Detailed information for compound 574111

Basic information

Technical information
  • TDR Targets ID: 574111
  • Name: cobaltous 2-[(N'E)-N'-(5-chloro-1-oxo-2-napht hylidene)hydrazino]-5-nitro-phenolate
  • MW: 744.36 | Formula: C32H18Cl2CoN6O8
  • H donors: 2 H acceptors: 8 LogP: 8.78 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 2
  • SMILES: [O-]c1cc(ccc1N/N=C\1/C=Cc2c(C1=O)cccc2Cl)[N+](=O)[O-].[O-]c1cc(ccc1N/N=C\1/C=Cc2c(C1=O)cccc2Cl)[N+](=O)[O-].[Co+2]
  • InChi: 1S/2C16H10ClN3O4.Co/c2*17-12-3-1-2-11-10(12)5-7-14(16(11)22)19-18-13-6-4-9(20(23)24)8-15(13)21;/h2*1-8,18,21H;/q;;+2/p-2/b2*19-14+;
  • InChiKey: QHKWRRYLDSFBSC-BFOTTZSISA-L  


Substructure search Similarity search

Network

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Synonyms

  • cobaltous 2-[(N'E)-N'-(5-chloro-1-oxo-2-naphthylidene)hydrazino]-5-nitrophenolate
  • 2-[(2E)-2-(5-chloro-1-oxo-naphthalen-2-ylidene)hydrazinyl]-5-nitro-phenolate; cobalt(2+)
  • cobaltous 2-[(N'E)-N'-(5-chloro-1-keto-2-naphthylidene)hydrazino]-5-nitro-phenolate
  • 2-[(2E)-2-(5-chloro-1-oxonaphthalen-2-ylidene)hydrazinyl]-5-nitrophenolate; cobalt(2+)
  • Orasol Navy Blue 2RB
  • 2-[(2E)-2-(5-chloro-1-oxonaphthalen-2-ylidene)hydrazinyl]-5-nitrophenolate; cobalt(+2) cation
  • 2-[(2E)-2-(5-chloro-1-oxo-naphthalen-2-ylidene)hydrazinyl]-5-nitro-phenolate; cobalt(+2) cation
  • 61969-42-4
  • 1-NAPHTHALENOL, 5-CHLORO-2-((2-HYDROXY-4-NITROPHENYL)AZO)-, COBALT SALT (2:1)
  • 5-Chloro-2-((2-hydroxy-4-nitrophenyl)azo)-1-naphthalenol cobalt
  • C.I. Solvent Blue 53

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0118 0.0445 0.0428
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0063 0.0017
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0084 0.0285 0.0267
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.004 0.0072 0.1663
Schistosoma mansoni methyl-cpg binding protein mbd 0.0053 0.0135 0.0117
Loa Loa (eye worm) hypothetical protein 0.013 0.0501 0.1263
Echinococcus granulosus cpg binding protein 0.0038 0.0063 0.0045
Giardia lamblia Fructose-bisphosphate aldolase 0.0309 0.136 1
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0029 0.002 0.0455
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0309 0.136 0.2914
Echinococcus granulosus jumonji domain containing protein 0.0123 0.0472 0.0455
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.004 0.0072 0.1663
Brugia malayi jmjC domain containing protein 0.0029 0.0018 0.0045
Leishmania major acetoin dehydrogenase e3 component-like protein 0.004 0.0072 0.1663
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0056 0.014
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.005 0.0122 0.0213
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0057 0.0156 0.0138
Loa Loa (eye worm) jmjC domain-containing protein 0.0115 0.0432 0.1087
Echinococcus multilocularis mitogen activated protein kinase 0.0054 0.0139 0.0121
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0115 0.0432 0.1243
Schistosoma mansoni hypothetical protein 0.0084 0.0285 0.0267
Mycobacterium tuberculosis Probable oxidoreductase 0.0292 0.1278 0.4095
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0029 0.002 0.0455
Echinococcus granulosus neuropeptide s receptor 0.0481 0.2183 0.2169
Loa Loa (eye worm) hypothetical protein 0.0084 0.0285 0.0717
Loa Loa (eye worm) hypothetical protein 0.0038 0.0063 0.0159
Loa Loa (eye worm) mbt repeat family protein 0.005 0.0122 0.0308
Loa Loa (eye worm) hypothetical protein 0.0038 0.0063 0.0159
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0063 0.1462
Loa Loa (eye worm) hypothetical protein 0.0089 0.0305 0.077
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0054 0.0139 0.3215
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0053 0.0135 0.0117
Loa Loa (eye worm) beta-lactamase 0.0038 0.0063 0.0159
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0054 0.0139 0.3215
Schistosoma mansoni hypothetical protein 0.0029 0.002 0.0002
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0139 0.0186
Brugia malayi beta-lactamase 0.0038 0.0063 0.0159
Brugia malayi follicle stimulating hormone receptor 0.0247 0.1065 0.2684
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0063 0.0159
Brugia malayi jmjC domain containing protein 0.0029 0.0018 0.0045
Echinococcus granulosus methyl CpG binding domain protein 2 0.0053 0.0135 0.0117
Plasmodium vivax SET domain protein, putative 0.0123 0.047 0.1551
Loa Loa (eye worm) hypothetical protein 0.0038 0.0063 0.0159
Giardia lamblia Kinase, CMGC MAPK 0.0054 0.0139 0.0638
Echinococcus granulosus neuropeptide receptor A26 0.0481 0.2183 0.2169
Leishmania major hypothetical protein, conserved 0.0038 0.0063 0.1462
Treponema pallidum fructose-bisphosphate aldolase 0.0309 0.136 0.4357
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0151 0.0604 0.1822
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.004 0.0072 0.1663
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0063 0.0208
Loa Loa (eye worm) MH2 domain-containing protein 0.0122 0.0463 0.1167
Echinococcus multilocularis zinc finger protein 0.0063 0.0181 0.0163
Brugia malayi Pre-SET motif family protein 0.0854 0.3968 1
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0056 0.1289
Loa Loa (eye worm) hypothetical protein 0.0029 0.0018 0.0045
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0056 0.0038
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.0139 0.3215
Echinococcus granulosus peregrin 0.0096 0.0341 0.0323
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0029 0.0021 0.0053
Plasmodium vivax 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, putative 0.0657 0.3029 1
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0029 0.0018 0.0059
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.0056 0.1289
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0056 0.1289
Schistosoma mansoni methyl-cpg binding protein mbd 0.0053 0.0135 0.0117
Loa Loa (eye worm) hypothetical protein 0.013 0.0501 0.1263
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0292 0.1278 0.5186
Onchocerca volvulus 0.0123 0.047 0.0984
Echinococcus multilocularis peregrin 0.0096 0.0341 0.0323
Brugia malayi jmjC domain containing protein 0.0115 0.0432 0.1087
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0262 0.1138 0.3622
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0176 0.0724 0.0707
Trichomonas vaginalis esterase, putative 0.0038 0.0063 0.0017
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0056 0.0038
Toxoplasma gondii thioredoxin reductase 0.0115 0.0432 0.1425
Leishmania major dihydrolipoamide dehydrogenase, putative 0.004 0.0072 0.1663
Loa Loa (eye worm) hypothetical protein 0.0057 0.0156 0.0392
Loa Loa (eye worm) jmjC domain-containing protein 0.0183 0.0758 0.1909
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0029 0.0021 0.0053
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.0215 0.498
Leishmania major hypothetical protein, conserved 0.0029 0.0018 0.0415
Schistosoma mansoni jumonji/arid domain-containing protein 0.0115 0.0432 0.0414
Wolbachia endosymbiont of Brugia malayi 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 0.0657 0.3029 1
Chlamydia trachomatis 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 0.0657 0.3029 1
Trypanosoma cruzi trypanothione reductase, putative 0.0115 0.0432 1
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0199 0.0832 0.0816
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0176 0.0724 0.0707
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.004 0.0072 0.1663
Loa Loa (eye worm) thioredoxin reductase 0.0115 0.0432 0.1088
Plasmodium vivax hypothetical protein, conserved 0.0089 0.0305 0.1008
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.007 0.0215 0.0542
Brugia malayi glutathione reductase 0.0115 0.0432 0.1088
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0123 0.047 0.0453
Loa Loa (eye worm) hypothetical protein 0.0147 0.0587 0.1479
Mycobacterium ulcerans 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 0.0657 0.3029 1
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0089 0.0305 0.0288
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0056 0.0038
Echinococcus multilocularis histone acetyltransferase MYST2 0.0057 0.0156 0.0138
Toxoplasma gondii ABC1 family protein 0.0038 0.0063 0.0208
Mycobacterium tuberculosis Probable reductase 0.0262 0.1138 0.3622
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.004 0.0072 0.0237
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0309 0.136 1
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0036 0.0055 0.0037
Trypanosoma brucei ISWI complex protein 0.0048 0.0109 0.252
Brugia malayi PHD-finger family protein 0.0037 0.0056 0.0142
Brugia malayi Bromodomain containing protein 0.0096 0.0341 0.0859
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0151 0.0604 0.1822
Echinococcus multilocularis lysine specific demethylase 5A 0.0107 0.0395 0.0378
Echinococcus granulosus histone lysine methyltransferase setb 0.0176 0.0724 0.0707
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.004 0.0072 0.0237
Plasmodium falciparum glutathione reductase 0.0115 0.0432 0.1425
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0041 0.0077 0.0059
Loa Loa (eye worm) PHD-finger family protein 0.0089 0.0305 0.077
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0063 0.0045
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0123 0.047 0.0453
Loa Loa (eye worm) glutathione reductase 0.0115 0.0432 0.1088
Plasmodium falciparum glutathione reductase 0.004 0.0072 0.0237
Brugia malayi Thioredoxin reductase 0.0115 0.0432 0.1088
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0854 0.3968 1
Onchocerca volvulus 0.0038 0.0063 0.0082
Toxoplasma gondii histone lysine methyltransferase SET1 0.0069 0.0213 0.0704
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.004 0.0072 0.0237
Plasmodium falciparum thioredoxin reductase 0.004 0.0072 0.0237
Echinococcus multilocularis mitogen activated protein kinase 3 0.0054 0.0139 0.0121
Plasmodium vivax glutathione reductase, putative 0.0115 0.0432 0.1425
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0309 0.136 0.2914
Loa Loa (eye worm) hypothetical protein 0.0038 0.0063 0.0159
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0309 0.136 0.2914
Mycobacterium leprae Probable 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase IspF (MECPS) (MECDP-synthase ) 0.0527 0.2405 1
Schistosoma mansoni hypothetical protein 0.0084 0.0285 0.0267
Mycobacterium tuberculosis Probable dehydrogenase 0.0262 0.1138 0.3622
Echinococcus granulosus mitogen activated protein kinase 0.0054 0.0139 0.0121
Echinococcus granulosus muscleblind protein 0.0147 0.0587 0.057
Onchocerca volvulus Huntingtin homolog 0.013 0.0501 0.1054
Schistosoma mansoni hypothetical protein 0.0432 0.1951 0.1937
Leishmania major dihydrolipoamide dehydrogenase, putative 0.004 0.0072 0.1663
Echinococcus multilocularis jumonji domain containing protein 0.0123 0.0472 0.0455
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0056 0.0038
Loa Loa (eye worm) hypothetical protein 0.0038 0.0063 0.0159
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0051 0.0033
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.004 0.0072 0.1663
Loa Loa (eye worm) hypothetical protein 0.0037 0.0056 0.0142
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.004 0.0072 0.0237
Plasmodium vivax JmjC domain containing protein 0.0029 0.0018 0.0059
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0084 0.0285 0.0267
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0056 0.0038
Schistosoma mansoni hypothetical protein 0.0089 0.0305 0.0288
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0122 0.0105
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0029 0.0018 0.0415
Echinococcus granulosus fetal alzheimer antigen falz 0.0072 0.0225 0.0208
Echinococcus granulosus polycomb protein SCMH1 0.005 0.0122 0.0105
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0292 0.1278 0.4095
Toxoplasma gondii PHD-finger domain-containing protein 0.0089 0.0305 0.1008
Brugia malayi beta-lactamase family protein 0.0038 0.0063 0.0159
Loa Loa (eye worm) hypothetical protein 0.0029 0.0018 0.0045
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0063 0.0045
Brugia malayi F/Y-rich N-terminus family protein 0.0049 0.0114 0.0287
Schistosoma mansoni apoptosis regulator bax 0.0084 0.0285 0.0267
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0057 0.0156 0.0138
Echinococcus multilocularis microtubule associated protein 2 0.2113 1 1
Schistosoma mansoni hypothetical protein 0.0307 0.1349 0.1333
Brugia malayi MH2 domain containing protein 0.0122 0.0463 0.1167
Loa Loa (eye worm) jmjC domain-containing protein 0.0029 0.0018 0.0045
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0262 0.1138 0.3622
Mycobacterium ulcerans flavoprotein disulfide reductase 0.004 0.0072 0.0029
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.007 0.0215 0.498
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0056 0.0038
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1657 0.7818 0.7814
Echinococcus granulosus zinc finger protein 0.0063 0.0181 0.0163
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0247 0.1065 0.2684
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0084 0.0285 0.0717
Toxoplasma gondii 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase domain-containing protein 0.0657 0.3029 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.004 0.0072 0.0054
Brugia malayi jmjC domain containing protein 0.0029 0.0018 0.0045
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0309 0.136 0.2914
Echinococcus multilocularis SAM and MBT domain containing protein 0.005 0.0122 0.0105
Brugia malayi PHD-finger family protein 0.0079 0.026 0.0656
Trypanosoma brucei protein kinase, putative 0.0054 0.0139 0.3215
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0123 0.047 0.1551
Onchocerca volvulus Alhambra homolog 0.0089 0.0305 0.062
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0072 0.0225 0.0208
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0309 0.136 1
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0054 0.0139 0.3215
Echinococcus multilocularis neuropeptide receptor A26 0.0481 0.2183 0.2169
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0187 0.0779 0.0762
Loa Loa (eye worm) jmjC domain-containing protein 0.0029 0.0018 0.0045
Loa Loa (eye worm) hypothetical protein 0.0176 0.0724 0.1824
Brugia malayi hypothetical protein 0.013 0.0501 0.1263
Loa Loa (eye worm) hypothetical protein 0.0127 0.0488 0.1229
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0063 0.0045
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.029 0.1271 0.1256
Echinococcus granulosus PHD finger protein rhinoceros 0.0089 0.0305 0.0288
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0054 0.0139 0.0458
Treponema pallidum hypothetical protein 0.0657 0.3029 1
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.005 0.0122 0.0105
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.002 0.0065
Toxoplasma gondii NADPH-glutathione reductase 0.004 0.0072 0.0237
Loa Loa (eye worm) hypothetical protein 0.0152 0.0609 0.1534
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.004 0.0072 0.1663
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.004 0.0072 0.1663
Loa Loa (eye worm) PHD-finger family protein 0.0064 0.0188 0.0475
Loa Loa (eye worm) hypothetical protein 0.0134 0.0525 0.1322
Loa Loa (eye worm) hypothetical protein 0.0038 0.0063 0.0159
Echinococcus granulosus thioredoxin glutathione reductase 0.0117 0.0439 0.0422
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0084 0.0285 0.0267
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0069 0.0211 0.0193
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.004 0.0072 0.1663
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0029 0.002 0.0065
Schistosoma mansoni hypothetical protein 0.0064 0.0188 0.0171
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0036 0.0055 0.0037
Echinococcus granulosus lysine specific demethylase 5A 0.0115 0.0432 0.0414
Brugia malayi Muscleblind-like protein 0.0147 0.0587 0.1479
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0026 0.0066
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.007 0.0215 0.0197
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0243 0.1045 0.3311
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0309 0.136 0.2914
Loa Loa (eye worm) MBCTL1 0.0057 0.0156 0.0392
Leishmania major hypothetical protein, conserved 0.0048 0.0109 0.252
Schistosoma mansoni jumonji/arid domain-containing protein 0.0115 0.0432 0.0414
Giardia lamblia PHD finger protein 15 0.0089 0.0305 0.1915
Echinococcus multilocularis transcription factor Dp 1 0.004 0.0074 0.0056
Echinococcus granulosus SAM and MBT domain containing protein 0.005 0.0122 0.0105
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0151 0.0604 0.2308
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0176 0.0724 0.0707
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0051 0.0033
Trichomonas vaginalis set domain proteins, putative 0.0971 0.4533 1
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0084 0.0285 0.0267
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0063 0.0159
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0122 0.0105
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0063 0.0017
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0056 0.1289
Schistosoma mansoni zinc finger protein 0.0063 0.0181 0.0163
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0084 0.0285 0.0267
Schistosoma mansoni cpg binding protein 0.0038 0.0063 0.0045
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0262 0.1138 0.3622
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0054 0.0139 0.3215
Echinococcus granulosus mitogen activated protein kinase 3 0.0054 0.0139 0.0121
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.007 0.0215 0.1253
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0309 0.136 0.2914
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0309 0.136 0.2914
Loa Loa (eye worm) hypothetical protein 0.0147 0.0587 0.1479
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.004 0.0072 0.0054
Echinococcus multilocularis thioredoxin glutathione reductase 0.0117 0.0439 0.0422
Brugia malayi AF-10 protein 0.0029 0.002 0.005
Brugia malayi hypothetical protein 0.0036 0.0051 0.0128
Echinococcus granulosus transcription factor Dp 1 0.004 0.0074 0.0056
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.004 0.0072 0.0029
Brugia malayi mbt repeat family protein 0.005 0.0122 0.0308
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0063 0.0017
Echinococcus multilocularis muscleblind protein 0.0147 0.0587 0.057
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.004 0.0072 0.0029
Loa Loa (eye worm) hypothetical protein 0.0119 0.0453 0.114
Mycobacterium tuberculosis Probable 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase IspF (MECPS) 0.0527 0.2405 0.7896
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.0056 0.0036
Echinococcus multilocularis muscleblind protein 1 0.0147 0.0587 0.057
Brugia malayi MAP kinase sur-1 0.0054 0.0139 0.035
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0187 0.0779 0.0762
Schistosoma mansoni cpg binding protein 0.003 0.0026 0.0008
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0056 0.0038
Plasmodium falciparum 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 0.0657 0.3029 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0122 0.0308
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0309 0.136 0.2914
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.004 0.0072 0.0029
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0139 0.0186
Onchocerca volvulus 0.0038 0.0063 0.0082
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.004 0.0072 0.1663
Echinococcus multilocularis dnaJ subfamily B 0.0432 0.1951 0.1937
Loa Loa (eye worm) transcription factor SMAD2 0.0122 0.0463 0.1167
Trypanosoma cruzi trypanothione reductase, putative 0.004 0.0072 0.1663
Loa Loa (eye worm) bromodomain containing protein 0.0055 0.0144 0.0363
Schistosoma mansoni myelin transcription factor 1 myt1 0.0057 0.0156 0.0138
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0051 0.0033
Echinococcus multilocularis polycomb protein SCMH1 0.005 0.0122 0.0105
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0029 0.0018 0.0059
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0063 0.1462
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0262 0.1138 0.3622
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0072 0.0225 0.0208
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.004 0.0072 0.1663
Schistosoma mansoni cpg binding protein 0.0038 0.0063 0.0045
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0063 0.1462
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0029 0.0018 0.0415
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.004 0.0072 0.1663
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0057 0.0156 0.0392
Brugia malayi jmjC domain containing protein 0.0029 0.0018 0.0045
Brugia malayi Pre-SET motif family protein 0.0123 0.047 0.1184
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.0215 0.498
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0029 0.0094
Plasmodium vivax thioredoxin reductase, putative 0.0115 0.0432 0.1425
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.004 0.0072 0.1663
Echinococcus multilocularis PHD finger protein rhinoceros 0.0089 0.0305 0.0288
Onchocerca volvulus 0.0038 0.0063 0.0082
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0063 0.0045
Brugia malayi PHD-finger family protein 0.0089 0.0305 0.077
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0139 0.0186
Echinococcus multilocularis neuropeptide s receptor 0.0481 0.2183 0.2169
Loa Loa (eye worm) jmjC domain-containing protein 0.0029 0.0018 0.0045
Loa Loa (eye worm) hypothetical protein 0.0036 0.0056 0.014
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.004 0.0072 0.1663
Plasmodium falciparum JmjC domain-containing protein, putative 0.0029 0.0018 0.0059
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.004 0.0072 0.0181
Echinococcus granulosus histone acetyltransferase MYST2 0.0057 0.0156 0.0138
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.007 0.0215 0.0542
Toxoplasma gondii PHD-finger domain-containing protein 0.0089 0.0305 0.1008
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.007 0.0215 0.0197
Loa Loa (eye worm) apoptosis regulator protein 0.0084 0.0285 0.0717
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0056 0.0038
Trypanosoma brucei trypanothione reductase 0.0115 0.0432 1
Brugia malayi beta-lactamase family protein 0.0038 0.0063 0.0159
Brugia malayi CXXC zinc finger family protein 0.003 0.0026 0.0066
Schistosoma mansoni hypothetical protein 0.0048 0.0109 0.0091
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0112 0.0416 0.0399
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.007 0.0215 0.0197
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0199 0.0832 0.0816
Trichomonas vaginalis glutathione reductase, putative 0.004 0.0072 0.0036
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0063 0.0017
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0054 0.0139 0.3215
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.029 0.1271 0.1256
Brugia malayi Bromodomain containing protein 0.0119 0.0452 0.1138
Onchocerca volvulus 0.0971 0.4533 1
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0054 0.0139 0.035
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0262 0.1138 0.4587
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0063 0.0017
Brugia malayi mbt repeat family protein 0.005 0.0122 0.0308
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.0215 0.498
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0123 0.047 0.0453
Echinococcus granulosus dnaJ subfamily B 0.0432 0.1951 0.1937
Schistosoma mansoni bromodomain containing protein 0.0199 0.0832 0.0816
Schistosoma mansoni microtubule-associated protein tau 0.2113 1 1
Schistosoma mansoni hypothetical protein 0.0084 0.0285 0.0267
Echinococcus multilocularis cpg binding protein 0.0038 0.0063 0.0045
Schistosoma mansoni hypothetical protein 0.0036 0.0051 0.0033
Brugia malayi jmjC domain containing protein 0.029 0.1271 0.3204
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0031 0.0029 0.0094
Leishmania major trypanothione reductase 0.0115 0.0432 1
Trypanosoma cruzi ISWI complex protein 0.0048 0.0109 0.252
Onchocerca volvulus Huntingtin homolog 0.013 0.0501 0.1054
Trichomonas vaginalis mercuric reductase, putative 0.004 0.0072 0.0036
Schistosoma mansoni zinc finger protein 0.0048 0.0109 0.0091
Onchocerca volvulus 0.005 0.0122 0.0213
Schistosoma mansoni jumonji domain containing protein 0.0231 0.0986 0.0969
Giardia lamblia NADH oxidase lateral transfer candidate 0.004 0.0072 0.0124
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0292 0.1278 0.4095
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.0139 0.3215
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0029 0.0018 0.0415
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0139 0.0186
Trypanosoma cruzi ISWI complex protein 0.0048 0.0109 0.252
Loa Loa (eye worm) hypothetical protein 0.022 0.0935 0.2355
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.0139 0.0121
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.004 0.0072 0.0054
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0112 0.0416 0.0399
Plasmodium falciparum phd finger protein, putative 0.0089 0.0305 0.1008
Plasmodium falciparum thioredoxin reductase 0.0115 0.0432 0.1425
Brugia malayi Bromodomain containing protein 0.0235 0.1007 0.2537
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.004 0.0072 0.0237

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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