Detailed information for compound 574046

Basic information

Technical information
  • TDR Targets ID: 574046
  • Name: (4-chlorophenyl) 2-(4-chlorophenoxy)-2-methyl -propanoate
  • MW: 325.187 | Formula: C16H14Cl2O3
  • H donors: 0 H acceptors: 1 LogP: 5.22 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)OC(=O)C(Oc1ccc(cc1)Cl)(C)C
  • InChi: 1S/C16H14Cl2O3/c1-16(2,21-14-9-5-12(18)6-10-14)15(19)20-13-7-3-11(17)4-8-13/h3-10H,1-2H3
  • InChiKey: NIVDRJXCJCEFDD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-(4-chlorophenoxy)-2-methylpropanoic acid (4-chlorophenyl) ester
  • 2-(4-chlorophenoxy)-2-methyl-propionic acid (4-chlorophenyl) ester
  • (4-chlorophenyl) 2-(4-chlorophenoxy)-2-methylpropanoate
  • dulofibrate
  • 61887-16-9
  • Dulofibrato [INN-Spanish]
  • Dulofibratum [INN-Latin]
  • p-Chlorophenyl 2-(p-chlorophenoxy)-2-methylpropionate
  • Dulofibrate [INN]

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi ISWI complex protein 0.0047 0.0089 0.1412
Echinococcus multilocularis thioredoxin glutathione reductase 0.0116 0.042 0.039
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0103 0.0103
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0241 0.1027 0.331
Toxoplasma gondii thioredoxin reductase 0.0114 0.0413 0.137
Brugia malayi PHD-finger family protein 0.0088 0.0286 0.0724
Echinococcus granulosus lysine specific demethylase 5A 0.0222 0.0937 0.0909
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0119 0.0185
Echinococcus granulosus JmjC domain containing protein 4 0.0057 0.0138 0.0107
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0029 0.0001 0.0004
Brugia malayi Bromodomain containing protein 0.0233 0.0989 0.2499
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0057 0.0138 0.2707
Echinococcus multilocularis mitogen activated protein kinase 0.0053 0.0119 0.0088
Schistosoma mansoni hypothetical protein 0.0035 0.0031 0.0031
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0057 0.0138 0.0138
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0306 0.1343 0.2913
Echinococcus multilocularis lysine specific demethylase 6a 0.0057 0.0138 0.0107
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0047 0.0087 0.022
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0043 0.0016
Trypanosoma brucei protein kinase, putative 0.0053 0.0119 0.2889
Brugia malayi latrophilin 2 splice variant baaae 0.0032 0.0015 0.0039
Loa Loa (eye worm) hypothetical protein 0.0047 0.0087 0.0204
Loa Loa (eye worm) hypothetical protein 0.0146 0.0568 0.1423
Trichomonas vaginalis esterase, putative 0.0038 0.0043 0.0016
Plasmodium falciparum glutathione reductase 0.0114 0.0413 0.1344
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0289 0.1261 0.4096
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0043 0.0016
Echinococcus multilocularis dnaJ subfamily B 0.0429 0.1935 0.1909
Onchocerca volvulus Huntingtin homolog 0.0128 0.0482 0.1053
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0071 0.0206 0.0175
Plasmodium falciparum phd finger protein, putative 0.0088 0.0286 0.0923
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.004 0.0052 0.0021
Schistosoma mansoni jumonji/arid domain-containing protein 0.0222 0.0937 0.0937
Echinococcus multilocularis microtubule associated protein 2 0.2096 1 1
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0119 0.0185
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.004 0.0052 0.0029
Onchocerca volvulus 0.0122 0.0451 0.0985
Onchocerca volvulus 0.0963 0.4522 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0289 0.1261 0.5187
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.026 0.112 0.4588
Schistosoma mansoni myelin transcription factor 1 myt1 0.0057 0.0136 0.0136
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.004 0.0052 0.0428
Echinococcus granulosus phd:f box containing protein 0.0057 0.0138 0.0107
Trypanosoma cruzi ISWI complex protein 0.0047 0.0089 0.1412
Loa Loa (eye worm) jmjC domain-containing protein 0.0222 0.0937 0.2356
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.004 0.0052 0.0173
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0071 0.0206 0.0206
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0053 0.0119 0.2208
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0043 0.0016
Loa Loa (eye worm) thioredoxin reductase 0.0114 0.0413 0.1029
Echinococcus granulosus transcription factor Dp 1 0.004 0.0055 0.0023
Plasmodium falciparum thioredoxin reductase 0.0114 0.0413 0.1344
Toxoplasma gondii PHD-finger domain-containing protein 0.0088 0.0286 0.095
Schistosoma mansoni hypothetical protein 0.0088 0.0286 0.0286
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0069 0.0196 0.0494
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0053 0.0119 0.0396
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0036 0.0005
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0069 0.0196 0.0165
Loa Loa (eye worm) PHD-finger family protein 0.0064 0.0169 0.0411
Brugia malayi beta-lactamase family protein 0.0038 0.0043 0.011
Brugia malayi PHD-finger family protein 0.0036 0.0037 0.0093
Schistosoma mansoni phd/f-box containing protein 0.0057 0.0138 0.0138
Echinococcus granulosus neuropeptide s receptor 0.0477 0.2167 0.2143
Brugia malayi mbt repeat family protein 0.005 0.0103 0.026
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0088 0.0286 0.0286
Trypanosoma cruzi trypanothione reductase, putative 0.004 0.0052 0.0428
Plasmodium falciparum thioredoxin reductase 0.004 0.0052 0.0144
Echinococcus multilocularis peregrin 0.0095 0.0322 0.0291
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.005 0.0103 0.0213
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0196 0.4233
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0133 0.0506 0.1264
Brugia malayi hypothetical protein 0.0035 0.0031 0.0079
Loa Loa (eye worm) MH2 domain-containing protein 0.0121 0.0444 0.1108
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0053 0.0119 0.2208
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0043 0.0012
Echinococcus multilocularis zinc finger protein 0.0062 0.0161 0.0131
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.004 0.0052 0.0428
Plasmodium falciparum glutathione reductase 0.004 0.0052 0.0144
Trypanosoma brucei ISWI complex protein 0.0047 0.0089 0.2163
Brugia malayi PHD-finger family protein 0.0079 0.0241 0.0609
Mycobacterium tuberculosis Probable oxidoreductase 0.0289 0.1261 0.4096
Leishmania major dihydrolipoamide dehydrogenase, putative 0.004 0.0052 0.0428
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0036 0.0005
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0043 0.1053
Echinococcus granulosus lysine specific demethylase 6a 0.0057 0.0138 0.0107
Echinococcus multilocularis jumonji domain containing 1A 0.0057 0.0138 0.0107
Brugia malayi jmjC domain containing protein 0.0057 0.0138 0.0349
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0047 0.0087 0.0204
Plasmodium vivax SET domain protein, putative 0.0122 0.0451 0.1471
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0053 0.0119 0.0285
Echinococcus granulosus dnaJ subfamily B 0.0429 0.1935 0.1909
Leishmania major hypothetical protein, conserved 0.0047 0.0089 0.1412
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0306 0.1343 0.2913
Brugia malayi jmjC domain containing protein 0.0057 0.0138 0.0349
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.004 0.0052 0.0132
Loa Loa (eye worm) MBCTL1 0.0057 0.0136 0.0328
Loa Loa (eye worm) hypothetical protein 0.0038 0.0043 0.0094
Treponema pallidum hypothetical protein 0.0652 0.3015 1
Echinococcus multilocularis cpg binding protein 0.0038 0.0043 0.0012
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.015 0.0585 0.1822
Loa Loa (eye worm) jmjC domain-containing protein 0.0057 0.0138 0.0333
Loa Loa (eye worm) hypothetical protein 0.0218 0.0917 0.2304
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.004 0.0052 0.0021
Brugia malayi mbt repeat family protein 0.005 0.0103 0.026
Loa Loa (eye worm) bromodomain containing protein 0.0055 0.0125 0.0299
Mycobacterium tuberculosis Probable 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase IspF (MECPS) 0.0523 0.239 0.7896
Schistosoma mansoni hypothetical protein 0.0032 0.0015 0.0015
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0043 0.0115
Loa Loa (eye worm) hypothetical protein 0.0175 0.0706 0.177
Echinococcus multilocularis jumonji domain containing protein 0.0122 0.0453 0.0423
Echinococcus multilocularis SAM and MBT domain containing protein 0.005 0.0103 0.0072
Schistosoma mansoni zinc finger protein 0.0047 0.0089 0.0089
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0306 0.1343 0.2913
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.015 0.0585 0.1822
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0036 0.0005
Loa Loa (eye worm) hypothetical protein 0.0038 0.0043 0.0094
Brugia malayi Calcitonin receptor-like protein seb-1 0.0047 0.0087 0.022
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0122 0.0451 0.0451
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0306 0.1343 0.2913
Plasmodium vivax JmjC domain containing protein 0.0057 0.0138 0.043
Echinococcus granulosus jumonji domain containing 1A 0.0057 0.0138 0.0107
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.026 0.112 0.3623
Echinococcus granulosus fetal alzheimer antigen falz 0.0071 0.0206 0.0175
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0065 0.0175 0.0144
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0084 0.0266 0.0266
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.004 0.0052 0.1265
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0084 0.0266 0.0235
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0043 0.0016
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0186 0.076 0.0731
Trichomonas vaginalis set domain proteins, putative 0.0963 0.4522 1
Onchocerca volvulus 0.0038 0.0043 0.0082
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.004 0.0052 0.0144
Mycobacterium ulcerans flavoprotein disulfide reductase 0.004 0.0052 0.0029
Schistosoma mansoni protein phosphatase 2C 0.0057 0.0138 0.0138
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.005 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.018 0.073 0.1832
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0029 0.0001 0.0004
Brugia malayi jmjC domain containing protein 0.0057 0.0138 0.0349
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.0119 0.2208
Schistosoma mansoni zinc finger protein 0.0062 0.0161 0.0161
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0069 0.0196 0.0479
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0306 0.1343 0.2913
Brugia malayi follicle stimulating hormone receptor 0.0245 0.1047 0.2646
Toxoplasma gondii PHD-finger domain-containing protein 0.0088 0.0286 0.095
Trypanosoma brucei trypanothione reductase 0.0114 0.0413 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0043 0.0094
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0196 0.4737
Loa Loa (eye worm) hypothetical protein 0.0038 0.0043 0.0094
Echinococcus granulosus histone lysine methyltransferase setb 0.0175 0.0706 0.0676
Echinococcus granulosus thioredoxin glutathione reductase 0.0116 0.042 0.039
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0069 0.0196 0.1253
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0122 0.0451 0.0451
Loa Loa (eye worm) apoptosis regulator protein 0.0084 0.0266 0.0656
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0041 0.0058 0.0058
Echinococcus granulosus SAM and MBT domain containing protein 0.005 0.0103 0.0072
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0036 0.0036
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0069 0.0196 0.0165
Echinococcus multilocularis muscleblind protein 1 0.0146 0.0568 0.0539
Echinococcus granulosus polycomb protein SCMH1 0.005 0.0103 0.0072
Loa Loa (eye worm) jmjC domain-containing protein 0.0182 0.0739 0.1855
Loa Loa (eye worm) mbt repeat family protein 0.005 0.0103 0.0244
Loa Loa (eye worm) hypothetical protein 0.0036 0.0036 0.0075
Schistosoma mansoni methyl-cpg binding protein mbd 0.0053 0.0115 0.0115
Schistosoma mansoni phosphatidylserine receptor 0.0057 0.0138 0.0138
Plasmodium falciparum 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 0.0652 0.3015 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0015 0.0023
Onchocerca volvulus Alhambra homolog 0.0088 0.0286 0.062
Giardia lamblia NADH oxidase lateral transfer candidate 0.004 0.0052 0.0124
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0289 0.1261 0.4096
Leishmania major hypothetical protein, conserved 0.0057 0.0138 0.2707
Schistosoma mansoni jumonji/arid domain-containing protein 0.0222 0.0937 0.0937
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0036 0.0005
Schistosoma mansoni jumonji domain containing protein 0.0337 0.1492 0.1492
Echinococcus multilocularis neuropeptide receptor A26 0.0477 0.2167 0.2143
Echinococcus granulosus histone acetyltransferase MYST2 0.0057 0.0136 0.0105
Brugia malayi hypothetical protein 0.0137 0.0523 0.1322
Schistosoma mansoni bromodomain containing protein 0.0197 0.0814 0.0814
Echinococcus granulosus muscleblind protein 0.0146 0.0568 0.0539
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0084 0.0266 0.0235
Loa Loa (eye worm) hypothetical protein 0.0137 0.0523 0.1308
Echinococcus granulosus peregrin 0.0095 0.0322 0.0291
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0306 0.1343 1
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0057 0.0136 0.0344
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0036 0.0005
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0053 0.0119 0.2208
Echinococcus multilocularis JmjC domain containing protein 4 0.0057 0.0138 0.0107
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0084 0.0266 0.0235
Plasmodium vivax 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, putative 0.0652 0.3015 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1644 0.7813 0.7806
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.0191 0.0191
Schistosoma mansoni apoptosis regulator bax 0.0084 0.0266 0.0266
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0245 0.1047 0.2634
Loa Loa (eye worm) hypothetical protein 0.0038 0.0043 0.0094
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0043 0.0043
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0122 0.0451 0.1496
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0069 0.0196 0.0196
Giardia lamblia Kinase, CMGC MAPK 0.0053 0.0119 0.0637
Mycobacterium tuberculosis Probable dehydrogenase 0.026 0.112 0.3623
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0306 0.1343 0.2913
Loa Loa (eye worm) jmjC domain-containing protein 0.0057 0.0138 0.0333
Schistosoma mansoni microtubule-associated protein tau 0.2096 1 1
Schistosoma mansoni hypothetical protein 0.0084 0.0266 0.0266
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0053 0.0119 0.2208
Echinococcus granulosus cpg binding protein 0.0038 0.0043 0.0012
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.004 0.0052 0.0428
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.004 0.0052 0.0428
Plasmodium vivax hypothetical protein, conserved 0.0088 0.0286 0.0923
Brugia malayi CXXC zinc finger family protein 0.003 0.0007 0.0017
Schistosoma mansoni methyl-cpg binding protein mbd 0.0053 0.0115 0.0115
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0306 0.1343 0.2913
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0084 0.0266 0.0671
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0036 0.0005
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0043 0.011
Brugia malayi beta-lactamase family protein 0.0038 0.0043 0.011
Schistosoma mansoni hypothetical protein 0.0084 0.0266 0.0266
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0119 0.0119
Echinococcus granulosus PHD finger protein rhinoceros 0.0088 0.0286 0.0256
Toxoplasma gondii NADPH-glutathione reductase 0.004 0.0052 0.0173
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0119 0.0185
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0053 0.0115 0.0084
Trichomonas vaginalis glutathione reductase, putative 0.004 0.0052 0.0036
Loa Loa (eye worm) hypothetical protein 0.0126 0.0469 0.1171
Schistosoma mansoni cpg binding protein 0.0038 0.0043 0.0043
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.004 0.0052 0.1265
Loa Loa (eye worm) hypothetical protein 0.0146 0.0568 0.1423
Schistosoma mansoni hypothetical protein 0.0429 0.1935 0.1935
Loa Loa (eye worm) hypothetical protein 0.005 0.0103 0.0244
Schistosoma mansoni hypothetical protein 0.0084 0.0266 0.0266
Mycobacterium leprae Probable 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase IspF (MECPS) (MECDP-synthase ) 0.0523 0.239 1
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.015 0.0585 0.2307
Mycobacterium tuberculosis Putative ferredoxin reductase 0.026 0.112 0.3623
Schistosoma mansoni jumonji domain containing protein 0.0057 0.0138 0.0138
Brugia malayi Bromodomain containing protein 0.0118 0.0433 0.1093
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0396 0.1779 0.1753
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.004 0.0052 0.1265
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0396 0.1779 0.1753
Echinococcus multilocularis phd:f box containing protein 0.0057 0.0138 0.0107
Onchocerca volvulus 0.005 0.0103 0.0213
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.004 0.0052 0.0428
Toxoplasma gondii histone lysine methyltransferase SET1 0.0069 0.0194 0.0643
Brugia malayi F/Y-rich N-terminus family protein 0.0048 0.0095 0.0239
Echinococcus multilocularis polycomb protein SCMH1 0.005 0.0103 0.0072
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0114 0.0413 0.1243
Brugia malayi Pre-SET motif family protein 0.0847 0.3956 1
Brugia malayi Pre-SET motif family protein 0.0122 0.0451 0.114
Onchocerca volvulus 0.0137 0.0523 0.1144
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.004 0.0052 0.1265
Echinococcus granulosus mitogen activated protein kinase 3 0.0053 0.0119 0.0088
Plasmodium vivax glutathione reductase, putative 0.0114 0.0413 0.1344
Echinococcus multilocularis PHD finger protein rhinoceros 0.0088 0.0286 0.0256
Echinococcus multilocularis mitogen activated protein kinase 3 0.0053 0.0119 0.0088
Brugia malayi glutathione reductase 0.0114 0.0413 0.1044
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0197 0.0814 0.0785
Leishmania major acetoin dehydrogenase e3 component-like protein 0.004 0.0052 0.0428
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0175 0.0706 0.0706
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0111 0.0397 0.0367
Brugia malayi jmjC domain containing protein 0.0396 0.1779 0.4496
Brugia malayi MAP kinase sur-1 0.0053 0.0119 0.0302
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0043 0.0012
Schistosoma mansoni hypothetical protein 0.0047 0.0089 0.0089
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.004 0.0052 0.0052
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.026 0.112 0.3623
Loa Loa (eye worm) hypothetical protein 0.0038 0.0043 0.0094
Brugia malayi Bromodomain containing protein 0.0095 0.0322 0.0813
Toxoplasma gondii 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase domain-containing protein 0.0652 0.3015 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0138 0.0333
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0069 0.0196 0.4233
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0175 0.0706 0.0676
Loa Loa (eye worm) hypothetical protein 0.0128 0.0482 0.1204
Plasmodium vivax thioredoxin reductase, putative 0.0114 0.0413 0.1344
Brugia malayi MH2 domain containing protein 0.0121 0.0444 0.1123
Giardia lamblia PHD finger protein 15 0.0088 0.0286 0.1916
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0103 0.0103
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0186 0.076 0.0731
Brugia malayi jmjC domain containing protein 0.0222 0.0937 0.2369
Leishmania major trypanothione reductase 0.0114 0.0413 1
Wolbachia endosymbiont of Brugia malayi 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 0.0652 0.3015 1
Trypanosoma cruzi trypanothione reductase, putative 0.0114 0.0413 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0037 0.0077
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0196 0.4233
Chlamydia trachomatis 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 0.0652 0.3015 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0215 0.09 0.0872
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.0036 0.0036
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0119 0.0185
Echinococcus granulosus zinc finger protein 0.0062 0.0161 0.0131
Loa Loa (eye worm) hypothetical protein 0.0118 0.0434 0.1081
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0043 0.0196
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.004 0.0052 0.0428
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0197 0.0814 0.0785
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0111 0.0397 0.0367
Onchocerca volvulus Huntingtin homolog 0.0128 0.0482 0.1053
Mycobacterium tuberculosis Probable reductase 0.026 0.112 0.3623
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0117 0.0426 0.0396
Echinococcus multilocularis muscleblind protein 0.0146 0.0568 0.0539
Giardia lamblia Fructose-bisphosphate aldolase 0.0306 0.1343 1
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0057 0.0138 0.3344
Leishmania major hypothetical protein, conserved 0.0038 0.0043 0.0196
Onchocerca volvulus 0.0038 0.0043 0.0082
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0036 0.0091
Mycobacterium ulcerans 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 0.0652 0.3015 1
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0036 0.0874
Brugia malayi Thioredoxin reductase 0.0114 0.0413 0.1044
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0043 0.0094
Loa Loa (eye worm) jmjC domain-containing protein 0.0057 0.0138 0.0333
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0043 0.0196
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0065 0.0175 0.0144
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0847 0.3956 1
Onchocerca volvulus 0.0038 0.0043 0.0082
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0122 0.0451 0.0421
Trichomonas vaginalis mercuric reductase, putative 0.004 0.0052 0.0036
Echinococcus granulosus methyl CpG binding domain protein 2 0.0053 0.0115 0.0084
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0175 0.0706 0.0706
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0306 0.1343 1
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.004 0.0052 0.0029
Echinococcus granulosus neuropeptide receptor A26 0.0477 0.2167 0.2143
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.004 0.0052 0.0144
Schistosoma mansoni cpg binding protein 0.003 0.0007 0.0007
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0057 0.0136 0.0105
Loa Loa (eye worm) hypothetical protein 0.0128 0.0482 0.1204
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.004 0.0052 0.0144
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0057 0.0138 0.0458
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0036 0.0036
Echinococcus multilocularis transcription factor Dp 1 0.004 0.0055 0.0023
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.026 0.112 0.3623
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0057 0.0138 0.0458
Schistosoma mansoni cpg binding protein 0.0038 0.0043 0.0043
Brugia malayi jmjC domain containing protein 0.0057 0.0138 0.0349
Echinococcus multilocularis histone acetyltransferase MYST2 0.0057 0.0136 0.0105
Loa Loa (eye worm) hypothetical protein 0.0057 0.0138 0.0333
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.004 0.0052 0.0428
Loa Loa (eye worm) hypothetical protein 0.0088 0.0286 0.0708
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0031 0.0031
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.004 0.0052 0.0428
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.004 0.0052 0.0144
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.004 0.0052 0.0428
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0057 0.0138 0.2707
Loa Loa (eye worm) hypothetical protein 0.0084 0.0266 0.0656
Echinococcus multilocularis neuropeptide s receptor 0.0477 0.2167 0.2143
Brugia malayi beta-lactamase 0.0038 0.0043 0.011
Loa Loa (eye worm) glutathione reductase 0.0114 0.0413 0.1029
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0084 0.0266 0.0235
Schistosoma mansoni hypothetical protein 0.0304 0.1331 0.1331
Schistosoma mansoni hypothetical protein 0.0064 0.0169 0.0169
Loa Loa (eye worm) hypothetical protein 0.0057 0.0136 0.0328
Loa Loa (eye worm) transcription factor SMAD2 0.0121 0.0444 0.1108
Plasmodium falciparum JmjC domain-containing protein, putative 0.0057 0.0138 0.043
Toxoplasma gondii ABC1 family protein 0.0038 0.0043 0.0144
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0043 0.0016
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0053 0.0119 0.2889
Echinococcus granulosus mitogen activated protein kinase 0.0053 0.0119 0.0088
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0306 0.1343 0.2913
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.004 0.0052 0.0029
Brugia malayi hypothetical protein 0.0128 0.0482 0.1218
Loa Loa (eye worm) beta-lactamase 0.0038 0.0043 0.0094
Treponema pallidum fructose-bisphosphate aldolase 0.0306 0.1343 0.4356
Brugia malayi Muscleblind-like protein 0.0146 0.0568 0.1437
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.0119 0.2208
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0057 0.0136 0.0105
Leishmania major dihydrolipoamide dehydrogenase, putative 0.004 0.0052 0.0428
Loa Loa (eye worm) PHD-finger family protein 0.0088 0.0286 0.0708
Echinococcus granulosus jumonji domain containing protein 0.0122 0.0453 0.0423

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.