-like protein, putative	0.0632	0.0622	0.1936
Onchocerca volvulus		0.1278	0.2616	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.1278	0.2616	0.2127
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0632	0.0622	0.0622
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1278	0.2616	0.8526
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.1278	0.2616	0.2561
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1372	0.2904	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0858	0.132	0.1653
Entamoeba histolytica	cysteine proteinase, putative	0.0757	0.1008	0.3676
Entamoeba histolytica	cysteine protease, putative	0.0757	0.1008	0.3676
Schistosoma mansoni	cathepsin F (C01 family)	0.1278	0.2616	0.2557
Schistosoma mansoni	calpain-7 (C02 family)	0.0632	0.0622	0.0546
Echinococcus granulosus	cysteine protease	0.0757	0.1008	0.0412
Loa Loa (eye worm)	calpain family protein 1	0.1251	0.2531	0.2476
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.183	0.4319	0.3943
Echinococcus granulosus	calpain A	0.1832	0.4326	0.395
Leishmania major	cathepsin L-like protease	0.1372	0.2904	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1278	0.2616	0.8526
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1372	0.2904	1
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.3671	1	1
Entamoeba histolytica	cysteine protease, putative	0.0757	0.1008	0.3676
Onchocerca volvulus		0.1278	0.2616	1
Entamoeba histolytica	cysteine protease, putative	0.0757	0.1008	0.3676
Leishmania major	cathepsin L-like protease	0.1278	0.2616	0.8983
Onchocerca volvulus	Cathepsin L homolog	0.1278	0.2616	1
Echinococcus multilocularis	cathepsin b	0.3671	1	1
Trypanosoma brucei	calpain-like protein, putative	0.0632	0.0622	0.1936
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.1368	0.2894	1
Entamoeba histolytica	cysteine protease, putative	0.0757	0.1008	0.3676
Loa Loa (eye worm)	hypothetical protein	0.1073	0.1983	0.1924
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1278	0.2616	0.8526
Trypanosoma cruzi	cysteine peptidase, putative	0.1372	0.2904	0.2904
Echinococcus multilocularis	calpain family protein 1, d	0.1251	0.2531	0.2036
Plasmodium vivax	vivapain-2	0.1278	0.2616	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1372	0.2904	1
Entamoeba histolytica	cysteine protease, putative	0.1278	0.2616	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0757	0.1008	0.1008
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0757	0.1008	0.3302
Trypanosoma cruzi	cysteine peptidase, putative	0.1372	0.2904	0.2904
Echinococcus multilocularis	cathepsin L cysteine protease	0.1278	0.2616	0.2127
Echinococcus granulosus	cathepsin L cysteine protease	0.0757	0.1008	0.0412
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0632	0.0622	0.0622
Echinococcus granulosus	cathepsin b	0.3671	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1278	0.2616	0.8526
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.1368	0.2894	0.2894
Echinococcus granulosus	cathepsin b	0.3671	1	1
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0632	0.0622	0.0622
Leishmania major	cathepsin L-like protease	0.1372	0.2904	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1278	0.2616	0.8526
Schistosoma mansoni	intracisternal A-particle retropepsin (A02 family)	0.2511	0.6422	0.6393
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1278	0.2616	0.8526
Onchocerca volvulus		0.1278	0.2616	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.1278	0.2616	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1278	0.2616	0.8526
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0632	0.0622	0.0622
Trypanosoma cruzi	cysteine proteinase, putative	0.0757	0.1008	0.1008
Entamoeba histolytica	cysteine protease, putative	0.0757	0.1008	0.3676
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1278	0.2616	0.8526
Loa Loa (eye worm)	calpain	0.0632	0.0622	0.0552
Echinococcus granulosus	cathepsin l1	0.0858	0.132	0.0745
Onchocerca volvulus		0.1073	0.1983	0.5117
Echinococcus granulosus	cathepsin L	0.0757	0.1008	0.0412
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0632	0.0622	0.1936
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1278	0.2616	0.8526
Leishmania major	cathepsin L-like protease	0.1372	0.2904	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1278	0.2616	0.8526
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.1705	0.3934	0.3886
Trypanosoma cruzi	cruzipain precursor, putative	0.1372	0.2904	0.2904
Loa Loa (eye worm)	hypothetical protein	0.0858	0.132	0.1255
Entamoeba histolytica	cysteine proteinase 1, putative	0.0757	0.1008	0.3676
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1278	0.2616	0.8526
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1372	0.2904	1
Schistosoma mansoni	calpain-7 (C02 family)	0.0632	0.0622	0.0546
Loa Loa (eye worm)	cathepsin B	0.1368	0.2894	0.2841
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1278	0.2616	0.8526
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.3671	1	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0757	0.1008	0.0936
Echinococcus granulosus	cathepsin l1	0.1278	0.2616	0.2127
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1372	0.2904	1
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0858	0.132	0.1255
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.183	0.4319	0.4274
Brugia malayi	calpain family protein 1	0.1705	0.3934	0.3889
Plasmodium vivax	vivapain-3	0.0757	0.1008	0.1938
Echinococcus granulosus	cathepsin l cysteine peptidase	0.1278	0.2616	0.2127
Schistosoma mansoni	cathepsin F (C01 family)	0.0858	0.132	0.125
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0632	0.0622	0.1936
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1278	0.2616	0.8526
Loa Loa (eye worm)	calpain family protein 1	0.1705	0.3934	0.3889

Activities

Activity type	Activity value	Assay description	Source	Reference
ED30 (functional)	= 20 ug kg-1	Beta agonistic activity as the dose required to increase heart rate by 30 beats/min in anesthetized rats upon intravenous administration	ChEMBL.	6138435
ED30 (functional)	= 20 ug kg-1	Beta agonistic activity as the dose required to increase heart rate by 30 beats/min in anesthetized rats upon intravenous administration	ChEMBL.	6138435
ED50 (functional)	= 15 ug kg-1	Beta-1 adrenoceptor blocking activity as the dose required to inhibit 50% of tachycardia in anesthetized rats	ChEMBL.	6138435
ED50 (functional)	= 15 ug kg-1	Beta-1 adrenoceptor blocking activity as the dose required to inhibit 50% of tachycardia in anesthetized rats	ChEMBL.	6138435
ED50 (functional)	> 50000 ug kg-1	Beta-2 adrenergic receptor antagonist activity as the dose required to inhibit 50% of vasodepressor response in anesthetized rats	ChEMBL.	6138435
ED50 (functional)	> 50000 ug kg-1	Beta-2 adrenergic receptor antagonist activity as the dose required to inhibit 50% of vasodepressor response in anesthetized rats	ChEMBL.	6138435

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL41360
PubChem: 13210828

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 57339